KCNT2

Potassium channel subfamily T, member 2, also known as KCNT2 is a human gene that encodes the K_Na protein. KCNT2, also known as the Slick channel (sequence like an intermediate calcium channel) is an outwardly rectifying potassium channel activated by internal raises in sodium or chloride ions.

KCNT2
Identifiers
Aliases	KCNT2, KCa4.2, SLICK, SLO2.1, potassium sodium-activated channel subfamily T member 2, EIEE57, DEE57
External IDs	OMIM: 610044; MGI: 3036273; HomoloGene: 16121; GeneCards: KCNT2; OMA:KCNT2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1q31.3 Start 196,225,779 bp End 196,609,225 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 F Start 140,173,896 bp End 140,539,805 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parietal pleura endothelial cell cartilage tissue Brodmann area 23 Brodmann area 46 middle temporal gyrus germinal epithelium Achilles tendon visceral pleura cardiac muscle tissue of right atrium Top expressed in aortic valve prefrontal cortex vas deferens primary motor cortex ascending aorta medial dorsal nucleus lateral septal nucleus cingulate gyrus dentate gyrus subdivision of hippocampus More reference expression data BioGPS n/a
Gene ontology Molecular function voltage-gated potassium channel activity ATP binding nucleotide binding potassium channel activity calcium-activated potassium channel activity intracellular sodium activated potassium channel activity outward rectifier potassium channel activity chloride-activated potassium channel activity Cellular component voltage-gated potassium channel complex integral component of membrane plasma membrane membrane Biological process potassium ion transmembrane transport potassium ion transport ion transport regulation of membrane potential potassium ion export across plasma membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 343450 240776 Ensembl ENSG00000162687 ENSMUSG00000052726 UniProt Q6UVM3 n/a RefSeq (mRNA) NM_001287819 NM_001287820 NM_198503 NM_001081027 RefSeq (protein) NP_001274748 NP_001274749 NP_940905 n/a Location (UCSC) Chr 1: 196.23 – 196.61 Mb Chr 1: 140.17 – 140.54 Mb PubMed search
Wikidata
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See also

• SK channel
• Voltage-gated potassium channel

Further reading

• Bhattacharjee A, Joiner WJ, Wu M, et al. (2003). "Slick (Slo2.1), a rapidly-gating sodium-activated potassium channel inhibited by ATP". J. Neurosci. 23 (37): 11681–91. doi:10.1523/JNEUROSCI.23-37-11681.2003. PMC 6740956. PMID 14684870.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Santi CM, Ferreira G, Yang B, et al. (2006). "Opposite regulation of Slick and Slack K+ channels by neuromodulators". J. Neurosci. 26 (19): 5059–68. doi:10.1523/JNEUROSCI.3372-05.2006. PMC 6674240. PMID 16687497.
• Wei AD, Gutman GA, Aldrich R, et al. (2005). "International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels". Pharmacol. Rev. 57 (4): 463–72. doi:10.1124/pr.57.4.9. PMID 16382103. S2CID 8290401.