Sym-norspermidine synthase

In enzymology, a sym-norspermidine synthase (EC 2.5.1.23) is an enzyme that catalyzes the chemical reaction

sym-norspermidine synthase
Identifiers
EC no.2.5.1.23
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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NCBIproteins
S-adenosylmethioninamine + propane-1,3-diamine 5'-methylthioadenosine + bis(3-aminopropyl)amine

Thus, the two substrates of this enzyme are S-adenosylmethioninamine and propane-1,3-diamine, whereas its two products are 5'-methylthioadenosine and bis(3-aminopropyl)amine.

This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is S-adenosylmethioninamine:propane-1,3-diamine 3-aminopropyltransferase. This enzyme participates in urea cycle and metabolism of amino groups.

References

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  • Aleksijevic A, Grove J, Schuber F (1979). "Studies on polyamine biosynthesis in Euglena gracilis". Biochim. Biophys. Acta. 565 (1): 199–207. doi:10.1016/0005-2787(79)90096-0. PMID 116684.
  • Villanueva VR, Adlakha RC, Calbayrac R (1980). "Biosynthesis of polyamines in Euglena gracilis". Phytochemistry. 19 (5): 787–790. doi:10.1016/0031-9422(80)85111-9.