TOMM70

Mitochondrial import receptor subunit TOM70, also known as translocase of outer mitochondrial membrane protein 70 is a protein that in humans is encoded by the TOMM70 gene.

TOMM70
Identifiers
Aliases	TOMM70, TOMM70A, Tom70, translocase of outer mitochondrial membrane 70
External IDs	OMIM: 606081; MGI: 106295; HomoloGene: 40112; GeneCards: TOMM70; OMA:TOMM70 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3q12.2 Start 100,363,431 bp End 100,401,089 bp
Gene location (Mouse) Chr. Chromosome 16 (mouse) Band 16 C1.1|16 34.22 cM Start 56,942,066 bp End 56,977,068 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell glutes Brodmann area 23 deltoid muscle parotid gland triceps brachii muscle Skeletal muscle tissue of biceps brachii Skeletal muscle tissue of rectus abdominis Brodmann area 46 middle temporal gyrus Top expressed in nucleus accumbens olfactory tubercle medullary collecting duct globus pallidus cingulate gyrus amygdala dorsomedial hypothalamic nucleus Paneth cell renal corpuscle Region I of hippocampus proper More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein transmembrane transporter activity protein binding Cellular component mitochondrial outer membrane extracellular exosome integral component of membrane mitochondrial outer membrane translocase complex membrane mitochondrion Biological process macroautophagy protein targeting to mitochondrion protein transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9868 28185 Ensembl ENSG00000154174 ENSMUSG00000022752 UniProt O94826 Q9CZW5 RefSeq (mRNA) NM_014820 NM_138599 RefSeq (protein) NP_055635 NP_613065 Location (UCSC) Chr 3: 100.36 – 100.4 Mb Chr 16: 56.94 – 56.98 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

The translocase of the outer mitochondrial membrane (TOM) complex is a multisubunit complex involved in the recognition, unfolding, and translocation of preproteins into the mitochondria. See TIM17A (MIM 605057).[supplied by OMIM]

See also

• TOMM20
• TOMM22
• TOMM40

Further reading

• Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
• Edmonson AM, Mayfield DK, Vervoort V, et al. (2002). "Characterization of a human import component of the mitochondrial outer membrane, TOMM70A". Cell Commun. Adhes. 9 (1): 15–27. doi:10.1080/15419060212186. PMID 12200962.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Young JC, Hoogenraad NJ, Hartl FU (2003). "Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the mitochondrial import receptor Tom70". Cell. 112 (1): 41–50. doi:10.1016/S0092-8674(02)01250-3. PMID 12526792.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Humphries AD, Streimann IC, Stojanovski D, et al. (2005). "Dissection of the mitochondrial import and assembly pathway for human Tom40". J. Biol. Chem. 280 (12): 11535–43. doi:10.1074/jbc.M413816200. PMID 15644312.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Chou CH, Lee RS, Yang-Yen HF (2006). "An Internal EELD Domain Facilitates Mitochondrial Targeting of Mcl-1 via a Tom70-dependent Pathway". Mol. Biol. Cell. 17 (9): 3952–63. doi:10.1091/mbc.E06-04-0319. PMC 1593170. PMID 16822835.
• Fan AC, Bhangoo MK, Young JC (2006). "Hsp90 functions in the targeting and outer membrane translocation steps of Tom70-mediated mitochondrial import". J. Biol. Chem. 281 (44): 33313–24. doi:10.1074/jbc.M605250200. PMID 16968702.