TRNA (cytidine32/guanosine34-2'-O)-methyltransferase (EC 2.1.1.205, Trm7p) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (cytidine32/guanosine34-2'-O)-methyltransferase.[1] This enzyme catalyses the following chemical reaction
| TRNA (cytidine32/guanosine34-2'-O)-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.205 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- S-adenosyl-L-methionine + cytidine32/guanosine34 in tRNA S-adenosyl-L-homocysteine + 2'-O-methylcytidine32/2'-O-methylguanosine34 in tRNA
The enzyme from Saccharomyces cerevisiae catalyses the formation of 2'-O-methylnucleotides at positions 32 and 34 of the yeast tRNAPhe and tRNATrp.
References
edit- ^ Pintard L, Lecointe F, Bujnicki JM, Bonnerot C, Grosjean H, Lapeyre B (April 2002). "Trm7p catalyses the formation of two 2'-O-methylriboses in yeast tRNA anticodon loop". The EMBO Journal. 21 (7): 1811–20. doi:10.1093/emboj/21.7.1811. PMC 125368. PMID 11927565.
External links
edit- TRNA+(cytidine32/guanosine34-2'-O)-methyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
