TRNA (cytidine32/guanosine34-2'-O)-methyltransferase

TRNA (cytidine32/guanosine34-2'-O)-methyltransferase (EC 2.1.1.205, Trm7p) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (cytidine32/guanosine34-2'-O)-methyltransferase.[1] This enzyme catalyses the following chemical reaction

TRNA (cytidine32/guanosine34-2'-O)-methyltransferase
Identifiers
EC no.2.1.1.205
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BRENDABRENDA entry
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MetaCycmetabolic pathway
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S-adenosyl-L-methionine + cytidine32/guanosine34 in tRNA S-adenosyl-L-homocysteine + 2'-O-methylcytidine32/2'-O-methylguanosine34 in tRNA

The enzyme from Saccharomyces cerevisiae catalyses the formation of 2'-O-methylnucleotides at positions 32 and 34 of the yeast tRNAPhe and tRNATrp.

References

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  1. ^ Pintard L, Lecointe F, Bujnicki JM, Bonnerot C, Grosjean H, Lapeyre B (April 2002). "Trm7p catalyses the formation of two 2'-O-methylriboses in yeast tRNA anticodon loop". The EMBO Journal. 21 (7): 1811–20. doi:10.1093/emboj/21.7.1811. PMC 125368. PMID 11927565.
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