tRNA-nucleotidyltransferase 1, is an enzyme that in humans is encoded by the TRNT1 gene .[ 5] [ 6] [ 7]
This enzyme adds the nucleotide sequence CCA to the 3' end of tRNA , using ATP and CTP as substrates. The sequence creates the binding site for an amino acid.[ 8]
^ a b c GRCh38: Ensembl release 89: ENSG00000072756 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000013736 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics" . Genome Res . 10 (5): 703–13. doi :10.1101/gr.10.5.703 . PMC 310876 . PMID 10810093 .
^ Nagaike T, Suzuki T, Tomari Y, Takemoto-Hori C, Negayama F, Watanabe K, Ueda T (Oct 2001). "Identification and characterization of mammalian mitochondrial tRNA nucleotidyltransferases" . J Biol Chem . 276 (43): 40041–9. doi :10.1074/jbc.M106202200 . PMID 11504732 .
^ "Entrez Gene: TRNT1 tRNA nucleotidyl transferase, CCA-adding, 1" .
^ Lizano E, Scheibe M, Rammelt C, Betat H, Mörl M (May 2008). "A comparative analysis of CCA-adding enzymes from human and E. coli: differences in CCA addition and tRNA 3'-end repair". Biochimie . 90 (5): 762–72. doi :10.1016/j.biochi.2007.12.007 . PMID 18226598 .
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Augustin MA, Reichert AS, Betat H, et al. (2003). "Crystal structure of the human CCA-adding enzyme: insights into template-independent polymerization" . J. Mol. Biol . 328 (5): 985–94. doi :10.1016/S0022-2836(03)00381-4 . PMID 12729736 .
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Lizano E, Schuster J, Müller M, et al. (2007). "A splice variant of the human CCA-adding enzyme with modified activity". J. Mol. Biol . 366 (4): 1258–65. doi :10.1016/j.jmb.2006.12.016 . PMID 17204286 .