TSEN2

tRNA-splicing endonuclease subunit Sen2 is an enzyme that in humans is encoded by the TSEN2 gene.

TSEN2
Identifiers
Aliases	TSEN2, PCH2B, SEN2, SEN2L, tRNA splicing endonuclease subunit 2
External IDs	OMIM: 608753; MGI: 2141599; HomoloGene: 41622; GeneCards: TSEN2; OMA:TSEN2 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3p25.2 Start 12,484,421 bp End 12,541,549 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 E3 Start 115,521,625 bp End 115,555,589 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell mucosa of transverse colon gonad ventricular zone testicle gastrocnemius muscle body of pancreas cerebellar hemisphere right uterine tube muscle of thigh Top expressed in Rostral migratory stream yolk sac epiblast primitive streak interventricular septum hand superior cervical ganglion otolith organ embryo utricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function tRNA-intron endonuclease activity protein binding lyase activity nucleic acid binding nuclease activity Cellular component centrosome nucleolus nucleus tRNA-intron endonuclease complex nucleoplasm cytosol Biological process mRNA processing tRNA-type intron splice site recognition and cleavage RNA phosphodiester bond hydrolysis, endonucleolytic tRNA splicing, via endonucleolytic cleavage and ligation RNA phosphodiester bond hydrolysis tRNA processing nucleic acid phosphodiester bond hydrolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 80746 381802 Ensembl ENSG00000154743 ENSMUSG00000042389 UniProt Q8NCE0 Q6P7W5 RefSeq (mRNA) NM_001145392 NM_001145393 NM_001145394 NM_001145395 NM_025265 NM_001321277 NM_001321278 NM_001321279 NM_199033 RefSeq (protein) NP_001138864 NP_001138865 NP_001138866 NP_001308206 NP_001308207 NP_001308208 NP_079541 NP_950198 Location (UCSC) Chr 3: 12.48 – 12.54 Mb Chr 6: 115.52 – 115.56 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

tRNA splicing is a fundamental process required for cell growth and division. SEN2 is a subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns, the first step in tRNA splicing (Paushkin et al., 2004).[supplied by OMIM]

Interactions

TSEN2 has been shown to interact with TSEN34 and TSEN15.

External links

• GeneReviews/NCBI/NIH/UW entry on Pontocerebellar Hypoplasia Type 2 and Type 4

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.