Talk:Cervical intraepithelial neoplasia

Wiki Education Foundation-supported course assignment

This article was the subject of a Wiki Education Foundation-supported course assignment, between 26 November 2018 and 21 December 2018. Further details are available on the course page. Student editor(s): Jhastie9. Peer reviewers: Kartafilos.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 18:50, 17 January 2022 (UTC)

Wiki Education Foundation-supported course assignment

This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): Grisreyes. Peer reviewers: Drus1a.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 17:08, 16 January 2022 (UTC)

CIN 4

CIN 4

When following the reference for CIN 4, it must be noted that the author of the paper does not talk or make any reference to CIN 4. The author talks about CIN 1 to 3, afterwhich he talks about the next stage of "invasive carcinoma". This "invasive carcinoma" is also called FIGO stage 0, or TNM Category Tis. I did a literature search and there is no mention about a CIN 4. I would like this seeing deleted. Objections??? Scubafish 15:40, 11 May 2007 (UTC)

You're right, it's nonsensical. I deleted it -Rustavo^{Talk/Contribs} 19:19, 11 May 2007 (UTC)

CIN Visual

I am a medical doctor specializing in internal medicine. I thought that the pictures in the Grades section were a bit confusing to those that may not understand CIN. Thus, I’d like to add the following graphic to help Wikipedians better understand the stages of CIN:

File:CINImage.jpg

I found this graphic on the following Web site and have obtained permission to post it on Wikipedia: http://www.thehpvtest.com/under-30/HPV-facts-cervical-cancer-faq.html#howlong

Drsavard (talk) 15:31, 14 March 2008 (UTC)

Merge Cervical dysplasia

The following discussion is closed. Please do not modify it. Subsequent comments should be made in a new section. A summary of the conclusions reached follows.

The result was merge into Cervical intraepithelial neoplasia. -- Zodon (talk) 07:16, 29 August 2008 (UTC)

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Suggest that Cervical dysplasia be merged into Cervical intraepithelial neoplasia they both say they are the same thing. Zodon (talk) 05:57, 26 August 2008 (UTC)

Agree They are effectively the same and the dysplasia article has nothing much in it. I support moving the content (if any) here and linking dysplasia to CIN. Chaldor (talk) 07:51, 26 August 2008 (UTC)

The discussion above is closed. Please do not modify it. Subsequent comments should be made on the appropriate discussion page. No further edits should be made to this discussion.

Integrating section from Bethesda System article

Recently the section on LSIL and HSIL was added (copied from Bethesda System). It needs some work to make the distinction between Pap results (cytology) and biopsy results (histology - CIN, etc.) clear. It could use some work to summarize the material on histology (no point in just duplicating material.)

The section in question is what was removed in this edit. (Sorry I didn't reproduce it here - a bit on large side). Suggestions for how to clearly handle? (Maintain distinction between cytology and histology (Pap vs. biopsy), and not duplicate material too much.) Thanks. Zodon (talk) 08:37, 6 April 2010 (UTC)

cervical cancer

We need to know abt the risk facter in cervical canser

Could have sections on Prevention, Clinical trials, Research

eg. a cancer vaccine is in Phase II clinical trials for cervical intraepithelial neoplasia.[1]. - Rod57 (talk) 12:46, 18 November 2016 (UTC)

Proposed Changes

- Article is in START status, would like to expand on article to include most/all components in the Wiki medicine Manual of Style: -Signs/symptoms -Causes and Risk factors -Subsection: Genetics -Pathogenesis / Pathophysiology -Diagnosis (biopsy findings) -Screening / Prevention -Treatment -Outcomes/Prognosis -Epidemiology -History -Research directions -Special populations (if possible)

-Would appreciate any feedback/questions/comments on proposed changes, thanks! Grisreyes (talk) 03:15, 14 March 2018 (UTC)

WikiProject medicine peer review

Overall some minor word and stylistic changes could greatly improve this article. I’m not sure which sections you worked on, comments for each section below with section header marked by bullets. General comments:

• Fix capitalisation in section headers throughout (only first word should be capitalised)
• Consider defining or simplifying complex medical terms throughout (ex: squamous lesions of the anogenital tract)
• Define acronyms at first use, use consistent language to refer to the same things
• Clarify difference between HPV infection, CIN, cancer - seems ‘infection’ is used interchangeably with CIN throughout the article when CIN is not an infection, right?

Specific section comments

• Header - Header could be simplified, for example first sentence could be broken up to make it more readable. Terms like “distinct degrees of differentiation” and “squamo-columnar” junction might be confusing to the lay person. Consider moving sentence about New Bethesda System classification to separate section
• Signs and symptoms - HPV - define or link to herpes article (definition appears in “Screening” section currently). Consider explaining link between HPV and CIN (HPV is risk factor for CIN?). Bethesda System sentence from header might fit best here.
• Prevention - Explanation of difference between primary and secondary prevention, or link to wiki articles) would be helpful here
• Causes and risk factors - This section would make sense as the first section (before signs and symptoms) since it explains
• Pathogenesis/pathophys - “While infection with HPV is needed for development of CIN” >> is this the only way to get CIN? If so, that could be clarified in causes and risk factors section. “anogenital epithelium” term might be confusing to layperson
• Classification - “the location of the infection” >> should ‘infection’ be replaces with ‘lesion’ or some other word? Is this referring to CIN or HPV? HPV-associated >> add dash
• Treatment - “Treatment for higher grade CIN involves removal or destruction of the neoplastic cervical cells” >> consider replacing neoplastic with abnormal, or defining it
• Outcomes and prognosis - “Progression to cancer typically takes 15 (3 to 40) years.” >> clarify that the parentheses are a range
• History - consider adding a citation or two

Cheers and happy editing! --Drus1a (talk) 01:08, 24 March 2018 (UTC)

Wikiproject Workplan Fall 2018

Aspect of workplan	Notes
Article chosen	Cervical Intraepithelial Neoplasia (Cervical Dysplasia)
Why this one?	Cervical intraepithelial neoplasia (CIN) is an important topic in women’s health that many patients are not educated on. This article is currently a Start and is of high and mid-importance in WikiProject Women’s Health and Wikiproject Medicine, respectively. As a future OB/GYN I would like to further my understanding of the management of CIN and learn how to explain follow-up to patients.
Initial Analysis of the article	The article is well organized and generally follows the WikiMedicine Manual of Style. The article covers each topic, but the subsections could be expanded
Overall organization, what changes	Change sections to provide more background/general information upfront; possibly divide prevention section into two categories: one aimed towards patients and the other towards providers; combine screening and prevention section path-> RF/causes-> S&S-> dx-> mgmt -> prevention/screening -> sequelae (need new word)
What will you add?	Graphics; links
What will you remove?	Considering removing History section - it doesn’t have a lot of text and isn’t relevant to the target audience (general population); primary sources in References
What will you augment?	Clarify HPV v CIN; diagnosis section - specifically description of Pap test; quality of links and References
What will you decrease coverage of?	n/a

Date	Goal
Mon 12/3 WP-WIP #1	Research started
Tues 12/11 WP-WIP #2	Finish research Edit content of diagnosis Merge screening and prevention Create provider and patient sections under prevention Gather image from WikiCommons or create own graphic remove history section
Fri 12/14 WP-WIP #3	Wrap up content changes organize references - remove primary sources Edit links (increase #, make more specific) Continue to gather images
Mon 12/17 WP-WIP #4	Complete first draft Work on self-edits to first draft Send 2nd draft to peer reviewer
Fri 12/21 Course Wrap-up	Incorporate edits from peer reviewer Finished product

Jhastie9 (talk) 04:47, 3 December 2018 (UTC)

 — Preceding unsigned comment added by Jhastie9 (talk • contribs) 04:34, 3 December 2018 (UTC) 

Overall, I'm very impressed with your work. I thought the article flows very well and is quite intelligible. A layperson could stumble on the page and, with a little assistance from internal Wiki links, have a solid grasp of CIN. The references look up-to-date and from authoritative sources.

In particular, I thought you did a great job distinguishing HPV and CIN - the article made the difference between the two quite clear. That said, I'd really hammer home the relationship between CIN and cervical cancer multiple times. For instance, in the "Signs and Symptoms" section, I'd add "If CIN is unchecked and becomes cervical cancer, possible symptoms include..."

Other suggestions:

The Berkeley rubric for Wiki articles recommends that info in the lead be also included in the body of the article. The CIN lead currently has info on the location of the lesion (at the junction) and the possible progression to squamous cell carcinoma that isn't in the body.

You've done a good job making the article accessible to non-practitioners, but there is still some opportunity to clear up the medical terminology (e.g., "basal," "managed expectantly", etc.).

In "Causes," it's unclear why some risk factors (e.g., birth before age 17) are given bullet points and others (e.g,. multiple sexual partners) are not. If the bullet point ones are more important risk factors, then say so explicitly. If they're all of comparable importance, then I'd give them all the same format.

I'd add a line or two explaining the relationship between College of American Pathology classification and the Bethesda system. If you can explain why the CAP felt the need to build on the Bethesda system (if that is indeed what they're doing), that'd be helpful.

In "Outcomes," it says that it was initially thought that CIN progressed through "these stages" but doesn't really say what "these stages" are. Presumably this means CIN I, CIN II, and CIN III?

Consider moving the discussion of HPV's effects on tumor suppressor genes from "Outcomes" to "Causes"

Consider adding the CIN/cervical cancer screening guidelines to the article.

I also made some minor edits myself (mostly changing "CIN1" to "CIN 1", a few intra-Wiki links), which you can see in the View History section.

--Kartafilos (talk) 04:28, 15 December 2018 (UTC)