Talk:Glyphosate

Neuro toxcity

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9101768/

Abstract

Glyphosate, a non-selective systemic biocide with broad-spectrum activity, is the most widely used herbicide in the world. It can persist in the environment for days or months, and its intensive and large-scale use can constitute a major environmental and health problem. In this systematic review, we investigate the current state of our knowledge related to the effects of this pesticide on the nervous system of various animal species and humans. The information provided indicates that exposure to glyphosate or its commercial formulations induces several neurotoxic effects. It has been shown that exposure to this pesticide during the early stages of life can seriously affect normal cell development by deregulating some of the signaling pathways involved in this process, leading to alterations in differentiation, neuronal growth, and myelination. Glyphosate also seems to exert a significant toxic effect on neurotransmission and to induce oxidative stress, neuroinflammation and mitochondrial dysfunction, processes that lead to neuronal death due to autophagy, necrosis, or apoptosis, as well as the appearance of behavioral and motor disorders. The doses of glyphosate that produce these neurotoxic effects vary widely but are lower than the limits set by regulatory agencies. Although there are important discrepancies between the analyzed findings, it is unequivocal that exposure to glyphosate produces important alterations in the structure and function of the nervous system of humans, rodents, fish, and invertebrates. 172.58.56.248 (talk) 01:12, 15 February 2024 (UTC)

MDPI predatory pay to publish journal. The International Journal of Molecular Science is an especially bad one, it seems. Since 2023, the journal has published over 11,000 papers. With 2023 alone having 24 issues of the journal with hundreds of papers in each issue. Add to that that the authors of this paper seem to almost exclusively publish papers on glyphosate and neonicotinoids and that they use multiple studies from discredited scientist Gilles-Éric Séralini and this isn't looking like much of an actual credible systematic review. Silverseren^C 01:32, 15 February 2024 (UTC)

+1

Besides, EFSA > other older metareviews.

Acc. to EFSA (Part 3, p 188): No issues, even the NOAEL are high: "The NOAEL for systemic toxicity is 395 mg/kg bw per day in males, based on reduced BWG and food consumption in the 90-day neurotoxicity study in rat (Report No. 2060-0010); in the absence of neurotoxicity findings, the NOAEL for sub-chronic neurotoxicity is confirmed to be ≥ 1499 mg/kg bw per day in males. This is in line with the conclusion reached in Report No. (additional 90-day neurotoxicity study in rats)." --Julius Senegal (talk) 12:01, 15 February 2024 (UTC)

Inaccurate sentence

Stauffer Chemical patented the agent as a chemical chelator - the source listed does not support that claim see also https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132386/ 156.146.156.168 (talk) 19:16, 15 March 2024 (UTC)

Thanks for catching that mistake. I made this edit, to correct it: [1]. --Tryptofish (talk) 21:15, 15 March 2024 (UTC)

Reference to parkinson disease

Why does the article contains no reference to parkinson disease? It has been notably linked to the subject, even if it might not be a causal relationship: https://www.euronews.com/health/2023/11/17/france-to-continue-compensating-farmers-with-parkinsons-disease-linked-to-glyphosate-use PhotographyEdits (talk) 21:25, 5 July 2024 (UTC)

Do you have actual published scientific studies showing such a link? Any sources related to medical effects would need to meet WP:MEDRS standards for inclusion. Silverseren^C 22:03, 5 July 2024 (UTC)

I have something, doi:10.1016/j.yrtph.2011.07.006: "Our review found no evidence of a consistent pattern of positive associations indicating a causal relationship between any disease and exposure to glyphosate.".

EFSA didn't find anything either. I think this concern comes mostly from Bastiaan Bloem.--Julius Senegal (talk) 12:27, 6 July 2024 (UTC)

That's pretty out of date in MEDRS terms (2011), but this was published in 2022: doi:10.1007/s00420-022-01878-0 and found the same: The five high-quality studies showed no association between glyphosate use and risk of depression, Parkinson disease, or peripheral nerve conduction velocity. SmartSE (talk) 12:54, 6 July 2024 (UTC)

Let me clarify: with 'link' I do not mean that the null hypothesis is false. The association has been made in the media at least, and if there are scientific studies that show there is no relationship, I think the proven lack of such relationship is worthy of inclusion. There is probably no health problems with phones (Wireless device radiation and health), but the studies are notable. PhotographyEdits (talk) 21:39, 6 July 2024 (UTC)

There have been, over the years, a lot of counter-scientific claims about supposed health harms associated with glyphosate. If we were to include this at all, it would be better to treat it as part of such a group. --Tryptofish (talk) 22:08, 6 July 2024 (UTC)

Inclusion into some counter-scientific section seems fine to me, assuming that is indeed the current scientific consensus (I'm surely no expert here). PhotographyEdits (talk) 00:11, 7 July 2024 (UTC)