Talk:Marfan syndrome

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Eyes

From the article:

Other reported symptoms are eye lenses falling out, and the inability to see objects moving in a direct line at the watcher. Some belief that the biblical story of Goliath is based on a man suffering from Marfan syndrome, which would explain his unusual height, and why he did not avoid a stone thrown at him.

Really? Evidence for all these assertions, please.

Oh I'm sorry! That's is acromegaly! Compare [1]. --Magnus Manske~

the wikipedia article on chromosome 19 lists marfan's as a disease of that gene. this article gives chromosome 15 as responsible for it. one of them must be correct. which is it?Cleobolus (talk) 17:23, 6 September 2009 (UTC)

Merger

This entry and the one on Marfan's syndrome clearly cover the same subject, so it would be good to unify them. -- Arteitle 06:50, 13 Sep 2003 (UTC)

Done. --Michael Snow 19:34, 10 Mar 2004 (UTC)

Lancet

The Lancet, Current Issue, Volume 366, Number 9501, 3 December 2005

has three articles about it. Anyone up to the job? JFW | T@lk 00:11, 4 December 2005 (UTC)

Losartan anyone

Works in mice: Habashi JP et al. Science. 2006;312:117-121 JFW | T@lk 23:39, 2 May 2006 (UTC)

Works in humans: Brooke BS et al. NEJM 358:2787 Nbauman (talk) 22:58, 28 June 2008 (UTC)

The reference 34 (Freeman, Elaine (Fall 2007). "A Silver Bullet for Blake". Johns Hopkins Magazine.) appears to be a magazine article about a young boy with Marfan's and the biography of the man leading the trial about losartan rather than a ?more reputable source. Perhaps it should be removed considering there are the resources mentioned above? RM 134.36.52.168 (talk) 00:40, 22 February 2013 (UTC)

Famous People

It is not proven that Jeffry Hyman AKA Joey Ramone had this syndrome.

I removed his name from the list. His brother has claimed in his biography and in multiple interviews that it was never diagnosed and that he didn't have it. The source on this article was from an interview with a woman with Marfan's who mentions Ramone. It's hearsay at best. --Utilizer (talk) 05:50, 8 August 2010 (UTC)

Is there any proof that Coulter has Marfan syndrome or is it just a rumor?

I added Kermit L. Hall given that from all the coverage of his sudden death that the circumstances of whatever "condition" that led to his death point to Mafans. (—Preceding unsigned comment added by Scrabbleship (talk • contribs) )

I have a big problem with adding speculative entries in the Famous people section. If you add an entry, I think it's incumbent upon you to cite the source. I am more concerned with living people as adding name here tends to have the appearance of an attack edit. I am not looking for a certified death certificate that says complications from Marfan Syndrome - just some WP:RS that qualifies if for inclusion. My $.02. --Geneb1955^Talk/_CVU 10:44, 5 October 2006 (UTC)

Speaking of "Famous Sufferers" of Marfan's, I find it doubtful that Osama bin Laden has Marfan's syndrome when his own Wiki page does not support the claim. Also, this site here (http://meaindia.nic.in/bestoftheweb/2002/04/17bow01.htm , simply CTRL + F (Marfan) and you'll find the relevant paragraph) does not support the statement, as it concludes there is no firm evidence for the claim (Another site cites that page to support that fact that it is unlikely he had it). Another site simply says he does (Without any evidence, and I am doubtful that any websites can qualify as primary sources... D: ). Another Wiki Page says this :Rumores dizem que Osama bin Laden também tem a Síndrome. Or, roughly translated, Rumours say that Osama has this syndome. The evidence seems to be, on the affirmative: Osama is lanky and tell, a bit like Lincoln (Or apparently Kerry). On the negative: Most people suffering from Marfan syndome are not likely to have well developed musculature. 24.89.197.136 01:40, 23 November 2006 (UTC)

To which of the 30 or so Robert Johnsons does this section intend to refer?

This section is somewhat problematic, I tagged it as needing sources. We need them for everything, but doubly so when we start diagnosing people who are still alive... - cohesion 02:55, 2 December 2006 (UTC)

"I find it doubtful that Osama bin Laden has Marfan's syndrome when his own Wiki page does not support the claim." Someone has an inordinate trust in Wiki pages! At any rate, he may have had it and there are some unofficial sources (news agencies etc.) that support this. of course it is generally thought that Lincoln had Marfans. Gingermint (talk) 00:42, 15 May 2011 (UTC)

Dural Ectasia

I added this to the requested articles list. Anyone care to take it on? I suffer from it, but am not a medical practitioner. So I'm looking for professional knowledge, not just web references that I can find on my own.

Dural ectasia --WS 22:57, 27 November 2006 (UTC)

Symptoms

I did some major revising of the symptoms section. I felt it read too much like a description of the disease, and not a description of how the symptoms present themselves. A paragraph still needs to be added on pneumothorax, because this is sometimes the first sign/symptom to show itself in individuals with the disease. The section also needs to have more references added. Leeirons 02:50, 5 December 2006 (UTC)

Bin Laden?

People have said that Osama Bin Laden has it? Could this be true? He certainly shows symptoms of it, also John Kerry does, but this isn't proven anywhere. —The preceding unsigned comment was added by 84.71.226.21 (talk) 22:01, 14 December 2006 (UTC).

Osama bin Laden is mentioned as having Marfan syndrome in this article: www.washingtontimes.com --Mycatlikesgarlic (talk) 12:53, 30 December 2010 (UTC)

We need a better reference than the one currently used, as it actually states that Osama died of Marfan's in 2001. LWG ^talk 14:10, 5 May 2011 (UTC)

This may be true. Unfortunately, outside of "official sources" saying so, there is nothing known of Bun Laden. Gingermint (talk) 00:44, 15 May 2011 (UTC)

Grafitti Attacks on the Article

I have reviewed the history of changes over the past few weeks and have noticed an occassional graffito is written into the article. The vandals perpetrating these attacks usually do it without logging in, thus leaving no contributor trace. I recommend that whenever any of the responsibly acting contributors log in to do some more editing, first look at the most recent edit. If it is an anonymous edit, just revert the article to the previous edit before doing more edits. Leeirons 13:02, 19 December 2006 (UTC)

It only takes a moment more to do a diff, and leave the appropriate {{test}} on the users page, thus helping reduce vandalism long term. Rich Farmbrough, 13:57 19 December 2006 (GMT).

I figured out how to do the diff, but what do you mean about "leave the appropriate test on the users page"? What does a "test" accomplish? :-) Leeirons 14:48, 19 December 2006 (UTC)

I nearly always do a diff anyway after clicking on the history tab, but I did not know that it was possible to edit without logging in. Are you wrong? Snowman 18:28, 19 December 2006 (UTC)

Yes, you can (generally) edit without logging in; the edit then shows up with your IP address as the username. —Ruakh_TALK 18:36, 19 December 2006 (UTC)

I count that as logged on with IP address (although not signed in with a personal name). He was actually stating the obvious. btw. Snowman 19:13, 19 December 2006 (UTC)

But there's nothing "logged on" about it … —Ruakh_TALK 21:53, 19 December 2006 (UTC)

Oops! Sorry, I just made some edits without logging on. I entered comments on the changes made, so it should be obvious that my anonymous entries are not grafitti. Leeirons 03:38, 28 December 2006 (UTC)

I made an edit a few days ago (just a grammar correction) but I do not have an account. Sorry for any trouble, just wanted to make sure no one uncorrects my correction. (Zippydaspinhead - 10:30 CMT, 6 February 2007)

What kind of a sick, twisted individual would deface an article like this? I have Marfan's syndrome, and I'm disgusted sometimes by people's utter lack of caring with respect to folks like me. I'm not taking it personally; I'm just amazed at how easily some can kick a man when he is down. On the other hand, I suppose that this is why the KKK exists. And yes -- Hitler WOULD have killed anyone with Marfan's, if he knew about it. SammyJames 01:45, 5 March 2007 (UTC)SammyJames

Well Known Persons

This list used to be very long and then was trimmed down due to lack of citations. It is beginning to grow again. I recommend that each new name should include a citation, or don't even bother adding it. Leeirons 14:45, 19 December 2006 (UTC)

I added citations for the three that were missing them.AlexMc 08:15, 20 December 2006 (UTC)

And added one person along with citation. AlexMc 08:31, 20 December 2006 (UTC)

Pulled the only non-notable person off the list. Hint: if they're not on Wikipedia, they're probably not all THAT prominent...--MattShepherd 20:57, 19 January 2007 (UTC)

I think i read in a book that a famous violin player... Paganini or Pa... i forgot the name :( It was said that he was able to play in very awkward ways because he could overstretch his fingers a lot. Maybe someone of you guys finds the book, its almost 10 years since i read that and i read it only once :/ all i know was that he was a great violin player of his time (i think he was italian but i aint sure..) —Preceding unsigned comment added by 80.108.103.172 (talk) 00:18, 10 November 2007 (UTC)

Niccolò Paganini is indeed said to owe his virtuosity to Marfan. Riyadi (talk) 20:36, 23 November 2016 (UTC)

Heads-up: Joey Ramone probably didn't have Marfan syndrome. I don't know why very tall people always get slapped with that diagnosis. . . anyhow, you won't find a reference for it anywhere. I looked. —Preceding unsigned comment added by Danierrr (talk • contribs) 18:11, 2 March 2008 (UTC)

Giant baba also had marfan's syndrom. He's one of the biggest japanese pro wrestlers of all time. He died in 1999. —Preceding unsigned comment added by 81.205.105.15 (talk) 16:02, 4 June 2009 (UTC)

Pharoah

The pharoah link is dead, though I also heard this assertion at the King Tut travelling exhibit. Does anyone have a new link for this information? Johhny "Appleseed" Chapman may have had it also. 71.202.53.228 (talk) 22:59, 17 February 2011 (UTC)

WPCD

I think the article should be considered for the WPCD again as it has been a WikiProjects Medicine project of the week and has had a lot of improvements. Snowman 10:53, 4 February 2007 (UTC)

Nice work

I'd just like to say that editors here have done a stellar job on the article. It is written in an intelligent but not alienating tone and provides a lot of information about this disorder.

Many of our health and medicine related articles I come across are incomplete and/or written at either a far too academic, or kindergarten level of explanation. This is very comprehensive. And well presented to cap it off.

My only criticism at present is that it lacks any footnotes in the the "symptoms" section.

Good job guys.--ZayZayEM (talk) 06:01, 5 December 2007 (UTC)

Not clear whether Lincoln should be excluded

I followed the two references that follow the sentence "Abraham Lincoln was once believed to have suffered from Marfan Sydrome, although recent research has argued that he probably did not.[28][29]". It turns out that neither of them conclude that he did not have Marfan's. They only note that there is some debate. Therefore this seems like a mis-citation.yes it does —Preceding unsigned comment added by 68.90.245.210 (talk) 04:48, 15 December 2007 (UTC)

I have heard that there is some debate, but I have never seen it in print. I have a doctorate in American History. Gingermint (talk) 00:45, 15 May 2011 (UTC)

Ghent criteria

PMID 8723076 apparently lists the most recent diagnostic criteria. JFW | T@lk 00:42, 18 February 2008 (UTC)

Hammertoes

My step dad, like his famous brother John Tavener, has Marfan syndrome, as does his son. Both my step father and step brother have a condition called hammer toes where their toes grow out at slightly perpendicular angles. They tell me that this is a common condition for Marfan sufferers, but it's not listed in the symptoms page so I'm adding it.Juggertrout (talk) 00:18, 17 August 2008 (UTC)

Michael Phelps

I read in the Sydney Morning Herald that they test him for Mafans every year. Does anyone know if this is true? - Tbsdy lives (talk) 11:36, 18 August 2008 (UTC)

The citation for Phelps having marfan goes to a book where he states he had marfan like symptoms, but not marfan. Maybe he should be taken off the list of famous people. —Preceding unsigned comment added by 68.94.23.202 (talk) 15:41, 16 August 2008 (UTC)

Recent additions have added Michael Phelps to the list of well known people who have or are believed to have Marfan’s. One edit was uncited, one was incorrectly cited, and the most recent one (now removed) cited something called "clevelandleader.com" (The Cleveland Leader), a website which appears to be a news blog. A few points:

• This claim involves a living person, and such a claim must be cited to a reliable source.
• A news blog (clevelandleader) is not a reliable source for a medical diagnosis.
• The article in question relies on Phelps own book, but the book itself does not support the interpretation placed on it by the article. Also see [2]; [3].
• At most the book says that Phelps may have a few of the physical attributes of those with the syndrome; there is no determination that he actually has it or is reliably believed to have it.

Accordingly the claim does not belong in the article. Kablammo (talk) 17:27, 18 August 2008 (UTC) (updated; Kablammo (talk) 23:55, 19 August 2008 (UTC))

People "believed to have" Marfan's

The listing of living people who are "believed" or "suspected" to have Marfan syndrome should be modified to list only those people who have been diagnosed with the condition. We have seen how journalists can turn a few symptoms into a diagnosis. WP:RS and WP:BLP should apply here. Kablammo (talk) 19:18, 18 August 2008 (UTC)

I have modified the section to eliminate those "believed to have" the syndrome, and expanded the hidden comment to require a valid reliable source confirming an actual diagnosis. Wikipedia should not engage in speculation nor repeat speculation, particularly about living persons. Kablammo (talk) 02:25, 20 August 2008 (UTC)

As the "speculative claims" section continued to attract rumors concerning living persons based on irresponsible "journalism", and as many of the names of historic figures had no citation, the list has been eliminated and only those names which are cited to a source have been retained. Kablammo (talk) 02:05, 7 January 2009 (UTC)

Osama Bin Laden does not have marfan Syndrome because he is short and some people, such as myself have large hands. it is not a valid arguement. —Preceding unsigned comment added by 209.175.88.246 (talk) 15:08, 18 February 2009 (UTC)

Does anybody know about Mick Fleetwood of Fleetwood Mac? I'm a 195cm Marfanic myself, and on some older album covers Fleetwood looks taller and thinner than I (he's been cited as being 198cm tall), with pectus excavatum and very thin arms and wrists. Harjasusi (talk) 14:47, 22 April 2009 (UTC)

See WP:MEDMOS and WP:MEDRS; a very reliable source would be needed at any rate. SandyGeorgia (Talk) 15:04, 22 April 2009 (UTC)

Free full-text review

Keane MG, Pyeritz RE (2008). "Medical management of Marfan syndrome". Circulation. 117 (21): 2802–13. doi:10.1161/CIRCULATIONAHA.107.693523. PMID 18506019. {{cite journal}}: Unknown parameter |month= ignored (help)

This 2008 review is available online and could be used to revise, update the article. I've added it to the Epidemiology section with refname=PMID18506019 . SandyGeorgia (Talk) 02:23, 17 January 2010 (UTC)

Phelps again

I have reverted this addition, because it misrepresented the source. Whether correctly written text could be added to the article is open to consensus; I don't see a need for it. (See above section.) SandyGeorgia (Talk) 19:12, 17 January 2010 (UTC)

Unclear Information

From the article:

"In addition to being a connective protein that forms the structural support for tissues outside the cell, the normal fibrillin-1 protein binds to another protein, transforming growth factor beta (TGF-β).[2] TGF-β has deleterious effects on vascular smooth muscle development and the integrity of the extracellular matrix. Researchers now believe that secondary to mutated fibrillin there is excessive TGF-β at the lungs, heart valves, and aorta, and this weakens the tissues and causes the features of Marfan syndrome."

These two pieces of information are contradictory and really don't make any sense at all. If it is true that in the Marfan disorder that TGF-β has deleterious effects on the ECM in the lungs, etc, then why on earth would normal fibrillin-1 bind to TGF-β and thereby have it end up causing problems in these tissues. I think that it should read "Mutated fibrillin-1 binds to TGF-β resulting in abnormally higher levels of the latter in these tissues resulting in the observed symptoms and phenotype..." Normal obviously means wild-type and would emcompass unaffected individuals. Can we have a better reference to primary literature or have a primary researcher opine please?

OK, nevermind, The latter paragraph explains it better, but this should be more smoothly and eloquently described earlier, but another suggestion to change to make it more clear:

Transforming growth factor beta (TGFβ) plays an important role in Marfan syndrome. Fibrillin-1 indirectly binds a latent form of TGFβ keeping it sequestered and unable to exert its biological activity. The simplest model of Marfan syndrome suggests that reduced levels of fibrillin-1 or more precisely haploinsufficiency (less wild-type fibrillin-1 capable of sequestering the TGFβ along with more of the mutated fibrillin-1 that is incapable of doing so) allows TGFβ levels to rise due to inadequate sequestration. Although it is not proven how elevated TGFβ levels are responsible for the specific pathology seen with the disease — Preceding unsigned comment added by 1PhDScientist1 (talk • contribs) 15:23, March 13, 2010

I'm a bit unsure about some of the genetic information in this article. Isn't the evidence itself still rather uncertain still? Maybe we should cut back the more specific claims? — Preceding unsigned comment added by Flatronal (talk • contribs) 14:37, 6 August 2011 (UTC)

I also agree there is trouble here. My edits tonight, 02 Feb 2014, hope to address this. I clarify that the disease comes from mis-regulation of TGF-B (in this case, improper sequestration and resulting increase of free circulating TGF-B) and not from TGF-B alone. Also, the former wording of these sections is a bit clunky, as noted here, since the disease etiology was completely revised after Dietz's work ~2005. So, some resolution between the old "its a structural connective tissue disease" and the new " its TGF-B" was needed. January2009 (talk) 03:36, 3 February 2014 (UTC)January2009

'Syndome' confusion

The first sentence: 'Marfan syndrome (also called Marfan's syndrome) is a genetic disorder of the connective tissue.' is wrong. A syndome (Marfan's or any other) is just a collection of symptoms. It is not a genetic disorder of anything. A genetic disorder may cause a syndrome. —Preceding unsigned comment added by 81.131.69.219 (talk) 17:10, 18 September 2010 (UTC)

I can assure you that the article is titled with the most commonly used name in medical publications. Also, the definition of a syndrome is not as restrictive as you say. As our wikipedia page points out, there is also Down syndrome (i.e. a genetic disorder) and many others. Lesion (talk) 22:20, 28 May 2013 (UTC)

Osama bin Laden

Please read WP:MEDRS; we don't report medical speculation from the laypress. Unless a reliable medical source discusses bin Laden and Marfan, please do not add it here. A ten-year-old speculative report from salon.com is not a reliable medical source, nor is the article even remotely conclusive. The BBC is another laysource that frequently gets medical information wrong, and even they say that the Marfan reports are "sketchy" and "wishful thinking". These are not the kinds of sources we use to report medical info, particularly when the accounts are sketchy. SandyGeorgia (Talk) 13:34, 6 May 2011 (UTC)

urinary & fecal incontinence secondary to dural ectasia in marfanoid syndromes...

While working on the former 2 articles, I found that dural ectasia can cause UI and FI, and is according to this article is one of the diagnostic criteria of this condition. Since these are major symptoms that might be the first presenting feature (people tend to notice them rather than many of the other symptoms listed here), maybe this should be mentioned in brackets after mentioning dural ectasia? Just a thought. First ref I found, listed on pubmed as a review, but looks like a case report, not sure if we can use it...Lesion (talk) 14:06, 5 February 2013 (UTC) <ref>{{cite journal|last=Nallamshetty|first=L|coauthors=Ahn, NU; Ahn, UM; Nallamshetty, HS; Rose, PS; Buchowski, JM; Sponseller, PD|title=Dural ectasia and back pain: review of the literature and case report.|journal=Journal of spinal disorders & techniques|date=2002 Aug|volume=15|issue=4|pages=326-9|pmid=12177551}}</ref>

Recent edits about intelligence in Marfan syndrome

After a very brief search I could not find any MEDRS source to support any statement about intelligence in Marfan syndrome. Of the 2 sources currently used, 1 is some kind of popular blog and the other a primary source, neither is MEDRS imo. Lesion (talk) 10:34, 27 April 2013 (UTC)

Notable society and culture section or trivia list?

Austin Carlile of the metalcore band Of Mice & Men has the disease. His mother had it also, and passed away due to it.[62]

How notable is this? and for that matter other "trivia" in the society section. It reads like a mixture of actual notable historical individuals - e.g. Lincoln, inter-spaced with trivia about non notable people. In MEDMOS it states that trivia sections should be avoided, and this society and culture section is really just a random list of people who have (or who are thought to have) marfan's syndrome. This is not what the society and culture section is really for. I think some of these people are living too.

Vincent Schiavelli, an actor and spokesperson for the National Marfan Foundation.

--I read the link and this person did not die of aortic dissection as suggested in the content. There is no info about how they contributed to public awareness about marfan's, please provide a proper source for this statement. Potentially this person is notable to include but the source provided is not suitable for the statement above.

I am removing what I feel is the non notable content. Anyone wishing to re-add this content please use the talk page to justify why you think it is notable.

So what we have left is some very famous musicians, Lincoln and 2 "celebrities" who died of aortic dissection publicly. I think this is notable and this is the standard we should follow, not just adding anyone who has the syndrome. Lesion (talk) 19:42, 25 May 2013 (UTC)

As shown by the sections above and the history of the article, it long has had some attributes of a coatrack, which now is under control. I agree with your changes, except for Schiavelli. It is undisputed that he had the condition, and was a spokesman for the Marfan Foundation. He therefore "affected the popular perception of a condition, such as through public awareness campaigns or enduring media coverage". See WP:MEDMOS#Notable_cases. I therefore restored him to the article. Kablammo (talk) 23:39, 28 May 2013 (UTC)

I thought this individual was likely to be notable to include, however the source did not support the statement that he contributed significantly to public awareness (can't remember exact previous wording). You have restored the same source, to support the statement that he was actor and spokesperson for the National Marfan Foundation, which no-one can argue with. Would be good to get another source describing their work as part of that foundation too. Lesion (talk) 23:44, 28 May 2013 (UTC)

This one may do: " Mr. Schiavelli raises the public profile of a syndrome most people know little about". Kablammo (talk) 03:05, 29 May 2013 (UTC)

Looks there is an intermittent edit war now. Please read the above about notability. Lesion (talk) 10:24, 14 June 2013 (UTC)

Hatnote - really necessary?

• We link to Antoine Marfan a few times in the article already, notably a few lines down fro this hatnote in the lead.

• Mafan in Iran has a population of 43. How notable is this for a hatnote on this page, especially considering the linked page is not spelt "Marfan" but "Mafan"?

I'm going to remove the entire hatnote, not just the recent addition as I don't think it can be justified as being needed. Lesion (talk) 22:13, 28 May 2013 (UTC)

Agreed. Neither is needed. Kablammo (talk) 23:32, 28 May 2013 (UTC)

Ghent Diagnostic criteria

Thank you whoever has written that new section. Suggest:

• Put Ghent criteria before that huge, mostly unreferenced list we still have in the diagnosis section. The Ghent criteria are the most widely accepted? If so then this list holds more weight than our list, and it should go first.
• remove from the original list all the signs and symptoms which are now mentioned in the Ghent criteria... don't need to mention them twice
• some of the terms used in the Ghent criteria need explanation, e.g. "thumb sign", "aortic root Z"-- jargon to most people I would imagine. Lesion (talk) 10:01, 3 July 2013 (UTC)

Agreed about aortic root z score -- it ought to be explained.

Burressd (talk) 16:00, 5 June 2023 (UTC)

Surgical mesh

A new simpler corrective operation has recently been developed, following a proposal from a sufferer, Tal Golesworthy, who was concerned at the prospect of the constraints (especially the risks from the required blood-thinning medication) following the traditional tissue replacement operation. An engineer with no medical background, he suggested that a sleeve of medical-grade mesh wrapped around the aorta would prevent the potentially fatal inelastic stretching. After four years of medical testing and preparation, he himself became the first patient of the new approach. Since then more than 40 people with similar conditions have benefitted.

Whilst BBC is generally reliable, it is not really a suitable medical source, per WP:MEDRS. Having said that this is potentially worthy of inclusion in the article, potentially in a "research" section since it sounds like it is still fairly new and not widely used. Lesion (talk) 22:15, 20 November 2013 (UTC)

Society and culture

I don't understand why this section is as currently composed. Additions of current notable people who have Marfan syndrome are removed, but society and culture has several names where there were merely rumors. There is no evidence they actually had it. "Studies suggest that Akhenaten, a Pharaoh of the eighteenth dynasty of Egypt, may have suffered from Marfan's syndrome" OK, so what? "Geneticists no longer believe Abraham Lincoln had the disease" That may belong in Lincoln's article, but I don't see why it merits mention here. Enigma^msg 06:22, 23 June 2014 (UTC)

Better to have the bar set high with regards notability. We should not let the society and culture section sink to it's previous state of being a "freak show" trivia list which gives as many names as possible, most of which have no other connection with the condition aside the diagnosis. As genetic disorders go, marfan's is not rare... we will be up to our tits in K list celebrities very quickly if we are not careful. 194.42.240.60 (talk) 07:09, 23 June 2014 (UTC)

Per WP:MEDMOS#Notable_cases we should limit such mentions. But the literature apparently contains numerous discussions of the pharoah and the president (and in fact our article at one time followed the then-common belief that Lincoln has the syndrome) so perhaps they are sufficiently widespread enough to warrant a mention here. If memory serves, there was a relatively recent edit again stating that Lincoln has Marfan (likely by someone not familiar with the new consensus), even after the article was changed to negate that. While the article may not suffer from the absence of these two items, it may take more work to maintain it thereafter. Kablammo (talk) 19:07, 23 June 2014 (UTC)

I understand not including every notable person who ever had Marfan's, I just can't reconcile that with including rumors and innuendo about a pharaoh and Abraham Lincoln. Discussing what disease Lincoln might've had is silly. Anyone who is curious can look at the Lincoln articles. As for the pharaoh, there's a lot more coverage now of recent cases of people having Marfan's than of the total coverage by scholars or what have you about an ancient figure who may or may not have had a genetic disorder. Enigma^msg 02:45, 25 June 2014 (UTC)

Lincoln and Pharoah are definitely notable historical figures to mention in relation to this condition. Historically, people thought that these figures had marfans, so it is good to include to get the record straight, so to speak. 92.41.80.13 (talk) 10:20, 25 June 2014 (UTC)

I shortened the text slightly and got rid of some detail best handled elsewhere. I hope that is an acceptable compromise.

As to other public figures who have, had, or believed to have had Marfan: If their condition contributes to the lasting public understanding of the syndrome, they can be included. But the mere fact that someone had the disease should not, without more, be a reason to include them, regardless of their fame in music, sports, or other fields. Kablammo (talk) 19:33, 25 June 2014 (UTC)

Looks better to me, cheers. Enigma^msg 05:17, 29 June 2014 (UTC)

Just curious why no living people? Wouldn't it be worthwhile to show healthy individuals living with Marfan, like Peter Mayhew? There are citations all over his wiki entry about Marfan. I just don't want people to hear about Isaiah Austin losing his career over this disorder and think that's the fate of people with Marfan. Adding someone like Peter Mayhew would add understanding that every case of Marfan is different in severity and some people may live to old age and have successful careers despite it. Mellison86 (talk) 20:22, 13 September 2014 (UTC)

Diagnosis section

Are the Ghent Criteria the most widely use world wide? Should they be moved to the first section of the diagnosis section in that case?

Also, I think it is unnecessary to repeat things again in that 3 column list that have already appeared in the Ghent criteria. 188.29.83.183 (talk) 14:50, 28 June 2014 (UTC)

Celebrities

Howdy! I'm a marf myself and am a member of several sites/forums/etc dealing with the topic. One thing that comes up often is "Did XXXX have Marfan Syndrome?", where XXXX is a celebrity. I'm compiling a list of suspected celebs, and listing as "Confirmed", "Debunked", "Rumored" with source links for verification. Would this be a welcome addition on this page or possibly another page? I know there's pages for "Notable German Americans" (https://en.wikipedia.org/wiki/List_of_German_Americans), so precedence does exist.

Trollboy665 (talk) 23:09, 15 January 2015 (UTC)

A separate List of notable people who had the condition, or category, may be the best way to handle them. Kablammo (talk) 18:02, 9 December 2016 (UTC)

People who have/had Marfans

As mentioned above and in the archives, this article is not the place for a list of folks with Marfans. See the relevant section of the Manual of Style for medical subject matter. Kablammo (talk) 18:19, 9 December 2016 (UTC)

External links modified

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• Added archive https://web.archive.org/web/20081015174003/http://www.hopkinsmedicine.org/CardiacSurgery/marfancenter/history.html to http://www.hopkinsmedicine.org/CardiacSurgery/marfancenter/history.html

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"cases"

Per WP:MEDMOS we generally don't have sections like this as they just become BLP violations/gossip mongering like this and as the edit comments visible in the wikitext below try to warn against. We do discuss notable cases if they contributed in some significant way to the history of disease.

Society and culture

Contributors to public perception of Marfan syndrome include:

• Studies suggest that Akhenaten, a pharaoh of the Eighteenth Dynasty of Egypt, may have had Marfan's syndrome.
• Isaiah Austin, a basketball player who was diagnosed with it, and forced to postpone his dream of an NBA career.
• Bradford Cox, frontman of the band Deerhunter.
• Austin Carlile, former frontman of the band Of Mice and Men.
• Flo Hyman, an Olympic silver medalist in women's volleyball (1984) who died suddenly at a match from an aortic dissection.
• Jonathan Larson, author and composer of Rent, who also died from aortic dissection the day before the opening of the musical.
• Abraham Lincoln was once thought to have had the disease, but that view has been contested, and considered to be unlikely by modern geneticists. Conclusive confirmation through DNA testing is not possible, as access to Lincoln's DNA was denied.
• Peter Mayhew, the actor who played Chewbacca in the Star Wars franchise, has been diagnosed with Marfan syndrome and owes his height to it.
• Vincent Schiavelli, an actor, food writer and spokesperson for The Marfan Foundation (then named the National Marfan Foundation), who had the syndrome, but died from an unrelated cause.
• Sir John Tavener, English composer.
• Javier Botet, a Spanish actor notable for his roles in Mama and It (2017) has been diagnosed with Marfan syndrome, making use of it to portray characters that could be considered unnerving.

References

-- Jytdog (talk) 00:12, 5 January 2018 (UTC)

Agreed. A category should be sufficient. Kablammo (talk) 00:27, 5 January 2018 (UTC)

Jonathan Larson had a major influence on awareness regarding the condition. Agree with removal off all the rest. Doc James (talk · contribs · email) 08:41, 5 January 2018 (UTC)

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Request for review of recent addition

Doc James, could you look at the recent addition to the last paragraph of the Surgery section?

Some years ago I removed this addition as it did not seem to me to be a reliable source. While the first sentence of the paragraph addition is better sourced, that source is not a review article (although the procedure appears promising).

Best wishes, Kablammo (talk) 16:54, 31 July 2018 (UTC)

Have adjusted it based on the source. Your thoughts? Doc James (talk · contribs · email) 19:14, 31 July 2018 (UTC)

It looks good. I've been unclear on whether and how we report new developments which are not yet discussed in reviews. It looks like we can mention them without making qualitative assertions until they have been the subject of reviews. Kablammo (talk) 13:23, 1 August 2018 (UTC)

See Also Section

Added "Nail Patella Syndrome" which is another connective tissue disease with similar phenotypes. I am pointing this out as the NPS page on Wikipedia is poorly written in comparison and the similarity may not be obvious to a casual reader.

Joey Ramone

Hey!

As far as I know, Joey Ramone of The Ramones had Marfan’s Syndrome.

Perhaps he could be added to the famous people section.

Cheers, LC 2A10:8001:CCF6:0:48A9:9730:EF4E:1EFD (talk) 13:37, 1 December 2022 (UTC)