This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II.[6]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Hsu SY, Hsueh AJ (Apr 2001). "Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor". Nat Med. 7 (5): 605–11. doi:10.1038/87936. PMID11329063. S2CID22916906.
Hauger RL, Grigoriadis DE, Dallman MF, et al. (2003). "International Union of Pharmacology. XXXVI. Current status of the nomenclature for receptors for corticotropin-releasing factor and their ligands". Pharmacol. Rev. 55 (1): 21–6. doi:10.1124/pr.55.1.3. PMID12615952. S2CID1572317.
Imperatore A, Florio P, Torres PB, et al. (2006). "Urocortin 2 and urocortin 3 are expressed by the human placenta, deciduas, and fetal membranes". Am. J. Obstet. Gynecol. 195 (1): 288–95. doi:10.1016/j.ajog.2005.12.048. PMID16626608.
Czimmer J, Million M, Taché Y (2006). "Urocortin 2 acts centrally to delay gastric emptying through sympathetic pathways while CRF and urocortin 1 inhibitory actions are vagal dependent in rats". Am. J. Physiol. Gastrointest. Liver Physiol. 290 (3): G511–8. CiteSeerX10.1.1.328.810. doi:10.1152/ajpgi.00289.2005. PMID16223946. S2CID10157248.
Chanalaris A, Lawrence KM, Stephanou A, et al. (2004). "Protective effects of the urocortin homologues stresscopin (SCP) and stresscopin-related peptide (SRP) against hypoxia/reoxygenation injury in rat neonatal cardiomyocytes". J. Mol. Cell. Cardiol. 35 (10): 1295–305. doi:10.1016/S0022-2828(03)00244-X. PMID14519439.