USP13

Ubiquitin carboxyl-terminal hydrolase 13 is an enzyme that in humans is encoded by the USP13 gene.

USP13
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2L80, 2LBC
Identifiers
Aliases	USP13, ISOT3, IsoT-3, ubiquitin specific peptidase 13 (isopeptidase T-3), ubiquitin specific peptidase 13
External IDs	OMIM: 603591; MGI: 1919857; HomoloGene: 68372; GeneCards: USP13; OMA:USP13 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3q26.33 Start 179,653,032 bp End 179,804,366 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3|3 A3 Start 32,871,695 bp End 32,992,220 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Skeletal muscle tissue of biceps brachii glutes thoracic diaphragm deltoid muscle vastus lateralis muscle tibialis anterior muscle triceps brachii muscle Skeletal muscle tissue of rectus abdominis right ventricle myocardium of left ventricle Top expressed in interventricular septum muscle of thigh triceps brachii muscle temporal muscle sternocleidomastoid muscle digastric muscle soleus muscle myocardium of ventricle gastrocnemius muscle skeletal muscle tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cysteine-type peptidase activity chaperone binding zinc ion binding BAT3 complex binding metal ion binding ubiquitin-like protein-specific protease activity proteasome binding peptidase activity ubiquitin binding protein binding ubiquitin-like protein ligase binding hydrolase activity ubiquitin protein ligase binding thiol-dependent deubiquitinase cysteine-type endopeptidase activity Cellular component nucleoplasm cytosol Biological process regulation of transcription, DNA-templated ubiquitin-dependent protein catabolic process positive regulation of ERAD pathway proteolysis autophagy regulation of autophagy protein K63-linked deubiquitination maintenance of unfolded protein involved in ERAD pathway cell population proliferation melanocyte differentiation protein deubiquitination protein K29-linked deubiquitination protein K6-linked deubiquitination protein stabilization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8975 72607 Ensembl ENSG00000058056 ENSMUSG00000056900 UniProt Q92995 Q5BKP2 RefSeq (mRNA) NM_003940 NM_001013024 RefSeq (protein) NP_003931 NP_001013042 Location (UCSC) Chr 3: 179.65 – 179.8 Mb Chr 3: 32.87 – 32.99 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• D'Andrea A, Pellman D (1999). "Deubiquitinating enzymes: a new class of biological regulators". Crit. Rev. Biochem. Mol. Biol. 33 (5): 337–52. doi:10.1080/10409239891204251. PMID 9827704.
• Timms KM, Ansari-Lari MA, Morris W, et al. (1998). "The genomic organization of Isopeptidase T-3 (ISOT-3), a new member of the ubiquitin specific protease family (UBP)". Gene. 217 (1–2): 101–6. doi:10.1016/S0378-1119(98)00341-2. PMID 9841226.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• McElhinny AS, Kakinuma K, Sorimachi H, et al. (2002). "Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1". J. Cell Biol. 157 (1): 125–36. doi:10.1083/jcb.200108089. PMC 2173255. PMID 11927605.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.