USP19

Ubiquitin specific peptidase 19 is a protein that in humans is encoded by the USP19 gene.

USP19
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WH0, 4X3G
Identifiers
Aliases	USP19, ZMYND9, ubiquitin specific peptidase 19
External IDs	OMIM: 614471; MGI: 1918722; HomoloGene: 41730; GeneCards: USP19; OMA:USP19 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3p21.31 Start 49,108,046 bp End 49,120,938 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 F2 Start 108,367,801 bp End 108,379,536 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle muscle of thigh right uterine tube right lobe of thyroid gland right adrenal cortex granulocyte apex of heart body of tongue right hemisphere of cerebellum left adrenal gland Top expressed in secondary oocyte primary oocyte zygote neural layer of retina muscle of thigh choroid plexus of fourth ventricle superior frontal gyrus granulocyte lip ventricular zone More reference expression data BioGPS n/a
Gene ontology Molecular function Hsp90 protein binding cysteine-type peptidase activity metal ion binding Lys48-specific deubiquitinase activity peptidase activity protein binding thiol-dependent deubiquitinase hydrolase activity ubiquitin protein ligase binding Cellular component integral component of membrane endoplasmic reticulum membrane membrane endoplasmic reticulum cytosol nucleus Biological process protein K48-linked deubiquitination regulation of protein stability ubiquitin-dependent protein catabolic process protein stabilization response to endoplasmic reticulum stress proteolysis regulation of ERAD pathway regulation of cellular response to hypoxia negative regulation of skeletal muscle tissue development positive regulation of cell cycle process ubiquitin-dependent ERAD pathway negative regulation of proteasomal protein catabolic process protein deubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10869 71472 Ensembl ENSG00000172046 ENSMUSG00000006676 UniProt O94966 Q3UJD6 RefSeq (mRNA) NM_001199160 NM_001199161 NM_001199162 NM_006677 NM_001351098 NM_001351099 NM_001351100 NM_001351101 NM_001351102 NM_001351103 NM_001351104 NM_001351105 NM_001351106 NM_001351107 NM_001351108 NM_001389594 NM_001389595 NM_001389596 NM_001389597 NM_001389598 NM_001389599 NM_001389600 NM_001389601 NM_001389602 NM_001389603 NM_001389604 NM_001389605 NM_001389606 NM_001389607 NM_001389608 NM_001400288 NM_001400290 NM_001400292 NM_001400293 NM_001400294 NM_001400295 NM_001400296 NM_001400297 NM_001400298 NM_001400299 NM_001168371 NM_001168372 NM_001168373 NM_027804 NM_145407 RefSeq (protein) NP_001186089 NP_001186090 NP_001186091 NP_006668 NP_001338027 NP_001338028 NP_001338029 NP_001338030 NP_001338031 NP_001338032 NP_001338033 NP_001338034 NP_001338035 NP_001338036 NP_001338037 NP_001161843 NP_001161844 NP_001161845 NP_082080 NP_663382 Location (UCSC) Chr 3: 49.11 – 49.12 Mb Chr 9: 108.37 – 108.38 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Ubiquitin carboxyl-terminal hydrolase 19 (USP19)