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Student enrolled in Carleton College Biology 310: Immunology.
For my main article project/Assignment #4, I will be adding to the page on Neonatal Fc receptor.
I want to add cited information about the role of FcRn and where it is expressed in adults.[1] I want to add an image on the mechanism of maternal IgG transfer to clarify the process.[2] Here is another source that details the role of FcRn in different organs of the body and also the implications of FcRn-IgG binding for immunotherapies.[3] There is already a short section in the current article about drugs that use FcRn to increase their half-lives, but I could add some more information. This next article has some interesting information about FcRn-IgG binding inhibitors as a possible treatment for autoimmune diseases that are caused by self-antigen-attacking IgG antibodies.[4] And finally, there is also plenty of evidence suggesting that FcRn plays a role in extending the half-life of serum albumin and not just IgG.[5]
- ^ Kuo, Timothy T., Kristi Baker, Masaru Yoshida, Shuo-Wang Qiao, Victoria G. Aveson, Wayne I. Lencer, and Richard S. Blumberg. 2010. Neonatal Fc receptor: from immunity to therapeutics. Journal of Clinical Immunology 30(6): 777-789.
- ^ Roopenian, Derry C.; Akilesh, Shreeram (2007-09-01). "FcRn: the neonatal Fc receptor comes of age". Nature Reviews Immunology. 7 (9): 715–725. doi:10.1038/nri2155. ISSN 1474-1733.
- ^ Kuo, Timothy T; Aveson, Victoria G (2011-01-01). "Neonatal Fc receptor and IgG-based therapeutics". mAbs. 3 (5): 422–430. doi:10.4161/mabs.3.5.16983. ISSN 1942-0862. PMC 3225846. PMID 22048693.
- ^ Sockolosky, Jonathan T.; Szoka, Francis C. (2015-08-30). "The neonatal Fc receptor, FcRn, as a target for drug delivery and therapy". Advanced Drug Delivery Reviews. Editor's Collection 2015. 91: 109–124. doi:10.1016/j.addr.2015.02.005. PMC 4544678. PMID 25703189.
- ^ Andersen, Jan Terje; Dalhus, Bjørn; Cameron, Jason; Daba, Muluneh Bekele; Plumridge, Andrew; Evans, Leslie; Brennan, Stephan O.; Gunnarsen, Kristin Støen; Bjørås, Magnar (2012-01-03). "Structure-based mutagenesis reveals the albumin-binding site of the neonatal Fc receptor". Nature Communications. 3: 610. doi:10.1038/ncomms1607. ISSN 2041-1723. PMC 3272563. PMID 22215085.