User:ManuelAlek56/sandbox

Histone deacetylase 2 (HDAC2) is an enzyme that in humans is encoded by the HDAC2 gene.[1] It belongs to the Histone deacetylase class of enzymes responsible for the removal of acetyl groups from lysine residues at the N-terminal region of the core histones (H2A,H2B,H3, and H4). As such, it plays an important role in gene expression by facilitating the formation of transcription repressor complexes and for this reason is often considered an important target for cancer therapy[2].

Though the functional role of the class to which HDAC2 belongs has been carefully studied, the mechanism by which HDAC2 interacts with other Histone deacetylases of other classes has yet to be elucidated. HDAC2 is broadly regulated by protein kinase 2 (CK2) and protein phosphatase 1 (PP1), but biochemical analysis suggests its regulation is more complex (evinced by the coexistence of HDAC1 and HDAC2 in three distinct protein complexes)[3]. Essentially, the mechanism by which HDAC2 is regulated is still unclear by virtue of its various interactions, though a mechanism involving p300/CBP-associated factor and HDAC5 has been proposed in the context of cardiac reprogramming[4].

This image shows the structure of the HDAC2 enzyme. The two consecutive benzene rings form the foot pocket, where as the single benzene rings forms the lipophilic tube.

Generally, HDAC2 is considered a putative target for the treatment for a variety of diseases, due to its involvement in key cell cycle progressions. Specifically, HDAC2 has been shown to play a role in cardiac hypertrophy[4], Alzheimer's disease[5], Parkinson's Disease [6], acute myeloid leukemia (AML)[7], osteosarcoma[8], and Gastric Cancer[9].

Structure and Mechanism

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HDAC2 belongs to the first class of Histone deactylases. The active site of HDAC2 contains either a Zn2+ metal ion coordinated to the carbonyl group of a lysine substrate and a water molecule. The metallic ion facilitates the nucleophilic attack of the carbonyl group by a coordinated water molecule, leading to the formation of a tetrahedral intermediate. This intermediate is momentarily stabilized by hydrogen bond interactions and metal coordination, until it ultimately collapses resulting in the deacetylation of the lysine residue[10].

The HDAC2 active site consists of a lipophilic tube which leads from the surface to the catalytic center, and a 'foot pocket' containing mostly water molecules. The active site is connected to Gly154, Phe155, His183, Phe210, and Leu276. The footpocket is connected to Tyr29, Met35, Phe114, and Leu144[11]

Function

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The HDAC2 enzyme attacking a lysine.

This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes and are responsible for the deacetylation of lysine residues on the N-terminal region of the core histones (H2A, H2B, H3 and H4). This protein also forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus it plays an important role in transcriptional regulation, cell cycle progression and developmental events.[12]

Disease Relevance

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Cardiac Hypertrophy

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HDAC2 has been shown to play a role in the regulatory pathway of cardiac hypertrophy. Deficiencies in HDAC2 were shown to mitigate cardiac hypertrophy in hearts exposed to hypertrophic stimuli. However, in HDAC2 transgenic mice with inactivated glycogen synthase kinase 3beta (Gsk3beta), hypertrophy was observed at a higher frequency. In mice with activated Gsk3beta enzymes and HDAC2 deficiencies, sensitivity to hypertrophic stimulus was observed at a higher rate. The results suggest regulatory roles of HDAC2 and GSk3beta[13].

Mechanisms by which HDAC2 responds to hypertrophic stress have been proposed, though no general consensus has been met. One suggested mechanism puts forth casein kinase dependent phosphorylation of HDAC2, while a more recent mechanism suggests acetylation regulated by p300/CBP-associated factor and HDAC5[4].

Alzheimer's Disease

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It has been found that patients with Alzheimer's Disease experience a decrease in the expression of neuronal genes[14]. Furthermore, a recent study found that inhibition of HDAC2 via c-Abl by tyrosine phosphorylation prevented cognitive and behavioral impairments in mice with Alzheimer's Disease[15]. The results of the study support the role of c-Abl and HDAC2 in the signaling pathway of gene expression in patients with Alzheimer's Disease. Currently, efforts to synthesize an HDAC2 inhibitor for the treatment of Alzheimer's Disease are based on a pharmacophore with four features: one Hydrogen Bond Acceptor, one Hydrogen Bond Donor, and two Aromatic Rings[5].

Parkinson's Disease

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HDAC inhibitors have been regarded as a potential treatment of neurodegenerative diseases such as Parkinson's Disease. Parkinson's Disease is usually accompanied by an increase in the number of microglial protein in the substantia Nigra of the brain. In vivo evidence has shown a correlation between the number of microglial proteins and the upregulation of HDAC2[6]. It is thought therefore that HDAC2 inhibitors could be effective in treating microglial-initiated dopaminergic loss of neurons in the brain.

Cancer Therapy

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The role of HDAC2 in various forms of cancer such as osteosarcoma, gastric cancer, and acute myeloid leukemia have been studied. Current research is focused on creating inhibitors that decrease the upregulation of HDAC2.

Interactions

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Histone deacetylase 2 has been shown to interact with:

See also

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References

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  1. ^ Betz R, Gray SG, Ekström C, Larsson C, Ekström TJ (December 1998). "Human histone deacetylase 2, HDAC2 (Human RPD3), is localized to 6q21 by radiation hybrid mapping". Genomics. 52 (2): 245–6. doi:10.1006/geno.1998.5435. PMID 9782097.
  2. ^ "Tissue expression of HDAC2 - Summary - The Human Protein Atlas". www.proteinatlas.org. Retrieved 2019-03-14.
  3. ^ Seto, Edward; Yoshida, Minoru (2014-4). "Erasers of Histone Acetylation: The Histone Deacetylase Enzymes". Cold Spring Harbor Perspectives in Biology. 6 (4). doi:10.1101/cshperspect.a018713. ISSN 1943-0264. PMC PMCPMC3970420. PMID 24691964. {{cite journal}}: Check |pmc= value (help); Check date values in: |date= (help)
  4. ^ a b c Eom, Gwang Hyeon; Nam, Yoon Seok; Oh, Jae Gyun; Choe, Nakwon; Min, Hyun-Ki; Yoo, Eun-Kyung; Kang, Gaeun; Nguyen, Vu Hong; Min, Jung-Joon (2014-03-28). "Regulation of acetylation of histone deacetylase 2 by p300/CBP-associated factor/histone deacetylase 5 in the development of cardiac hypertrophy". Circulation Research. 114 (7): 1133–1143. doi:10.1161/CIRCRESAHA.114.303429. ISSN 1524-4571. PMID 24526703.
  5. ^ a b Choubey, Sanjay K.; Jeyakanthan, Jeyaraman (2018-6). "Molecular dynamics and quantum chemistry-based approaches to identify isoform selective HDAC2 inhibitor - a novel target to prevent Alzheimer's disease". Journal of Receptor and Signal Transduction Research. 38 (3): 266–278. doi:10.1080/10799893.2018.1476541. ISSN 1532-4281. PMID 29932788. {{cite journal}}: Check date values in: |date= (help)
  6. ^ a b Tan, Yuyan; Delvaux, Elaine; Nolz, Jennifer; Coleman, Paul D.; Chen, Shengdi; Mastroeni, Diego (08 2018). "Upregulation of histone deacetylase 2 in laser capture nigral microglia in Parkinson's disease". Neurobiology of Aging. 68: 134–141. doi:10.1016/j.neurobiolaging.2018.02.018. ISSN 1558-1497. PMID 29803514. {{cite journal}}: Check date values in: |date= (help)
  7. ^ Lei, Lijun; Xia, Siyu; Liu, Dan; Li, Xiaoqing; Feng, Jing; Zhu, Yaqi; Hu, Jun; Xia, Linjian; Guo, Lieping (07 20, 2018). "Genome-wide characterization of lncRNAs in acute myeloid leukemia". Briefings in Bioinformatics. 19 (4): 627–635. doi:10.1093/bib/bbx007. ISSN 1477-4054. PMC PMCPMC6355113. PMID 28203711. {{cite journal}}: Check |pmc= value (help); Check date values in: |date= (help)
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Further reading

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