- INFO: Beginning work on ACE... {October 1, 2007 8:03:05 PM PDT}
- AMBIGUITY: More than one potential page found for updating, ACE CD143 DCP Angiotensin-converting enzyme {October 1, 2007 8:03:36 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB = {{PDB2|1o86}}, {{PDB2|1o8a}}, {{PDB2|1uze}}, {{PDB2|1uzf}}, {{PDB2|2c6f}}, {{PDB2|2c6n}}, {{PDB2|2iul}}, {{PDB2|2iux}}, {{PDB2|2oc2}}
| Name = Angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
| HGNCid = 2707
| Symbol = ACE
| AltSymbols =; ACE1; CD143; DCP; DCP1; MGC26566
| OMIM = 106180
| ECnumber =
| Homologene = 37351
| MGIid = 87874
| GeneAtlas_image1 = 209749_s_at
| GeneAtlas_image2 = 227463_at
| GeneAtlas_image3 = 37013_at
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0004180 |text = carboxypeptidase activity}} {{GNF_GO|id=GO:0004246 |text = peptidyl-dipeptidase A activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016798 |text = hydrolase activity, acting on glycosyl bonds}} {{GNF_GO|id=GO:0031404 |text = chloride ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005625 |text = soluble fraction}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0008152 |text = metabolic process}} {{GNF_GO|id=GO:0008217 |text = blood pressure regulation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1636
| Hs_Ensembl = ENSG00000159640
| Hs_RefseqProtein = NP_000780
| Hs_RefseqmRNA = NM_000789
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 58908166
| Hs_GenLoc_end = 58938721
| Hs_Uniprot = P12821
| Mm_EntrezGene = 11421
| Mm_Ensembl = ENSMUSG00000020681
| Mm_RefseqmRNA = NM_009598
| Mm_RefseqProtein = NP_033728
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 105784052
| Mm_GenLoc_end = 105805352
| Mm_Uniprot = Q3TU20
}}
}}
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Two most abundant alternatively spliced variants of this gene encode two isozymes - the somatic form and the testicular form that are equally active. Multiple additional alternatively spliced variants have been identified but their full length nature has not been determined.<ref>{{cite web | title = Entrez Gene: ACE angiotensin I converting enzyme (peptidyl-dipeptidase A) 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1636| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Niu T, Chen X, Xu X |title=Angiotensin converting enzyme gene insertion/deletion polymorphism and cardiovascular disease: therapeutic implications. |journal=Drugs |volume=62 |issue= 7 |pages= 977-93 |year= 2002 |pmid= 11985486 |doi= }}
*{{cite journal | author=Roĭtberg GE, Tikhonravov AV, Dorosh ZhV |title=[Role of angiotensin-converting enzyme gene polymorphism in the development of metabolic syndrome] |journal=Ter. Arkh. |volume=75 |issue= 12 |pages= 72-7 |year= 2004 |pmid= 14959477 |doi= }}
*{{cite journal | author=Vynohradova SV |title=[The role of angiotensin-converting enzyme gene I/D polymorphism in development of metabolic disorders in patients with cardiovascular pathology] |journal=Tsitol. Genet. |volume=39 |issue= 1 |pages= 63-70 |year= 2005 |pmid= 16018179 |doi= }}
*{{cite journal | author=König S, Luger TA, Scholzen TE |title=Monitoring neuropeptide-specific proteases: processing of the proopiomelanocortin peptides adrenocorticotropin and alpha-melanocyte-stimulating hormone in the skin. |journal=Exp. Dermatol. |volume=15 |issue= 10 |pages= 751-61 |year= 2006 |pmid= 16984256 |doi= 10.1111/j.1600-0625.2006.00472.x }}
*{{cite journal | author=Sabbagh AS, Otrock ZK, Mahfoud ZR, ''et al.'' |title=Angiotensin-converting enzyme gene polymorphism and allele frequencies in the Lebanese population: prevalence and review of the literature. |journal=Mol. Biol. Rep. |volume=34 |issue= 1 |pages= 47-52 |year= 2007 |pmid= 17103020 |doi= 10.1007/s11033-006-9013-y }}
*{{cite journal | author=Castellon R, Hamdi HK |title=Demystifying the ACE polymorphism: from genetics to biology. |journal=Curr. Pharm. Des. |volume=13 |issue= 12 |pages= 1191-8 |year= 2007 |pmid= 17504229 |doi= }}
*{{cite journal | author=Lazartigues E, Feng Y, Lavoie JL |title=The two fACEs of the tissue renin-angiotensin systems: implication in cardiovascular diseases. |journal=Curr. Pharm. Des. |volume=13 |issue= 12 |pages= 1231-45 |year= 2007 |pmid= 17504232 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on ARNTL... {October 1, 2007 7:57:30 PM PDT}
- AMBIGUITY: More than one potential page found for updating, TIC Tic {October 1, 2007 7:58:06 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Aryl hydrocarbon receptor nuclear translocator-like
| HGNCid = 701
| Symbol = ARNTL
| AltSymbols =; BMAL1; BMAL1c; JAP3; MGC47515; MOP3; PASD3; TIC
| OMIM = 602550
| ECnumber =
| Homologene = 910
| MGIid = 1096381
| GeneAtlas_image1 = 210971_s_at
| GeneAtlas_image2 = 209824_s_at
| GeneAtlas_image3 = 36896_s_at
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007623 |text = circadian rhythm}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 406
| Hs_Ensembl = ENSG00000133794
| Hs_RefseqProtein = NP_001025443
| Hs_RefseqmRNA = NM_001030272
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 13255921
| Hs_GenLoc_end = 13365345
| Hs_Uniprot = O00327
| Mm_EntrezGene = 11865
| Mm_Ensembl = ENSMUSG00000055116
| Mm_RefseqmRNA = NM_007489
| Mm_RefseqProtein = NP_031515
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 112998646
| Mm_GenLoc_end = 113105303
| Mm_Uniprot = Q3UHZ2
}}
}}
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This complex binds an E-box upstream of the PER1 gene, activating this gene and possibly other circadian rhythym-associated genes. Three transcript variants encoding two different isoforms have been found for this gene.<ref>{{cite web | title = Entrez Gene: ARNTL aryl hydrocarbon receptor nuclear translocator-like| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=406| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on ARNTL2... {October 1, 2007 8:23:17 PM PDT}
- CREATED: Created new protein page: ARNTL2 {October 1, 2007 8:24:20 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB = {{PDB2|1i7w}}, {{PDB2|1i7x}}, {{PDB2|1o6s}}, {{PDB2|2omv}}, {{PDB2|2omy}}
| Name = Cadherin 1, type 1, E-cadherin (epithelial)
| HGNCid = 1748
| Symbol = CDH1
| AltSymbols =; Arc-1; CD324; CDHE; ECAD; LCAM; UVO
| OMIM = 192090
| ECnumber =
| Homologene = 20917
| MGIid = 88354
| GeneAtlas_image1 = 2082_s_at
| GeneAtlas_image2 = 977_s_at
| GeneAtlas_image3 = 201131_s_at
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007156 |text = homophilic cell adhesion}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 999
| Hs_Ensembl = ENSG00000039068
| Hs_RefseqProtein = NP_004351
| Hs_RefseqmRNA = NM_004360
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 16
| Hs_GenLoc_start = 67328696
| Hs_GenLoc_end = 67426943
| Hs_Uniprot = P12830
| Mm_EntrezGene = 12550
| Mm_Ensembl = ENSMUSG00000000303
| Mm_RefseqmRNA = NM_009864
| Mm_RefseqProtein = NP_033994
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 8
| Mm_GenLoc_start = 109492497
| Mm_GenLoc_end = 109559375
| Mm_Uniprot = Q4KML8
}}
}}
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites.<ref>{{cite web | title = Entrez Gene: CDH1 cadherin 1, type 1, E-cadherin (epithelial)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=999| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Berx G, Becker KF, Höfler H, van Roy F |title=Mutations of the human E-cadherin (CDH1) gene. |journal=Hum. Mutat. |volume=12 |issue= 4 |pages= 226-37 |year= 1998 |pmid= 9744472 |doi= 10.1002/(SICI)1098-1004(1998)12:4<226::AID-HUMU2>3.0.CO;2-D }}
*{{cite journal | author=Wijnhoven BP, Dinjens WN, Pignatelli M |title=E-cadherin-catenin cell-cell adhesion complex and human cancer. |journal=The British Journal of Surgery |volume=87 |issue= 8 |pages= 992-1005 |year= 2000 |pmid= 10931041 |doi= 10.1046/j.1365-2168.2000.01513.x }}
*{{cite journal | author=Beavon IR |title=The E-cadherin-catenin complex in tumour metastasis: structure, function and regulation. |journal=Eur. J. Cancer |volume=36 |issue= 13 Spec No |pages= 1607-20 |year= 2000 |pmid= 10959047 |doi= }}
*{{cite journal | author=Wilson PD |title=Polycystin: new aspects of structure, function, and regulation. |journal=J. Am. Soc. Nephrol. |volume=12 |issue= 4 |pages= 834-45 |year= 2001 |pmid= 11274246 |doi= }}
*{{cite journal | author=Chun YS, Lindor NM, Smyrk TC, ''et al.'' |title=Germline E-cadherin gene mutations: is prophylactic total gastrectomy indicated? |journal=Cancer |volume=92 |issue= 1 |pages= 181-7 |year= 2001 |pmid= 11443625 |doi= }}
*{{cite journal | author=Hazan RB, Qiao R, Keren R, ''et al.'' |title=Cadherin switch in tumor progression. |journal=Ann. N. Y. Acad. Sci. |volume=1014 |issue= |pages= 155-63 |year= 2004 |pmid= 15153430 |doi= }}
*{{cite journal | author=Bryant DM, Stow JL |title=The ins and outs of E-cadherin trafficking. |journal=Trends Cell Biol. |volume=14 |issue= 8 |pages= 427-34 |year= 2005 |pmid= 15308209 |doi= 10.1016/j.tcb.2004.07.007 }}
*{{cite journal | author=Wang HD, Ren J, Zhang L |title=CDH1 germline mutation in hereditary gastric carcinoma. |journal=World J. Gastroenterol. |volume=10 |issue= 21 |pages= 3088-93 |year= 2004 |pmid= 15457549 |doi= }}
*{{cite journal | author=Reynolds AB, Carnahan RH |title=Regulation of cadherin stability and turnover by p120ctn: implications in disease and cancer. |journal=Semin. Cell Dev. Biol. |volume=15 |issue= 6 |pages= 657-63 |year= 2005 |pmid= 15561585 |doi= 10.1016/j.semcdb.2004.09.003 }}
*{{cite journal | author=Moran CJ, Joyce M, McAnena OJ |title=CDH1 associated gastric cancer: a report of a family and review of the literature. |journal=Eur J Surg Oncol |volume=31 |issue= 3 |pages= 259-64 |year= 2005 |pmid= 15780560 |doi= 10.1016/j.ejso.2004.12.010 }}
*{{cite journal | author=Georgolios A, Batistatou A, Manolopoulos L, Charalabopoulos K |title=Role and expression patterns of E-cadherin in head and neck squamous cell carcinoma (HNSCC). |journal=J. Exp. Clin. Cancer Res. |volume=25 |issue= 1 |pages= 5-14 |year= 2006 |pmid= 16761612 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CFTR... {October 1, 2007 7:59:01 PM PDT}
- SEARCH REDIRECT: One high potential page found for updating: cystic fibrosis transmembrane conductance regulator {October 1, 2007 7:59:31 PM PDT}
- UPLOAD: Added new Image to wikiCreated new protein page: <a href=http://en.wikipedia.org/w/index.php?title=cystic fibrosis transmembrane conductance regulator>cystic fibrosis transmembrane conductance regulator</a> {October 1, 2007 7:59:40 PM PDT}
- BAD FORMAT: There is a problem with the BOT commands for this protein: cystic fibrosis transmembrane conductance regulator. Invoking a Mandantory Inspection. {October 1, 2007 7:59:52 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CFTR_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1xmi.
| PDB = {{PDB2|1xmi}}, {{PDB2|1xmj}}, {{PDB2|2bbo}}, {{PDB2|2bbs}}, {{PDB2|2bbt}}
| Name = Cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
| HGNCid = 1884
| Symbol = CFTR
| AltSymbols =; ABC35; ABCC7; CF; CFTR/MRP; MRP7; TNR-CFTR; dJ760C5.1
| OMIM = 602421
| ECnumber =
| Homologene = 55465
| MGIid = 88388
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005216 |text = ion channel activity}} {{GNF_GO|id=GO:0005224 |text = ATP-binding and phosphorylation-dependent chloride channel activity}} {{GNF_GO|id=GO:0005254 |text = chloride channel activity}} {{GNF_GO|id=GO:0005260 |text = channel-conductance-controlling ATPase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016887 |text = ATPase activity}} {{GNF_GO|id=GO:0030165 |text = PDZ domain binding}} {{GNF_GO|id=GO:0031404 |text = chloride ion binding}} {{GNF_GO|id=GO:0042626 |text = ATPase activity, coupled to transmembrane movement of substances}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0016323 |text = basolateral plasma membrane}} {{GNF_GO|id=GO:0016324 |text = apical plasma membrane}}
| Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0007585 |text = respiratory gaseous exchange}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1080
| Hs_Ensembl = ENSG00000001626
| Hs_RefseqProtein = NP_000483
| Hs_RefseqmRNA = NM_000492
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 116907253
| Hs_GenLoc_end = 117095951
| Hs_Uniprot = P13569
| Mm_EntrezGene = 12638
| Mm_Ensembl = ENSMUSG00000041301
| Mm_RefseqmRNA = NM_021050
| Mm_RefseqProtein = NP_066388
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 18120687
| Mm_GenLoc_end = 18272767
| Mm_Uniprot = Q8CC89
}}
}}
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily that is involved in multi-drug resistance. The encoded protein functions as a chloride channel and controls the regulation of other transport pathways. Mutations in this gene are associated with the autosomal recessive disorders cystic fibrosis and congenital bilateral aplasia of the vas deferens. Alternatively spliced transcript variants have been described, many of which result from mutations in this gene.<ref>{{cite web | title = Entrez Gene: CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1080| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Tsui LC |title=Mutations and sequence variations detected in the cystic fibrosis transmembrane conductance regulator (CFTR) gene: a report from the Cystic Fibrosis Genetic Analysis Consortium. |journal=Hum. Mutat. |volume=1 |issue= 3 |pages= 197-203 |year= 1993 |pmid= 1284534 |doi= 10.1002/humu.1380010304 }}
*{{cite journal | author=McIntosh I, Cutting GR |title=Cystic fibrosis transmembrane conductance regulator and the etiology and pathogenesis of cystic fibrosis. |journal=FASEB J. |volume=6 |issue= 10 |pages= 2775-82 |year= 1992 |pmid= 1378801 |doi= }}
*{{cite journal | author=Drumm ML, Collins FS |title=Molecular biology of cystic fibrosis. |journal=Mol. Genet. Med. |volume=3 |issue= |pages= 33-68 |year= 1993 |pmid= 7693108 |doi= }}
*{{cite journal | author=Kerem B, Kerem E |title=The molecular basis for disease variability in cystic fibrosis. |journal=Eur. J. Hum. Genet. |volume=4 |issue= 2 |pages= 65-73 |year= 1996 |pmid= 8744024 |doi= }}
*{{cite journal | author=Devidas S, Guggino WB |title=CFTR: domains, structure, and function. |journal=J. Bioenerg. Biomembr. |volume=29 |issue= 5 |pages= 443-51 |year= 1998 |pmid= 9511929 |doi= }}
*{{cite journal | author=Nagel G |title=Differential function of the two nucleotide binding domains on cystic fibrosis transmembrane conductance regulator. |journal=Biochim. Biophys. Acta |volume=1461 |issue= 2 |pages= 263-74 |year= 2000 |pmid= 10581360 |doi= }}
*{{cite journal | author=Boyle MP |title=Unique presentations and chronic complications in adult cystic fibrosis: do they teach us anything about CFTR? |journal=Respir. Res. |volume=1 |issue= 3 |pages= 133-5 |year= 2003 |pmid= 11667976 |doi= }}
*{{cite journal | author=Greger R, Schreiber R, Mall M, ''et al.'' |title=Cystic fibrosis and CFTR. |journal=Pflugers Arch. |volume=443 Suppl 1 |issue= |pages= S3-7 |year= 2002 |pmid= 11845294 |doi= 10.1007/s004240100635 }}
*{{cite journal | author=Bradbury NA |title=cAMP signaling cascades and CFTR: is there more to learn? |journal=Pflugers Arch. |volume=443 Suppl 1 |issue= |pages= S85-91 |year= 2002 |pmid= 11845310 |doi= 10.1007/s004240100651 }}
*{{cite journal | author=Dahan D, Evagelidis A, Hanrahan JW, ''et al.'' |title=Regulation of the CFTR channel by phosphorylation. |journal=Pflugers Arch. |volume=443 Suppl 1 |issue= |pages= S92-6 |year= 2002 |pmid= 11845311 |doi= 10.1007/s004240100652 }}
*{{cite journal | author=Cohn JA, Noone PG, Jowell PS |title=Idiopathic pancreatitis related to CFTR: complex inheritance and identification of a modifier gene. |journal=J. Investig. Med. |volume=50 |issue= 5 |pages= 247S-255S |year= 2002 |pmid= 12227654 |doi= }}
*{{cite journal | author=Kulczycki LL, Kostuch M, Bellanti JA |title=A clinical perspective of cystic fibrosis and new genetic findings: relationship of CFTR mutations to genotype-phenotype manifestations. |journal=Am. J. Med. Genet. A |volume=116 |issue= 3 |pages= 262-7 |year= 2003 |pmid= 12503104 |doi= 10.1002/ajmg.a.10886 }}
*{{cite journal | author=Schwartz M |title=[Cystic fibrosis transmembrane conductance regulator (CFTR) gene: mutations and clinical phenotypes] |journal=Ugeskr. Laeg. |volume=165 |issue= 9 |pages= 912-6 |year= 2003 |pmid= 12661515 |doi= }}
*{{cite journal | author=Wong LJ, Alper OM, Wang BT, ''et al.'' |title=Two novel null mutations in a Taiwanese cystic fibrosis patient and a survey of East Asian CFTR mutations. |journal=Am. J. Med. Genet. A |volume=120 |issue= 2 |pages= 296-8 |year= 2004 |pmid= 12833420 |doi= 10.1002/ajmg.a.20039 }}
*{{cite journal | author=Cuppens H, Cassiman JJ |title=CFTR mutations and polymorphisms in male infertility. |journal=Int. J. Androl. |volume=27 |issue= 5 |pages= 251-6 |year= 2005 |pmid= 15379964 |doi= 10.1111/j.1365-2605.2004.00485.x }}
*{{cite journal | author=Cohn JA, Mitchell RM, Jowell PS |title=The impact of cystic fibrosis and PSTI/SPINK1 gene mutations on susceptibility to chronic pancreatitis. |journal=Clin. Lab. Med. |volume=25 |issue= 1 |pages= 79-100 |year= 2005 |pmid= 15749233 |doi= 10.1016/j.cll.2004.12.007 }}
*{{cite journal | author=Southern KW, Peckham D |title=Establishing a diagnosis of cystic fibrosis. |journal=Chronic respiratory disease |volume=1 |issue= 4 |pages= 205-10 |year= 2005 |pmid= 16281647 |doi= }}
*{{cite journal | author=Kandula L, Whitcomb DC, Lowe ME |title=Genetic issues in pediatric pancreatitis. |journal=Current gastroenterology reports |volume=8 |issue= 3 |pages= 248-53 |year= 2006 |pmid= 16764792 |doi= }}
*{{cite journal | author=Marcet B, Boeynaems JM |title=Relationships between cystic fibrosis transmembrane conductance regulator, extracellular nucleotides and cystic fibrosis. |journal=Pharmacol. Ther. |volume=112 |issue= 3 |pages= 719-32 |year= 2007 |pmid= 16828872 |doi= 10.1016/j.pharmthera.2006.05.010 }}
*{{cite journal | author=Wilschanski M, Durie PR |title=Patterns of GI disease in adulthood associated with mutations in the CFTR gene. |journal=Gut |volume=56 |issue= 8 |pages= 1153-63 |year= 2007 |pmid= 17446304 |doi= 10.1136/gut.2004.062786 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CLOCK... {October 1, 2007 8:16:26 PM PDT}
- SEARCH REDIRECT: One high potential page found for updating: CLOCK {October 1, 2007 8:16:55 PM PDT}
- BAD FORMAT: There is a problem with the BOT commands for this protein: CLOCK. Invoking a Mandantory Inspection. {October 1, 2007 8:16:58 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Clock homolog (mouse)
| HGNCid = 2082
| Symbol = CLOCK
| AltSymbols =; KIAA0334
| OMIM = 601851
| ECnumber =
| Homologene = 3603
| MGIid = 99698
| GeneAtlas_image1 = 764_s_at
| GeneAtlas_image2 = 204980_at
| GeneAtlas_image3 = 36080_at
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007623 |text = circadian rhythm}} {{GNF_GO|id=GO:0009648 |text = photoperiodism}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 9575
| Hs_Ensembl = ENSG00000134852
| Hs_RefseqProtein = NP_004889
| Hs_RefseqmRNA = NM_004898
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 4
| Hs_GenLoc_start = 55988827
| Hs_GenLoc_end = 56107754
| Hs_Uniprot = O15516
| Mm_EntrezGene = 12753
| Mm_Ensembl = ENSMUSG00000029238
| Mm_RefseqmRNA = NM_007715
| Mm_RefseqProtein = NP_031741
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 77285742
| Mm_GenLoc_end = 77379567
| Mm_Uniprot = Q8BRU1
}}
}}
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a protein that belongs to the basic helix-loop-helix (bHLH) family of transcription factors. Polymorphisms within the encoded protein have been associated with circadian rhythm sleep disorders. A similar protein in mice is a circadian regulator that acts as a transcription factor and forms a heterodimer with aryl hydrocarbon receptor nuclear translocator-like to activate transcription of mouse period 1.<ref>{{cite web | title = Entrez Gene: CLOCK clock homolog (mouse)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9575| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Wager-Smith K, Kay SA |title=Circadian rhythm genetics: from flies to mice to humans. |journal=Nat. Genet. |volume=26 |issue= 1 |pages= 23-7 |year= 2000 |pmid= 10973243 |doi= 10.1038/79134 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CRY1... {October 1, 2007 7:59:52 PM PDT}
- CREATED: Created new protein page: CRY1 {October 1, 2007 8:00:14 PM PDT}
- INFO: Beginning work on CRY2... {October 1, 2007 8:00:14 PM PDT}
- CREATED: Created new protein page: CRY2 {October 1, 2007 8:00:44 PM PDT}
- INFO: Beginning work on CSNK1D... {October 1, 2007 8:01:56 PM PDT}
- SEARCH REDIRECT: One low potential page found for updating, casein kinase 1 {October 1, 2007 8:02:11 PM PDT}
- UPLOAD: Added new Image to wikiCreated new protein page: <a href=http://en.wikipedia.org/w/index.php?title=casein kinase 1>casein kinase 1</a> {October 1, 2007 8:02:20 PM PDT}
- BAD FORMAT: There is a problem with the BOT commands for this protein: casein kinase 1. Invoking a Mandantory Inspection. {October 1, 2007 8:02:28 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CSNK1D_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1cki.
| PDB = {{PDB2|1cki}}, {{PDB2|1ckj}}
| Name = Casein kinase 1, delta
| HGNCid = 2452
| Symbol = CSNK1D
| AltSymbols =; HCKID
| OMIM = 600864
| ECnumber =
| Homologene = 74841
| MGIid = 1355272
| GeneAtlas_image1 = 493_at
| GeneAtlas_image2 = 207945_s_at
| GeneAtlas_image3 = 208774_at
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004681 |text = casein kinase I activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component =
| Process = {{GNF_GO|id=GO:0006281 |text = DNA repair}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0016055 |text = Wnt receptor signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1453
| Hs_Ensembl = ENSG00000141551
| Hs_RefseqProtein = XP_001132734
| Hs_RefseqmRNA = XM_001132734
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 77795946
| Hs_GenLoc_end = 77824546
| Hs_Uniprot = P48730
| Mm_EntrezGene = 104318
| Mm_Ensembl = ENSMUSG00000025162
| Mm_RefseqmRNA = NM_027874
| Mm_RefseqProtein = NP_082150
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 120775296
| Mm_GenLoc_end = 120807423
| Mm_Uniprot = Q9DC28
}}
}}
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the casein kinase I (CKI) gene family whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is highly similar to the mouse and rat CK1 delta homologs. Two transcript variants encoding different isoforms have been found for this gene.<ref>{{cite web | title = Entrez Gene: CSNK1D casein kinase 1, delta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1453| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CSNK1E... {October 1, 2007 8:02:28 PM PDT}
- SEARCH REDIRECT: One low potential page found for updating, casein kinase 1 {October 1, 2007 8:02:50 PM PDT}
- UPLOAD: Added new Image to wikiCreated new protein page: <a href=http://en.wikipedia.org/w/index.php?title=casein kinase 1>casein kinase 1</a> {October 1, 2007 8:02:58 PM PDT}
- BAD FORMAT: There is a problem with the BOT commands for this protein: casein kinase 1. Invoking a Mandantory Inspection. {October 1, 2007 8:03:05 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CSNK1E_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1cki.
| PDB = {{PDB2|1cki}}, {{PDB2|1ckj}}
| Name = Casein kinase 1, epsilon
| HGNCid = 2453
| Symbol = CSNK1E
| AltSymbols =; HCKIE; MGC10398
| OMIM = 600863
| ECnumber =
| Homologene = 37548
| MGIid = 1351660
| GeneAtlas_image1 = 202332_at
| GeneAtlas_image2 = 225756_at
| GeneAtlas_image3 = 38019_at
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004681 |text = casein kinase I activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component =
| Process = {{GNF_GO|id=GO:0006281 |text = DNA repair}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007165 |text = signal transduction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1454
| Hs_Ensembl = ENSG00000100181
| Hs_RefseqProtein = NP_001885
| Hs_RefseqmRNA = NM_001894
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 22
| Hs_GenLoc_start = 37017870
| Hs_GenLoc_end = 37124473
| Hs_Uniprot = P49674
| Mm_EntrezGene = 27373
| Mm_Ensembl = ENSMUSG00000022433
| Mm_RefseqmRNA = NM_013767
| Mm_RefseqProtein = NP_038795
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 15
| Mm_GenLoc_start = 79245107
| Mm_GenLoc_end = 79266120
| Mm_Uniprot = Q8CBH9
}}
}}
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Two transcript variants encoding the same protein have been found for this gene.<ref>{{cite web | title = Entrez Gene: CSNK1E casein kinase 1, epsilon| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1454| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on FAS... {October 1, 2007 7:56:23 PM PDT}
- SEARCH REDIRECT: One high potential page found for updating: Fas receptor {October 1, 2007 7:57:14 PM PDT}
- UPLOAD: Added new Image to wikiCreated new protein page: <a href=http://en.wikipedia.org/w/index.php?title=Fas receptor>Fas receptor</a> {October 1, 2007 7:57:22 PM PDT}
- BAD FORMAT: There is a problem with the BOT commands for this protein: Fas receptor. Invoking a Mandantory Inspection. {October 1, 2007 7:57:29 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_FAS_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ddf.
| PDB = {{PDB2|1ddf}}
| Name = Fas (TNF receptor superfamily, member 6)
| HGNCid = 11920
| Symbol = FAS
| AltSymbols =; ALPS1A; APO-1; APT1; CD95; FAS1; FASTM; TNFRSF6
| OMIM = 134637
| ECnumber =
| Homologene = 27
| MGIid = 95484
| GeneAtlas_image1 = 1441_s_at
| GeneAtlas_image2 = 1808_s_at
| GeneAtlas_image3 = 389_s_at
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0004888 |text = transmembrane receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}}
| Component = {{GNF_GO|id=GO:0005625 |text = soluble fraction}} {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006461 |text = protein complex assembly}} {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0006916 |text = anti-apoptosis}} {{GNF_GO|id=GO:0006917 |text = induction of apoptosis}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0042981 |text = regulation of apoptosis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 355
| Hs_Ensembl = ENSG00000026103
| Hs_RefseqProtein = NP_000034
| Hs_RefseqmRNA = NM_000043
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 10
| Hs_GenLoc_start = 90739206
| Hs_GenLoc_end = 90765521
| Hs_Uniprot = P25445
| Mm_EntrezGene = 14102
| Mm_Ensembl = ENSMUSG00000024778
| Mm_RefseqmRNA = NM_007987
| Mm_RefseqProtein = NP_032013
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 19
| Mm_GenLoc_start = 34356663
| Mm_GenLoc_end = 34393767
| Mm_Uniprot = Q6GT31
}}
}}
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. At least eight alternatively spliced transcript variants encoding seven distinct isoforms have been described. The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.<ref>{{cite web | title = Entrez Gene: FAS Fas (TNF receptor superfamily, member 6)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=355| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Nagata S |title=Apoptosis by death factor. |journal=Cell |volume=88 |issue= 3 |pages= 355-65 |year= 1997 |pmid= 9039262 |doi= }}
*{{cite journal | author=Cascino I, Papoff G, Eramo A, Ruberti G |title=Soluble Fas/Apo-1 splicing variants and apoptosis. |journal=Front. Biosci. |volume=1 |issue= |pages= d12-8 |year= 2004 |pmid= 9159204 |doi= }}
*{{cite journal | author=Uckun FM |title=Bruton's tyrosine kinase (BTK) as a dual-function regulator of apoptosis. |journal=Biochem. Pharmacol. |volume=56 |issue= 6 |pages= 683-91 |year= 1998 |pmid= 9751072 |doi= }}
*{{cite journal | author=Krammer PH |title=CD95's deadly mission in the immune system. |journal=Nature |volume=407 |issue= 6805 |pages= 789-95 |year= 2000 |pmid= 11048730 |doi= 10.1038/35037728 }}
*{{cite journal | author=Siegel RM, Chan FK, Chun HJ, Lenardo MJ |title=The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity. |journal=Nat. Immunol. |volume=1 |issue= 6 |pages= 469-74 |year= 2001 |pmid= 11101867 |doi= 10.1038/82712 }}
*{{cite journal | author=Wajant H |title=The Fas signaling pathway: more than a paradigm. |journal=Science |volume=296 |issue= 5573 |pages= 1635-6 |year= 2002 |pmid= 12040174 |doi= 10.1126/science.1071553 }}
*{{cite journal | author=Yonehara S |title=Death receptor Fas and autoimmune disease: from the original generation to therapeutic application of agonistic anti-Fas monoclonal antibody. |journal=Cytokine Growth Factor Rev. |volume=13 |issue= 4-5 |pages= 393-402 |year= 2003 |pmid= 12220552 |doi= }}
*{{cite journal | author=Choi C, Benveniste EN |title=Fas ligand/Fas system in the brain: regulator of immune and apoptotic responses. |journal=Brain Res. Brain Res. Rev. |volume=44 |issue= 1 |pages= 65-81 |year= 2004 |pmid= 14739003 |doi= }}
*{{cite journal | author=Poppema S, Maggio E, van den Berg A |title=Development of lymphoma in Autoimmune Lymphoproliferative Syndrome (ALPS) and its relationship to Fas gene mutations. |journal=Leuk. Lymphoma |volume=45 |issue= 3 |pages= 423-31 |year= 2004 |pmid= 15160902 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on FBXL3... {October 1, 2007 8:17:57 PM PDT}
- CREATED: Created new protein page: FBXL3 {October 1, 2007 8:18:37 PM PDT}
- INFO: Beginning work on GSK3A... {October 1, 2007 8:03:36 PM PDT}
- CREATED: Created new protein page: GSK3A {October 1, 2007 8:04:01 PM PDT}
- INFO: Beginning work on MAPK14... {October 1, 2007 8:00:44 PM PDT}
- SEARCH REDIRECT: One high potential page found for updating: P38 mitogen-activated protein kinases {October 1, 2007 8:01:41 PM PDT}
- UPLOAD: Added new Image to wikiCreated new protein page: <a href=http://en.wikipedia.org/w/index.php?title=P38 mitogen-activated protein kinases>P38 mitogen-activated protein kinases</a> {October 1, 2007 8:01:49 PM PDT}
- BAD FORMAT: There is a problem with the BOT commands for this protein: P38 mitogen-activated protein kinases. Invoking a Mandantory Inspection. {October 1, 2007 8:01:56 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_MAPK14_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1a9u.
| PDB = {{PDB2|1a9u}}, {{PDB2|1bl6}}, {{PDB2|1bl7}}, {{PDB2|1bmk}}, {{PDB2|1di9}}, {{PDB2|1ian}}, {{PDB2|1kv1}}, {{PDB2|1kv2}}, {{PDB2|1lew}}, {{PDB2|1lez}}, {{PDB2|1m7q}}, {{PDB2|1ouk}}, {{PDB2|1ouy}}, {{PDB2|1ove}}, {{PDB2|1oz1}}, {{PDB2|1p38}}, {{PDB2|1r39}}, {{PDB2|1r3c}}, {{PDB2|1w7h}}, {{PDB2|1w82}}, {{PDB2|1w83}}, {{PDB2|1w84}}, {{PDB2|1wbn}}, {{PDB2|1wbo}}, {{PDB2|1wbs}}, {{PDB2|1wbt}}, {{PDB2|1wbv}}, {{PDB2|1wbw}}, {{PDB2|1wfc}}, {{PDB2|1yqj}}, {{PDB2|1yw2}}, {{PDB2|1ywr}}, {{PDB2|1zyj}}, {{PDB2|1zz2}}, {{PDB2|1zzl}}, {{PDB2|2baj}}, {{PDB2|2bak}}, {{PDB2|2bal}}, {{PDB2|2baq}}, {{PDB2|2ewa}}, {{PDB2|2fsl}}, {{PDB2|2fsm}}, {{PDB2|2fso}}, {{PDB2|2fst}}, {{PDB2|2gfs}}, {{PDB2|2ghl}}, {{PDB2|2ghm}}, {{PDB2|2gtm}}, {{PDB2|2gtn}}, {{PDB2|2i0h}}, {{PDB2|2okr}}, {{PDB2|2onl}}, {{PDB2|2oza}}
| Name = Mitogen-activated protein kinase 14
| HGNCid = 6876
| Symbol = MAPK14
| AltSymbols =; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; PRKM14; PRKM15; RK; SAPK2A; p38; p38ALPHA
| OMIM = 600289
| ECnumber =
| Homologene = 31777
| MGIid = 1346865
| GeneAtlas_image1 = 1671_s_at
| GeneAtlas_image2 = 1999_s_at
| GeneAtlas_image3 = 202530_at
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004707 |text = MAP kinase activity}} {{GNF_GO|id=GO:0004708 |text = MAP kinase kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008339 |text = MP kinase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0000922 |text = spindle pole}} {{GNF_GO|id=GO:0005623 |text = cell}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0000077 |text = DNA damage checkpoint}} {{GNF_GO|id=GO:0001525 |text = angiogenesis}} {{GNF_GO|id=GO:0006006 |text = glucose metabolic process}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0006928 |text = cell motility}} {{GNF_GO|id=GO:0006935 |text = chemotaxis}} {{GNF_GO|id=GO:0006950 |text = response to stress}} {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}} {{GNF_GO|id=GO:0007243 |text = protein kinase cascade}} {{GNF_GO|id=GO:0007519 |text = striated muscle development}} {{GNF_GO|id=GO:0019395 |text = fatty acid oxidation}} {{GNF_GO|id=GO:0019735 |text = antimicrobial humoral response}} {{GNF_GO|id=GO:0045648 |text = positive regulation of erythrocyte differentiation}} {{GNF_GO|id=GO:0045944 |text = positive regulation of transcription from RNA polymerase II promoter}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1432
| Hs_Ensembl = ENSG00000112062
| Hs_RefseqProtein = NP_001306
| Hs_RefseqmRNA = NM_001315
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 36103551
| Hs_GenLoc_end = 36186513
| Hs_Uniprot = Q16539
| Mm_EntrezGene = 26416
| Mm_Ensembl = ENSMUSG00000053436
| Mm_RefseqmRNA = NM_011951
| Mm_RefseqProtein = NP_036081
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 28418955
| Mm_GenLoc_end = 28475994
| Mm_Uniprot = P47811
}}
}}
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.<ref>{{cite web | title = Entrez Gene: MAPK14 mitogen-activated protein kinase 14| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1432| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Ben-Levy R, Hooper S, Wilson R, ''et al.'' |title=Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2. |journal=Curr. Biol. |volume=8 |issue= 19 |pages= 1049-57 |year= 1999 |pmid= 9768359 |doi= }}
*{{cite journal | author=Bradham C, McClay DR |title=p38 MAPK in development and cancer. |journal=Cell Cycle |volume=5 |issue= 8 |pages= 824-8 |year= 2006 |pmid= 16627995 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on MAPT... {October 1, 2007 8:04:01 PM PDT}
- AMBIGUITY: More than one potential page found for updating, TAU Tau Tel Aviv University {October 1, 2007 8:05:12 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Microtubule-associated protein tau
| HGNCid = 6893
| Symbol = MAPT
| AltSymbols =; DDPAC; FLJ31424; FTDP-17; MAPTL; MGC138549; MSTD; MTBT1; MTBT2; PPND; TAU
| OMIM = 157140
| ECnumber =
| Homologene = 44834
| MGIid =
| GeneAtlas_image1 = 113_i_at
| GeneAtlas_image2 = 310_s_at
| GeneAtlas_image3 = 203929_s_at
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0005200 |text = structural constituent of cytoskeleton}} {{GNF_GO|id=GO:0008017 |text = microtubule binding}} {{GNF_GO|id=GO:0008034 |text = lipoprotein binding}} {{GNF_GO|id=GO:0017124 |text = SH3 domain binding}} {{GNF_GO|id=GO:0019899 |text = enzyme binding}}
| Component = {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0005856 |text = cytoskeleton}} {{GNF_GO|id=GO:0005875 |text = microtubule associated complex}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0030424 |text = axon}} {{GNF_GO|id=GO:0030426 |text = growth cone}} {{GNF_GO|id=GO:0045298 |text = tubulin complex}}
| Process = {{GNF_GO|id=GO:0000226 |text = microtubule cytoskeleton organization and biogenesis}} {{GNF_GO|id=GO:0007026 |text = negative regulation of microtubule depolymerization}} {{GNF_GO|id=GO:0031116 |text = positive regulation of microtubule polymerization}} {{GNF_GO|id=GO:0045773 |text = positive regulation of axon extension}} {{GNF_GO|id=GO:0048699 |text = generation of neurons}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4137
| Hs_Ensembl = ENSG00000186868
| Hs_RefseqProtein = NP_005901
| Hs_RefseqmRNA = NM_005910
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 41327624
| Hs_GenLoc_end = 41461547
| Hs_Uniprot = P10636
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.<ref>{{cite web | title = Entrez Gene: MAPT microtubule-associated protein tau| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4137| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Goedert M, Crowther RA, Garner CC |title=Molecular characterization of microtubule-associated proteins tau and MAP2. |journal=Trends Neurosci. |volume=14 |issue= 5 |pages= 193-9 |year= 1991 |pmid= 1713721 |doi= }}
*{{cite journal | author=Morishima-Kawashima M, Hasegawa M, Takio K, ''et al.'' |title=Hyperphosphorylation of tau in PHF. |journal=Neurobiol. Aging |volume=16 |issue= 3 |pages= 365-71; discussion 371-80 |year= 1995 |pmid= 7566346 |doi= }}
*{{cite journal | author=Heutink P |title=Untangling tau-related dementia. |journal=Hum. Mol. Genet. |volume=9 |issue= 6 |pages= 979-86 |year= 2000 |pmid= 10767321 |doi= }}
*{{cite journal | author=Goedert M, Spillantini MG |title=Tau mutations in frontotemporal dementia FTDP-17 and their relevance for Alzheimer's disease. |journal=Biochim. Biophys. Acta |volume=1502 |issue= 1 |pages= 110-21 |year= 2000 |pmid= 10899436 |doi= }}
*{{cite journal | author=Morishima-Kawashima M, Ihara Y |title=[Recent advances in Alzheimer's disease] |journal=Seikagaku |volume=73 |issue= 11 |pages= 1297-307 |year= 2002 |pmid= 11831025 |doi= }}
*{{cite journal | author=Blennow K, Vanmechelen E, Hampel H |title=CSF total tau, Abeta42 and phosphorylated tau protein as biomarkers for Alzheimer's disease. |journal=Mol. Neurobiol. |volume=24 |issue= 1-3 |pages= 87-97 |year= 2002 |pmid= 11831556 |doi= }}
*{{cite journal | author=Ingram EM, Spillantini MG |title=Tau gene mutations: dissecting the pathogenesis of FTDP-17. |journal=Trends in molecular medicine |volume=8 |issue= 12 |pages= 555-62 |year= 2003 |pmid= 12470988 |doi= }}
*{{cite journal | author=Pickering-Brown S |title=The tau gene locus and frontotemporal dementia. |journal=Dementia and geriatric cognitive disorders |volume=17 |issue= 4 |pages= 258-60 |year= 2004 |pmid= 15178931 |doi= 10.1159/000077149 }}
*{{cite journal | author=van Swieten JC, Rosso SM, van Herpen E, ''et al.'' |title=Phenotypic variation in frontotemporal dementia and parkinsonism linked to chromosome 17. |journal=Dementia and geriatric cognitive disorders |volume=17 |issue= 4 |pages= 261-4 |year= 2004 |pmid= 15178932 |doi= 10.1159/000077150 }}
*{{cite journal | author=Kowalska A, Jamrozik Z, Kwieciński H |title=Progressive supranuclear palsy--parkinsonian disorder with tau pathology. |journal=Folia neuropathologica / Association of Polish Neuropathologists and Medical Research Centre, Polish Academy of Sciences |volume=42 |issue= 2 |pages= 119-23 |year= 2004 |pmid= 15266787 |doi= }}
*{{cite journal | author=Rademakers R, Cruts M, van Broeckhoven C |title=The role of tau (MAPT) in frontotemporal dementia and related tauopathies. |journal=Hum. Mutat. |volume=24 |issue= 4 |pages= 277-95 |year= 2005 |pmid= 15365985 |doi= 10.1002/humu.20086 }}
*{{cite journal | author=Lee HG, Perry G, Moreira PI, ''et al.'' |title=Tau phosphorylation in Alzheimer's disease: pathogen or protector? |journal=Trends in molecular medicine |volume=11 |issue= 4 |pages= 164-9 |year= 2005 |pmid= 15823754 |doi= 10.1016/j.molmed.2005.02.008 }}
*{{cite journal | author=Hardy J, Pittman A, Myers A, ''et al.'' |title=Evidence suggesting that Homo neanderthalensis contributed the H2 MAPT haplotype to Homo sapiens. |journal=Biochem. Soc. Trans. |volume=33 |issue= Pt 4 |pages= 582-5 |year= 2005 |pmid= 16042549 |doi= 10.1042/BST0330582 }}
*{{cite journal | author=Deutsch SI, Rosse RB, Lakshman RM |title=Dysregulation of tau phosphorylation is a hypothesized point of convergence in the pathogenesis of alzheimer's disease, frontotemporal dementia and schizophrenia with therapeutic implications. |journal=Prog. Neuropsychopharmacol. Biol. Psychiatry |volume=30 |issue= 8 |pages= 1369-80 |year= 2007 |pmid= 16793187 |doi= 10.1016/j.pnpbp.2006.04.007 }}
*{{cite journal | author=Williams DR |title=Tauopathies: classification and clinical update on neurodegenerative diseases associated with microtubule-associated protein tau. |journal=Internal medicine journal |volume=36 |issue= 10 |pages= 652-60 |year= 2006 |pmid= 16958643 |doi= 10.1111/j.1445-5994.2006.01153.x }}
*{{cite journal | author=Pittman AM, Fung HC, de Silva R |title=Untangling the tau gene association with neurodegenerative disorders. |journal=Hum. Mol. Genet. |volume=15 Spec No 2 |issue= |pages= R188-95 |year= 2006 |pmid= 16987883 |doi= 10.1093/hmg/ddl190 }}
*{{cite journal | author=Roder HM, Hutton ML |title=Microtubule-associated protein tau as a therapeutic target in neurodegenerative disease. |journal=Expert Opin. Ther. Targets |volume=11 |issue= 4 |pages= 435-42 |year= 2007 |pmid= 17373874 |doi= 10.1517/14728222.11.4.435 }}
*{{cite journal | author=van Swieten J, Spillantini MG |title=Hereditary frontotemporal dementia caused by Tau gene mutations. |journal=Brain Pathol. |volume=17 |issue= 1 |pages= 63-73 |year= 2007 |pmid= 17493040 |doi= 10.1111/j.1750-3639.2007.00052.x }}
*{{cite journal | author=Caffrey TM, Wade-Martins R |title=Functional MAPT haplotypes: bridging the gap between genotype and neuropathology. |journal=Neurobiol. Dis. |volume=27 |issue= 1 |pages= 1-10 |year= 2007 |pmid= 17555970 |doi= 10.1016/j.nbd.2007.04.006 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on MTHFR... {October 1, 2007 8:05:41 PM PDT}
- SEARCH REDIRECT: One high potential page found for updating: Methylenetetrahydrofolate reductase {October 1, 2007 8:06:08 PM PDT}
- BAD FORMAT: There is a problem with the BOT commands for this protein: Methylenetetrahydrofolate reductase. Invoking a Mandantory Inspection. {October 1, 2007 8:06:13 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = 5,10-methylenetetrahydrofolate reductase (NADPH)
| HGNCid = 7436
| Symbol = MTHFR
| AltSymbols =;
| OMIM = 607093
| ECnumber =
| Homologene = 4349
| MGIid = 106639
| GeneAtlas_image1 = 206800_at
| GeneAtlas_image2 = 217071_s_at
| GeneAtlas_image3 = 226929_at
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0004489 |text = methylenetetrahydrofolate reductase (NADPH) activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016491 |text = oxidoreductase activity}}
| Component =
| Process = {{GNF_GO|id=GO:0006520 |text = amino acid metabolic process}} {{GNF_GO|id=GO:0006555 |text = methionine metabolic process}} {{GNF_GO|id=GO:0008015 |text = circulation}} {{GNF_GO|id=GO:0009086 |text = methionine biosynthetic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4524
| Hs_Ensembl = ENSG00000177000
| Hs_RefseqProtein = NP_005948
| Hs_RefseqmRNA = NM_005957
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 11768367
| Hs_GenLoc_end = 11788702
| Hs_Uniprot = P42898
| Mm_EntrezGene = 17769
| Mm_Ensembl = ENSMUSG00000029009
| Mm_RefseqmRNA = NM_010840
| Mm_RefseqProtein = NP_034970
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 146882883
| Mm_GenLoc_end = 146903353
| Mm_Uniprot = Q3V399
}}
}}
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Methylenetetrahydrofolate reductase (EC 1.5.1.20) catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a cosubstrate for homocysteine remethylation to methionine.[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: MTHFR 5,10-methylenetetrahydrofolate reductase (NADPH)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4524| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Matthews RG |title=Methylenetetrahydrofolate reductase: a common human polymorphism and its biochemical implications. |journal=Chemical record (New York, N.Y.) |volume=2 |issue= 1 |pages= 4-12 |year= 2003 |pmid= 11933257 |doi= }}
*{{cite journal | author=Schwahn B, Rozen R |title=Polymorphisms in the methylenetetrahydrofolate reductase gene: clinical consequences. |journal=American journal of pharmacogenomics : genomics-related research in drug development and clinical practice |volume=1 |issue= 3 |pages= 189-201 |year= 2002 |pmid= 12083967 |doi= }}
*{{cite journal | author=Iqbal MP, Frossard PM |title=Methylene tetrahydrofolate reductase gene and coronary artery disease. |journal=JPMA. The Journal of the Pakistan Medical Association |volume=53 |issue= 1 |pages= 33-6 |year= 2003 |pmid= 12666851 |doi= }}
*{{cite journal | author=Bailey LB |title=Folate, methyl-related nutrients, alcohol, and the MTHFR 677C-->T polymorphism affect cancer risk: intake recommendations. |journal=J. Nutr. |volume=133 |issue= 11 Suppl 1 |pages= 3748S-3753S |year= 2003 |pmid= 14608109 |doi= }}
*{{cite journal | author=Wiwanitkit V |title=Roles of methylenetetrahydrofolate reductase C677T polymorphism in repeated pregnancy loss. |journal=Clin. Appl. Thromb. Hemost. |volume=11 |issue= 3 |pages= 343-5 |year= 2005 |pmid= 16015422 |doi= }}
*{{cite journal | author=Muntjewerff JW, Kahn RS, Blom HJ, den Heijer M |title=Homocysteine, methylenetetrahydrofolate reductase and risk of schizophrenia: a meta-analysis. |journal=Mol. Psychiatry |volume=11 |issue= 2 |pages= 143-9 |year= 2006 |pmid= 16172608 |doi= 10.1038/sj.mp.4001746 }}
*{{cite journal | author=Lewis SJ, Lawlor DA, Davey Smith G, ''et al.'' |title=The thermolabile variant of MTHFR is associated with depression in the British Women's Heart and Health Study and a meta-analysis. |journal=Mol. Psychiatry |volume=11 |issue= 4 |pages= 352-60 |year= 2006 |pmid= 16402130 |doi= 10.1038/sj.mp.4001790 }}
*{{cite journal | author=Pereira TV, Rudnicki M, Pereira AC, ''et al.'' |title=5,10-Methylenetetrahydrofolate reductase polymorphisms and acute lymphoblastic leukemia risk: a meta-analysis. |journal=Cancer Epidemiol. Biomarkers Prev. |volume=15 |issue= 10 |pages= 1956-63 |year= 2007 |pmid= 17035405 |doi= 10.1158/1055-9965.EPI-06-0334 }}
*{{cite journal | author=Leclerc D, Rozen R |title=[Molecular genetics of MTHFR: polymorphisms are not all benign] |journal=Med Sci (Paris) |volume=23 |issue= 3 |pages= 297-302 |year= 2007 |pmid= 17349292 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on NPAS2... {October 1, 2007 8:06:13 PM PDT}
- CREATED: Created new protein page: NPAS2 {October 1, 2007 8:06:44 PM PDT}
- INFO: Beginning work on NR1D1... {October 1, 2007 8:15:38 PM PDT}
- UPLOAD: Added new Image to wikiCreated new protein page: <a href=http://en.wikipedia.org/w/index.php?title=NR1D1>NR1D1</a> {October 1, 2007 8:16:13 PM PDT}
- CREATED: Created new protein page: NR1D1 {October 1, 2007 8:16:26 PM PDT}
- INFO: Beginning work on NR1D2... {October 1, 2007 8:16:58 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update, but did find a redirect or disambig page: RVR {October 1, 2007 8:17:30 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
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| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB = {{PDB2|1a6y}}, {{PDB2|1ga5}}, {{PDB2|1hlz}}
| Name = Nuclear receptor subfamily 1, group D, member 2
| HGNCid = 7963
| Symbol = NR1D2
| AltSymbols =; HZF2; BD73; EAR-1r; Hs.37288; RVR
| OMIM = 602304
| ECnumber =
| Homologene = 3763
| MGIid = 2449205
| GeneAtlas_image1 = 209750_at
| GeneAtlas_image2 = 225768_at
| GeneAtlas_image3 = 35705_at
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003707 |text = steroid hormone receptor activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 9975
| Hs_Ensembl = ENSG00000174738
| Hs_RefseqProtein = XP_001130839
| Hs_RefseqmRNA = XM_001130839
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 23961810
| Hs_GenLoc_end = 23996240
| Hs_Uniprot = Q14995
| Mm_EntrezGene = 353187
| Mm_Ensembl = ENSMUSG00000021775
| Mm_RefseqmRNA = NM_011584
| Mm_RefseqProtein = NP_035714
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 14
| Mm_GenLoc_start = 16997124
| Mm_GenLoc_end = 17032066
| Mm_Uniprot = Q4VAB7
}}
}}
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PER1... {October 1, 2007 8:06:44 PM PDT}
- AMBIGUITY: More than one potential page found for updating, PER Per {October 1, 2007 8:07:07 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
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| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Period homolog 1 (Drosophila)
| HGNCid = 8845
| Symbol = PER1
| AltSymbols =; MGC88021; PER; RIGUI; hPER
| OMIM = 602260
| ECnumber =
| Homologene = 1966
| MGIid = 1098283
| GeneAtlas_image1 = 36829_at
| GeneAtlas_image2 = 202861_at
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0009649 |text = entrainment of circadian clock}} {{GNF_GO|id=GO:0016481 |text = negative regulation of transcription}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5187
| Hs_Ensembl = ENSG00000179094
| Hs_RefseqProtein = NP_002607
| Hs_RefseqmRNA = NM_002616
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 7984534
| Hs_GenLoc_end = 7996427
| Hs_Uniprot = O15534
| Mm_EntrezGene = 18626
| Mm_Ensembl = ENSMUSG00000020893
| Mm_RefseqmRNA = NM_011065
| Mm_RefseqProtein = NP_035195
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 68915129
| Mm_GenLoc_end = 68926158
| Mm_Uniprot = Q3U378
}}
}}
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. Circadian expression in the suprachiasmatic nucleus continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of gene expression in the suprachiasmatic nucleus. The specific function of this gene is not yet known. Alternative splicing has been observed in this gene; however, these variants have not been fully described.<ref>{{cite web | title = Entrez Gene: PER1 period homolog 1 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5187| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PER2... {October 1, 2007 8:14:39 PM PDT}
- CREATED: Created new protein page: PER2 {October 1, 2007 8:15:13 PM PDT}
- INFO: Beginning work on PER3... {October 1, 2007 8:14:08 PM PDT}
- CREATED: Created new protein page: PER3 {October 1, 2007 8:14:39 PM PDT}
- INFO: Beginning work on RORA... {October 1, 2007 8:07:07 PM PDT}
- SEARCH REDIRECT: One high potential page found for updating: ROR2 {October 1, 2007 8:07:49 PM PDT}
- UPLOAD: Added new Image to wikiCreated new protein page: <a href=http://en.wikipedia.org/w/index.php?title=ROR2>ROR2</a> {October 1, 2007 8:07:57 PM PDT}
- BAD FORMAT: There is a problem with the BOT commands for this protein: ROR2. Invoking a Mandantory Inspection. {October 1, 2007 8:08:05 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_RORA_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1n83.
| PDB = {{PDB2|1n83}}, {{PDB2|1s0x}}
| Name = RAR-related orphan receptor A
| HGNCid = 10258
| Symbol = RORA
| AltSymbols =; ROR1; ROR2; MGC119326; MGC119329; NR1F1; ROR3; RZRA
| OMIM = 600825
| ECnumber =
| Homologene = 56594
| MGIid = 104661
| GeneAtlas_image1 = 210479_s_at
| GeneAtlas_image2 = 210426_x_at
| GeneAtlas_image3 = 240951_at
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003707 |text = steroid hormone receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006809 |text = nitric oxide biosynthetic process}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0043030 |text = regulation of macrophage activation}} {{GNF_GO|id=GO:0046068 |text = cGMP metabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6095
| Hs_Ensembl = ENSG00000069667
| Hs_RefseqProtein = NP_002934
| Hs_RefseqmRNA = NM_002943
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 15
| Hs_GenLoc_start = 58576755
| Hs_GenLoc_end = 59308709
| Hs_Uniprot = P35398
| Mm_EntrezGene = 19883
| Mm_Ensembl = ENSMUSG00000032238
| Mm_RefseqmRNA = XM_903197
| Mm_RefseqProtein = XP_908290
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 9
| Mm_GenLoc_start = 68452971
| Mm_GenLoc_end = 69178125
| Mm_Uniprot = Q3U1P4
}}
}}
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The specific functions of this protein are not known, but it has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Four transcript variants encoding different isoforms have been described for this gene.<ref>{{cite web | title = Entrez Gene: RORA RAR-related orphan receptor A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6095| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on RORB... {October 1, 2007 8:08:05 PM PDT}
- UPLOAD: Added new Image to wikiCreated new protein page: <a href=http://en.wikipedia.org/w/index.php?title=RORB>RORB</a> {October 1, 2007 8:08:40 PM PDT}
- CREATED: Created new protein page: RORB {October 1, 2007 8:08:53 PM PDT}
- INFO: Beginning work on STAT3... {October 1, 2007 8:08:53 PM PDT}
- SEARCH REDIRECT: One high potential page found for updating: STAT3 {October 1, 2007 8:09:26 PM PDT}
- UPLOAD: Added new Image to wikiCreated new protein page: <a href=http://en.wikipedia.org/w/index.php?title=STAT3>STAT3</a> {October 1, 2007 8:09:36 PM PDT}
- BAD FORMAT: There is a problem with the BOT commands for this protein: STAT3. Invoking a Mandantory Inspection. {October 1, 2007 8:09:43 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_STAT3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1bg1.
| PDB = {{PDB2|1bg1}}
| Name = Signal transducer and activator of transcription 3 (acute-phase response factor)
| HGNCid = 11364
| Symbol = STAT3
| AltSymbols =; APRF; FLJ20882; MGC16063
| OMIM = 102582
| ECnumber =
| Homologene = 7960
| MGIid = 103038
| GeneAtlas_image1 = 289_at
| GeneAtlas_image2 = 208991_at
| GeneAtlas_image3 = 208992_s_at
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005062 |text = hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0008134 |text = transcription factor binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0000122 |text = negative regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006928 |text = cell motility}} {{GNF_GO|id=GO:0006953 |text = acute-phase response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0007259 |text = JAK-STAT cascade}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0019221 |text = cytokine and chemokine mediated signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6774
| Hs_Ensembl = ENSG00000168610
| Hs_RefseqProtein = NP_003141
| Hs_RefseqmRNA = NM_003150
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 37718869
| Hs_GenLoc_end = 37794039
| Hs_Uniprot = P40763
| Mm_EntrezGene = 20848
| Mm_Ensembl = ENSMUSG00000004040
| Mm_RefseqmRNA = XM_001005155
| Mm_RefseqProtein = XP_001005155
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 100701188
| Mm_GenLoc_end = 100755630
| Mm_Uniprot = Q8CFJ6
}}
}}
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.<ref>{{cite web | title = Entrez Gene: STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6774| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Hoey T, Grusby MJ |title=STATs as mediators of cytokine-induced responses. |journal=Adv. Immunol. |volume=71 |issue= |pages= 145-62 |year= 1999 |pmid= 9917912 |doi= }}
*{{cite journal | author=Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW |title=Signaling through the JAK/STAT pathway, recent advances and future challenges. |journal=Gene |volume=285 |issue= 1-2 |pages= 1-24 |year= 2002 |pmid= 12039028 |doi= }}
*{{cite journal | author=Joseph AM, Kumar M, Mitra D |title=Nef: "necessary and enforcing factor" in HIV infection. |journal=Curr. HIV Res. |volume=3 |issue= 1 |pages= 87-94 |year= 2005 |pmid= 15638726 |doi= }}
*{{cite journal | author=Inghirami G, Chiarle R, Simmons WJ, ''et al.'' |title=New and old functions of STAT3: a pivotal target for individualized treatment of cancer. |journal=Cell Cycle |volume=4 |issue= 9 |pages= 1131-3 |year= 2006 |pmid= 16082218 |doi= }}
*{{cite journal | author=Leeman RJ, Lui VW, Grandis JR |title=STAT3 as a therapeutic target in head and neck cancer. |journal=Expert opinion on biological therapy |volume=6 |issue= 3 |pages= 231-41 |year= 2006 |pmid= 16503733 |doi= 10.1517/14712598.6.3.231 }}
*{{cite journal | author=Aggarwal BB, Sethi G, Ahn KS, ''et al.'' |title=Targeting signal-transducer-and-activator-of-transcription-3 for prevention and therapy of cancer: modern target but ancient solution. |journal=Ann. N. Y. Acad. Sci. |volume=1091 |issue= |pages= 151-69 |year= 2007 |pmid= 17341611 |doi= 10.1196/annals.1378.063 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TRPA1... {October 1, 2007 8:15:13 PM PDT}
- CREATED: Created new protein page: TRPA1 {October 1, 2007 8:15:38 PM PDT}
- INFO: Beginning work on TRPC1... {October 1, 2007 8:09:43 PM PDT}
- CREATED: Created new protein page: TRPC1 {October 1, 2007 8:10:21 PM PDT}
- INFO: Beginning work on TRPC2... {October 1, 2007 8:10:21 PM PDT}
- CREATED: Created new protein page: TRPC2 {October 1, 2007 8:10:41 PM PDT}
- INFO: Beginning work on TRPC3... {October 1, 2007 8:10:41 PM PDT}
- CREATED: Created new protein page: TRPC3 {October 1, 2007 8:11:07 PM PDT}
- INFO: Beginning work on TRPC4... {October 1, 2007 8:11:07 PM PDT}
- CREATED: Created new protein page: TRPC4 {October 1, 2007 8:11:48 PM PDT}
- INFO: Beginning work on TRPC4AP... {October 1, 2007 8:17:30 PM PDT}
- SEARCH REDIRECT: One low potential page found for updating, Truss {October 1, 2007 8:17:53 PM PDT}
- BAD FORMAT: There is a problem with the BOT commands for this protein: Truss. Invoking a Mandantory Inspection. {October 1, 2007 8:17:57 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Transient receptor potential cation channel, subfamily C, member 4 associated protein
| HGNCid = 16181
| Symbol = TRPC4AP
| AltSymbols =; C20orf188; TRRP4AP; TRUSS
| OMIM = 608430
| ECnumber =
| Homologene = 9224
| MGIid = 1930751
| GeneAtlas_image1 = 212059_s_at
| GeneAtlas_image2 = 40462_at
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0015197 |text = peptide transporter activity}} {{GNF_GO|id=GO:0015433 |text = peptide antigen-transporting ATPase activity}} {{GNF_GO|id=GO:0042288 |text = MHC class I protein binding}} {{GNF_GO|id=GO:0042301 |text = phosphate binding}} {{GNF_GO|id=GO:0042605 |text = peptide antigen binding}} {{GNF_GO|id=GO:0042803 |text = protein homodimerization activity}} {{GNF_GO|id=GO:0046978 |text = TAP1 binding}} {{GNF_GO|id=GO:0046979 |text = TAP2 binding}} {{GNF_GO|id=GO:0046980 |text = tapasin binding}} {{GNF_GO|id=GO:0046982 |text = protein heterodimerization activity}}
| Component = {{GNF_GO|id=GO:0005788 |text = endoplasmic reticulum lumen}} {{GNF_GO|id=GO:0005829 |text = cytosol}}
| Process = {{GNF_GO|id=GO:0006461 |text = protein complex assembly}} {{GNF_GO|id=GO:0006886 |text = intracellular protein transport}} {{GNF_GO|id=GO:0015833 |text = peptide transport}} {{GNF_GO|id=GO:0019885 |text = antigen processing and presentation of endogenous peptide antigen via MHC class I}} {{GNF_GO|id=GO:0046967 |text = cytosol to ER transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 26133
| Hs_Ensembl = ENSG00000100991
| Hs_RefseqProtein = NP_056453
| Hs_RefseqmRNA = NM_015638
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 20
| Hs_GenLoc_start = 33053876
| Hs_GenLoc_end = 33144279
| Hs_Uniprot = Q8TEL6
| Mm_EntrezGene = 56407
| Mm_Ensembl = ENSMUSG00000038324
| Mm_RefseqmRNA = NM_019828
| Mm_RefseqProtein = NP_062802
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 155325727
| Mm_GenLoc_end = 155383801
| Mm_Uniprot = Q3TB80
}}
}}
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TRPC5... {October 1, 2007 8:11:48 PM PDT}
- CREATED: Created new protein page: TRPC5 {October 1, 2007 8:12:12 PM PDT}
- INFO: Beginning work on TRPC6... {October 1, 2007 8:12:12 PM PDT}
- SEARCH REDIRECT: One high potential page found for updating: TRPC6 {October 1, 2007 8:12:34 PM PDT}
- BAD FORMAT: There is a problem with the BOT commands for this protein: TRPC6. Invoking a Mandantory Inspection. {October 1, 2007 8:12:37 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Transient receptor potential cation channel, subfamily C, member 6
| HGNCid = 12338
| Symbol = TRPC6
| AltSymbols =; FLJ11098; FLJ14863; FSGS2; TRP6
| OMIM = 603652
| ECnumber =
| Homologene = 37944
| MGIid = 109523
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0005216 |text = ion channel activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0015279 |text = store-operated calcium channel activity}} {{GNF_GO|id=GO:0015281 |text = cation channel activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006812 |text = cation transport}} {{GNF_GO|id=GO:0006816 |text = calcium ion transport}} {{GNF_GO|id=GO:0007204 |text = elevation of cytosolic calcium ion concentration}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7225
| Hs_Ensembl =
| Hs_RefseqProtein = NP_004612
| Hs_RefseqmRNA = NM_004621
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 22068
| Mm_Ensembl = ENSMUSG00000031997
| Mm_RefseqmRNA = NM_013838
| Mm_RefseqProtein = NP_038866
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 9
| Mm_GenLoc_start = 8544711
| Mm_GenLoc_end = 8642583
| Mm_Uniprot = Q61143
}}
}}
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Heiner I, Eisfeld J, Lückhoff A |title=Role and regulation of TRP channels in neutrophil granulocytes. |journal=Cell Calcium |volume=33 |issue= 5-6 |pages= 533-40 |year= 2004 |pmid= 12765698 |doi= }}
*{{cite journal | author=Walz G |title=Slit or pore? A mutation of the ion channel TRPC6 causes FSGS. |journal=Nephrol. Dial. Transplant. |volume=20 |issue= 9 |pages= 1777-9 |year= 2006 |pmid= 15998650 |doi= 10.1093/ndt/gfh961 }}
*{{cite journal | author=Clapham DE, Julius D, Montell C, Schultz G |title=International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 427-50 |year= 2006 |pmid= 16382100 |doi= 10.1124/pr.57.4.6 }}
*{{cite journal | author=Schlöndorff JS, Pollak MR |title=TRPC6 in glomerular health and disease: what we know and what we believe. |journal=Semin. Cell Dev. Biol. |volume=17 |issue= 6 |pages= 667-74 |year= 2007 |pmid= 17116414 |doi= 10.1016/j.semcdb.2006.11.003 }}
*{{cite journal | author=Dietrich A, Gudermann T |title=TRPC6. |journal=Handb Exp Pharmacol |volume= |issue= 179 |pages= 125-41 |year= 2007 |pmid= 17217054 |doi= 10.1007/978-3-540-34891-7_7 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TRPC7... {October 1, 2007 8:24:20 PM PDT}
- CREATED: Created new protein page: TRPC7 {October 1, 2007 8:24:41 PM PDT}
- INFO: Beginning work on TRPM1... {October 1, 2007 8:05:12 PM PDT}
- CREATED: Created new protein page: TRPM1 {October 1, 2007 8:05:41 PM PDT}
- INFO: Beginning work on TRPM2... {October 1, 2007 8:12:37 PM PDT}
- CREATED: Created new protein page: TRPM2 {October 1, 2007 8:13:18 PM PDT}
- INFO: Beginning work on TRPM3... {October 1, 2007 8:25:52 PM PDT}
- CREATED: Created new protein page: TRPM3 {October 1, 2007 8:26:24 PM PDT}
- INFO: Beginning work on TRPM4... {October 1, 2007 8:19:53 PM PDT}
- CREATED: Created new protein page: TRPM4 {October 1, 2007 8:21:29 PM PDT}
- INFO: Beginning work on TRPM5... {October 1, 2007 8:18:37 PM PDT}
- CREATED: Created new protein page: TRPM5 {October 1, 2007 8:18:59 PM PDT}
- INFO: Beginning work on TRPM6... {October 1, 2007 8:26:53 PM PDT}
- SEARCH REDIRECT: One high potential page found for updating: TRPM6 {October 1, 2007 8:27:19 PM PDT}
- BAD FORMAT: There is a problem with the BOT commands for this protein: TRPM6. Invoking a Mandantory Inspection. {October 1, 2007 8:27:22 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Transient receptor potential cation channel, subfamily M, member 6
| HGNCid = 17995
| Symbol = TRPM6
| AltSymbols =; CHAK2; HMGX; HOMG; HSH
| OMIM = 607009
| ECnumber =
| Homologene = 9767
| MGIid = 2675603
| GeneAtlas_image1 = 234864_s_at
| GeneAtlas_image2 = 221102_s_at
| GeneAtlas_image3 = 224412_s_at
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005216 |text = ion channel activity}} {{GNF_GO|id=GO:0005262 |text = calcium channel activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016301 |text = kinase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006816 |text = calcium ion transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 140803
| Hs_Ensembl = ENSG00000119121
| Hs_RefseqProtein = NP_060132
| Hs_RefseqmRNA = NM_017662
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 9
| Hs_GenLoc_start = 76527231
| Hs_GenLoc_end = 76692830
| Hs_Uniprot = Q9BX84
| Mm_EntrezGene = 225997
| Mm_Ensembl = ENSMUSG00000024727
| Mm_RefseqmRNA = XM_987699
| Mm_RefseqProtein = XP_992793
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 19
| Mm_GenLoc_start = 18817002
| Mm_GenLoc_end = 18959534
| Mm_Uniprot = Q8CIR4
}}
}}
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Chubanov V, Gudermann T, Schlingmann KP |title=Essential role for TRPM6 in epithelial magnesium transport and body magnesium homeostasis. |journal=Pflugers Arch. |volume=451 |issue= 1 |pages= 228-34 |year= 2006 |pmid= 16075242 |doi= 10.1007/s00424-005-1470-y }}
*{{cite journal | author=Clapham DE, Julius D, Montell C, Schultz G |title=International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 427-50 |year= 2006 |pmid= 16382100 |doi= 10.1124/pr.57.4.6 }}
*{{cite journal | author=Bödding M |title=TRPM6: A Janus-like protein. |journal=Handb Exp Pharmacol |volume= |issue= 179 |pages= 299-311 |year= 2007 |pmid= 17217065 |doi= 10.1007/978-3-540-34891-7_18 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TRPM7... {October 1, 2007 8:21:29 PM PDT}
- SEARCH REDIRECT: One low potential page found for updating, Chak {October 1, 2007 8:22:04 PM PDT}
- UPLOAD: Added new Image to wikiCreated new protein page: <a href=http://en.wikipedia.org/w/index.php?title=Chak>Chak</a> {October 1, 2007 8:22:11 PM PDT}
- BAD FORMAT: There is a problem with the BOT commands for this protein: Chak. Invoking a Mandantory Inspection. {October 1, 2007 8:22:19 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_TRPM7_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ia9.
| PDB = {{PDB2|1ia9}}, {{PDB2|1iah}}, {{PDB2|1iaj}}
| Name = Transient receptor potential cation channel, subfamily M, member 7
| HGNCid = 17994
| Symbol = TRPM7
| AltSymbols =; CHAK; CHAK1; FLJ20117; FLJ25718; LTRPC7; TRP-PLIK
| OMIM = 605692
| ECnumber =
| Homologene = 9774
| MGIid = 1929996
| GeneAtlas_image1 = 223323_x_at
| GeneAtlas_image2 = 223324_s_at
| GeneAtlas_image3 = 62139_at
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003779 |text = actin binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0005216 |text = ion channel activity}} {{GNF_GO|id=GO:0005262 |text = calcium channel activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016301 |text = kinase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0017022 |text = myosin binding}}
| Component = {{GNF_GO|id=GO:0001726 |text = ruffle}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006816 |text = calcium ion transport}} {{GNF_GO|id=GO:0016340 |text = calcium-dependent cell-matrix adhesion}} {{GNF_GO|id=GO:0031032 |text = actomyosin structure organization and biogenesis}} {{GNF_GO|id=GO:0046777 |text = protein amino acid autophosphorylation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 54822
| Hs_Ensembl = ENSG00000092439
| Hs_RefseqProtein = NP_060142
| Hs_RefseqmRNA = NM_017672
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 15
| Hs_GenLoc_start = 48639785
| Hs_GenLoc_end = 48766287
| Hs_Uniprot = Q96QT4
| Mm_EntrezGene = 58800
| Mm_Ensembl = ENSMUSG00000027365
| Mm_RefseqmRNA = NM_021450
| Mm_RefseqProtein = NP_067425
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 126483006
| Mm_GenLoc_end = 126567671
| Mm_Uniprot = Q923J1
}}
}}
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = TRPCs, mammalian homologs of the Drosophila transient receptor potential (trp) protein, are ion channels that are thought to mediate capacitative calcium entry into the cell. TRP-PLIK is a protein that is both an ion channel and a kinase. As a channel, it conducts calcium and monovalent cations to depolarize cells and increase intracellular calcium. As a kinase, it is capable of phosphorylating itself and other substrates. The kinase activity is necessary for channel function, as shown by its dependence on intracellular ATP and by the kinase mutants.[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: TRPM7 transient receptor potential cation channel, subfamily M, member 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54822| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Chubanov V, Gudermann T, Schlingmann KP |title=Essential role for TRPM6 in epithelial magnesium transport and body magnesium homeostasis. |journal=Pflugers Arch. |volume=451 |issue= 1 |pages= 228-34 |year= 2006 |pmid= 16075242 |doi= 10.1007/s00424-005-1470-y }}
*{{cite journal | author=Clapham DE, Julius D, Montell C, Schultz G |title=International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 427-50 |year= 2006 |pmid= 16382100 |doi= 10.1124/pr.57.4.6 }}
*{{cite journal | author=Penner R, Fleig A |title=The Mg2+ and Mg(2+)-nucleotide-regulated channel-kinase TRPM7. |journal=Handb Exp Pharmacol |volume= |issue= 179 |pages= 313-28 |year= 2007 |pmid= 17217066 |doi= 10.1007/978-3-540-34891-7_19 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TRPM8... {October 1, 2007 8:25:24 PM PDT}
- CREATED: Created new protein page: TRPM8 {October 1, 2007 8:25:52 PM PDT}
- INFO: Beginning work on TRPS1... {October 1, 2007 8:13:18 PM PDT}
- CREATED: Created new protein page: TRPS1 {October 1, 2007 8:13:45 PM PDT}
- INFO: Beginning work on TRPT1... {October 1, 2007 8:26:24 PM PDT}
- CREATED: Created new protein page: TRPT1 {October 1, 2007 8:26:53 PM PDT}
- INFO: Beginning work on TRPV1... {October 1, 2007 8:13:45 PM PDT}
- SEARCH REDIRECT: One high potential page found for updating: TRPV1 {October 1, 2007 8:14:04 PM PDT}
- BAD FORMAT: There is a problem with the BOT commands for this protein: TRPV1. Invoking a Mandantory Inspection. {October 1, 2007 8:14:08 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Transient receptor potential cation channel, subfamily V, member 1
| HGNCid = 12716
| Symbol = TRPV1
| AltSymbols =; DKFZp434K0220; VR1
| OMIM = 602076
| ECnumber =
| Homologene = 12920
| MGIid = 1341787
| GeneAtlas_image1 = 219632_s_at
| GeneAtlas_image2 = 50775_at
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005216 |text = ion channel activity}} {{GNF_GO|id=GO:0005262 |text = calcium channel activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005516 |text = calmodulin binding}} {{GNF_GO|id=GO:0008324 |text = cation transmembrane transporter activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0001659 |text = thermoregulation}} {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006816 |text = calcium ion transport}} {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}} {{GNF_GO|id=GO:0007635 |text = chemosensory behavior}} {{GNF_GO|id=GO:0009268 |text = response to pH}} {{GNF_GO|id=GO:0009408 |text = response to heat}} {{GNF_GO|id=GO:0019233 |text = sensory perception of pain}} {{GNF_GO|id=GO:0050955 |text = thermoception}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7442
| Hs_Ensembl = ENSG00000196689
| Hs_RefseqProtein = NP_061197
| Hs_RefseqmRNA = NM_018727
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 3415493
| Hs_GenLoc_end = 3447141
| Hs_Uniprot = Q8NER1
| Mm_EntrezGene = 193034
| Mm_Ensembl = ENSMUSG00000005952
| Mm_RefseqmRNA = NM_001001445
| Mm_RefseqProtein = NP_001001445
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 73050516
| Mm_GenLoc_end = 73077434
| Mm_Uniprot = Q3V318
}}
}}
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene.<ref>{{cite web | title = Entrez Gene: TRPV1 transient receptor potential cation channel, subfamily V, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7442| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Heiner I, Eisfeld J, Lückhoff A |title=Role and regulation of TRP channels in neutrophil granulocytes. |journal=Cell Calcium |volume=33 |issue= 5-6 |pages= 533-40 |year= 2004 |pmid= 12765698 |doi= }}
*{{cite journal | author=Geppetti P, Trevisani M |title=Activation and sensitisation of the vanilloid receptor: role in gastrointestinal inflammation and function. |journal=Br. J. Pharmacol. |volume=141 |issue= 8 |pages= 1313-20 |year= 2004 |pmid= 15051629 |doi= 10.1038/sj.bjp.0705768 }}
*{{cite journal | author=Clapham DE, Julius D, Montell C, Schultz G |title=International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 427-50 |year= 2006 |pmid= 16382100 |doi= 10.1124/pr.57.4.6 }}
*{{cite journal | author=Szallasi A, Cruz F, Geppetti P |title=TRPV1: a therapeutic target for novel analgesic drugs? |journal=Trends in molecular medicine |volume=12 |issue= 11 |pages= 545-54 |year= 2007 |pmid= 16996800 |doi= 10.1016/j.molmed.2006.09.001 }}
*{{cite journal | author=Pingle SC, Matta JA, Ahern GP |title=Capsaicin receptor: TRPV1 a promiscuous TRP channel. |journal=Handb Exp Pharmacol |volume= |issue= 179 |pages= 155-71 |year= 2007 |pmid= 17217056 |doi= 10.1007/978-3-540-34891-7_9 }}
*{{cite journal | author=Liddle RA |title=The role of Transient Receptor Potential Vanilloid 1 (TRPV1) channels in pancreatitis. |journal=Biochim. Biophys. Acta |volume=1772 |issue= 8 |pages= 869-78 |year= 2007 |pmid= 17428642 |doi= 10.1016/j.bbadis.2007.02.012 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TRPV2... {October 1, 2007 8:18:59 PM PDT}
- UPLOAD: Added new Image to wikiCreated new protein page: <a href=http://en.wikipedia.org/w/index.php?title=TRPV2>TRPV2</a> {October 1, 2007 8:19:36 PM PDT}
- CREATED: Created new protein page: TRPV2 {October 1, 2007 8:19:53 PM PDT}
- INFO: Beginning work on TRPV3... {October 1, 2007 8:27:22 PM PDT}
- CREATED: Created new protein page: TRPV3 {October 1, 2007 8:27:46 PM PDT}
- INFO: Beginning work on TRPV4... {October 1, 2007 8:24:41 PM PDT}
- CREATED: Created new protein page: TRPV4 {October 1, 2007 8:25:24 PM PDT}
- INFO: Beginning work on TRPV5... {October 1, 2007 8:22:52 PM PDT}
- AMBIGUITY: More than one potential page found for updating, CAT2 Category 2 cable {October 1, 2007 8:23:17 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Transient receptor potential cation channel, subfamily V, member 5
| HGNCid = 3145
| Symbol = TRPV5
| AltSymbols =; CAT2; ECAC1; OTRPC3
| OMIM = 606679
| ECnumber =
| Homologene = 10520
| MGIid = 2429764
| GeneAtlas_image1 = 208267_at
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0005216 |text = ion channel activity}} {{GNF_GO|id=GO:0005262 |text = calcium channel activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016324 |text = apical plasma membrane}}
| Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006816 |text = calcium ion transport}} {{GNF_GO|id=GO:0006874 |text = cellular calcium ion homeostasis}} {{GNF_GO|id=GO:0051262 |text = protein tetramerization}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 56302
| Hs_Ensembl = ENSG00000127412
| Hs_RefseqProtein = NP_062815
| Hs_RefseqmRNA = NM_019841
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 142315389
| Hs_GenLoc_end = 142341027
| Hs_Uniprot = Q9NQA5
| Mm_EntrezGene = 194352
| Mm_Ensembl = ENSMUSG00000036899
| Mm_RefseqmRNA = NM_001007572
| Mm_RefseqProtein = NP_001007573
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 41581780
| Mm_GenLoc_end = 41610376
| Mm_Uniprot = Q2TB50
}}
}}
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the transient receptor family and the TrpV subfamily. The calcium-selective channel encoded by this gene has 6 transmembrane-spanning domains, multiple potential phosphorylation sites, an N-linked glycosylation site, and 5 ANK repeats. This protein forms homotetramers or heterotetramers and is activated by a low internal calcium level.<ref>{{cite web | title = Entrez Gene: TRPV5 transient receptor potential cation channel, subfamily V, member 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56302| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Vennekens R, Droogmans G, Nilius B |title=Functional properties of the epithelial Ca2+ channel, ECaC. |journal=Gen. Physiol. Biophys. |volume=20 |issue= 3 |pages= 239-53 |year= 2002 |pmid= 11765215 |doi= }}
*{{cite journal | author=Heiner I, Eisfeld J, Lückhoff A |title=Role and regulation of TRP channels in neutrophil granulocytes. |journal=Cell Calcium |volume=33 |issue= 5-6 |pages= 533-40 |year= 2004 |pmid= 12765698 |doi= }}
*{{cite journal | author=Nijenhuis T, Hoenderop JG, Bindels RJ |title=TRPV5 and TRPV6 in Ca(2+) (re)absorption: regulating Ca(2+) entry at the gate. |journal=Pflugers Arch. |volume=451 |issue= 1 |pages= 181-92 |year= 2006 |pmid= 16044309 |doi= 10.1007/s00424-005-1430-6 }}
*{{cite journal | author=Clapham DE, Julius D, Montell C, Schultz G |title=International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 427-50 |year= 2006 |pmid= 16382100 |doi= 10.1124/pr.57.4.6 }}
*{{cite journal | author=Mensenkamp AR, Hoenderop JG, Bindels RJ |title=TRPV5, the gateway to Ca2+ homeostasis. |journal=Handb Exp Pharmacol |volume= |issue= 179 |pages= 207-20 |year= 2007 |pmid= 17217059 |doi= 10.1007/978-3-540-34891-7_12 }}
*{{cite journal | author=Schoeber JP, Hoenderop JG, Bindels RJ |title=Concerted action of associated proteins in the regulation of TRPV5 and TRPV6. |journal=Biochem. Soc. Trans. |volume=35 |issue= Pt 1 |pages= 115-9 |year= 2007 |pmid= 17233615 |doi= 10.1042/BST0350115 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TRPV6... {October 1, 2007 8:22:19 PM PDT}
- SEARCH REDIRECT: One high potential page found for updating: TRPV6 {October 1, 2007 8:22:50 PM PDT}
- BAD FORMAT: There is a problem with the BOT commands for this protein: TRPV6. Invoking a Mandantory Inspection. {October 1, 2007 8:22:52 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Transient receptor potential cation channel, subfamily V, member 6
| HGNCid = 14006
| Symbol = TRPV6
| AltSymbols =; CAT1; CATL; ABP/ZF; ECAC2; HSA277909; LP6728; ZFAB
| OMIM = 606680
| ECnumber =
| Homologene = 56812
| MGIid = 1927259
| GeneAtlas_image1 = 206827_s_at
| GeneAtlas_image2 = 36806_at
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0005216 |text = ion channel activity}} {{GNF_GO|id=GO:0005262 |text = calcium channel activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005516 |text = calmodulin binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006816 |text = calcium ion transport}} {{GNF_GO|id=GO:0017158 |text = regulation of calcium ion-dependent exocytosis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 55503
| Hs_Ensembl = ENSG00000165125
| Hs_RefseqProtein = XP_001126541
| Hs_RefseqmRNA = XM_001126541
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 142279083
| Hs_GenLoc_end = 142293629
| Hs_Uniprot = Q9H1D0
| Mm_EntrezGene = 64177
| Mm_Ensembl = ENSMUSG00000029868
| Mm_RefseqmRNA = XM_977638
| Mm_RefseqProtein = XP_982732
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 41550232
| Mm_GenLoc_end = 41565942
| Mm_Uniprot = Q91WD2
}}
}}
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Calcium-permeable channels, such as TRPV6, participate in neurotransmission, muscle contraction, and exocytosis by providing calcium as an intracellular second messenger. Depending on the tissue, transcellular calcium transport may be regulated by vitamin D, parathyroid hormone (PTH; MIM 168450), or calcitonin (CALCA; MIM 114130).[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: TRPV6 transient receptor potential cation channel, subfamily V, member 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55503| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Heiner I, Eisfeld J, Lückhoff A |title=Role and regulation of TRP channels in neutrophil granulocytes. |journal=Cell Calcium |volume=33 |issue= 5-6 |pages= 533-40 |year= 2004 |pmid= 12765698 |doi= }}
*{{cite journal | author=Peng JB, Brown EM, Hediger MA |title=Epithelial Ca2+ entry channels: transcellular Ca2+ transport and beyond. |journal=J. Physiol. (Lond.) |volume=551 |issue= Pt 3 |pages= 729-40 |year= 2004 |pmid= 12869611 |doi= 10.1113/jphysiol.2003.043349 }}
*{{cite journal | author=Clapham DE, Julius D, Montell C, Schultz G |title=International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 427-50 |year= 2006 |pmid= 16382100 |doi= 10.1124/pr.57.4.6 }}
*{{cite journal | author=Wissenbach U, Niemeyer BA |title=TRPV6. |journal=Handb Exp Pharmacol |volume= |issue= 179 |pages= 221-34 |year= 2007 |pmid= 17217060 |doi= 10.1007/978-3-540-34891-7_13 }}
*{{cite journal | author=Schoeber JP, Hoenderop JG, Bindels RJ |title=Concerted action of associated proteins in the regulation of TRPV5 and TRPV6. |journal=Biochem. Soc. Trans. |volume=35 |issue= Pt 1 |pages= 115-9 |year= 2007 |pmid= 17233615 |doi= 10.1042/BST0350115 }}
}}
{{refend}}
{{protein-stub}}
end log.
