- INFO: Beginning work on CCRL2... {November 25, 2007 8:45:41 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 8:46:05 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Chemokine (C-C motif) receptor-like 2
| HGNCid = 1612
| Symbol = CCRL2
| AltSymbols =; CKRX; CRAM-A; CRAM-B; HCR; MGC116710
| OMIM = 608379
| ECnumber =
| Homologene = 2948
| MGIid = 1920904
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0016493 |text = C-C chemokine receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006935 |text = chemotaxis}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0019735 |text = antimicrobial humoral response}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 9034
| Hs_Ensembl =
| Hs_RefseqProtein = NP_003956
| Hs_RefseqmRNA = NM_003965
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 54199
| Mm_Ensembl = ENSMUSG00000043953
| Mm_RefseqmRNA = XM_979714
| Mm_RefseqProtein = XP_984808
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 9
| Mm_GenLoc_start = 110899651
| Mm_GenLoc_end = 110902322
| Mm_Uniprot = O35457
}}
}}
'''Chemokine (C-C motif) receptor-like 2''', also known as '''CCRL2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CCRL2 chemokine (C-C motif) receptor-like 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9034| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a chemokine receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. This gene is mapped to the region where the chemokine receptor gene cluster is located.<ref name="entrez">{{cite web | title = Entrez Gene: CCRL2 chemokine (C-C motif) receptor-like 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9034| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Daugherty BL, Springer MS |title=The beta-chemokine receptor genes CCR1 (CMKBR1), CCR2 (CMKBR2), and CCR3 (CMKBR3) cluster within 285 kb on human chromosome 3p21. |journal=Genomics |volume=41 |issue= 2 |pages= 294-5 |year= 1997 |pmid= 9143512 |doi= 10.1006/geno.1997.4626 }}
*{{cite journal | author=Fan P, Kyaw H, Su K, ''et al.'' |title=Cloning and characterization of a novel human chemokine receptor. |journal=Biochem. Biophys. Res. Commun. |volume=243 |issue= 1 |pages= 264-8 |year= 1998 |pmid= 9473515 |doi= 10.1006/bbrc.1997.7981 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Galligan CL, Matsuyama W, Matsukawa A, ''et al.'' |title=Up-regulated expression and activation of the orphan chemokine receptor, CCRL2, in rheumatoid arthritis. |journal=Arthritis Rheum. |volume=50 |issue= 6 |pages= 1806-14 |year= 2004 |pmid= 15188357 |doi= 10.1002/art.20275 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Muzny DM, Scherer SE, Kaul R, ''et al.'' |title=The DNA sequence, annotation and analysis of human chromosome 3. |journal=Nature |volume=440 |issue= 7088 |pages= 1194-8 |year= 2006 |pmid= 16641997 |doi= 10.1038/nature04728 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on EDG4... {November 25, 2007 8:47:09 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 8:48:08 PM PST}
- CREATED: Created new protein page: EDG4 {November 25, 2007 8:48:17 PM PST}
- INFO: Beginning work on EDG6... {November 25, 2007 8:42:03 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 8:43:03 PM PST}
- CREATED: Created new protein page: EDG6 {November 25, 2007 8:43:11 PM PST}
- INFO: Beginning work on F2RL3... {November 25, 2007 8:44:48 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 8:45:31 PM PST}
- CREATED: Created new protein page: F2RL3 {November 25, 2007 8:45:41 PM PST}
- INFO: Beginning work on FZD7... {November 25, 2007 8:30:22 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 8:31:18 PM PST}
- CREATED: Created new protein page: FZD7 {November 25, 2007 8:31:27 PM PST}
- INFO: Beginning work on FZD8... {November 25, 2007 8:31:27 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein FZD8 image.jpg {November 25, 2007 8:32:06 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 8:32:19 PM PST}
- CREATED: Created new protein page: FZD8 {November 25, 2007 8:32:27 PM PST}
- INFO: Beginning work on FZD9... {November 25, 2007 8:32:27 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 8:33:09 PM PST}
- CREATED: Created new protein page: FZD9 {November 25, 2007 8:33:22 PM PST}
- INFO: Beginning work on GALR2... {November 25, 2007 8:43:11 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 8:44:09 PM PST}
- CREATED: Created new protein page: GALR2 {November 25, 2007 8:44:17 PM PST}
- INFO: Beginning work on GALR3... {November 25, 2007 8:39:27 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 8:40:04 PM PST}
- CREATED: Created new protein page: GALR3 {November 25, 2007 8:40:13 PM PST}
- INFO: Beginning work on GPR109B... {November 25, 2007 8:44:17 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 8:44:40 PM PST}
- CREATED: Created new protein page: GPR109B {November 25, 2007 8:44:48 PM PST}
- INFO: Beginning work on GPR37L1... {November 25, 2007 8:48:58 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 8:49:43 PM PST}
- CREATED: Created new protein page: GPR37L1 {November 25, 2007 8:49:51 PM PST}
- INFO: Beginning work on GPR50... {November 25, 2007 8:48:17 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 8:48:58 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = G protein-coupled receptor 50
| HGNCid = 4506
| Symbol = GPR50
| AltSymbols =; H9; MGC125342
| OMIM = 300207
| ECnumber =
| Homologene = 3113
| MGIid = 1333877
| GeneAtlas_image1 = PBB_GE_GPR50_208311_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0008502 |text = melatonin receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 9248
| Hs_Ensembl = ENSG00000102195
| Hs_RefseqProtein = NP_004215
| Hs_RefseqmRNA = NM_004224
| Hs_GenLoc_db =
| Hs_GenLoc_chr = X
| Hs_GenLoc_start = 150095783
| Hs_GenLoc_end = 150100595
| Hs_Uniprot = Q13585
| Mm_EntrezGene = 14765
| Mm_Ensembl = ENSMUSG00000056380
| Mm_RefseqmRNA = XM_990925
| Mm_RefseqProtein = XP_996019
| Mm_GenLoc_db =
| Mm_GenLoc_chr = X
| Mm_GenLoc_start = 67924323
| Mm_GenLoc_end = 67928645
| Mm_Uniprot = Q3V1S8
}}
}}
'''G protein-coupled receptor 50''', also known as '''GPR50''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GPR50 G protein-coupled receptor 50| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9248| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Reppert SM, Weaver DR, Ebisawa T, ''et al.'' |title=Cloning of a melatonin-related receptor from human pituitary. |journal=FEBS Lett. |volume=386 |issue= 2-3 |pages= 219-24 |year= 1996 |pmid= 8647286 |doi= }}
*{{cite journal | author=Gubitz AK, Reppert SM |title=Assignment of the melatonin-related receptor to human chromosome X (GPR50) and mouse chromosome X (Gpr50). |journal=Genomics |volume=55 |issue= 2 |pages= 248-51 |year= 1999 |pmid= 9933574 |doi= 10.1006/geno.1998.5661 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Slominski A, Pisarchik A, Zbytek B, ''et al.'' |title=Functional activity of serotoninergic and melatoninergic systems expressed in the skin. |journal=J. Cell. Physiol. |volume=196 |issue= 1 |pages= 144-53 |year= 2003 |pmid= 12767050 |doi= 10.1002/jcp.10287 }}
*{{cite journal | author=Suzuki Y, Yamashita R, Shirota M, ''et al.'' |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711-8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 }}
*{{cite journal | author=Thomson PA, Wray NR, Thomson AM, ''et al.'' |title=Sex-specific association between bipolar affective disorder in women and GPR50, an X-linked orphan G protein-coupled receptor. |journal=Mol. Psychiatry |volume=10 |issue= 5 |pages= 470-8 |year= 2005 |pmid= 15452587 |doi= 10.1038/sj.mp.4001593 }}
*{{cite journal | author=Bhattacharyya S, Luan J, Challis B, ''et al.'' |title=Sequence variants in the melatonin-related receptor gene (GPR50) associate with circulating triglyceride and HDL levels. |journal=J. Lipid Res. |volume=47 |issue= 4 |pages= 761-6 |year= 2006 |pmid= 16436372 |doi= 10.1194/jlr.M500338-JLR200 }}
*{{cite journal | author=Levoye A, Dam J, Ayoub MA, ''et al.'' |title=The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization. |journal=EMBO J. |volume=25 |issue= 13 |pages= 3012-23 |year= 2006 |pmid= 16778767 |doi= 10.1038/sj.emboj.7601193 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GPR65... {November 25, 2007 8:38:40 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 8:39:18 PM PST}
- CREATED: Created new protein page: GPR65 {November 25, 2007 8:39:27 PM PST}
- INFO: Beginning work on GPRC5A... {November 25, 2007 8:46:46 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 8:47:09 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = G protein-coupled receptor, family C, group 5, member A
| HGNCid = 9836
| Symbol = GPRC5A
| AltSymbols =; GPCR5A; RAI3; RAIG1
| OMIM = 604138
| ECnumber =
| Homologene = 2961
| MGIid = 1891250
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0008067 |text = metabotropic glutamate, GABA-B-like receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 9052
| Hs_Ensembl = ENSG00000013588
| Hs_RefseqProtein = NP_003970
| Hs_RefseqmRNA = NM_003979
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 12934983
| Hs_GenLoc_end = 12957833
| Hs_Uniprot = Q8NFJ5
| Mm_EntrezGene = 232431
| Mm_Ensembl = ENSMUSG00000046733
| Mm_RefseqmRNA = NM_181444
| Mm_RefseqProtein = NP_852109
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 135031383
| Mm_GenLoc_end = 135050402
| Mm_Uniprot = Q8BHL4
}}
}}
'''G protein-coupled receptor, family C, group 5, member A''', also known as '''GPRC5A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GPRC5A G protein-coupled receptor, family C, group 5, member A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9052| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the type 3 G protein-coupling receptor family, characterized by the signature 7-transmembrane domain motif. The encoded protein may be involved in interaction between retinoid acid and G protein signalling pathways. Retinoic acid plays a critical role in development, cellular growth, and differentiation. This gene may play a role in embryonic development and epithelial cell differentiation.<ref name="entrez">{{cite web | title = Entrez Gene: GPRC5A G protein-coupled receptor, family C, group 5, member A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9052| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Cafferata EG, Gonzalez-Guerrico AM, Pivetta OH, Santa-Coloma TA |title=Identification by differential display of a mRNA specifically induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in T84 human colon carcinoma cells. |journal=Cell. Mol. Biol. (Noisy-le-grand) |volume=42 |issue= 5 |pages= 797-804 |year= 1997 |pmid= 8832110 |doi= }}
*{{cite journal | author=Cheng Y, Lotan R |title=Molecular cloning and characterization of a novel retinoic acid-inducible gene that encodes a putative G protein-coupled receptor. |journal=J. Biol. Chem. |volume=273 |issue= 52 |pages= 35008-15 |year= 1999 |pmid= 9857033 |doi= }}
*{{cite journal | author=Bräuner-Osborne H, Krogsgaard-Larsen P |title=Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain. |journal=Genomics |volume=65 |issue= 2 |pages= 121-8 |year= 2000 |pmid= 10783259 |doi= 10.1006/geno.2000.6164 }}
*{{cite journal | author=Robbins MJ, Michalovich D, Hill J, ''et al.'' |title=Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C). |journal=Genomics |volume=67 |issue= 1 |pages= 8-18 |year= 2001 |pmid= 10945465 |doi= 10.1006/geno.2000.6226 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Tao Q, Cheng Y, Clifford J, Lotan R |title=Characterization of the murine orphan G-protein-coupled receptor gene Rai3 and its regulation by retinoic acid. |journal=Genomics |volume=83 |issue= 2 |pages= 270-80 |year= 2004 |pmid= 14706456 |doi= }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Wu Q, Ding W, Mirza A, ''et al.'' |title=Integrative genomics revealed RAI3 is a cell growth-promoting gene and a novel P53 transcriptional target. |journal=J. Biol. Chem. |volume=280 |issue= 13 |pages= 12935-43 |year= 2005 |pmid= 15659406 |doi= 10.1074/jbc.M409901200 }}
*{{cite journal | author=Zhang Y, Wolf-Yadlin A, Ross PL, ''et al.'' |title=Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. |journal=Mol. Cell Proteomics |volume=4 |issue= 9 |pages= 1240-50 |year= 2005 |pmid= 15951569 |doi= 10.1074/mcp.M500089-MCP200 }}
*{{cite journal | author=Nousiainen M, Silljé HH, Sauer G, ''et al.'' |title=Phosphoproteome analysis of the human mitotic spindle. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 14 |pages= 5391-6 |year= 2006 |pmid= 16565220 |doi= 10.1073/pnas.0507066103 }}
*{{cite journal | author=Hirano M, Zang L, Oka T, ''et al.'' |title=Novel reciprocal regulation of cAMP signaling and apoptosis by orphan G-protein-coupled receptor GPRC5A gene expression. |journal=Biochem. Biophys. Res. Commun. |volume=351 |issue= 1 |pages= 185-91 |year= 2006 |pmid= 17055459 |doi= 10.1016/j.bbrc.2006.10.016 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on LGR5... {November 25, 2007 8:40:13 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 8:41:20 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Leucine-rich repeat-containing G protein-coupled receptor 5
| HGNCid = 4504
| Symbol = LGR5
| AltSymbols =; FEX; GPR49; GPR67; GRP49; HG38; MGC117008
| OMIM = 606667
| ECnumber =
| Homologene = 20807
| MGIid = 1341817
| GeneAtlas_image1 = PBB_GE_LGR5_213880_at_tn.png
| GeneAtlas_image2 = PBB_GE_LGR5_210393_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016500 |text = protein-hormone receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8549
| Hs_Ensembl = ENSG00000139292
| Hs_RefseqProtein = NP_003658
| Hs_RefseqmRNA = NM_003667
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 70120031
| Hs_GenLoc_end = 70264781
| Hs_Uniprot = O75473
| Mm_EntrezGene = 14160
| Mm_Ensembl = ENSMUSG00000020140
| Mm_RefseqmRNA = NM_010195
| Mm_RefseqProtein = NP_034325
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 10
| Mm_GenLoc_start = 114855736
| Mm_GenLoc_end = 114991603
| Mm_Uniprot = Q3V1L2
}}
}}
'''Leucine-rich repeat-containing G protein-coupled receptor 5''', also known as '''LGR5''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: LGR5 leucine-rich repeat-containing G protein-coupled receptor 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8549| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=McDonald T, Wang R, Bailey W, ''et al.'' |title=Identification and cloning of an orphan G protein-coupled receptor of the glycoprotein hormone receptor subfamily. |journal=Biochem. Biophys. Res. Commun. |volume=247 |issue= 2 |pages= 266-70 |year= 1998 |pmid= 9642114 |doi= 10.1006/bbrc.1998.8774 }}
*{{cite journal | author=Hsu SY, Liang SG, Hsueh AJ |title=Characterization of two LGR genes homologous to gonadotropin and thyrotropin receptors with extracellular leucine-rich repeats and a G protein-coupled, seven-transmembrane region. |journal=Mol. Endocrinol. |volume=12 |issue= 12 |pages= 1830-45 |year= 1999 |pmid= 9849958 |doi= }}
*{{cite journal | author=Hsu SY, Kudo M, Chen T, ''et al.'' |title=The three subfamilies of leucine-rich repeat-containing G protein-coupled receptors (LGR): identification of LGR6 and LGR7 and the signaling mechanism for LGR7. |journal=Mol. Endocrinol. |volume=14 |issue= 8 |pages= 1257-71 |year= 2001 |pmid= 10935549 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Yamamoto Y, Sakamoto M, Fujii G, ''et al.'' |title=Overexpression of orphan G-protein-coupled receptor, Gpr49, in human hepatocellular carcinomas with beta-catenin mutations. |journal=Hepatology |volume=37 |issue= 3 |pages= 528-33 |year= 2003 |pmid= 12601349 |doi= 10.1053/jhep.2003.50029 }}
*{{cite journal | author=McClanahan T, Koseoglu S, Smith K, ''et al.'' |title=Identification of overexpression of orphan G protein-coupled receptor GPR49 in human colon and ovarian primary tumors. |journal=Cancer Biol. Ther. |volume=5 |issue= 4 |pages= 419-26 |year= 2007 |pmid= 16575208 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on OR1A1... {November 25, 2007 8:33:22 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 8:34:00 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Olfactory receptor, family 1, subfamily A, member 1
| HGNCid = 8179
| Symbol = OR1A1
| AltSymbols =; OR17-7
| OMIM =
| ECnumber =
| Homologene = 8219
| MGIid = 1333770
| GeneAtlas_image1 = PBB_GE_OR1A1_221388_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004984 |text = olfactory receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007608 |text = sensory perception of smell}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8383
| Hs_Ensembl = ENSG00000172146
| Hs_RefseqProtein = NP_055380
| Hs_RefseqmRNA = NM_014565
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 3065665
| Hs_GenLoc_end = 3066594
| Hs_Uniprot = Q9P1Q5
| Mm_EntrezGene = 258706
| Mm_Ensembl = ENSMUSG00000070377
| Mm_RefseqmRNA = NM_146711
| Mm_RefseqProtein = NP_666922
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 74022468
| Mm_GenLoc_end = 74023409
| Mm_Uniprot =
}}
}}
'''Olfactory receptor, family 1, subfamily A, member 1''', also known as '''OR1A1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OR1A1 olfactory receptor, family 1, subfamily A, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8383| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez">{{cite web | title = Entrez Gene: OR1A1 olfactory receptor, family 1, subfamily A, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8383| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Glusman G, Sosinsky A, Ben-Asher E, ''et al.'' |title=Sequence, structure, and evolution of a complete human olfactory receptor gene cluster. |journal=Genomics |volume=63 |issue= 2 |pages= 227-45 |year= 2000 |pmid= 10673334 |doi= 10.1006/geno.1999.6030 }}
*{{cite journal | author=Fuchs T, Malecova B, Linhart C, ''et al.'' |title=DEFOG: a practical scheme for deciphering families of genes. |journal=Genomics |volume=80 |issue= 3 |pages= 295-302 |year= 2003 |pmid= 12213199 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Malnic B, Godfrey PA, Buck LB |title=The human olfactory receptor gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2584-9 |year= 2004 |pmid= 14983052 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on OR1D4... {November 25, 2007 8:34:00 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 8:34:20 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Olfactory receptor, family 1, subfamily D, member 4
| HGNCid = 8185
| Symbol = OR1D4
| AltSymbols =; MGC125396; OR17-30
| OMIM =
| ECnumber =
| Homologene = 55761
| MGIid =
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004984 |text = olfactory receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007608 |text = sensory perception of smell}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8385
| Hs_Ensembl =
| Hs_RefseqProtein = NP_003543
| Hs_RefseqmRNA = NM_003552
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Olfactory receptor, family 1, subfamily D, member 4''', also known as '''OR1D4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OR1D4 olfactory receptor, family 1, subfamily D, member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8385| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez">{{cite web | title = Entrez Gene: OR1D4 olfactory receptor, family 1, subfamily D, member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8385| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Ben-Arie N, Lancet D, Taylor C, ''et al.'' |title=Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire. |journal=Hum. Mol. Genet. |volume=3 |issue= 2 |pages= 229-35 |year= 1994 |pmid= 8004088 |doi= }}
*{{cite journal | author=Glusman G, Sosinsky A, Ben-Asher E, ''et al.'' |title=Sequence, structure, and evolution of a complete human olfactory receptor gene cluster. |journal=Genomics |volume=63 |issue= 2 |pages= 227-45 |year= 2000 |pmid= 10673334 |doi= 10.1006/geno.1999.6030 }}
*{{cite journal | author=Fuchs T, Malecova B, Linhart C, ''et al.'' |title=DEFOG: a practical scheme for deciphering families of genes. |journal=Genomics |volume=80 |issue= 3 |pages= 295-302 |year= 2003 |pmid= 12213199 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Malnic B, Godfrey PA, Buck LB |title=The human olfactory receptor gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2584-9 |year= 2004 |pmid= 14983052 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on OR1D5... {November 25, 2007 8:34:20 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 8:34:42 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Olfactory receptor, family 1, subfamily D, member 5
| HGNCid = 8186
| Symbol = OR1D5
| AltSymbols =; OR17-30; OR17-2; OR17-31
| OMIM =
| ECnumber =
| Homologene =
| MGIid =
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004984 |text = olfactory receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007608 |text = sensory perception of smell}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8386
| Hs_Ensembl =
| Hs_RefseqProtein = XP_931407
| Hs_RefseqmRNA = XM_926314
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Olfactory receptor, family 1, subfamily D, member 5''', also known as '''OR1D5''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OR1D5 olfactory receptor, family 1, subfamily D, member 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8386| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez">{{cite web | title = Entrez Gene: OR1D5 olfactory receptor, family 1, subfamily D, member 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8386| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Selbie LA, Townsend-Nicholson A, Iismaa TP, Shine J |title=Novel G protein-coupled receptors: a gene family of putative human olfactory receptor sequences. |journal=Brain Res. Mol. Brain Res. |volume=13 |issue= 1-2 |pages= 159-63 |year= 1992 |pmid= 1315913 |doi= }}
*{{cite journal | author=Glusman G, Sosinsky A, Ben-Asher E, ''et al.'' |title=Sequence, structure, and evolution of a complete human olfactory receptor gene cluster. |journal=Genomics |volume=63 |issue= 2 |pages= 227-45 |year= 2000 |pmid= 10673334 |doi= 10.1006/geno.1999.6030 }}
*{{cite journal | author=Fuchs T, Malecova B, Linhart C, ''et al.'' |title=DEFOG: a practical scheme for deciphering families of genes. |journal=Genomics |volume=80 |issue= 3 |pages= 295-302 |year= 2003 |pmid= 12213199 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Malnic B, Godfrey PA, Buck LB |title=The human olfactory receptor gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2584-9 |year= 2004 |pmid= 14983052 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on OR1E1... {November 25, 2007 8:34:42 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 8:36:13 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Olfactory receptor, family 1, subfamily E, member 1
| HGNCid = 8189
| Symbol = OR1E1
| AltSymbols =; OR17-2; HGM071; OR13-66; OR17-32; OR1E5; OR1E6; OR1E8P; OR1E9P; OST547
| OMIM =
| ECnumber =
| Homologene = 73918
| MGIid = 109315
| GeneAtlas_image1 = PBB_GE_OR1E1_208587_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_OR1E1_214515_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004984 |text = olfactory receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007608 |text = sensory perception of smell}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8387
| Hs_Ensembl = ENSG00000180016
| Hs_RefseqProtein = NP_003544
| Hs_RefseqmRNA = NM_003553
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 3247510
| Hs_GenLoc_end = 3248454
| Hs_Uniprot = P30953
| Mm_EntrezGene = 258925
| Mm_Ensembl = ENSMUSG00000062128
| Mm_RefseqmRNA = NM_146923
| Mm_RefseqProtein = NP_667134
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 73169950
| Mm_GenLoc_end = 73170894
| Mm_Uniprot =
}}
}}
'''Olfactory receptor, family 1, subfamily E, member 1''', also known as '''OR1E1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OR1E1 olfactory receptor, family 1, subfamily E, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8387| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez">{{cite web | title = Entrez Gene: OR1E1 olfactory receptor, family 1, subfamily E, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8387| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Parmentier M, Libert F, Schurmans S, ''et al.'' |title=Expression of members of the putative olfactory receptor gene family in mammalian germ cells. |journal=Nature |volume=355 |issue= 6359 |pages= 453-5 |year= 1992 |pmid= 1370859 |doi= 10.1038/355453a0 }}
*{{cite journal | author=Ben-Arie N, Lancet D, Taylor C, ''et al.'' |title=Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire. |journal=Hum. Mol. Genet. |volume=3 |issue= 2 |pages= 229-35 |year= 1994 |pmid= 8004088 |doi= }}
*{{cite journal | author=Rouquier S, Taviaux S, Trask BJ, ''et al.'' |title=Distribution of olfactory receptor genes in the human genome. |journal=Nat. Genet. |volume=18 |issue= 3 |pages= 243-50 |year= 1998 |pmid= 9500546 |doi= 10.1038/ng0398-243 }}
*{{cite journal | author=Glusman G, Sosinsky A, Ben-Asher E, ''et al.'' |title=Sequence, structure, and evolution of a complete human olfactory receptor gene cluster. |journal=Genomics |volume=63 |issue= 2 |pages= 227-45 |year= 2000 |pmid= 10673334 |doi= 10.1006/geno.1999.6030 }}
*{{cite journal | author=Rouquier S, Blancher A, Giorgi D |title=The olfactory receptor gene repertoire in primates and mouse: evidence for reduction of the functional fraction in primates. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 6 |pages= 2870-4 |year= 2000 |pmid= 10706615 |doi= 10.1073/pnas.040580197 }}
*{{cite journal | author=Fuchs T, Malecova B, Linhart C, ''et al.'' |title=DEFOG: a practical scheme for deciphering families of genes. |journal=Genomics |volume=80 |issue= 3 |pages= 295-302 |year= 2003 |pmid= 12213199 |doi= }}
*{{cite journal | author=Malnic B, Godfrey PA, Buck LB |title=The human olfactory receptor gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2584-9 |year= 2004 |pmid= 14983052 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on OR1E2... {November 25, 2007 8:36:13 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 8:37:01 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Olfactory receptor, family 1, subfamily E, member 2
| HGNCid = 8190
| Symbol = OR1E2
| AltSymbols =; OR17-135; OR17-93; OR1E4; OR1E7; OST529
| OMIM =
| ECnumber =
| Homologene = 74111
| MGIid = 109312
| GeneAtlas_image1 = PBB_GE_OR1E2_208587_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004984 |text = olfactory receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007608 |text = sensory perception of smell}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8388
| Hs_Ensembl = ENSG00000127780
| Hs_RefseqProtein = NP_003545
| Hs_RefseqmRNA = NM_003554
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 3282914
| Hs_GenLoc_end = 3283885
| Hs_Uniprot = P47887
| Mm_EntrezGene = 18321
| Mm_Ensembl = ENSMUSG00000069816
| Mm_RefseqmRNA = NM_010970
| Mm_RefseqProtein = NP_035100
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 73756443
| Mm_GenLoc_end = 73757420
| Mm_Uniprot =
}}
}}
'''Olfactory receptor, family 1, subfamily E, member 2''', also known as '''OR1E2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OR1E2 olfactory receptor, family 1, subfamily E, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8388| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez">{{cite web | title = Entrez Gene: OR1E2 olfactory receptor, family 1, subfamily E, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8388| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Gotschlich EC |title=Development of polysaccharide vaccines for the prevention of meningococcal diseases. |journal=Monographs in allergy |volume=9 |issue= |pages= 245-58 |year= 1975 |pmid= 804088 |doi= }}
*{{cite journal | author=Ben-Arie N, Lancet D, Taylor C, ''et al.'' |title=Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire. |journal=Hum. Mol. Genet. |volume=3 |issue= 2 |pages= 229-35 |year= 1994 |pmid= 8004088 |doi= }}
*{{cite journal | author=Rouquier S, Taviaux S, Trask BJ, ''et al.'' |title=Distribution of olfactory receptor genes in the human genome. |journal=Nat. Genet. |volume=18 |issue= 3 |pages= 243-50 |year= 1998 |pmid= 9500546 |doi= 10.1038/ng0398-243 }}
*{{cite journal | author=Glusman G, Sosinsky A, Ben-Asher E, ''et al.'' |title=Sequence, structure, and evolution of a complete human olfactory receptor gene cluster. |journal=Genomics |volume=63 |issue= 2 |pages= 227-45 |year= 2000 |pmid= 10673334 |doi= 10.1006/geno.1999.6030 }}
*{{cite journal | author=Fuchs T, Malecova B, Linhart C, ''et al.'' |title=DEFOG: a practical scheme for deciphering families of genes. |journal=Genomics |volume=80 |issue= 3 |pages= 295-302 |year= 2003 |pmid= 12213199 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Malnic B, Godfrey PA, Buck LB |title=The human olfactory receptor gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2584-9 |year= 2004 |pmid= 14983052 |doi= }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on OR1G1... {November 25, 2007 8:37:01 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 8:37:44 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Olfactory receptor, family 1, subfamily G, member 1
| HGNCid = 8204
| Symbol = OR1G1
| AltSymbols =; OR17-130; OR17-209; OR1G2
| OMIM =
| ECnumber =
| Homologene = 81589
| MGIid = 3648768
| GeneAtlas_image1 = PBB_GE_OR1G1_221375_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004984 |text = olfactory receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007608 |text = sensory perception of smell}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8390
| Hs_Ensembl = ENSG00000183024
| Hs_RefseqProtein = NP_003546
| Hs_RefseqmRNA = NM_003555
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 2976654
| Hs_GenLoc_end = 2977709
| Hs_Uniprot = P47890
| Mm_EntrezGene = 545417
| Mm_Ensembl = ENSMUSG00000049094
| Mm_RefseqmRNA = XM_001000818
| Mm_RefseqProtein = XP_001000818
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 37092455
| Mm_GenLoc_end = 37093396
| Mm_Uniprot =
}}
}}
'''Olfactory receptor, family 1, subfamily G, member 1''', also known as '''OR1G1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OR1G1 olfactory receptor, family 1, subfamily G, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8390| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez">{{cite web | title = Entrez Gene: OR1G1 olfactory receptor, family 1, subfamily G, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8390| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Ben-Arie N, Lancet D, Taylor C, ''et al.'' |title=Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire. |journal=Hum. Mol. Genet. |volume=3 |issue= 2 |pages= 229-35 |year= 1994 |pmid= 8004088 |doi= }}
*{{cite journal | author=Rouquier S, Taviaux S, Trask BJ, ''et al.'' |title=Distribution of olfactory receptor genes in the human genome. |journal=Nat. Genet. |volume=18 |issue= 3 |pages= 243-50 |year= 1998 |pmid= 9500546 |doi= 10.1038/ng0398-243 }}
*{{cite journal | author=Glusman G, Sosinsky A, Ben-Asher E, ''et al.'' |title=Sequence, structure, and evolution of a complete human olfactory receptor gene cluster. |journal=Genomics |volume=63 |issue= 2 |pages= 227-45 |year= 2000 |pmid= 10673334 |doi= 10.1006/geno.1999.6030 }}
*{{cite journal | author=Matarazzo V, Zsürger N, Guillemot JC, ''et al.'' |title=Porcine odorant-binding protein selectively binds to a human olfactory receptor. |journal=Chem. Senses |volume=27 |issue= 8 |pages= 691-701 |year= 2003 |pmid= 12379593 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Malnic B, Godfrey PA, Buck LB |title=The human olfactory receptor gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2584-9 |year= 2004 |pmid= 14983052 |doi= }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on OR3A3... {November 25, 2007 8:37:44 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 8:38:40 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Olfactory receptor, family 3, subfamily A, member 3
| HGNCid = 8284
| Symbol = OR3A3
| AltSymbols =; OR17-137; OR17-16; OR17-201; OR3A6; OR3A7; OR3A8P
| OMIM =
| ECnumber =
| Homologene = 74999
| MGIid = 3030245
| GeneAtlas_image1 = PBB_GE_OR3A3_221426_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004984 |text = olfactory receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007608 |text = sensory perception of smell}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8392
| Hs_Ensembl = ENSG00000159961
| Hs_RefseqProtein = NP_036505
| Hs_RefseqmRNA = NM_012373
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 3270612
| Hs_GenLoc_end = 3271577
| Hs_Uniprot = P47888
| Mm_EntrezGene = 258704
| Mm_Ensembl = ENSMUSG00000054406
| Mm_RefseqmRNA = NM_146709
| Mm_RefseqProtein = NP_666920
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 74162830
| Mm_GenLoc_end = 74163777
| Mm_Uniprot =
}}
}}
'''Olfactory receptor, family 3, subfamily A, member 3''', also known as '''OR3A3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OR3A3 olfactory receptor, family 3, subfamily A, member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8392| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez">{{cite web | title = Entrez Gene: OR3A3 olfactory receptor, family 3, subfamily A, member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8392| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Ben-Arie N, Lancet D, Taylor C, ''et al.'' |title=Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire. |journal=Hum. Mol. Genet. |volume=3 |issue= 2 |pages= 229-35 |year= 1994 |pmid= 8004088 |doi= }}
*{{cite journal | author=Rouquier S, Taviaux S, Trask BJ, ''et al.'' |title=Distribution of olfactory receptor genes in the human genome. |journal=Nat. Genet. |volume=18 |issue= 3 |pages= 243-50 |year= 1998 |pmid= 9500546 |doi= 10.1038/ng0398-243 }}
*{{cite journal | author=Glusman G, Sosinsky A, Ben-Asher E, ''et al.'' |title=Sequence, structure, and evolution of a complete human olfactory receptor gene cluster. |journal=Genomics |volume=63 |issue= 2 |pages= 227-45 |year= 2000 |pmid= 10673334 |doi= 10.1006/geno.1999.6030 }}
*{{cite journal | author=Fuchs T, Malecova B, Linhart C, ''et al.'' |title=DEFOG: a practical scheme for deciphering families of genes. |journal=Genomics |volume=80 |issue= 3 |pages= 295-302 |year= 2003 |pmid= 12213199 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Gilad Y, Lancet D |title=Population differences in the human functional olfactory repertoire. |journal=Mol. Biol. Evol. |volume=20 |issue= 3 |pages= 307-14 |year= 2003 |pmid= 12644552 |doi= }}
*{{cite journal | author=Malnic B, Godfrey PA, Buck LB |title=The human olfactory receptor gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2584-9 |year= 2004 |pmid= 14983052 |doi= }}
*{{cite journal | author=Zody MC, Garber M, Adams DJ, ''et al.'' |title=DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. |journal=Nature |volume=440 |issue= 7087 |pages= 1045-9 |year= 2006 |pmid= 16625196 |doi= 10.1038/nature04689 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on OR6A2... {November 25, 2007 8:41:20 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 8:42:03 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Olfactory receptor, family 6, subfamily A, member 2
| HGNCid = 15301
| Symbol = OR6A2
| AltSymbols =; I7; MGC126538; MGC126540; OR11-55; OR6A1; OR6A2P
| OMIM = 608495
| ECnumber =
| Homologene = 2743
| MGIid = 97432
| GeneAtlas_image1 = PBB_GE_OR6A2_221465_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004984 |text = olfactory receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007608 |text = sensory perception of smell}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8590
| Hs_Ensembl = ENSG00000184933
| Hs_RefseqProtein = NP_003687
| Hs_RefseqmRNA = NM_003696
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 6772532
| Hs_GenLoc_end = 6773515
| Hs_Uniprot = O95222
| Mm_EntrezGene = 18317
| Mm_Ensembl = ENSMUSG00000070417
| Mm_RefseqmRNA = NM_010983
| Mm_RefseqProtein = NP_035113
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 106794524
| Mm_GenLoc_end = 106795507
| Mm_Uniprot =
}}
}}
'''Olfactory receptor, family 6, subfamily A, member 2''', also known as '''OR6A2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OR6A2 olfactory receptor, family 6, subfamily A, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8590| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez">{{cite web | title = Entrez Gene: OR6A2 olfactory receptor, family 6, subfamily A, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8590| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Buettner JA, Glusman G, Ben-Arie N, ''et al.'' |title=Organization and evolution of olfactory receptor genes on human chromosome 11. |journal=Genomics |volume=53 |issue= 1 |pages= 56-68 |year= 1998 |pmid= 9787077 |doi= 10.1006/geno.1998.5422 }}
*{{cite journal | author=Lane RP, Cutforth T, Young J, ''et al.'' |title=Genomic analysis of orthologous mouse and human olfactory receptor loci. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 13 |pages= 7390-5 |year= 2001 |pmid= 11416212 |doi= 10.1073/pnas.131215398 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Malnic B, Godfrey PA, Buck LB |title=The human olfactory receptor gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2584-9 |year= 2004 |pmid= 14983052 |doi= }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TAAR2... {November 25, 2007 8:49:51 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 8:50:27 PM PST}
- CREATED: Created new protein page: TAAR2 {November 25, 2007 8:50:34 PM PST}
- INFO: Beginning work on TAAR5... {November 25, 2007 8:46:05 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 8:46:46 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Trace amine associated receptor 5
| HGNCid = 30236
| Symbol = TAAR5
| AltSymbols =; MGC138414; MGC138416; PNR; RP11-295F4.5
| OMIM = 607405
| ECnumber =
| Homologene = 20850
| MGIid = 2685073
| GeneAtlas_image1 = PBB_GE_TAAR5_221459_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 9038
| Hs_Ensembl = ENSG00000135569
| Hs_RefseqProtein = NP_003958
| Hs_RefseqmRNA = NM_003967
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 132951505
| Hs_GenLoc_end = 132952518
| Hs_Uniprot = O14804
| Mm_EntrezGene = 215854
| Mm_Ensembl = ENSMUSG00000069706
| Mm_RefseqmRNA = NM_001009574
| Mm_RefseqProtein = NP_001009574
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 10
| Mm_GenLoc_start = 23660122
| Mm_GenLoc_end = 23661135
| Mm_Uniprot = Q5QD14
}}
}}
'''Trace amine associated receptor 5''', also known as '''TAAR5''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TAAR5 trace amine associated receptor 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9038| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Zeng Z, Fan P, Rand E, ''et al.'' |title=Cloning of a putative human neurotransmitter receptor expressed in skeletal muscle and brain. |journal=Biochem. Biophys. Res. Commun. |volume=242 |issue= 3 |pages= 575-8 |year= 1998 |pmid= 9464258 |doi= 10.1006/bbrc.1997.7591 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Lindemann L, Ebeling M, Kratochwil NA, ''et al.'' |title=Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors. |journal=Genomics |volume=85 |issue= 3 |pages= 372-85 |year= 2005 |pmid= 15718104 |doi= 10.1016/j.ygeno.2004.11.010 }}
}}
{{refend}}
{{protein-stub}}
end log.
