INFO: Beginning work on ABCC2... {November 7, 2007 3:33:52 PM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 3:34:37 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = ATP-binding cassette, sub-family C (CFTR/MRP), member 2
| HGNCid = 53
| Symbol = ABCC2
| AltSymbols =; ABC30; CMOAT; DJS; KIAA1010; MRP2; cMRP
| OMIM = 601107
| ECnumber =
| Homologene = 68052
| MGIid = 1352447
| GeneAtlas_image1 = PBB_GE_ABCC2_206155_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008514 |text = organic anion transmembrane transporter activity}} {{GNF_GO|id=GO:0016887 |text = ATPase activity}} {{GNF_GO|id=GO:0042626 |text = ATPase activity, coupled to transmembrane movement of substances}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016324 |text = apical plasma membrane}} {{GNF_GO|id=GO:0046581 |text = intercellular canaliculus}}
| Process = {{GNF_GO|id=GO:0006810 |text = transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1244
| Hs_Ensembl = ENSG00000023839
| Hs_RefseqProtein = NP_000383
| Hs_RefseqmRNA = NM_000392
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 10
| Hs_GenLoc_start = 101532479
| Hs_GenLoc_end = 101601939
| Hs_Uniprot = Q92887
| Mm_EntrezGene = 12780
| Mm_Ensembl = ENSMUSG00000025194
| Mm_RefseqmRNA = NM_013806
| Mm_RefseqProtein = NP_038834
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 19
| Mm_GenLoc_start = 43835715
| Mm_GenLoc_end = 43891262
| Mm_Uniprot = Q8VI46
}}
}}
'''ATP-binding cassette, sub-family C (CFTR/MRP), member 2''', also known as '''ABCC2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia.<ref>{{cite web | title = Entrez Gene: ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1244| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Keppler D, König J |title=Hepatic secretion of conjugated drugs and endogenous substances. |journal=Semin. Liver Dis. |volume=20 |issue= 3 |pages= 265-72 |year= 2001 |pmid= 11076395 |doi= }}
*{{cite journal | author=Gerk PM, Vore M |title=Regulation of expression of the multidrug resistance-associated protein 2 (MRP2) and its role in drug disposition. |journal=J. Pharmacol. Exp. Ther. |volume=302 |issue= 2 |pages= 407-15 |year= 2002 |pmid= 12130697 |doi= 10.1124/jpet.102.035014 }}
}}
{{refend}}
{{protein-stub}}
INFO: Beginning work on BCL10... {November 7, 2007 3:48:07 PM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 3:48:33 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
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| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = B-cell CLL/lymphoma 10
| HGNCid = 989
| Symbol = BCL10
| AltSymbols =; CARMEN; CIPER; CLAP; c-E10; mE10
| OMIM = 603517
| ECnumber =
| Homologene = 2912
| MGIid = 1337994
| Function = {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0008022 |text = protein C-terminus binding}} {{GNF_GO|id=GO:0019209 |text = kinase activator activity}} {{GNF_GO|id=GO:0031625 |text = ubiquitin protein ligase binding}} {{GNF_GO|id=GO:0043130 |text = ubiquitin binding}} {{GNF_GO|id=GO:0043422 |text = protein kinase B binding}} {{GNF_GO|id=GO:0043621 |text = protein self-association}} {{GNF_GO|id=GO:0051059 |text = NF-kappaB binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005764 |text = lysosome}} {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0032449 |text = CBM complex}} {{GNF_GO|id=GO:0042101 |text = T cell receptor complex}} {{GNF_GO|id=GO:0045121 |text = lipid raft}} {{GNF_GO|id=GO:0046696 |text = lipopolysaccharide receptor complex}} {{GNF_GO|id=GO:0048471 |text = perinuclear region of cytoplasm}}
| Process = {{GNF_GO|id=GO:0002224 |text = toll-like receptor signaling pathway}} {{GNF_GO|id=GO:0002237 |text = response to molecule of bacterial origin}} {{GNF_GO|id=GO:0002250 |text = adaptive immune response}} {{GNF_GO|id=GO:0002906 |text = negative regulation of mature B cell apoptosis}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007249 |text = I-kappaB kinase/NF-kappaB cascade}} {{GNF_GO|id=GO:0008219 |text = cell death}} {{GNF_GO|id=GO:0016064 |text = immunoglobulin mediated immune response}} {{GNF_GO|id=GO:0031398 |text = positive regulation of protein ubiquitination}} {{GNF_GO|id=GO:0032765 |text = positive regulation of mast cell cytokine production}} {{GNF_GO|id=GO:0042109 |text = lymphotoxin A biosynthetic process}} {{GNF_GO|id=GO:0042221 |text = response to chemical stimulus}} {{GNF_GO|id=GO:0042226 |text = interleukin-6 biosynthetic process}} {{GNF_GO|id=GO:0042327 |text = positive regulation of phosphorylation}} {{GNF_GO|id=GO:0042981 |text = regulation of apoptosis}} {{GNF_GO|id=GO:0043123 |text = positive regulation of I-kappaB kinase/NF-kappaB cascade}} {{GNF_GO|id=GO:0045087 |text = innate immune response}} {{GNF_GO|id=GO:0045416 |text = positive regulation of interleukin-8 biosynthetic process}} {{GNF_GO|id=GO:0045786 |text = negative regulation of progression through cell cycle}} {{GNF_GO|id=GO:0045893 |text = positive regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0050852 |text = T cell receptor signaling pathway}} {{GNF_GO|id=GO:0051092 |text = activation of NF-kappaB transcription factor}} {{GNF_GO|id=GO:0051260 |text = protein homooligomerization}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8915
| Hs_Ensembl =
| Hs_RefseqProtein = NP_003912
| Hs_RefseqmRNA = NM_003921
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 12042
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_009740
| Mm_RefseqProtein = NP_033870
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''B-cell CLL/lymphoma 10''', also known as '''BCL10''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.<ref>{{cite web | title = Entrez Gene: BCL10 B-cell CLL/lymphoma 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8915| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Bertoni F, Cavalli F, Cotter FE, Zucca E |title=Genetic alterations underlying the pathogenesis of MALT lymphoma. |journal=Hematol. J. |volume=3 |issue= 1 |pages= 10-3 |year= 2003 |pmid= 11960389 |doi= 10.1038/sj/thj/6200146 }}
}}
{{refend}}
{{protein-stub}}
INFO: Beginning work on CA9... {November 7, 2007 3:32:16 PM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 3:32:50 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Carbonic anhydrase IX
| HGNCid = 1383
| Symbol = CA9
| AltSymbols =; CAIX; MN
| OMIM = 603179
| ECnumber =
| Homologene = 20325
| MGIid = 2447188
| GeneAtlas_image1 = PBB_GE_CA9_205199_at_tn.png
| Function = {{GNF_GO|id=GO:0004089 |text = carbonate dehydratase activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016829 |text = lyase activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0002009 |text = morphogenesis of an epithelium}} {{GNF_GO|id=GO:0006730 |text = one-carbon compound metabolic process}} {{GNF_GO|id=GO:0046903 |text = secretion}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 768
| Hs_Ensembl = ENSG00000107159
| Hs_RefseqProtein = NP_001207
| Hs_RefseqmRNA = NM_001216
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 9
| Hs_GenLoc_start = 35663853
| Hs_GenLoc_end = 35671156
| Hs_Uniprot = Q16790
| Mm_EntrezGene = 230099
| Mm_Ensembl = ENSMUSG00000028463
| Mm_RefseqmRNA = NM_139305
| Mm_RefseqProtein = NP_647466
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 43528107
| Mm_GenLoc_end = 43534829
| Mm_Uniprot = Q3TLN7
}}
}}
'''Carbonic anhydrase IX''', also known as '''CA9''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and the only tumor-associated carbonic anhydrase isoenzyme known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12.<ref>{{cite web | title = Entrez Gene: CA9 carbonic anhydrase IX| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=768| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Nishimori I, Onishi S |title=Carbonic anhydrase isozymes in the human pancreas. |journal=Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver |volume=33 |issue= 1 |pages= 68-74 |year= 2001 |pmid= 11303978 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO: Beginning work on LAT... {November 7, 2007 3:49:15 PM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 3:49:29 PM PST}
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{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Linker for activation of T cells
| HGNCid = 18874
| Symbol = LAT
| AltSymbols =; LAT1; pp36
| OMIM = 602354
| ECnumber =
| Homologene = 7811
| MGIid = 1342293
| Function = {{GNF_GO|id=GO:0005070 |text = SH3/SH2 adaptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0001772 |text = immunological synapse}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0045121 |text = lipid raft}}
| Process = {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007229 |text = integrin-mediated signaling pathway}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0007265 |text = Ras protein signal transduction}} {{GNF_GO|id=GO:0019722 |text = calcium-mediated signaling}} {{GNF_GO|id=GO:0043303 |text = mast cell degranulation}} {{GNF_GO|id=GO:0050863 |text = regulation of T cell activation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 27040
| Hs_Ensembl =
| Hs_RefseqProtein = NP_001014987
| Hs_RefseqmRNA = NM_001014987
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 16797
| Mm_Ensembl = ENSMUSG00000030742
| Mm_RefseqmRNA = NM_010689
| Mm_RefseqProtein = NP_034819
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 126154975
| Mm_GenLoc_end = 126160691
| Mm_Uniprot = Q546H1
}}
}}
'''Linker for activation of T cells''', also known as '''LAT''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms.<ref>{{cite web | title = Entrez Gene: LAT linker for activation of T cells| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27040| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Wange RL |title=LAT, the linker for activation of T cells: a bridge between T cell-specific and general signaling pathways. |journal=Sci. STKE |volume=2000 |issue= 63 |pages= RE1 |year= 2002 |pmid= 11752630 |doi= 10.1126/stke.2000.63.re1 }}
*{{cite journal | author=Sommers CL, Samelson LE, Love PE |title=LAT: a T lymphocyte adapter protein that couples the antigen receptor to downstream signaling pathways. |journal=Bioessays |volume=26 |issue= 1 |pages= 61-7 |year= 2004 |pmid= 14696041 |doi= 10.1002/bies.10384 }}
*{{cite journal | author=Rivera J |title=NTAL/LAB and LAT: a balancing act in mast-cell activation and function. |journal=Trends Immunol. |volume=26 |issue= 3 |pages= 119-22 |year= 2005 |pmid= 15745852 |doi= 10.1016/j.it.2005.01.001 }}
}}
{{refend}}
{{protein-stub}}
INFO: Beginning work on PTTG1... {November 7, 2007 3:48:33 PM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 3:49:15 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Pituitary tumor-transforming 1
| HGNCid = 9690
| Symbol = PTTG1
| AltSymbols =; EAP1; HPTTG; MGC126883; MGC138276; PTTG; SECURIN; TUTR1
| OMIM = 604147
| ECnumber =
| Homologene = 3110
| MGIid = 1353578
| GeneAtlas_image1 = PBB_GE_PTTG1_203554_x_at_tn.png
| Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}} {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0004869 |text = cysteine protease inhibitor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006259 |text = DNA metabolic process}} {{GNF_GO|id=GO:0006281 |text = DNA repair}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007059 |text = chromosome segregation}} {{GNF_GO|id=GO:0007067 |text = mitosis}} {{GNF_GO|id=GO:0007283 |text = spermatogenesis}} {{GNF_GO|id=GO:0051276 |text = chromosome organization and biogenesis}} {{GNF_GO|id=GO:0051301 |text = cell division}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 9232
| Hs_Ensembl = ENSG00000164611
| Hs_RefseqProtein = NP_004210
| Hs_RefseqmRNA = NM_004219
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 159781418
| Hs_GenLoc_end = 159788323
| Hs_Uniprot = O95997
| Mm_EntrezGene = 30939
| Mm_Ensembl = ENSMUSG00000020415
| Mm_RefseqmRNA = NM_013917
| Mm_RefseqProtein = NP_038945
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 43263685
| Mm_GenLoc_end = 43269674
| Mm_Uniprot = Q3Y5K4
}}
}}
'''Pituitary tumor-transforming 1''', also known as '''PTTG1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus.<ref>{{cite web | title = Entrez Gene: PTTG1 pituitary tumor-transforming 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9232| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Yu R, Melmed S |title=Pituitary tumor transforming gene: an update. |journal=Frontiers of hormone research |volume=32 |issue= |pages= 175-85 |year= 2004 |pmid= 15281346 |doi= }}
*{{cite journal | author=Tfelt-Hansen J, Kanuparthi D, Chattopadhyay N |title=The emerging role of pituitary tumor transforming gene in tumorigenesis. |journal=Clinical medicine & research |volume=4 |issue= 2 |pages= 130-7 |year= 2006 |pmid= 16809406 |doi= }}
}}
{{refend}}
{{protein-stub}}
AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 3:43:04 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_RGS4_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1agr.
| PDB = {{PDB2|1agr}}, {{PDB2|1ezt}}, {{PDB2|1ezy}}
| Name = Regulator of G-protein signalling 4
| HGNCid = 10000
| Symbol = RGS4
| AltSymbols =; MGC2124; MGC60244; RGP4; SCZD9
| OMIM = 602516
| ECnumber =
| Homologene = 4100
| MGIid = 108409
| GeneAtlas_image1 = PBB_GE_RGS4_204337_at_tn.png
| GeneAtlas_image2 = PBB_GE_RGS4_204338_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_RGS4_204339_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005096 |text = GTPase activator activity}} {{GNF_GO|id=GO:0005516 |text = calmodulin binding}}
| Component =
| Process = {{GNF_GO|id=GO:0000188 |text = inactivation of MAPK activity}} {{GNF_GO|id=GO:0008277 |text = regulation of G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0009968 |text = negative regulation of signal transduction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5999
| Hs_Ensembl = ENSG00000117152
| Hs_RefseqProtein = NP_005604
| Hs_RefseqmRNA = NM_005613
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 161305673
| Hs_GenLoc_end = 161313006
| Hs_Uniprot = P49798
| Mm_EntrezGene = 19736
| Mm_Ensembl = ENSMUSG00000038530
| Mm_RefseqmRNA = NM_009062
| Mm_RefseqProtein = NP_033088
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 171578985
| Mm_GenLoc_end = 171584317
| Mm_Uniprot = Q5D078
}}
}}
'''Regulator of G-protein signalling 4''', also known as '''RGS4''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm.<ref>{{cite web | title = Entrez Gene: RGS4 regulator of G-protein signalling 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5999| accessdate = }}</ref>
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==References==
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==Further reading==
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| citations =
*{{cite journal | author=Levitt P, Ebert P, Mirnics K, ''et al.'' |title=Making the case for a candidate vulnerability gene in schizophrenia: Convergent evidence for regulator of G-protein signaling 4 (RGS4). |journal=Biol. Psychiatry |volume=60 |issue= 6 |pages= 534-7 |year= 2006 |pmid= 16860780 |doi= 10.1016/j.biopsych.2006.04.028 }}
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