INFO : Beginning work on ACVRL1... {November 8, 2007 1:28:26 AM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 8, 2007 1:29:13 AM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Activin A receptor type II-like 1
| HGNCid = 175
| Symbol = ACVRL1
| AltSymbols =; ACVRLK1; ALK-1; ALK1; HHT; HHT2; ORW2; SKR3; TSR-I
| OMIM = 601284
| ECnumber =
| Homologene = 20058
| MGIid = 1338946
| GeneAtlas_image1 = PBB_GE_ACVRL1_210838_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016361 |text = activin receptor activity, type I}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0030145 |text = manganese ion binding}} {{GNF_GO|id=GO:0046332 |text = SMAD binding}} {{GNF_GO|id=GO:0048185 |text = activin binding}} {{GNF_GO|id=GO:0050431 |text = transforming growth factor beta binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0009986 |text = cell surface}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0001525 |text = angiogenesis}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007162 |text = negative regulation of cell adhesion}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007179 |text = transforming growth factor beta receptor signaling pathway}} {{GNF_GO|id=GO:0008217 |text = blood pressure regulation}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0030336 |text = negative regulation of cell migration}} {{GNF_GO|id=GO:0035313 |text = wound healing, spreading of epidermal cells}} {{GNF_GO|id=GO:0045941 |text = positive regulation of transcription}} {{GNF_GO|id=GO:0051895 |text = negative regulation of focal adhesion formation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 94
| Hs_Ensembl = ENSG00000139567
| Hs_RefseqProtein = NP_000011
| Hs_RefseqmRNA = NM_000020
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 50587469
| Hs_GenLoc_end = 50601120
| Hs_Uniprot = P37023
| Mm_EntrezGene = 11482
| Mm_Ensembl = ENSMUSG00000000530
| Mm_RefseqmRNA = NM_009612
| Mm_RefseqProtein = NP_033742
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 15
| Mm_GenLoc_start = 100956556
| Mm_GenLoc_end = 100971674
| Mm_Uniprot = Q91YR0
}}
}}
'''Activin A receptor type II-like 1''', also known as '''ACVRL1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2.<ref>{{cite web | title = Entrez Gene: ACVRL1 activin A receptor type II-like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=94| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on CCK... {November 8, 2007 1:29:13 AM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 8, 2007 1:29:45 AM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Cholecystokinin
| HGNCid = 1569
| Symbol = CCK
| AltSymbols =; MGC117187
| OMIM = 118440
| ECnumber =
| Homologene = 583
| MGIid = 88297
| GeneAtlas_image1 = PBB_GE_CCK_205827_at_tn.png
| Function = {{GNF_GO|id=GO:0005184 |text = neuropeptide hormone activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005625 |text = soluble fraction}} {{GNF_GO|id=GO:0030424 |text = axon}}
| Process = {{GNF_GO|id=GO:0001764 |text = neuron migration}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007409 |text = axonogenesis}} {{GNF_GO|id=GO:0042755 |text = eating behavior}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 885
| Hs_Ensembl = ENSG00000187094
| Hs_RefseqProtein = NP_000720
| Hs_RefseqmRNA = NM_000729
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 42274322
| Hs_GenLoc_end = 42281399
| Hs_Uniprot = P06307
| Mm_EntrezGene = 12424
| Mm_Ensembl = ENSMUSG00000032532
| Mm_RefseqmRNA = NM_031161
| Mm_RefseqProtein = NP_112438
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 9
| Mm_GenLoc_start = 121338523
| Mm_GenLoc_end = 121344360
| Mm_Uniprot = Q53WS9
}}
}}
'''Cholecystokinin''', also known as '''CCK''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Cholecystokinin is a brain/gut peptide. In the gut, it induces the release of pancreatic enzymes and the contraction of the gallbladder. In the brain, its physiologic role is unclear. The cholecystokinin pro-hormone is processed by endo- and exo-proteolytic cleavages.<ref>{{cite web | title = Entrez Gene: CCK cholecystokinin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=885| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Beinfeld MC |title=CCK biosynthesis and processing: recent progress and future challenges. |journal=Life Sci. |volume=61 |issue= 24 |pages= 2359-66 |year= 1997 |pmid= 9399627 |doi= }}
*{{cite journal | author=Bradwejn J, Koszycki D |title=Cholecystokinin and panic disorder: past and future clinical research strategies. |journal=Scand. J. Clin. Lab. Invest. Suppl. |volume=234 |issue= |pages= 19-27 |year= 2002 |pmid= 11713976 |doi= }}
*{{cite journal | author=Hansen TV, Nielsen FC |title=Regulation of neuronal cholecystokinin gene transcription. |journal=Scand. J. Clin. Lab. Invest. Suppl. |volume=234 |issue= |pages= 61-7 |year= 2002 |pmid= 11713982 |doi= }}
*{{cite journal | author=Jønson L, Johnsen AH |title=Post-translational modifications of heterologously expressed cholecystokinin in Saccharomyces cerevisiae. |journal=Scand. J. Clin. Lab. Invest. Suppl. |volume=234 |issue= |pages= 87-92 |year= 2002 |pmid= 11713985 |doi= }}
*{{cite journal | author=Beinfeld MC |title=Biosynthesis and processing of pro CCK: recent progress and future challenges. |journal=Life Sci. |volume=72 |issue= 7 |pages= 747-57 |year= 2003 |pmid= 12479974 |doi= }}
*{{cite journal | author=Herranz R |title=Cholecystokinin antagonists: pharmacological and therapeutic potential. |journal=Med Res Rev |volume=23 |issue= 5 |pages= 559-605 |year= 2004 |pmid= 12789687 |doi= 10.1002/med.10042 }}
*{{cite journal | author=Varga G, Bálint A, Burghardt B, D'Amato M |title=Involvement of endogenous CCK and CCK1 receptors in colonic motor function. |journal=Br. J. Pharmacol. |volume=141 |issue= 8 |pages= 1275-84 |year= 2004 |pmid= 15100163 |doi= 10.1038/sj.bjp.0705769 }}
*{{cite journal | author=Rehfeld JF |title=Clinical endocrinology and metabolism. Cholecystokinin. |journal=Best Pract. Res. Clin. Endocrinol. Metab. |volume=18 |issue= 4 |pages= 569-86 |year= 2005 |pmid= 15533776 |doi= 10.1016/j.beem.2004.07.002 }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on CCND2... {November 8, 2007 1:29:45 AM PST} CREATE : Found no pages, creating new page. {November 8, 2007 10:03:15 AM PST} CREATED : Created new protein page: CCND2 {November 8, 2007 10:03:22 AM PST} INFO : Beginning work on CDK5R1... {November 8, 2007 10:20:11 AM PST} UPLOAD : Added new Image to wiki: {November 8, 2007 10:21:04 AM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 8, 2007 10:21:27 AM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CDK5R1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1h4l.
| PDB = {{PDB2|1h4l}}, {{PDB2|1ung}}, {{PDB2|1unh}}, {{PDB2|1unl}}
| Name = Cyclin-dependent kinase 5, regulatory subunit 1 (p35)
| HGNCid = 1775
| Symbol = CDK5R1
| AltSymbols =; CDK5P35; CDK5R; MGC33831; NCK5A; p23; p25; p35; p35nck5a
| OMIM = 603460
| ECnumber =
| Homologene = 31200
| MGIid = 101764
| GeneAtlas_image1 = PBB_GE_CDK5R1_204995_at_tn.png
| GeneAtlas_image2 = PBB_GE_CDK5R1_204996_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004672 |text = protein kinase activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016534 |text = cyclin-dependent protein kinase 5 activator activity}} {{GNF_GO|id=GO:0043539 |text = protein serine/threonine kinase activator activity}} {{GNF_GO|id=GO:0045296 |text = cadherin binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016533 |text = cyclin-dependent protein kinase 5 activator complex}} {{GNF_GO|id=GO:0030424 |text = axon}} {{GNF_GO|id=GO:0030426 |text = growth cone}} {{GNF_GO|id=GO:0031594 |text = neuromuscular junction}} {{GNF_GO|id=GO:0043025 |text = cell soma}} {{GNF_GO|id=GO:0043197 |text = dendritic spine}} {{GNF_GO|id=GO:0043292 |text = contractile fiber}}
| Process = {{GNF_GO|id=GO:0000079 |text = regulation of cyclin-dependent protein kinase activity}} {{GNF_GO|id=GO:0001764 |text = neuron migration}} {{GNF_GO|id=GO:0007158 |text = neuron adhesion}} {{GNF_GO|id=GO:0007213 |text = acetylcholine receptor signaling, muscarinic pathway}} {{GNF_GO|id=GO:0007411 |text = axon guidance}} {{GNF_GO|id=GO:0007413 |text = axonal fasciculation}} {{GNF_GO|id=GO:0007420 |text = brain development}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0009790 |text = embryonic development}} {{GNF_GO|id=GO:0031175 |text = neurite development}} {{GNF_GO|id=GO:0035235 |text = ionotropic glutamate receptor signaling pathway}} {{GNF_GO|id=GO:0043525 |text = positive regulation of neuron apoptosis}} {{GNF_GO|id=GO:0045664 |text = regulation of neuron differentiation}} {{GNF_GO|id=GO:0048675 |text = axon extension}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8851
| Hs_Ensembl = ENSG00000176749
| Hs_RefseqProtein = NP_003876
| Hs_RefseqmRNA = NM_003885
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 27838214
| Hs_GenLoc_end = 27842383
| Hs_Uniprot = Q15078
| Mm_EntrezGene = 12569
| Mm_Ensembl = ENSMUSG00000048895
| Mm_RefseqmRNA = XM_001001743
| Mm_RefseqProtein = XP_001001743
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 80293218
| Mm_GenLoc_end = 80297379
| Mm_Uniprot = Q3V3I8
}}
}}
'''Cyclin-dependent kinase 5, regulatory subunit 1 (p35)''', also known as '''CDK5R1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease.<ref>{{cite web | title = Entrez Gene: CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8851| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Peruzzi F, Gordon J, Darbinian N, Amini S |title=Tat-induced deregulation of neuronal differentiation and survival by nerve growth factor pathway. |journal=J. Neurovirol. |volume=8 Suppl 2 |issue= |pages= 91-6 |year= 2003 |pmid= 12491158 |doi= 10.1080/13550280290167885 }}
*{{cite journal | author=Studzinski GP, Harrison JS |title=The neuronal cyclin-dependent kinase 5 activator p35Nck5a and Cdk5 activity in monocytic cells. |journal=Leuk. Lymphoma |volume=44 |issue= 2 |pages= 235-40 |year= 2003 |pmid= 12688339 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on CGB... {November 8, 2007 10:03:22 AM PST} UPLOAD : Added new Image to wiki: {November 8, 2007 10:03:39 AM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 8, 2007 10:04:16 AM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CGB_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1hcn.
| PDB = {{PDB2|1hcn}}, {{PDB2|1hrp}}, {{PDB2|1qfw}}
| Name = Chorionic gonadotropin, beta polypeptide
| HGNCid = 1886
| Symbol = CGB
| AltSymbols =; CGB3; hCGB; HCG; MGC119822
| OMIM = 118860
| ECnumber =
| Homologene = 37338
| MGIid =
| Function = {{GNF_GO|id=GO:0005179 |text = hormone activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process =
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1082
| Hs_Ensembl =
| Hs_RefseqProtein = NP_000728
| Hs_RefseqmRNA = NM_000737
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Chorionic gonadotropin, beta polypeptide''', also known as '''CGB''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 3 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene.<ref>{{cite web | title = Entrez Gene: CGB chorionic gonadotropin, beta polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1082| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on CHRM3... {November 8, 2007 10:04:17 AM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 8, 2007 10:04:30 AM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Cholinergic receptor, muscarinic 3
| HGNCid = 1952
| Symbol = CHRM3
| AltSymbols =; HM3
| OMIM = 118494
| ECnumber =
| Homologene = 20191
| MGIid = 88398
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004435 |text = phosphoinositide phospholipase C activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004981 |text = muscarinic acetylcholine receptor activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0045211 |text = postsynaptic membrane}}
| Process = {{GNF_GO|id=GO:0006464 |text = protein modification process}} {{GNF_GO|id=GO:0006939 |text = smooth muscle contraction}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0007586 |text = digestion}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0045987 |text = positive regulation of smooth muscle contraction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1131
| Hs_Ensembl =
| Hs_RefseqProtein = XP_001130695
| Hs_RefseqmRNA = XM_001130695
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 12671
| Mm_Ensembl = ENSMUSG00000046159
| Mm_RefseqmRNA = NM_033269
| Mm_RefseqProtein = NP_150372
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 13
| Mm_GenLoc_start = 9876475
| Mm_GenLoc_end = 9878244
| Mm_Uniprot = Q542R4
}}
}}
'''Cholinergic receptor, muscarinic 3''', also known as '''CHRM3''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue.<ref>{{cite web | title = Entrez Gene: CHRM3 cholinergic receptor, muscarinic 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1131| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Goyal RK |title=Muscarinic receptor subtypes. Physiology and clinical implications. |journal=N. Engl. J. Med. |volume=321 |issue= 15 |pages= 1022-9 |year= 1989 |pmid= 2674717 |doi= }}
*{{cite journal | author=Eglen RM, Reddy H, Watson N, Challiss RA |title=Muscarinic acetylcholine receptor subtypes in smooth muscle. |journal=Trends Pharmacol. Sci. |volume=15 |issue= 4 |pages= 114-9 |year= 1994 |pmid= 8016895 |doi= }}
*{{cite journal | author=Brann MR, Ellis J, Jørgensen H, ''et al.'' |title=Muscarinic acetylcholine receptor subtypes: localization and structure/function. |journal=Prog. Brain Res. |volume=98 |issue= |pages= 121-7 |year= 1994 |pmid= 8248499 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on CMA1... {November 8, 2007 10:04:30 AM PST} UPLOAD : Added new Image to wiki: File:PBB Protein CMA1 image.jpg {November 8, 2007 10:05:01 AM PST} CREATE : Found no pages, creating new page. {November 8, 2007 10:05:18 AM PST} CREATED : Created new protein page: CMA1 {November 8, 2007 10:05:25 AM PST} INFO : Beginning work on COL4A2... {November 8, 2007 10:05:25 AM PST} UPLOAD : Added new Image to wiki: File:PBB Protein COL4A2 image.jpg {November 8, 2007 10:06:17 AM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 8, 2007 10:06:29 AM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_COL4A2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1li1.
| PDB = {{PDB2|1li1}}, {{PDB2|1m3d}}, {{PDB2|1t60}}, {{PDB2|1t61}}
| Name = Collagen, type IV, alpha 2
| HGNCid = 2203
| Symbol = COL4A2
| AltSymbols =; DKFZp686I14213; FLJ22259
| OMIM = 120090
| ECnumber =
| Homologene = 1390
| MGIid = 88455
| GeneAtlas_image1 = PBB_GE_COL4A2_211964_at_tn.png
| GeneAtlas_image2 = PBB_GE_COL4A2_211966_at_tn.png
| Function = {{GNF_GO|id=GO:0005201 |text = extracellular matrix structural constituent}}
| Component = {{GNF_GO|id=GO:0005581 |text = collagen}} {{GNF_GO|id=GO:0005587 |text = collagen type IV}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006817 |text = phosphate transport}} {{GNF_GO|id=GO:0030198 |text = extracellular matrix organization and biogenesis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1284
| Hs_Ensembl = ENSG00000134871
| Hs_RefseqProtein = NP_001837
| Hs_RefseqmRNA = NM_001846
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 13
| Hs_GenLoc_start = 109757632
| Hs_GenLoc_end = 109963375
| Hs_Uniprot = P08572
| Mm_EntrezGene = 12827
| Mm_Ensembl = ENSMUSG00000031503
| Mm_RefseqmRNA = NM_009932
| Mm_RefseqProtein = NP_034062
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 8
| Mm_GenLoc_start = 11354249
| Mm_GenLoc_end = 11448288
| Mm_Uniprot = Q53WU4
}}
}}
'''Collagen, type IV, alpha 2''', also known as '''COL4A2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. The C-terminal portion of the protein, known as canstatin, is an inhibitor of angiogenesis and tumor growth. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter.<ref>{{cite web | title = Entrez Gene: COL4A2 collagen, type IV, alpha 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1284| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Hinek A |title=Nature and the multiple functions of the 67-kD elastin-/laminin binding protein. |journal=Cell Adhes. Commun. |volume=2 |issue= 3 |pages= 185-93 |year= 1995 |pmid= 7827955 |doi= }}
*{{cite journal | author=Ständer M, Naumann U, Wick W, Weller M |title=Transforming growth factor-beta and p-21: multiple molecular targets of decorin-mediated suppression of neoplastic growth. |journal=Cell Tissue Res. |volume=296 |issue= 2 |pages= 221-7 |year= 1999 |pmid= 10382266 |doi= }}
*{{cite journal | author=Kurpakus Wheater M, Kernacki KA, Hazlett LD |title=Corneal cell proteins and ocular surface pathology. |journal=Biotechnic & histochemistry : official publication of the Biological Stain Commission |volume=74 |issue= 3 |pages= 146-59 |year= 1999 |pmid= 10416788 |doi= }}
*{{cite journal | author=Kalluri R, Sukhatme VP |title=Fibrosis and angiogenesis. |journal=Curr. Opin. Nephrol. Hypertens. |volume=9 |issue= 4 |pages= 413-8 |year= 2000 |pmid= 10926178 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on CUL1... {November 8, 2007 10:18:31 AM PST} UPLOAD : Added new Image to wiki: File:PBB Protein CUL1 image.jpg {November 8, 2007 10:19:07 AM PST} CREATE : Found no pages, creating new page. {November 8, 2007 10:19:19 AM PST} CREATED : Created new protein page: CUL1 {November 8, 2007 10:19:27 AM PST} INFO : Beginning work on CXADR... {November 8, 2007 10:06:29 AM PST} UPLOAD : Added new Image to wiki: File:PBB Protein CXADR image.jpg {November 8, 2007 10:07:08 AM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 8, 2007 10:07:23 AM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CXADR_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1eaj.
| PDB = {{PDB2|1eaj}}, {{PDB2|1f5w}}, {{PDB2|1jew}}, {{PDB2|1kac}}, {{PDB2|1p69}}, {{PDB2|1p6a}}, {{PDB2|1rsf}}, {{PDB2|2j12}}, {{PDB2|2j1k}}, {{PDB2|2npl}}
| Name = Coxsackie virus and adenovirus receptor
| HGNCid = 2559
| Symbol = CXADR
| AltSymbols =; CAR; HCAR
| OMIM = 602621
| ECnumber =
| Homologene = 1024
| MGIid = 1201679
| GeneAtlas_image1 = PBB_GE_CXADR_203917_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0005923 |text = tight junction}}
| Process = {{GNF_GO|id=GO:0007005 |text = mitochondrion organization and biogenesis}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007507 |text = heart development}} {{GNF_GO|id=GO:0048739 |text = cardiac muscle fiber development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1525
| Hs_Ensembl = ENSG00000154639
| Hs_RefseqProtein = NP_001329
| Hs_RefseqmRNA = NM_001338
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 21
| Hs_GenLoc_start = 17807201
| Hs_GenLoc_end = 17861135
| Hs_Uniprot = P78310
| Mm_EntrezGene = 13052
| Mm_Ensembl = ENSMUSG00000022865
| Mm_RefseqmRNA = NM_001025192
| Mm_RefseqProtein = NP_001020363
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 16
| Mm_GenLoc_start = 78184283
| Mm_GenLoc_end = 78222167
| Mm_Uniprot = Q3TV22
}}
}}
'''Coxsackie virus and adenovirus receptor''', also known as '''CXADR''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a type I membrane receptor for group B coxsackieviruses and subgroup C adenoviruses. Pseudogenes of this gene are found on chromosomes 15, 18, and 21.<ref>{{cite web | title = Entrez Gene: CXADR coxsackie virus and adenovirus receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1525| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Carson SD |title=Receptor for the group B coxsackieviruses and adenoviruses: CAR. |journal=Rev. Med. Virol. |volume=11 |issue= 4 |pages= 219-26 |year= 2002 |pmid= 11479928 |doi= }}
*{{cite journal | author=Selinka HC, Wolde A, Sauter M, ''et al.'' |title=Virus-receptor interactions of coxsackie B viruses and their putative influence on cardiotropism. |journal=Med. Microbiol. Immunol. |volume=193 |issue= 2-3 |pages= 127-31 |year= 2004 |pmid= 12920584 |doi= 10.1007/s00430-003-0193-y }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on MTTP... {November 8, 2007 10:07:23 AM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 8, 2007 10:07:59 AM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Microsomal triglyceride transfer protein
| HGNCid = 7467
| Symbol = MTTP
| AltSymbols =; ABL; MTP; MGC149819; MGC149820
| OMIM = 157147
| ECnumber =
| Homologene = 212
| MGIid = 106926
| GeneAtlas_image1 = PBB_GE_MTTP_205675_at_tn.png
| Function = {{GNF_GO|id=GO:0005319 |text = lipid transporter activity}} {{GNF_GO|id=GO:0008289 |text = lipid binding}}
| Component = {{GNF_GO|id=GO:0005625 |text = soluble fraction}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005792 |text = microsome}}
| Process = {{GNF_GO|id=GO:0006629 |text = lipid metabolic process}} {{GNF_GO|id=GO:0006869 |text = lipid transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4547
| Hs_Ensembl = ENSG00000138823
| Hs_RefseqProtein = NP_000244
| Hs_RefseqmRNA = NM_000253
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 4
| Hs_GenLoc_start = 100715004
| Hs_GenLoc_end = 100763649
| Hs_Uniprot = P55157
| Mm_EntrezGene = 17777
| Mm_Ensembl = ENSMUSG00000028158
| Mm_RefseqmRNA = NM_008642
| Mm_RefseqProtein = NP_032668
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 3
| Mm_GenLoc_start = 138028273
| Mm_GenLoc_end = 138071492
| Mm_Uniprot = Q3TVF2
}}
}}
'''Microsomal triglyceride transfer protein''', also known as '''MTTP''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia.<ref>{{cite web | title = Entrez Gene: MTTP microsomal triglyceride transfer protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4547| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Luz JM, Lennarz WJ |title=Protein disulfide isomerase: a multifunctional protein of the endoplasmic reticulum. |journal=EXS |volume=77 |issue= |pages= 97-117 |year= 1996 |pmid= 8856971 |doi= }}
*{{cite journal | author=Wetterau JR, Lin MC, Jamil H |title=Microsomal triglyceride transfer protein. |journal=Biochim. Biophys. Acta |volume=1345 |issue= 2 |pages= 136-50 |year= 1997 |pmid= 9106493 |doi= }}
*{{cite journal | author=Gordon DA |title=Recent advances in elucidating the role of the microsomal triglyceride transfer protein in apolipoprotein B lipoprotein assembly. |journal=Curr. Opin. Lipidol. |volume=8 |issue= 3 |pages= 131-7 |year= 1997 |pmid= 9211060 |doi= }}
*{{cite journal | author=Ye J |title=Reliance of host cholesterol metabolic pathways for the life cycle of hepatitis C virus. |journal=PLoS Pathog. |volume=3 |issue= 8 |pages= e108 |year= 2007 |pmid= 17784784 |doi= 10.1371/journal.ppat.0030108 }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on MYBL2... {November 8, 2007 10:07:59 AM PST} UPLOAD : Added new Image to wiki: File:PBB Protein MYBL2 image.jpg {November 8, 2007 10:08:12 AM PST} CREATE : Found no pages, creating new page. {November 8, 2007 10:08:26 AM PST} CREATED : Created new protein page: MYBL2 {November 8, 2007 10:08:33 AM PST} INFO : Beginning work on NR1H4... {November 8, 2007 10:21:27 AM PST} UPLOAD : Added new Image to wiki: {November 8, 2007 10:22:01 AM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 8, 2007 10:22:35 AM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_NR1H4_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1osh.
| PDB = {{PDB2|1osh}}, {{PDB2|1osv}}, {{PDB2|1ot7}}
| Name = Nuclear receptor subfamily 1, group H, member 4
| HGNCid = 7967
| Symbol = NR1H4
| AltSymbols =; BAR; FXR; HRR-1; HRR1; MGC163445; RIP14
| OMIM = 603826
| ECnumber =
| Homologene = 3760
| MGIid = 1352464
| GeneAtlas_image1 = PBB_GE_NR1H4_206340_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003707 |text = steroid hormone receptor activity}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0003714 |text = transcription corepressor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0008206 |text = bile acid metabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 9971
| Hs_Ensembl = ENSG00000012504
| Hs_RefseqProtein = NP_005114
| Hs_RefseqmRNA = NM_005123
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 99391810
| Hs_GenLoc_end = 99481772
| Hs_Uniprot = Q96RI1
| Mm_EntrezGene = 20186
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_009108
| Mm_RefseqProtein = NP_033134
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Nuclear receptor subfamily 1, group H, member 4''', also known as '''NR1H4''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Kalaany NY, Mangelsdorf DJ |title=LXRS and FXR: the yin and yang of cholesterol and fat metabolism. |journal=Annu. Rev. Physiol. |volume=68 |issue= |pages= 159-91 |year= 2006 |pmid= 16460270 |doi= 10.1146/annurev.physiol.68.033104.152158 }}
*{{cite journal | author=Kuipers F, Stroeve JH, Caron S, Staels B |title=Bile acids, farnesoid X receptor, atherosclerosis and metabolic control. |journal=Curr. Opin. Lipidol. |volume=18 |issue= 3 |pages= 289-97 |year= 2007 |pmid= 17495603 |doi= 10.1097/MOL.0b013e3281338d08 }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on OSM... {November 8, 2007 10:08:33 AM PST} UPLOAD : Added new Image to wiki: File:PBB Protein OSM image.jpg {November 8, 2007 10:08:50 AM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 8, 2007 10:09:00 AM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_OSM_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1evs.
| PDB = {{PDB2|1evs}}
| Name = Oncostatin M
| HGNCid = 8506
| Symbol = OSM
| AltSymbols =; MGC20461
| OMIM = 165095
| ECnumber =
| Homologene = 10741
| MGIid = 104749
| Function = {{GNF_GO|id=GO:0005125 |text = cytokine activity}} {{GNF_GO|id=GO:0005147 |text = oncostatin-M receptor binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0001558 |text = regulation of cell growth}} {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007422 |text = peripheral nervous system development}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0009408 |text = response to heat}} {{GNF_GO|id=GO:0042503 |text = tyrosine phosphorylation of Stat3 protein}} {{GNF_GO|id=GO:0042506 |text = tyrosine phosphorylation of Stat5 protein}} {{GNF_GO|id=GO:0042508 |text = tyrosine phosphorylation of Stat1 protein}} {{GNF_GO|id=GO:0048266 |text = behavioral response to pain}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5008
| Hs_Ensembl = ENSG00000099985
| Hs_RefseqProtein = NP_065391
| Hs_RefseqmRNA = NM_020530
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 22
| Hs_GenLoc_start = 28988821
| Hs_GenLoc_end = 28992840
| Hs_Uniprot = P13725
| Mm_EntrezGene = 18413
| Mm_Ensembl = ENSMUSG00000058755
| Mm_RefseqmRNA = NM_001013365
| Mm_RefseqProtein = NP_001013383
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 4136423
| Mm_GenLoc_end = 4141029
| Mm_Uniprot = Q3U1Y5
}}
}}
'''Oncostatin M''', also known as '''OSM''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. This gene encodes a growth regulator which inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells.<ref>{{cite web | title = Entrez Gene: OSM oncostatin M| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5008| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on PAFAH1B1... {November 8, 2007 10:09:00 AM PST} UPLOAD : Added new Image to wiki: File:PBB Protein PAFAH1B1 image.jpg {November 8, 2007 10:09:30 AM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 8, 2007 10:09:47 AM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PAFAH1B1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1uuj.
| PDB = {{PDB2|1uuj}}, {{PDB2|1vyh}}
| Name = Platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa
| HGNCid = 8574
| Symbol = PAFAH1B1
| AltSymbols =; MDCR; LIS1; LIS2; PAFAH
| OMIM = 601545
| ECnumber =
| Homologene = 371
| MGIid = 109520
| GeneAtlas_image1 = PBB_GE_PAFAH1B1_211547_s_at_tn.png
| Function = {{GNF_GO|id=GO:0008017 |text = microtubule binding}} {{GNF_GO|id=GO:0045502 |text = dynein binding}}
| Component = {{GNF_GO|id=GO:0000235 |text = astral microtubule}} {{GNF_GO|id=GO:0000776 |text = kinetochore}} {{GNF_GO|id=GO:0005635 |text = nuclear envelope}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005813 |text = centrosome}} {{GNF_GO|id=GO:0005856 |text = cytoskeleton}} {{GNF_GO|id=GO:0005874 |text = microtubule}} {{GNF_GO|id=GO:0005875 |text = microtubule associated complex}} {{GNF_GO|id=GO:0005938 |text = cell cortex}}
| Process = {{GNF_GO|id=GO:0000132 |text = establishment of mitotic spindle orientation}} {{GNF_GO|id=GO:0000226 |text = microtubule cytoskeleton organization and biogenesis}} {{GNF_GO|id=GO:0001675 |text = acrosome formation}} {{GNF_GO|id=GO:0001764 |text = neuron migration}} {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0006928 |text = cell motility}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007067 |text = mitosis}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0007405 |text = neuroblast proliferation}} {{GNF_GO|id=GO:0008090 |text = retrograde axon cargo transport}} {{GNF_GO|id=GO:0016042 |text = lipid catabolic process}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}} {{GNF_GO|id=GO:0047496 |text = vesicle transport along microtubule}} {{GNF_GO|id=GO:0051301 |text = cell division}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5048
| Hs_Ensembl = ENSG00000007168
| Hs_RefseqProtein = NP_000421
| Hs_RefseqmRNA = NM_000430
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 2443686
| Hs_GenLoc_end = 2535638
| Hs_Uniprot = P43034
| Mm_EntrezGene = 18472
| Mm_Ensembl = ENSMUSG00000020745
| Mm_RefseqmRNA = XM_982651
| Mm_RefseqProtein = XP_987745
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 74490144
| Mm_GenLoc_end = 74540865
| Mm_Uniprot = Q3TUH5
}}
}}
'''Platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa''', also known as '''PAFAH1B1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = PAFAH1B1 was identified as encoding a gene that when mutated or lost caused the lissencephaly associated with Miller-Dieker lissencephaly syndrome. PAFAH1B1 encodes the non-catalytic alpha subunit of the intracellular Ib isoform of platelet-activating factor acteylhydrolase, a heterotrimeric enzyme that specifically catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist: one composed of multiple subunits, the other, a single subunit. In addition, a single-subunit isoform of this enzyme is found in serum.<ref>{{cite web | title = Entrez Gene: PAFAH1B1 platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5048| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Tjoelker LW, Eberhardt C, Wilder C, ''et al.'' |title=Functional and structural features of plasma platelet-activating factor acetylhydrolase. |journal=Adv. Exp. Med. Biol. |volume=416 |issue= |pages= 107-11 |year= 1997 |pmid= 9131135 |doi= }}
*{{cite journal | author=Stafforini DM, McIntyre TM, Zimmerman GA, Prescott SM |title=Platelet-activating factor acetylhydrolases. |journal=J. Biol. Chem. |volume=272 |issue= 29 |pages= 17895-8 |year= 1997 |pmid= 9218411 |doi= }}
*{{cite journal | author=Yamada Y, Yokota M |title=Roles of plasma platelet-activating factor acetylhydrolase in allergic, inflammatory, and atherosclerotic diseases. |journal=Jpn. Circ. J. |volume=62 |issue= 5 |pages= 328-35 |year= 1998 |pmid= 9626899 |doi= }}
*{{cite journal | author=Reiner O, Cahana A, Escamez T, Martinez S |title=LIS1-no more no less. |journal=Mol. Psychiatry |volume=7 |issue= 1 |pages= 12-6 |year= 2002 |pmid= 11803439 |doi= 10.1038/sj/mp/4000975 }}
*{{cite journal | author=Guerrini R, Carrozzo R |title=Epileptogenic brain malformations: clinical presentation, malformative patterns and indications for genetic testing. |journal=Seizure : the journal of the British Epilepsy Association |volume=11 Suppl A |issue= |pages= 532-43; quiz 544-7 |year= 2002 |pmid= 12185771 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on POLH... {November 8, 2007 10:09:47 AM PST} UPLOAD : Added new Image to wiki: File:PBB Protein POLH image.jpg {November 8, 2007 10:10:20 AM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 8, 2007 10:10:38 AM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_POLH_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2i5o.
| PDB = {{PDB2|2i5o}}
| Name = Polymerase (DNA directed), eta
| HGNCid = 9181
| Symbol = POLH
| AltSymbols =; FLJ16395; FLJ21978; RAD30A; XP-V; XPV
| OMIM = 603968
| ECnumber =
| Homologene = 38189
| MGIid = 1891457
| GeneAtlas_image1 = PBB_GE_POLH_219380_x_at_tn.png
| Function = {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0003684 |text = damaged DNA binding}} {{GNF_GO|id=GO:0015999 |text = eta DNA polymerase activity}} {{GNF_GO|id=GO:0016451 |text = nu DNA polymerase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005654 |text = nucleoplasm}}
| Process = {{GNF_GO|id=GO:0006260 |text = DNA replication}} {{GNF_GO|id=GO:0006281 |text = DNA repair}} {{GNF_GO|id=GO:0006282 |text = regulation of DNA repair}} {{GNF_GO|id=GO:0006290 |text = pyrimidine dimer repair}} {{GNF_GO|id=GO:0006301 |text = postreplication repair}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5429
| Hs_Ensembl = ENSG00000170734
| Hs_RefseqProtein = NP_006493
| Hs_RefseqmRNA = NM_006502
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 43651865
| Hs_GenLoc_end = 43691375
| Hs_Uniprot = Q9Y253
| Mm_EntrezGene = 80905
| Mm_Ensembl = ENSMUSG00000023953
| Mm_RefseqmRNA = XM_001002709
| Mm_RefseqProtein = XP_001002709
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 45634936
| Mm_GenLoc_end = 45666176
| Mm_Uniprot = A1A556
}}
}}
'''Polymerase (DNA directed), eta''', also known as '''POLH''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on PSMB9... {November 8, 2007 10:10:38 AM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 8, 2007 10:11:15 AM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)
| HGNCid = 9546
| Symbol = PSMB9
| AltSymbols =; LMP2; MGC70470; RING12
| OMIM = 177045
| ECnumber =
| Homologene = 2094
| MGIid = 1346526
| GeneAtlas_image1 = PBB_GE_PSMB9_204279_at_tn.png
| Function = {{GNF_GO|id=GO:0004298 |text = threonine endopeptidase activity}}
| Component = {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0005839 |text = proteasome core complex (sensu Eukaryota)}}
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0006511 |text = ubiquitin-dependent protein catabolic process}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0019882 |text = antigen processing and presentation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5698
| Hs_Ensembl = ENSG00000204261
| Hs_RefseqProtein = NP_002791
| Hs_RefseqmRNA = NM_002800
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 32929916
| Hs_GenLoc_end = 32935606
| Hs_Uniprot = P28065
| Mm_EntrezGene = 16912
| Mm_Ensembl = ENSMUSG00000024337
| Mm_RefseqmRNA = NM_013585
| Mm_RefseqProtein = NP_038613
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 33792336
| Mm_GenLoc_end = 33797608
| Mm_Uniprot = Q3TAR7
}}
}}
'''Proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)''', also known as '''PSMB9''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 1 (proteasome beta 6 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding different isoforms have been identified; both isoforms are processed to yield the same mature subunit.<ref>{{cite web | title = Entrez Gene: PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5698| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Coux O, Tanaka K, Goldberg AL |title=Structure and functions of the 20S and 26S proteasomes. |journal=Annu. Rev. Biochem. |volume=65 |issue= |pages= 801-47 |year= 1996 |pmid= 8811196 |doi= 10.1146/annurev.bi.65.070196.004101 }}
*{{cite journal | author=Goff SP |title=Death by deamination: a novel host restriction system for HIV-1. |journal=Cell |volume=114 |issue= 3 |pages= 281-3 |year= 2003 |pmid= 12914693 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on RAD9A... {November 8, 2007 10:11:15 AM PST} CREATE : Found no pages, creating new page. {November 8, 2007 10:11:49 AM PST} CREATED : Created new protein page: RAD9A {November 8, 2007 10:11:57 AM PST} INFO : Beginning work on SET... {November 8, 2007 10:11:57 AM PST} UPLOAD : Added new Image to wiki: File:PBB Protein SET image.jpg {November 8, 2007 10:12:12 AM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 8, 2007 10:12:32 AM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_SET_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2e50.
| PDB = {{PDB2|2e50}}
| Name = SET translocation (myeloid leukemia-associated)
| HGNCid = 10760
| Symbol = SET
| AltSymbols =; 2PP2A; I2PP2A; IGAAD; PHAPII; TAF-IBETA
| OMIM = 600960
| ECnumber =
| Homologene = 55707
| MGIid = 1860267
| Function = {{GNF_GO|id=GO:0004864 |text = protein phosphatase inhibitor activity}} {{GNF_GO|id=GO:0008601 |text = protein phosphatase type 2A regulator activity}} {{GNF_GO|id=GO:0042393 |text = histone binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0048471 |text = perinuclear region of cytoplasm}}
| Process = {{GNF_GO|id=GO:0006260 |text = DNA replication}} {{GNF_GO|id=GO:0006334 |text = nucleosome assembly}} {{GNF_GO|id=GO:0006337 |text = nucleosome disassembly}} {{GNF_GO|id=GO:0006913 |text = nucleocytoplasmic transport}} {{GNF_GO|id=GO:0035067 |text = negative regulation of histone acetylation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6418
| Hs_Ensembl =
| Hs_RefseqProtein = NP_003002
| Hs_RefseqmRNA = NM_003011
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 56086
| Mm_Ensembl =
| Mm_RefseqmRNA = XM_978154
| Mm_RefseqProtein = XP_983248
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''SET translocation (myeloid leukemia-associated)''', also known as '''SET''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on SLC11A1... {November 8, 2007 10:14:08 AM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 8, 2007 10:15:43 AM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
| HGNCid = 10907
| Symbol = SLC11A1
| AltSymbols =; LSH; NRAMP; NRAMP1
| OMIM = 600266
| ECnumber =
| Homologene = 73884
| MGIid = 1345275
| GeneAtlas_image1 = PBB_GE_SLC11A1_210423_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SLC11A1_210422_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_SLC11A1_217473_x_at_tn.png
| Function = {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0005506 |text = iron ion binding}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006826 |text = iron ion transport}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0009617 |text = response to bacterium}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6556
| Hs_Ensembl = ENSG00000018280
| Hs_RefseqProtein = NP_000569
| Hs_RefseqmRNA = NM_000578
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 218955203
| Hs_GenLoc_end = 218968994
| Hs_Uniprot = P49279
| Mm_EntrezGene = 18173
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_013612
| Mm_RefseqProtein = NP_038640
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1''', also known as '''SLC11A1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as tuberculosis and leprosy, and inflammatory diseases such as rheumatoid arthritis and Crohn disease. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined.<ref>{{cite web | title = Entrez Gene: SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6556| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Blackwell JM, Searle S, Mohamed H, White JK |title=Divalent cation transport and susceptibility to infectious and autoimmune disease: continuation of the Ity/Lsh/Bcg/Nramp1/Slc11a1 gene story. |journal=Immunol. Lett. |volume=85 |issue= 2 |pages= 197-203 |year= 2003 |pmid= 12527228 |doi= }}
*{{cite journal | author=Awomoyi AA |title=The human solute carrier family 11 member 1 protein (SLC11A1): linking infections, autoimmunity and cancer? |journal=FEMS Immunol. Med. Microbiol. |volume=49 |issue= 3 |pages= 324-9 |year= 2007 |pmid= 17378896 |doi= 10.1111/j.1574-695X.2007.00231.x }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on SLC6A2... {November 8, 2007 10:12:32 AM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 8, 2007 10:14:08 AM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
| HGNCid = 11048
| Symbol = SLC6A2
| AltSymbols =; NAT1; NET; NET1; SLC6A5
| OMIM = 163970
| ECnumber =
| Homologene = 816
| MGIid = 1270850
| GeneAtlas_image1 = PBB_GE_SLC6A2_210353_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SLC6A2_216611_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_SLC6A2_217621_at_tn.png
| Function = {{GNF_GO|id=GO:0005328 |text = neurotransmitter:sodium symporter activity}} {{GNF_GO|id=GO:0005334 |text = norephinephrine:sodium symporter activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008504 |text = monoamine transmembrane transporter activity}} {{GNF_GO|id=GO:0015293 |text = symporter activity}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006836 |text = neurotransmitter transport}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}} {{GNF_GO|id=GO:0015844 |text = monoamine transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6530
| Hs_Ensembl = ENSG00000103546
| Hs_RefseqProtein = NP_001034
| Hs_RefseqmRNA = NM_001043
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 16
| Hs_GenLoc_start = 54248057
| Hs_GenLoc_end = 54296685
| Hs_Uniprot = P23975
| Mm_EntrezGene = 20538
| Mm_Ensembl = ENSMUSG00000055368
| Mm_RefseqmRNA = NM_009209
| Mm_RefseqProtein = NP_033235
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 8
| Mm_GenLoc_start = 95850358
| Mm_GenLoc_end = 95890795
| Mm_Uniprot = Q6NZB4
}}
}}
'''Solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2''', also known as '''SLC6A2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Eisenhofer G |title=The role of neuronal and extraneuronal plasma membrane transporters in the inactivation of peripheral catecholamines. |journal=Pharmacol. Ther. |volume=91 |issue= 1 |pages= 35-62 |year= 2001 |pmid= 11707293 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on TAL1... {November 8, 2007 10:17:08 AM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 8, 2007 10:18:00 AM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = T-cell acute lymphocytic leukemia 1
| HGNCid = 11556
| Symbol = TAL1
| AltSymbols =; SCL; TCL5; tal-1
| OMIM = 187040
| ECnumber =
| Homologene = 2400
| MGIid = 98480
| GeneAtlas_image1 = PBB_GE_TAL1_206283_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_TAL1_216925_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0030528 |text = transcription regulator activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}} {{GNF_GO|id=GO:0045449 |text = regulation of transcription}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6886
| Hs_Ensembl = ENSG00000162367
| Hs_RefseqProtein = NP_003180
| Hs_RefseqmRNA = NM_003189
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 47454550
| Hs_GenLoc_end = 47469974
| Hs_Uniprot = P17542
| Mm_EntrezGene = 21349
| Mm_Ensembl = ENSMUSG00000028717
| Mm_RefseqmRNA = NM_011527
| Mm_RefseqProtein = NP_035657
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 114554358
| Mm_GenLoc_end = 114569687
| Mm_Uniprot = Q3TZH7
}}
}}
'''T-cell acute lymphocytic leukemia 1''', also known as '''TAL1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Green AR, Begley CG |title=SCL and related hemopoietic helix-loop-helix transcription factors. |journal=Int. J. Cell Cloning |volume=10 |issue= 5 |pages= 269-76 |year= 1993 |pmid= 1453013 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on TNFRSF11A... {November 8, 2007 10:19:27 AM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 8, 2007 10:20:11 AM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Tumor necrosis factor receptor superfamily, member 11a, NFKB activator
| HGNCid = 11908
| Symbol = TNFRSF11A
| AltSymbols =; CD265; ODFR; OFE; RANK; TRANCER
| OMIM = 603499
| ECnumber =
| Homologene = 2848
| MGIid = 1314891
| GeneAtlas_image1 = PBB_GE_TNFRSF11A_207037_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0001503 |text = ossification}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007605 |text = sensory perception of sound}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}} {{GNF_GO|id=GO:0048535 |text = lymph node development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8792
| Hs_Ensembl = ENSG00000141655
| Hs_RefseqProtein = NP_003830
| Hs_RefseqmRNA = NM_003839
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 18
| Hs_GenLoc_start = 58143500
| Hs_GenLoc_end = 58205872
| Hs_Uniprot = Q9Y6Q6
| Mm_EntrezGene = 21934
| Mm_Ensembl = ENSMUSG00000026321
| Mm_RefseqmRNA = NM_009399
| Mm_RefseqProtein = NP_033425
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 107608270
| Mm_GenLoc_end = 107672751
| Mm_Uniprot = O35305
}}
}}
'''Tumor necrosis factor receptor superfamily, member 11a, NFKB activator''', also known as '''TNFRSF11A''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Studies of the mouse counterpart suggest that this receptor directly mediates the osteoprotegerin ligand (OPGL)-induced osteoclastogenesis in osteoclast precursor cells.<ref>{{cite web | title = Entrez Gene: TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8792| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Romas E, Gillespie MT, Martin TJ |title=Involvement of receptor activator of NFkappaB ligand and tumor necrosis factor-alpha in bone destruction in rheumatoid arthritis. |journal=Bone |volume=30 |issue= 2 |pages= 340-6 |year= 2002 |pmid= 11856640 |doi= }}
*{{cite journal | author=Collin-Osdoby P |title=Regulation of vascular calcification by osteoclast regulatory factors RANKL and osteoprotegerin. |journal=Circ. Res. |volume=95 |issue= 11 |pages= 1046-57 |year= 2005 |pmid= 15564564 |doi= 10.1161/01.RES.0000149165.99974.12 }}
*{{cite journal | author=Clohisy DR, Mantyh PW |title=Bone cancer pain and the role of RANKL/OPG. |journal=Journal of musculoskeletal & neuronal interactions |volume=4 |issue= 3 |pages= 293-300 |year= 2005 |pmid= 15615497 |doi= }}
*{{cite journal | author=Anandarajah AP, Schwarz EM |title=Anti-RANKL therapy for inflammatory bone disorders: Mechanisms and potential clinical applications. |journal=J. Cell. Biochem. |volume=97 |issue= 2 |pages= 226-32 |year= 2006 |pmid= 16240334 |doi= 10.1002/jcb.20674 }}
*{{cite journal | author=Baud'huin M, Duplomb L, Ruiz Velasco C, ''et al.'' |title=Key roles of the OPG-RANK-RANKL system in bone oncology. |journal=Expert Rev Anticancer Ther |volume=7 |issue= 2 |pages= 221-32 |year= 2007 |pmid= 17288531 |doi= 10.1586/14737140.7.2.221 }}
*{{cite journal | author=Boyce BF, Xing L |title=Biology of RANK, RANKL, and osteoprotegerin. |journal=Arthritis Res. Ther. |volume=9 Suppl 1 |issue= |pages= S1 |year= 2007 |pmid= 17634140 |doi= 10.1186/ar2165 }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on TYK2... {November 8, 2007 10:18:00 AM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 8, 2007 10:18:31 AM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Tyrosine kinase 2
| HGNCid = 12440
| Symbol = TYK2
| AltSymbols =; JTK1
| OMIM = 176941
| ECnumber =
| Homologene = 20712
| MGIid = 1929470
| GeneAtlas_image1 = PBB_GE_TYK2_205546_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004715 |text = non-membrane spanning protein tyrosine kinase activity}} {{GNF_GO|id=GO:0004718 |text = Janus kinase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005856 |text = cytoskeleton}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7297
| Hs_Ensembl = ENSG00000105397
| Hs_RefseqProtein = NP_003322
| Hs_RefseqmRNA = NM_003331
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 10322205
| Hs_GenLoc_end = 10350114
| Hs_Uniprot = P29597
| Mm_EntrezGene = 54721
| Mm_Ensembl = ENSMUSG00000032175
| Mm_RefseqmRNA = NM_018793
| Mm_RefseqProtein = NP_061263
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 9
| Mm_GenLoc_start = 20854476
| Mm_GenLoc_end = 20881612
| Mm_Uniprot = Q2M4G5
}}
}}
'''Tyrosine kinase 2''', also known as '''TYK2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on VAMP2... {November 8, 2007 10:15:43 AM PST} UPLOAD : Added new Image to wiki: File:PBB Protein VAMP2 image.jpg {November 8, 2007 10:16:51 AM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 8, 2007 10:17:08 AM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_VAMP2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1kil.
| PDB = {{PDB2|1kil}}, {{PDB2|1n7s}}, {{PDB2|1sfc}}
| Name = Vesicle-associated membrane protein 2 (synaptobrevin 2)
| HGNCid = 12643
| Symbol = VAMP2
| AltSymbols =; FLJ11460; SYB2; VAMP-2
| OMIM = 185881
| ECnumber =
| Homologene = 7591
| MGIid = 1313277
| GeneAtlas_image1 = PBB_GE_VAMP2_201556_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_VAMP2_201557_at_tn.png
| GeneAtlas_image3 = PBB_GE_VAMP2_214792_x_at_tn.png
| Function = {{GNF_GO|id=GO:0000149 |text = SNARE binding}} {{GNF_GO|id=GO:0005516 |text = calmodulin binding}} {{GNF_GO|id=GO:0005543 |text = phospholipid binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0019717 |text = synaptosome}} {{GNF_GO|id=GO:0030141 |text = secretory granule}} {{GNF_GO|id=GO:0030672 |text = synaptic vesicle membrane}} {{GNF_GO|id=GO:0042589 |text = zymogen granule membrane}} {{GNF_GO|id=GO:0045202 |text = synapse}}
| Process = {{GNF_GO|id=GO:0006944 |text = membrane fusion}} {{GNF_GO|id=GO:0016079 |text = synaptic vesicle exocytosis}} {{GNF_GO|id=GO:0016192 |text = vesicle-mediated transport}} {{GNF_GO|id=GO:0017156 |text = calcium ion-dependent exocytosis}} {{GNF_GO|id=GO:0017157 |text = regulation of exocytosis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6844
| Hs_Ensembl = ENSG00000179036
| Hs_RefseqProtein = NP_055047
| Hs_RefseqmRNA = NM_014232
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 8003189
| Hs_GenLoc_end = 8007017
| Hs_Uniprot = P63027
| Mm_EntrezGene = 22318
| Mm_Ensembl = ENSMUSG00000020894
| Mm_RefseqmRNA = NM_009497
| Mm_RefseqProtein = NP_033523
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 68904705
| Mm_GenLoc_end = 68908573
| Mm_Uniprot = O35619
}}
}}
'''Vesicle-associated membrane protein 2 (synaptobrevin 2)''', also known as '''VAMP2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. VAMP2 is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. VAMP2 is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG. VAMP2 is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin.<ref>{{cite web | title = Entrez Gene: VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6844| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
end log.
{November 8, 2007 10:21:04 AM PST} 
{November 8, 2007 10:03:39 AM PST} 
{November 8, 2007 10:22:01 AM PST} 
