- INFO: Beginning work on ATIC... {December 20, 2007 12:55:59 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein ATIC image.jpg {December 20, 2007 12:56:48 PM PST}
- REDIRECT: Page directory gave bad page (Inosine monophosphate synthase). Continuing with search.. Please correct entry: <471,Inosine monophosphate synthase>. {December 20, 2007 12:56:55 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {December 20, 2007 12:57:09 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_ATIC_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1p4r.
| PDB = {{PDB2|1p4r}}, {{PDB2|1pkx}}, {{PDB2|1pl0}}
| Name = 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
| HGNCid = 794
| Symbol = ATIC
| AltSymbols =; AICAR; AICARFT; IMPCHASE; PURH
| OMIM = 601731
| ECnumber =
| Homologene = 2983
| MGIid = 1351352
| GeneAtlas_image1 = PBB_GE_ATIC_208758_at_tn.png
| Function = {{GNF_GO|id=GO:0003937 |text = IMP cyclohydrolase activity}} {{GNF_GO|id=GO:0004643 |text = phosphoribosylaminoimidazolecarboxamide formyltransferase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component =
| Process = {{GNF_GO|id=GO:0006139 |text = nucleobase, nucleoside, nucleotide and nucleic acid metabolic process}} {{GNF_GO|id=GO:0006164 |text = purine nucleotide biosynthetic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 471
| Hs_Ensembl = ENSG00000138363
| Hs_RefseqProtein = NP_004035
| Hs_RefseqmRNA = NM_004044
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 215885036
| Hs_GenLoc_end = 215922724
| Hs_Uniprot = P31939
| Mm_EntrezGene = 108147
| Mm_Ensembl = ENSMUSG00000026192
| Mm_RefseqmRNA = XM_987290
| Mm_RefseqProtein = XP_992384
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 71490367
| Mm_GenLoc_end = 71512612
| Mm_Uniprot = Q3UTQ3
}}
}}
'''5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase''', also known as '''ATIC''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=471| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Rasmussen HH, van Damme J, Puype M, ''et al.'' |title=Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. |journal=Electrophoresis |volume=13 |issue= 12 |pages= 960-9 |year= 1993 |pmid= 1286667 |doi= }}
*{{cite journal | author=Rayl EA, Moroson BA, Beardsley GP |title=The human purH gene product, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. Cloning, sequencing, expression, purification, kinetic analysis, and domain mapping. |journal=J. Biol. Chem. |volume=271 |issue= 4 |pages= 2225-33 |year= 1996 |pmid= 8567683 |doi= }}
*{{cite journal | author=Yamauchi M, Seki N, Mita K, ''et al.'' |title=Isolation of human purH gene expressed in the rodent transformant cells by subtractive enrichment of 3'-untranslated region of human transcript. |journal=DNA Res. |volume=2 |issue= 6 |pages= 269-75 |year= 1996 |pmid= 8867801 |doi= }}
*{{cite journal | author=Sugita T, Aya H, Ueno M, ''et al.'' |title=Characterization of molecularly cloned human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase. |journal=J. Biochem. |volume=122 |issue= 2 |pages= 309-13 |year= 1997 |pmid= 9378707 |doi= }}
*{{cite journal | author=Beardsley GP, Rayl EA, Gunn K, ''et al.'' |title=Structure and functional relationships in human pur H. |journal=Adv. Exp. Med. Biol. |volume=431 |issue= |pages= 221-6 |year= 1998 |pmid= 9598063 |doi= }}
*{{cite journal | author=Vergis JM, Bulock KG, Fleming KG, Beardsley GP |title=Human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase. A bifunctional protein requiring dimerization for transformylase activity but not for cyclohydrolase activity. |journal=J. Biol. Chem. |volume=276 |issue= 11 |pages= 7727-33 |year= 2001 |pmid= 11096114 |doi= 10.1074/jbc.M009940200 }}
*{{cite journal | author=Bulock KG, Beardsley GP, Anderson KS |title=The kinetic mechanism of the human bifunctional enzyme ATIC (5-amino-4-imidazolecarboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase). A surprising lack of substrate channeling. |journal=J. Biol. Chem. |volume=277 |issue= 25 |pages= 22168-74 |year= 2002 |pmid= 11948179 |doi= 10.1074/jbc.M111964200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Cheong CG, Wolan DW, Greasley SE, ''et al.'' |title=Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates. |journal=J. Biol. Chem. |volume=279 |issue= 17 |pages= 18034-45 |year= 2004 |pmid= 14966129 |doi= 10.1074/jbc.M313691200 }}
*{{cite journal | author=Marie S, Heron B, Bitoun P, ''et al.'' |title=AICA-ribosiduria: a novel, neurologically devastating inborn error of purine biosynthesis caused by mutation of ATIC. |journal=Am. J. Hum. Genet. |volume=74 |issue= 6 |pages= 1276-81 |year= 2004 |pmid= 15114530 |doi= 10.1086/421475 }}
*{{cite journal | author=Dervieux T, Furst D, Lein DO, ''et al.'' |title=Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis. |journal=Arthritis Rheum. |volume=50 |issue= 9 |pages= 2766-74 |year= 2004 |pmid= 15457444 |doi= 10.1002/art.20460 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on MYBL2... {December 20, 2007 12:57:09 PM PST}
- REDIRECT: Protein Redirected to: MYBL2 {December 20, 2007 12:57:24 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {December 20, 2007 12:57:25 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {December 20, 2007 12:57:25 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {December 20, 2007 12:57:25 PM PST}
- UPDATED: Updated protein page: MYBL2 {December 20, 2007 12:57:32 PM PST}
- INFO: Beginning work on MYC... {December 20, 2007 12:57:32 PM PST}
- REDIRECT: Protein Redirected to: Myc {December 20, 2007 12:57:47 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {December 20, 2007 12:57:49 PM PST}
- SKIP SUMMARY: SKIPPING Summary, No Errors. {December 20, 2007 12:57:49 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {December 20, 2007 12:57:49 PM PST}
- UPDATED: Updated protein page: Myc {December 20, 2007 12:57:56 PM PST}
- INFO: Beginning work on NCL... {December 20, 2007 12:57:56 PM PST}
- REDIRECT: Protein Redirected to: Nucleolin {December 20, 2007 12:58:14 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {December 20, 2007 12:58:16 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {December 20, 2007 12:58:16 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {December 20, 2007 12:58:16 PM PST}
- UPDATED: Updated protein page: Nucleolin {December 20, 2007 12:58:22 PM PST}
- INFO: Beginning work on NFKBIB... {December 20, 2007 12:58:22 PM PST}
- REDIRECT: Protein Redirected to: NFKBIB {December 20, 2007 12:58:39 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {December 20, 2007 12:58:42 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {December 20, 2007 12:58:42 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {December 20, 2007 12:58:42 PM PST}
- UPDATED: Updated protein page: NFKBIB {December 20, 2007 12:58:49 PM PST}
- INFO: Beginning work on NME1... {December 20, 2007 12:58:49 PM PST}
- REDIRECT: Protein Redirected to: NME1 {December 20, 2007 12:59:04 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {December 20, 2007 12:59:05 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {December 20, 2007 12:59:05 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {December 20, 2007 12:59:05 PM PST}
- UPDATED: Updated protein page: NME1 {December 20, 2007 12:59:11 PM PST}
- INFO: Beginning work on NP... {December 20, 2007 12:59:11 PM PST}
- REDIRECT: Page directory gave bad page (Purine nucleoside phosphorylase). Continuing with search.. Please correct entry: <4860,Purine nucleoside phosphorylase>. {December 20, 2007 12:59:27 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {December 20, 2007 12:59:45 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_NP_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1m73.
| PDB = {{PDB2|1m73}}, {{PDB2|1pf7}}, {{PDB2|1pwy}}, {{PDB2|1rct}}, {{PDB2|1rfg}}, {{PDB2|1rr6}}, {{PDB2|1rsz}}, {{PDB2|1rt9}}, {{PDB2|1ula}}, {{PDB2|1ulb}}, {{PDB2|1v2h}}, {{PDB2|1v3q}}, {{PDB2|1v41}}, {{PDB2|1v45}}, {{PDB2|1yry}}, {{PDB2|2a0w}}, {{PDB2|2a0x}}, {{PDB2|2a0y}}, {{PDB2|2oc4}}, {{PDB2|2oc9}}, {{PDB2|2on6}}
| Name = Nucleoside phosphorylase
| HGNCid = 7892
| Symbol = NP
| AltSymbols =; MGC117396; MGC125915; MGC125916; PNP; PRO1837; PUNP
| OMIM = 164050
| ECnumber =
| Homologene = 227
| MGIid =
| GeneAtlas_image1 = PBB_GE_NP_201695_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004731 |text = purine-nucleoside phosphorylase activity}}
| Component =
| Process = {{GNF_GO|id=GO:0006139 |text = nucleobase, nucleoside, nucleotide and nucleic acid metabolic process}} {{GNF_GO|id=GO:0006304 |text = DNA modification}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4860
| Hs_Ensembl = ENSG00000198805
| Hs_RefseqProtein = NP_000261
| Hs_RefseqmRNA = NM_000270
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 14
| Hs_GenLoc_start = 20007409
| Hs_GenLoc_end = 20015082
| Hs_Uniprot = P00491
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Nucleoside phosphorylase''', also known as '''NP''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NP nucleoside phosphorylase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4860| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = NP encodes the enzyme purine nucleoside phosphorylase that together with adenosine deaminase (ADA) serves a key role in purine catabolism, referred to as the salvage pathway. Mutations in either enzyme result in a severe combined immunodeficiency (SCID).<ref name="entrez">{{cite web | title = Entrez Gene: NP nucleoside phosphorylase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4860| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Markert ML |title=Purine nucleoside phosphorylase deficiency. |journal=Immunodeficiency reviews |volume=3 |issue= 1 |pages= 45-81 |year= 1991 |pmid= 1931007 |doi= }}
*{{cite journal | author=Borgers M, Verhaegen H, De Brabander M, ''et al.'' |title=Purine nucleoside phosphorylase in chronic lymphocytic leukemia (CLL). |journal=Blood |volume=52 |issue= 5 |pages= 886-95 |year= 1978 |pmid= 100152 |doi= }}
*{{cite journal | author=Aust MR, Andrews LG, Barrett MJ, ''et al.'' |title=Molecular analysis of mutations in a patient with purine nucleoside phosphorylase deficiency. |journal=Am. J. Hum. Genet. |volume=51 |issue= 4 |pages= 763-72 |year= 1992 |pmid= 1384322 |doi= }}
*{{cite journal | author=Andrews LG, Markert ML |title=Exon skipping in purine nucleoside phosphorylase mRNA processing leading to severe immunodeficiency. |journal=J. Biol. Chem. |volume=267 |issue= 11 |pages= 7834-8 |year= 1992 |pmid= 1560016 |doi= }}
*{{cite journal | author=Jonsson JJ, Williams SR, McIvor RS |title=Sequence and functional characterization of the human purine nucleoside phosphorylase promoter. |journal=Nucleic Acids Res. |volume=19 |issue= 18 |pages= 5015-20 |year= 1991 |pmid= 1923769 |doi= }}
*{{cite journal | author=Ealick SE, Rule SA, Carter DC, ''et al.'' |title=Three-dimensional structure of human erythrocytic purine nucleoside phosphorylase at 3.2 A resolution. |journal=J. Biol. Chem. |volume=265 |issue= 3 |pages= 1812-20 |year= 1990 |pmid= 2104852 |doi= }}
*{{cite journal | author=Williams SR, Gekeler V, McIvor RS, Martin DW |title=A human purine nucleoside phosphorylase deficiency caused by a single base change. |journal=J. Biol. Chem. |volume=262 |issue= 5 |pages= 2332-8 |year= 1987 |pmid= 3029074 |doi= }}
*{{cite journal | author=Williams SR, Goddard JM, Martin DW |title=Human purine nucleoside phosphorylase cDNA sequence and genomic clone characterization. |journal=Nucleic Acids Res. |volume=12 |issue= 14 |pages= 5779-87 |year= 1984 |pmid= 6087295 |doi= }}
*{{cite journal | author=Pannicke U, Tuchschmid P, Friedrich W, ''et al.'' |title=Two novel missense and frameshift mutations in exons 5 and 6 of the purine nucleoside phosphorylase (PNP) gene in a severe combined immunodeficiency (SCID) patient. |journal=Hum. Genet. |volume=98 |issue= 6 |pages= 706-9 |year= 1997 |pmid= 8931706 |doi= }}
*{{cite journal | author=Markert ML, Finkel BD, McLaughlin TM, ''et al.'' |title=Mutations in purine nucleoside phosphorylase deficiency. |journal=Hum. Mutat. |volume=9 |issue= 2 |pages= 118-21 |year= 1997 |pmid= 9067751 |doi= 10.1002/(SICI)1098-1004(1997)9:2<118::AID-HUMU3>3.0.CO;2-5 }}
*{{cite journal | author=Erion MD, Takabayashi K, Smith HB, ''et al.'' |title=Purine nucleoside phosphorylase. 1. Structure-function studies. |journal=Biochemistry |volume=36 |issue= 39 |pages= 11725-34 |year= 1997 |pmid= 9305962 |doi= 10.1021/bi961969w }}
*{{cite journal | author=Erion MD, Stoeckler JD, Guida WC, ''et al.'' |title=Purine nucleoside phosphorylase. 2. Catalytic mechanism. |journal=Biochemistry |volume=36 |issue= 39 |pages= 11735-48 |year= 1997 |pmid= 9305963 |doi= 10.1021/bi961970v }}
*{{cite journal | author=Stoeckler JD, Poirot AF, Smith RM, ''et al.'' |title=Purine nucleoside phosphorylase. 3. Reversal of purine base specificity by site-directed mutagenesis. |journal=Biochemistry |volume=36 |issue= 39 |pages= 11749-56 |year= 1997 |pmid= 9305964 |doi= 10.1021/bi961971n }}
*{{cite journal | author=Sasaki Y, Iseki M, Yamaguchi S, ''et al.'' |title=Direct evidence of autosomal recessive inheritance of Arg24 to termination codon in purine nucleoside phosphorylase gene in a family with a severe combined immunodeficiency patient. |journal=Hum. Genet. |volume=103 |issue= 1 |pages= 81-5 |year= 1998 |pmid= 9737781 |doi= }}
*{{cite journal | author=Sheppard TL, Ordoukhanian P, Joyce GF |title=A DNA enzyme with N-glycosylase activity. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 14 |pages= 7802-7 |year= 2000 |pmid= 10884411 |doi= }}
*{{cite journal | author=Dalal I, Grunebaum E, Cohen A, Roifman CM |title=Two novel mutations in a purine nucleoside phosphorylase (PNP)-deficient patient. |journal=Clin. Genet. |volume=59 |issue= 6 |pages= 430-7 |year= 2001 |pmid= 11453975 |doi= }}
*{{cite journal | author=Ivings L, Pennington SR, Jenkins R, ''et al.'' |title=Identification of Ca2+-dependent binding partners for the neuronal calcium sensor protein neurocalcin delta: interaction with actin, clathrin and tubulin. |journal=Biochem. J. |volume=363 |issue= Pt 3 |pages= 599-608 |year= 2002 |pmid= 11964161 |doi= }}
*{{cite journal | author=Falkenberg M, Gaspari M, Rantanen A, ''et al.'' |title=Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA. |journal=Nat. Genet. |volume=31 |issue= 3 |pages= 289-94 |year= 2002 |pmid= 12068295 |doi= 10.1038/ng909 }}
*{{cite journal | author=Stoychev G, Kierdaszuk B, Shugar D |title=Xanthosine and xanthine. Substrate properties with purine nucleoside phosphorylases, and relevance to other enzyme systems. |journal=Eur. J. Biochem. |volume=269 |issue= 16 |pages= 4048-57 |year= 2002 |pmid= 12180982 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on NPM1... {December 20, 2007 12:59:45 PM PST}
- REDIRECT: Protein Redirected to: NPM1 {December 20, 2007 1:00:04 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {December 20, 2007 1:00:05 PM PST}
- SKIP SUMMARY: SKIPPING Summary, No Errors. {December 20, 2007 1:00:05 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {December 20, 2007 1:00:05 PM PST}
- UPDATED: Warning while updating page: Could not find summary box. {December 20, 2007 1:00:11 PM PST}
- UPDATED: Updated protein page (with warnings): NPM1 {December 20, 2007 1:00:11 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_NPM1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2p1b.
| PDB = {{PDB2|2p1b}}
| Name = Nucleophosmin (nucleolar phosphoprotein B23, numatrin)
| HGNCid = 7910
| Symbol = NPM1
| AltSymbols =; B23; MGC104254; NPM
| OMIM = 164040
| ECnumber =
| Homologene = 87629
| MGIid = 3647121
| GeneAtlas_image1 = PBB_GE_NPM1_221691_x_at_tn.png
| Function = {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0030957 |text = Tat protein binding}} {{GNF_GO|id=GO:0042803 |text = protein homodimerization activity}} {{GNF_GO|id=GO:0046982 |text = protein heterodimerization activity}} {{GNF_GO|id=GO:0051059 |text = NF-kappaB binding}} {{GNF_GO|id=GO:0051082 |text = unfolded protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005730 |text = nucleolus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005813 |text = centrosome}}
| Process = {{GNF_GO|id=GO:0006886 |text = intracellular protein transport}} {{GNF_GO|id=GO:0006913 |text = nucleocytoplasmic transport}} {{GNF_GO|id=GO:0006916 |text = anti-apoptosis}} {{GNF_GO|id=GO:0006950 |text = response to stress}} {{GNF_GO|id=GO:0007098 |text = centrosome cycle}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007569 |text = cell aging}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0042255 |text = ribosome assembly}} {{GNF_GO|id=GO:0051092 |text = activation of NF-kappaB transcription factor}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4869
| Hs_Ensembl = ENSG00000181163
| Hs_RefseqProtein = NP_001032827
| Hs_RefseqmRNA = NM_001037738
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 170746725
| Hs_GenLoc_end = 170770492
| Hs_Uniprot = P06748
| Mm_EntrezGene = 434373
| Mm_Ensembl =
| Mm_RefseqmRNA = XM_486188
| Mm_RefseqProtein = XP_486188
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Nucleophosmin (nucleolar phosphoprotein B23, numatrin)''', also known as '''NPM1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4869| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Li L, Li HS, Pauza CD, ''et al.'' |title=Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions. |journal=Cell Res. |volume=15 |issue= 11-12 |pages= 923-34 |year= 2006 |pmid= 16354571 |doi= 10.1038/sj.cr.7290370 }}
*{{cite journal | author=Gjerset RA |title=DNA damage, p14ARF, nucleophosmin (NPM/B23), and cancer. |journal=J. Mol. Histol. |volume=37 |issue= 5-7 |pages= 239-51 |year= 2007 |pmid= 16855788 |doi= 10.1007/s10735-006-9040-y }}
*{{cite journal | author=Chen W, Rassidakis GZ, Medeiros LJ |title=Nucleophosmin gene mutations in acute myeloid leukemia. |journal=Arch. Pathol. Lab. Med. |volume=130 |issue= 11 |pages= 1687-92 |year= 2006 |pmid= 17076533 |doi= }}
*{{cite journal | author=Falini B, Nicoletti I, Bolli N, ''et al.'' |title=Translocations and mutations involving the nucleophosmin (NPM1) gene in lymphomas and leukemias. |journal=Haematologica |volume=92 |issue= 4 |pages= 519-32 |year= 2007 |pmid= 17488663 |doi= }}
*{{cite journal | author=Fankhauser C, Izaurralde E, Adachi Y, ''et al.'' |title=Specific complex of human immunodeficiency virus type 1 rev and nucleolar B23 proteins: dissociation by the Rev response element. |journal=Mol. Cell. Biol. |volume=11 |issue= 5 |pages= 2567-75 |year= 1991 |pmid= 2017166 |doi= }}
*{{cite journal | author=Venkatesh LK, Mohammed S, Chinnadurai G |title=Functional domains of the HIV-1 rev gene required for trans-regulation and subcellular localization. |journal=Virology |volume=176 |issue= 1 |pages= 39-47 |year= 1990 |pmid= 2109912 |doi= }}
*{{cite journal | author=Cochrane AW, Perkins A, Rosen CA |title=Identification of sequences important in the nucleolar localization of human immunodeficiency virus Rev: relevance of nucleolar localization to function. |journal=J. Virol. |volume=64 |issue= 2 |pages= 881-5 |year= 1990 |pmid= 2404140 |doi= }}
*{{cite journal | author=Chan PK, Chan WY, Yung BY, ''et al.'' |title=Amino acid sequence of a specific antigenic peptide of protein B23. |journal=J. Biol. Chem. |volume=261 |issue= 30 |pages= 14335-41 |year= 1986 |pmid= 2429957 |doi= }}
*{{cite journal | author=Zhang XX, Thomis DC, Samuel CE |title=Isolation and characterization of a molecular cDNA clone of a human mRNA from interferon-treated cells encoding nucleolar protein B23, numatrin. |journal=Biochem. Biophys. Res. Commun. |volume=164 |issue= 1 |pages= 176-84 |year= 1989 |pmid= 2478125 |doi= }}
*{{cite journal | author=Hale TK, Mansfield BC |title=Nucleotide sequence of a cDNA clone representing a third allele of human protein B23. |journal=Nucleic Acids Res. |volume=17 |issue= 23 |pages= 10112 |year= 1990 |pmid= 2602120 |doi= }}
*{{cite journal | author=Chan WY, Liu QR, Borjigin J, ''et al.'' |title=Characterization of the cDNA encoding human nucleophosmin and studies of its role in normal and abnormal growth. |journal=Biochemistry |volume=28 |issue= 3 |pages= 1033-9 |year= 1989 |pmid= 2713355 |doi= }}
*{{cite journal | author=Li XZ, McNeilage LJ, Whittingham S |title=The nucleotide sequence of a human cDNA encoding the highly conserved nucleolar phosphoprotein B23. |journal=Biochem. Biophys. Res. Commun. |volume=163 |issue= 1 |pages= 72-8 |year= 1989 |pmid= 2775293 |doi= }}
*{{cite journal | author=Chan PK, Aldrich M, Cook RG, Busch H |title=Amino acid sequence of protein B23 phosphorylation site. |journal=J. Biol. Chem. |volume=261 |issue= 4 |pages= 1868-72 |year= 1986 |pmid= 3944116 |doi= }}
*{{cite journal | author=Bocker T, Bittinger A, Wieland W, ''et al.'' |title=In vitro and ex vivo expression of nucleolar proteins B23 and p120 in benign and malignant epithelial lesions of the prostate. |journal=Mod. Pathol. |volume=8 |issue= 3 |pages= 226-31 |year= 1995 |pmid= 7542384 |doi= }}
*{{cite journal | author=Dundr M, Leno GH, Hammarskjöld ML, ''et al.'' |title=The roles of nucleolar structure and function in the subcellular location of the HIV-1 Rev protein. |journal=J. Cell. Sci. |volume=108 ( Pt 8) |issue= |pages= 2811-23 |year= 1995 |pmid= 7593322 |doi= }}
*{{cite journal | author=Miyazaki Y, Takamatsu T, Nosaka T, ''et al.'' |title=The cytotoxicity of human immunodeficiency virus type 1 Rev: implications for its interaction with the nucleolar protein B23. |journal=Exp. Cell Res. |volume=219 |issue= 1 |pages= 93-101 |year= 1995 |pmid= 7628555 |doi= 10.1006/excr.1995.1209 }}
*{{cite journal | author=Szebeni A, Herrera JE, Olson MO |title=Interaction of nucleolar protein B23 with peptides related to nuclear localization signals. |journal=Biochemistry |volume=34 |issue= 25 |pages= 8037-42 |year= 1995 |pmid= 7794916 |doi= }}
*{{cite journal | author=Kato S, Sekine S, Oh SW, ''et al.'' |title=Construction of a human full-length cDNA bank. |journal=Gene |volume=150 |issue= 2 |pages= 243-50 |year= 1995 |pmid= 7821789 |doi= }}
*{{cite journal | author=Marasco WA, Szilvay AM, Kalland KH, ''et al.'' |title=Spatial association of HIV-1 tat protein and the nucleolar transport protein B23 in stably transfected Jurkat T-cells. |journal=Arch. Virol. |volume=139 |issue= 1-2 |pages= 133-54 |year= 1995 |pmid= 7826206 |doi= }}
*{{cite journal | author=Valdez BC, Perlaky L, Henning D, ''et al.'' |title=Identification of the nuclear and nucleolar localization signals of the protein p120. Interaction with translocation protein B23. |journal=J. Biol. Chem. |volume=269 |issue= 38 |pages= 23776-83 |year= 1994 |pmid= 8089149 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on NPPB... {December 20, 2007 1:00:11 PM PST}
- REDIRECT: Protein Redirected to: Brain natriuretic peptide {December 20, 2007 1:00:28 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {December 20, 2007 1:00:31 PM PST}
- SKIP SUMMARY: SKIPPING Summary, No Errors. {December 20, 2007 1:00:31 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {December 20, 2007 1:00:31 PM PST}
- UPDATED: Updated protein page: Brain natriuretic peptide {December 20, 2007 1:00:37 PM PST}
- INFO: Beginning work on NTHL1... {December 20, 2007 1:00:37 PM PST}
- REDIRECT: Protein Redirected to: NTHL1 {December 20, 2007 1:00:54 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {December 20, 2007 1:00:57 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {December 20, 2007 1:00:57 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {December 20, 2007 1:00:57 PM PST}
- UPDATED: Updated protein page: NTHL1 {December 20, 2007 1:01:04 PM PST}
- INFO: Beginning work on ORC1L... {December 20, 2007 1:01:04 PM PST}
- REDIRECT: Protein Redirected to: ORC1L {December 20, 2007 1:01:20 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {December 20, 2007 1:01:23 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {December 20, 2007 1:01:23 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {December 20, 2007 1:01:23 PM PST}
- UPDATED: Updated protein page: ORC1L {December 20, 2007 1:01:30 PM PST}
- INFO: Beginning work on ORC2L... {December 20, 2007 1:01:30 PM PST}
- REDIRECT: Protein Redirected to: ORC2L {December 20, 2007 1:01:51 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {December 20, 2007 1:01:53 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {December 20, 2007 1:01:53 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {December 20, 2007 1:01:53 PM PST}
- UPDATED: Updated protein page: ORC2L {December 20, 2007 1:01:59 PM PST}
- INFO: Beginning work on WDR8... {December 20, 2007 1:01:59 PM PST}
- REDIRECT: Protein Redirected to: WDR8 {December 20, 2007 1:02:45 PM PST}
- CREATED: Created new protein page: WDR8 {December 20, 2007 1:02:53 PM PST}
end log.
