- INFO: Beginning work on EXOSC3... {December 20, 2007 1:07:11 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein EXOSC3 image.jpg {December 20, 2007 1:07:56 PM PST}
- REDIRECT: Protein Redirected to: EXOSC3 {December 20, 2007 1:08:03 PM PST}
- CREATED: Created new protein page: EXOSC3 {December 20, 2007 1:08:12 PM PST}
- INFO: Beginning work on GMNN... {December 20, 2007 1:09:02 PM PST}
- REDIRECT: Page directory gave bad page (Geminin). Continuing with search.. Please correct entry: <51053,Geminin>. {December 20, 2007 1:09:20 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {December 20, 2007 1:09:31 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_GMNN_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1t6f.
| PDB = {{PDB2|1t6f}}, {{PDB2|1uii}}
| Name = Geminin, DNA replication inhibitor
| HGNCid = 17493
| Symbol = GMNN
| AltSymbols =; Gem; RP3-369A17.3
| OMIM = 602842
| ECnumber =
| Homologene = 9292
| MGIid = 1927344
| GeneAtlas_image1 = PBB_GE_GMNN_218350_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0008156 |text = negative regulation of DNA replication}} {{GNF_GO|id=GO:0009887 |text = organ morphogenesis}} {{GNF_GO|id=GO:0045786 |text = negative regulation of progression through cell cycle}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 51053
| Hs_Ensembl = ENSG00000112312
| Hs_RefseqProtein = NP_056979
| Hs_RefseqmRNA = NM_015895
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 24883138
| Hs_GenLoc_end = 24894306
| Hs_Uniprot = O75496
| Mm_EntrezGene = 57441
| Mm_Ensembl = ENSMUSG00000006715
| Mm_RefseqmRNA = NM_020567
| Mm_RefseqProtein = NP_065592
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 13
| Mm_GenLoc_start = 24759311
| Mm_GenLoc_end = 24769328
| Mm_Uniprot = Q5SZV9
}}
}}
'''Geminin, DNA replication inhibitor''', also known as '''GMNN''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GMNN geminin, DNA replication inhibitor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51053| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal | author=McGarry TJ, Kirschner MW |title=Geminin, an inhibitor of DNA replication, is degraded during mitosis. |journal=Cell |volume=93 |issue= 6 |pages= 1043-53 |year= 1998 |pmid= 9635433 |doi= }}
*{{cite journal | author=Kroll KL, Salic AN, Evans LM, Kirschner MW |title=Geminin, a neuralizing molecule that demarcates the future neural plate at the onset of gastrulation. |journal=Development |volume=125 |issue= 16 |pages= 3247-58 |year= 1998 |pmid= 9671596 |doi= }}
*{{cite journal | author=Wohlschlegel JA, Dwyer BT, Dhar SK, ''et al.'' |title=Inhibition of eukaryotic DNA replication by geminin binding to Cdt1. |journal=Science |volume=290 |issue= 5500 |pages= 2309-12 |year= 2001 |pmid= 11125146 |doi= 10.1126/science.290.5500.2309 }}
*{{cite journal | author=Bermejo R, Vilaboa N, Calés C |title=Regulation of CDC6, geminin, and CDT1 in human cells that undergo polyploidization. |journal=Mol. Biol. Cell |volume=13 |issue= 11 |pages= 3989-4000 |year= 2003 |pmid= 12429841 |doi= 10.1091/mbc.E02-04-0217 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Biswas N, Sanchez V, Spector DH |title=Human cytomegalovirus infection leads to accumulation of geminin and inhibition of the licensing of cellular DNA replication. |journal=J. Virol. |volume=77 |issue= 4 |pages= 2369-76 |year= 2003 |pmid= 12551974 |doi= }}
*{{cite journal | author=Kulartz M, Kreitz S, Hiller E, ''et al.'' |title=Expression and phosphorylation of the replication regulator protein geminin. |journal=Biochem. Biophys. Res. Commun. |volume=305 |issue= 2 |pages= 412-20 |year= 2003 |pmid= 12745091 |doi= }}
*{{cite journal | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Del Bene F, Tessmar-Raible K, Wittbrodt J |title=Direct interaction of geminin and Six3 in eye development. |journal=Nature |volume=427 |issue= 6976 |pages= 745-9 |year= 2004 |pmid= 14973488 |doi= 10.1038/nature02292 }}
*{{cite journal | author=Luo L, Yang X, Takihara Y, ''et al.'' |title=The cell-cycle regulator geminin inhibits Hox function through direct and polycomb-mediated interactions. |journal=Nature |volume=427 |issue= 6976 |pages= 749-53 |year= 2004 |pmid= 14973489 |doi= 10.1038/nature02305 }}
*{{cite journal | author=Sugimoto N, Tatsumi Y, Tsurumi T, ''et al.'' |title=Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding. |journal=J. Biol. Chem. |volume=279 |issue= 19 |pages= 19691-7 |year= 2004 |pmid= 14993212 |doi= 10.1074/jbc.M313175200 }}
*{{cite journal | author=Melixetian M, Ballabeni A, Masiero L, ''et al.'' |title=Loss of Geminin induces rereplication in the presence of functional p53. |journal=J. Cell Biol. |volume=165 |issue= 4 |pages= 473-82 |year= 2004 |pmid= 15159417 |doi= 10.1083/jcb.200403106 }}
*{{cite journal | author=Ramachandran N, Hainsworth E, Bhullar B, ''et al.'' |title=Self-assembling protein microarrays. |journal=Science |volume=305 |issue= 5680 |pages= 86-90 |year= 2004 |pmid= 15232106 |doi= 10.1126/science.1097639 }}
*{{cite journal | author=Ballabeni A, Melixetian M, Zamponi R, ''et al.'' |title=Human geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosis. |journal=EMBO J. |volume=23 |issue= 15 |pages= 3122-32 |year= 2005 |pmid= 15257290 |doi= 10.1038/sj.emboj.7600314 }}
*{{cite journal | author=Saxena S, Yuan P, Dhar SK, ''et al.'' |title=A dimerized coiled-coil domain and an adjoining part of geminin interact with two sites on Cdt1 for replication inhibition. |journal=Mol. Cell |volume=15 |issue= 2 |pages= 245-58 |year= 2004 |pmid= 15260975 |doi= 10.1016/j.molcel.2004.06.045 }}
*{{cite journal | author=Zhu W, Chen Y, Dutta A |title=Rereplication by depletion of geminin is seen regardless of p53 status and activates a G2/M checkpoint. |journal=Mol. Cell. Biol. |volume=24 |issue= 16 |pages= 7140-50 |year= 2004 |pmid= 15282313 |doi= 10.1128/MCB.24.16.7140-7150.2004 }}
*{{cite journal | author=Kulartz M, Knippers R |title=The replicative regulator protein geminin on chromatin in the HeLa cell cycle. |journal=J. Biol. Chem. |volume=279 |issue= 40 |pages= 41686-94 |year= 2004 |pmid= 15284237 |doi= 10.1074/jbc.M405798200 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on HSPA14... {December 20, 2007 1:10:25 PM PST}
- REDIRECT: Protein Redirected to: HSPA14 {December 20, 2007 1:11:08 PM PST}
- CREATED: Created new protein page: HSPA14 {December 20, 2007 1:11:17 PM PST}
- INFO: Beginning work on OTX2... {December 20, 2007 1:03:50 PM PST}
- REDIRECT: Protein Redirected to: OTX2 {December 20, 2007 1:04:11 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {December 20, 2007 1:04:12 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {December 20, 2007 1:04:12 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {December 20, 2007 1:04:12 PM PST}
- UPDATED: Updated protein page: OTX2 {December 20, 2007 1:04:18 PM PST}
- INFO: Beginning work on PA2G4... {December 20, 2007 1:04:18 PM PST}
- REDIRECT: Protein Redirected to: PA2G4 {December 20, 2007 1:04:39 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {December 20, 2007 1:04:42 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {December 20, 2007 1:04:42 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {December 20, 2007 1:04:42 PM PST}
- UPDATED: Updated protein page: PA2G4 {December 20, 2007 1:04:48 PM PST}
- INFO: Beginning work on PAK1... {December 20, 2007 1:04:48 PM PST}
- REDIRECT: Protein Redirected to: PAK1 {December 20, 2007 1:05:39 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {December 20, 2007 1:05:40 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {December 20, 2007 1:05:40 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {December 20, 2007 1:05:40 PM PST}
- UPDATED: Updated protein page: PAK1 {December 20, 2007 1:05:47 PM PST}
- INFO: Beginning work on PAK3... {December 20, 2007 1:05:47 PM PST}
- REDIRECT: Protein Redirected to: PAK3 {December 20, 2007 1:06:07 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {December 20, 2007 1:06:08 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {December 20, 2007 1:06:08 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {December 20, 2007 1:06:08 PM PST}
- UPDATED: Updated protein page: PAK3 {December 20, 2007 1:06:15 PM PST}
- INFO: Beginning work on PBX1... {December 20, 2007 1:06:15 PM PST}
- REDIRECT: Protein Redirected to: PBX1 {December 20, 2007 1:06:31 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {December 20, 2007 1:06:33 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {December 20, 2007 1:06:33 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {December 20, 2007 1:06:33 PM PST}
- UPDATED: Updated protein page: PBX1 {December 20, 2007 1:06:40 PM PST}
- INFO: Beginning work on PCNA... {December 20, 2007 1:06:40 PM PST}
- REDIRECT: Protein Redirected to: PCNA {December 20, 2007 1:07:01 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {December 20, 2007 1:07:03 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {December 20, 2007 1:07:03 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {December 20, 2007 1:07:03 PM PST}
- UPDATED: Updated protein page: PCNA {December 20, 2007 1:07:11 PM PST}
- INFO: Beginning work on POLR1D... {December 20, 2007 1:09:31 PM PST}
- REDIRECT: Protein Redirected to: POLR1D {December 20, 2007 1:10:16 PM PST}
- CREATED: Created new protein page: POLR1D {December 20, 2007 1:10:25 PM PST}
- INFO: Beginning work on POP5... {December 20, 2007 1:11:17 PM PST}
- REDIRECT: Protein Redirected to: POP5 {December 20, 2007 1:11:50 PM PST}
- CREATED: Created new protein page: POP5 {December 20, 2007 1:11:59 PM PST}
- INFO: Beginning work on ZNF593... {December 20, 2007 1:08:12 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein ZNF593 image.jpg {December 20, 2007 1:08:46 PM PST}
- REDIRECT: Protein Redirected to: ZNF593 {December 20, 2007 1:08:54 PM PST}
- CREATED: Created new protein page: ZNF593 {December 20, 2007 1:09:02 PM PST}
end log.
