Mnemcek

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Hello, Mnemcek, and welcome to Wikipedia! Thank you for your contributions. I hope you like the place and decide to stay. Here are a few links to pages you might find helpful:

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Please remember to sign your messages on talk pages by typing four tildes (~~~~); this will automatically insert your username and the date. If you need help, check out Wikipedia:Questions, ask me on my talk page, or ask your question on this page and then place {{Help me}} before the question. Again, welcome! Acalamari 16:06, 16 February 2014 (UTC)

Introductions

Hi, Mitch!

It looks like we are partners on our semester project for Molecular Biology. I look forward to working with you! How did you like living in the Midwest? Is Utah a lot of different than where you grew up? I'm originally from middle TN, but I recently just moved from CA to NC. What's the most interesting thing you have done working for the genomic testing company?

Oops, I forgot to add my signature! Kneal0627 (talk) 20:03, 17 February 2014 (UTC)

I really liked growing up in the midwest, but since I've moved out west I have really fallen in love with all the outdoor recreation and beauty. Utah is definitely very different from anywhere I've lived. The views are absolutely stunning, I never get used to seeing the mountains. Southern Utah's landscape is like another planet. Actually, I believe NASA has some land in Utah that they use to simulate astronauts living on Mars! It sounds like you have moved around quite a bit. I'm in the same boat (5 states so far, probably more to come!). I started working at my job last fall, and I have been working on all sorts of projects. All of it has been interesting to me. I am on the business development side right now and a lot of it is new to me, but I'm really enjoying learning the ins and outs of this industry. It has definitely been eye-opening. Mnemcek (talk) 21:07, 17 February 2014 (UTC)

That's great! My husband and I also thoroughly enjoy the outdoors. Since we live on the coast, there isn't very much to do during cold weather. We're definitely looking forward to warmer weather, which I hope arrives soon! I do believe they have something of the sorts. My father works as a contractor for NASA, and I've heard him mention Utah a few times. I honestly don't remember the name of it though. That's great that you enjoy your job! Kneal0627 (talk) 02:22, 18 February 2014 (UTC)

Preliminary Outline

Good afternoon, Mitch!

Hope you are doing well. I apologize for being MIA. I've been very ill over the last few days. It looks like this week's assignment is to do a preliminary outline and a list of references on one of the user's sandboxes. I can only see your Introduction and nothing else on your user page. Have you started on the outline? If so, I can add from there.

Also, for the list of references, it was suggested that if we find the reference to describe what we find useful about the page (i.e. pages, etc.). I think this is a great idea! What do you think?

The other part of our assignment is to make suggestions to the article talk page. I looked over your article summary from a couple of weeks ago and agree that the article would greatly benefit from figures, citations, and more references. Kneal0627 (talk) 17:56, 10 March 2014 (UTC)

This is the preliminary outline and references (with notes) I have right now. Please let me know what you think.

I. Gene Cluster defined

a. Creation of gene clusters

i. Gene Duplication

ii. Tandem arrays vs. Gene Clusters

b. Examples

II. Bioinformatics

a. Cluster trees

b. Maps

III. Research

References

1. Sherwood EJ, Hesketh AR, Bibb MJ. Cloning and analysis of the planosporicin lantibiotic biosynthetic gene cluster of Planomonospora alba. J Bacteriol. 2013;195(10):2309-21. http://www.ncbi.nlm.nih.gov/pubmed/23475977
2. Higgs DR, Vickers MA, Wilkie AO, Pretorius IM, Jarman AP, Weatherall DJ. A review of the molecular genetics of the human alpha-globin gene cluster. Blood. 1989;73(5):1081-104. http://www.ncbi.nlm.nih.gov/pubmed/2649166
3. Hardison R, Miller W. Use of long sequence alignments to study the evolution and regulation of mammalian globin gene clusters. Mol Biol Evol. 1993;10(1):73-102. http://www.ncbi.nlm.nih.gov/pubmed/8383794
4. Graham, G. (1995). Tandem genes and clustered genes. Journal of Theoretical Biology, 175(1), 71-87. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/7564393 (This is a great article about the difference between tandem arrays and gene clusters and how they can turn into each.)
5. Caron, H. et al. (2001). The human transcriptome: clustering of highly expressed genes in chromosomal domains. Science, 291, Retrieved from http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.169.4274&rep=rep1&type=pdf (This article contains great figures and elaborates on human gene clusters.)
6. I’m not sure we can actually use this as a reference since it is technically a lecture; however, it does present some great figures and information. Perhaps we can look for something similar. http://www.discoveryandinnovation.com/BIOL202/notes/lecture26.html
7. Garcia-Fernàndez, J. (2005). Genesis and evolution of homeobox gene clusters. Nature Reviews Genetics, 6, 881-892. doi: 10.1038/nrg1723. http://www.nature.com/nrg/journal/v6/n12/box/nrg1723_BX2.html (Excellent specific example)
8. Haselkorn, R. (1998). The use of gene clusters to infer functional coupling. Proceedings of the National Academy of Sciences, 96(6), 2896-2901. doi: 10.1073/pnas.96.6.2896 http://www.pnas.org/content/96/6/2896.short (Research)
9. Blanco, E., Pignatelli, M., Beltran, S., Punset, A., Pérez-Lluch, S., Serras, F., Guigó, R., & Corominas, M. (2008). Conserved chromosomal clustering of genes governed by chromatin regulators in drosophila. Genome Biology, 9(R134), doi: 10.1186/gb-2008-9-9-r134 http://genomebiology.com/2008/9/9/R134 (Research)
10. http://david.abcc.ncifcrf.gov/gene2gene.jsp (Bioinformatics)
11. http://segmine.ijs.si/use_cases/ (Bioinformatics)

Forgot to sign my post Kneal0627 (talk) 18:58, 10 March 2014 (UTC)

Hi Katelyn, no worries, I hope you're feeling better. I have been very busy as well and I just had a chance to start working on this today. We need to migrate this discussion to our "Team" talk page, so I will copy and paste your post above to that page. See Wikipedia talk:USEP/Courses/JHU MolBio Ogg SP14/Group 81F. We can continue our conversation there!

A barnstar for you!

	The Original Barnstar
	Thank you for your work as part of the Molecular Biology course project. I hope you enjoyed editing Wikipedia, and hope you continue to edit it whenever you find problems, or find something that you would like to add. Don't hesitate to contact me or any of the other OAs with any questions, any time you want. I wish you well in your future studies! Klortho (talk) 01:46, 12 May 2014 (UTC)