WDR6

WD repeat-containing protein 6 is a protein that in humans is encoded by the WDR6 gene.

WDR6
Identifiers
Aliases	WDR6, WD repeat domain 6, Trm734
External IDs	OMIM: 606031; MGI: 1930140; HomoloGene: 117682; GeneCards: WDR6; OMA:WDR6 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3p21.31 Start 49,007,062 bp End 49,015,953 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 F2 Start 108,449,510 bp End 108,455,938 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube Pituitary Gland anterior pituitary right lobe of thyroid gland left lobe of thyroid gland left ovary right ovary tendon of biceps brachii canal of the cervix body of uterus Top expressed in arcuate nucleus ventromedial nucleus median eminence paraventricular nucleus of hypothalamus dorsomedial hypothalamic nucleus mammillary body lateral hypothalamus anterior amygdaloid area lateral septal nucleus ventral tegmental area More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding RNA binding Cellular component cytoplasm COP9 signalosome cytosol plasma membrane Biological process cell cycle negative regulation of autophagy negative regulation of cell population proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11180 83669 Ensembl ENSG00000178252 ENSMUSG00000066357 UniProt Q9NNW5 Q99ME2 RefSeq (mRNA) NM_018031 NM_001320546 NM_001320547 NM_031392 RefSeq (protein) NP_001307475 NP_001307476 NP_060501 NP_113569 Location (UCSC) Chr 3: 49.01 – 49.02 Mb Chr 9: 108.45 – 108.46 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is ubiquitously expressed in adult and fetal tissues.

Further reading

• Li D, Roberts R (2002). "WD-repeat proteins: structure characteristics, biological function, and their involvement in human diseases". Cell. Mol. Life Sci. 58 (14): 2085–97. doi:10.1007/PL00000838. PMC 11337334. PMID 11814058. S2CID 20646422.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Li D, Burch P, Gonzalez O, et al. (2000). "Molecular cloning, expression analysis, and chromosome mapping of WDR6, a novel human WD-repeat gene". Biochem. Biophys. Res. Commun. 274 (1): 117–23. doi:10.1006/bbrc.2000.3012. PMID 10903905.
• Sano H, Liu SC, Lane WS, et al. (2002). "Insulin receptor substrate 4 associates with the protein IRAS". J. Biol. Chem. 277 (22): 19439–47. doi:10.1074/jbc.M111838200. PMID 11912194.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Xie X, Wang Z, Chen Y (2007). "Association of LKB1 with a WD-repeat protein WDR6 is implicated in cell growth arrest and p27(Kip1) induction". Mol. Cell. Biochem. 301 (1–2): 115–22. doi:10.1007/s11010-006-9402-5. PMID 17216128. S2CID 25503392.