There are some listed at [1] that are just cities; these have not been listed below.
- A-B-C Trail
- Abe Lincoln Trail
- Abo Pass Highway
- Adeway
- Agate Highway
- Air Line Highway
- Albany-Buffalo Highway
- Alamo-Victoria-San Jacinto Highway
- Albert Pike Highway (Albert Pike Highway Association)
- Hot Springs, AR to Colorado Springs, CO
- Alfalfa Trail
- Alton-Jacksonville Airline
- Altoona-Bellefonte-Cumberland Trail
- Anchor Line
- Anchor Way
- Anthracite Trail
- Apache Trail
- Appalachian Scenic Highway (Appalachian Scenic Highway Association)
- Quebec, QC - Montreal, QC - Saratoga Springs, NY - Schenectady - Binghamton, NY - Scranton, PA - Harrisburg, PA - Hagerstown, MD - Winchester, VA - Staunton - Lexington - Natural Bridge - Roanoke, VA - Bristol, TN - Johnson City, TN - Asheville, NC - Bryson City, NC - Gainesville, GA - Stone Mountain - Atlanta, GA - (Birmingham, AL - Tuscaloosa, AL - New Orleans, LA) + (Macon, GA - Cordele - Valdosta, GA - Tampa, FL) (1925)
- Aroostook Trail
- Arkansas, Rio Grande, Gunnison & Grande River Highway
- Arrowhead Trail
- Ashokan Reservoir Route
- Atlantic Highway
- Atlantic & Gulf Highway
- Atlantic-Pacific Highway
- Atlantic Yellowstone Pacific Hiway
- Auburn-Niles Route
- Ayr Line
- "B" Line Highway
- B.F. Blue Pole Trail
- Baltimore Pike
- Banff Grand Canyon Road
- Bankhead Highway, Washington, DC to San Diego, CA
- Battlefield Route
- Beartooth Trail
- Bedford-Danbury Route
- Bee Line
- Bee Line Highway
- Belleville-Carlyle Trail
- Belt Line
- Ben Hur Highway, St. Louis, MO to Fort Dodge, IA
- Ben Hur Route
- Berkshire-Burlington Way
- Better Way
- Big Creek-Cohocton Valley Route
- Big Four Route
- Billings Cody Way
- Birmingham-Montgomery Highway
- Black Trail
- Black and Yellow Trail, Chicago, IL to Yellowstone Park
- Black Hills Trail
- Black Hills-Lake Metigoshe Highway
- Black Hills Loop Highway
- Black Hills Loop, River & Omaha Trail
- Black Hills, Rose Bud & Omaha Scenic Highway
- Black Hills Sioux Trail
- Black Hills-Yellowstone Park Highway
- Black River Valley Route
- Blackhawk Highway, Beloit, WI to Dixon, IL
- Bloomington Way
- Blue Grass Road
- Blue Grass Way
- Blue J Route
- Blue Line
- Blue Pole Highway
- Blue Valley Drive
- Bob Dunn Highway
- Boone Way
- Borderland Route
- Boston Haverhill Road
- Boston Post Road
- Boston Sakonnet Point Road
- Boston-Wareham Road
- Brewster-Danbury Route
- Brewster-Middletown Route
- Bridge Route (Bear Mountain Bridge)
- Broadway of America
- Broadway-Salem Way Glastonbury East Hartford Route
- Buffalo Highway
- Buffalo Pittsburgh Highway
- Burlington & Peoria Air Line
- Burlington Highway
- California Banff Bee Line
- Camp Dix Way
- Canada, Kansas City and Gulf Road
- Cannon Ball Route
- Cannon Ball Trail
- Canton-Alliance-Pittsburgh Trail
- Cape May Way
- Capital Highway, Washington, DC to Atlanta, GA
- Capital Route, Omaha, NE to Austin, TX
- Capital Trail
- Caterpillar Trail
- Central Highway
- Central Route
- Central Colorado Highway
- Central Dixie Highway
- Central Florida Highway
- Central Michigan Pike
- Central Montana Highway
- Central Nebraska Highway
- Central Texas Highway
- Charlotte-Wilmington Highway
- Chenango Valley Route
- Cheshire Road
- Chicago Trail
- Chicago, Black Hills and Yellowstone National Park Highway
- Chicago Buffalo Highway
- Chicago Dubuque Trail
- Chicago Iowa Trail
- Chicago, Kansas City and Gulf Highway, Chicago, IL to Galveston, TX
- Cincinnati Lookout Mountain Air Line
- Cincinnati-Parkersburg Way
- Clarion Way
- Cleveland-Canton-Parkersburg Way
- Coal Oil Highway
- Coast Route
- Coast to Coast Highway
- Coast to Coast Route
- Colchester Yantic, Norwich-Pawcatuck Routes
- Colorado to Gulf Highway, Denver, CO to Galveston, TX and Brownsville, TX
- Columbia River Highway
- Connecticut River Way
- Contoocook Valley Road
- Cooley Highway
- Corn Belt Highway (also listed as Corn Belt Road)
- Corn Belt Route
- Cornhusker Highway, Sioux City, IA to Oklahoma City, OK
- Cotton Belt Highway
- Council Bluffs, Sioux City & Spirit Lake Highway
- Cranberry Trail
- Cross State Trail
- Custer Trail
- Custer Battlefield Highway, Omaha, NE to Glacier National Park, MT
- Custer Battlefield Way
- Dahlonega Trail
- Dallas-Canadian-Denver Highway, Galveston, TX to Boulder, CO
- Danbury-Bridgeport Route
- Daniel Boone Trail
- Daniel Webster Highway
- Dansville Corning Route
- Dartmouth College Route
- Davis Highway
- Decatur-Birmingham Highway
- Denver-Black Hills Highway
- Denver Estevan Highway
- Denver-Joplin Highway
- Denver-Chicago Highway
- Des Moines-Fort Dodge & Spirit Lake Highway
- Detroit-Lincoln-Denver Highway, Detroit, MI to Denver, CO
- Diagonal Trail
- Diamond Trail
- Dixie Route A
- Dixie Bee Line, Chicago, IL to Nashville, TN
- Dixie Highway, Chicago, IL and Sault Ste. Marie, MI to Miami, FL
- Dixie Overland Highway, Savannah, GA to San Diego, CA
- Duluth-Fargo Highway
- Dunes Highway
- G. P. C. Highway
- Galatin Trail
- Galesburg-Peoria Trail
- Gap Way
- General Sullivan Trail
- Genesee Valley Route
- Geneva-Clifton Springs Route
- Geneva-Lyons Route
- George Washington Highway
- George Washington National Highway, Seattle, WA to Savannah, GA
- Gettysburg-Baltimore-Annapolis Trail
- Geysers-to-Glaciers Highway, Yellowstone Park to Glacier Park
- Geysers to Glaciers Road
- Geysers to Glaciers Trail
- Glacier Trail, Seattle, WA to Miami, FL
- Glacier to Gulf Highway
- Glacier to Gulf Motorway, Calgary to Tampico
- Glen Falls-Lake Champlain Route
- Glidden Route
- Golden Belt Highway
- Golden Belt Road
- Golden Rod Highway
- Golden Rod Trail
- Grainland Highway
- Grand Central Highway
- Grand Circle Tour
- Grand River Road
- Grant Highway, Chicago, IL to Portland, OR
- Great Plains Highway
- Great White Way
- Green Road
- Green Trail
- Green Mountain Pass
- Gulf to Panhandle Highway
- Jackson Highway, Chicago, IL and Niagara Falls, NY to New Orleans, LA
- Jefferson Highway, Winnipeg to New Orleans, LA
- Jefferson Davis Highway
- Jefferson Davis National Highway, Washington, DC or Miami, FL to San Francisco, CA or Los Angeles, CA (including the Borderland Trail, Border Military Highway, Gulf Coast Highway, and Old Spanish Trail)
- Jericho Turnpike
- Jersey Link
- Jersey Coast Way
- Jim Hogg Highway
- L. T. K. Trail
- Lackawanna Trail, Delaware, NJ to Binghamton, NY
- Lake Harris Route
- Lakes to Gulf Highway, Duluth, MN to Galveston, TX
- Lakes & River Drive
- Lakes to Sea Highway, Erie, PA to Atlantic City, NJ
- Lawrence-Salem Way
- Leather-Stocking Trail
- Lee Highway, Washington, DC or New York, NY to San Diego, CA or San Francisco, CA
- Lee-Jackson Highway
- Lewis and Clark Highway,[disambiguation needed] Lewiston, ID to Missoula, MT
- Liberty Way
- Lincoln Highway, New York, NY to San Francisco, CA
- Lincoln Trail
- Lincoln-Crete-Dorchester Trail
- Lincoln Hawkeye Pike
- Lincoln Memorial Road, Washington, DC to Gettysburg, PA
- Lincoln-Sterling Highway
- Lincoln-Valparaiso Highway
- Little Rock-Texarkana Highway
- Logan-Lee Highway, Rock Island, IL to Paducah, KY
- Lone Star Route, Chicago, IL to Brownsville, TX or Lake Charles, LA
- Lone Star Trail
- Longfellow Highway
- Louisville-Lexington-Latonia Trail
- Lynn-Salem Way
- Mackinaw Indian Trail
- Manchester Somers Route
- Magnolia Route
- Mandan Killdeer Mountain Highway
- Marion Kenton Trail
- McDavid Trail
- Memorial Boulevard
- Memphis-Bristol Highway
- Meridian Highway, Winnipeg to Laredo, TX or Mexico City
- Meridian Road, Pembina, ND to Galveston, TX
- Michigan Road
- Michigan-Detroit-Chicago Highway
- Mid-State Highway
- Middle Buster Highway
- Midland Trail, Washington, DC and Richmond, VA to Oakland, CA and Los Angeles, CA
- Midwest Trail
- Miller Trunk Line
- Mineral Wells Trail
- Minnesota Scenic Highway
- Minute Man Route
- Mississippi River Highway
- Mississippi River Scenic Highway, Winnipeg and Port Arthur, ON to New Orleans, LA and Tampa, FL or Fort Myers, FL and Port Arthur, TX
- Mississippi Scenic Route
- Mississippi Valley Highway (formerly Burlington Way), Duluth, MN or Ely, MN to New Orleans, LA or Gulfport, MS
- Moberly Quincy Air Line
- Mohawk Trail
- Mohawk-Lake Ontario Route
- Montauk Highway
- Montgomery-Lowndes-Dallas Highway
- Montour Falls Cayuta Route
- Mount Desert Trail
- Muncie Lima Fremont
- National Highway
- National Midland Trail, Eastern Division, East St. Louis, IL to Washington, DC
- National Old Trails Road, Washington, DC and Baltimore, MD to Los Angeles, CA
- National Park-to-Park Highway, "circuit of National Parks"
- National Parks Highway (Northwest Trail), Boston, MA and New York, NY to Seattle, WA
- National Parks Pike
- National Roosevelt Midland Trail, Washington, DC and Newport News, VA to Los Angeles, CA
- National Short Cut Highway
- National White Way
- Naugatuck-New Haven Route
- Naugatuck River Route
- Navajo Trail
- Nelson Trail
- New Hampshire College Road
- New Haven Derby Road
- New Haven Farmington Way
- New Haven Middletown Way
- New Haven Springfield Way
- New London Colchester Route
- New London Colchester Glastonbury Route
- New London Fitchburg Route
- New London-Norwich-Stafford Route
- New Santa Fe Trail
- New York and Berkshire Route
- New York-Albany-Montreal Route
- New York-Albany-Troy Post Road
- Newtown-Bridgeport Way
- Niagara River Route
- North and South Pike
- North Hampton Pittsfield Way
- North Hempstead Turnpike
- North Iowa Pike
- North Missouri Cross-State Highway
- North Platte Valley Highway
- North Shore Trail
- North & South Pike
- North Star Highway
- North Star Route
- North Star Trail
- North Texas Highway
- Northern Highway
- Northern Tier Route
- Northwestern Highway
- Nutmeg Trail
- O. A. A. Trail
- O. K. Short Line
- Oakdale Trail
- Ocean-to-Ocean Highway
- Oconomowoc-Milwaukee Road
- Ohio Indiana Michigan Way
- Oil Belt Route
- Oil City Route
- Okaw Trail
- Oklahoma City Lincoln Highway
- Oklahoma-Kansas-Colorado Highway
- Okoboji Trail
- Old Burlington Way
- Old Oregon Trail, Independence, MO to Seaside, OR and Olympia, WA
- Old Santa Fe Trail
- Old Spanish Trail, St. Augustine, FL to San Diego, CA
- Old Trails Road
- Omaha Trail
- Omaha-Lincoln-Denver Trail
- Omaha-Lincoln-Denver Trans-Continental Route
- Omaha-St. Louis Short Line
- Omaha-Topeka Trail
- Oregon Trail
- Osage Highway
- Oswego River Route
- Overland Trail
- Ozark Trails, Kansas City, Hannibal, St. Louis, and Memphis to Denver, Las Vegas, and El Paso
- Sacandaga-Lake Pleasant Route
- Sa-Ka-Ka-Wea Trail
- Salt Lake Yellowstone Highway
- San Antonio-Atascosa and Gulf Highway
- San Antonio-Blanco and Granite Highway
- San Antonio-Laredo Highway
- San Antonio-Port O'Connor Highway
- Santa Fe, Grand Canyon and Needles National Highway
- Santa Fe Trail, New York, NY to San Diego, CA
- Saranac-Lake Placid Route
- Schenectady-Lake George Route
- Schuylkill River Route
- Scioto Trail
- Sedalia Joplit Short Line
- Sedalia-Springfield Highway
- Sequoyah Trail
- Shabbona Trail
- Shenandoah Valley Pike
- Sherman Pike
- Sherman-Sheridan Highway
- Shore Road
- Short Cut West Highway
- Short Line Route
- Sioux City, Dennison Cut Off
- Sioux Falls-Salem-Huron Road
- Sioux Falls-Salem-Iroquois Highway
- Skaneateles Route
- Solomon Valley Highway
- South Atlantic Coastal Highway
- South Dakota Scenic Highway
- South Shore Trail
- South Side Road
- Southeastern Highway
- Southern Highway
- Southern Minnesota Air Line
- Southern National Highway, Washington, DC to San Diego, CA
- Southern Ocean to Ocean Highway
- Southern Tier Route
- Southern Tier Trail
- South West Trail, Chicago, IL to El Paso, TX
- Spanish Trail
- St. Augustine Road
- St. Joe-Des Moines Ayr Line
- St. Joe-Des Moines Interstate Trail
- St. Lawrence River Route
- Star Highway
- Starved Rock Trail
- Suncook Valley Road
- Sunflower Trail
- Sunset Trail
- Sunshine Highway
- Susquehanna Trail, Buffalo, NY to Washington, DC
- Susquehanna Valley Route
- Swastika Trail
- Talladega-Montgomery Highway
- Tamiami Trail
- Tecumseh Trail
- Terre Haute-Columbus-Cincinnati Trail
- Terre Haute-Decatur-Springfield Trail
- Texas, Arkansas and Louisiana Highway
- Texas Mexico Division (Bankhead Highway)
- Texas Oklahoma Colorado Highway
- Theodore Roosevelt International Highway, Portland, ME to Portland, OR
- Thompsonville-Stafford Springs Way
- Thousand Islands Trail
- Three "C" Highway, Cleveland, OH to Cincinnati, OH
- Tidewater Trail, Norfolk, VA to Washington, DC
- Tip Top Trail
- Toledo Chicago Pike
- Toledo-Angola-Goshen Trail
- Toledo-Cleveland-Buffalo Route
- Toledo-Cleveland-Buffalo Trail
- Top of Michigan Trail
- Torrington-Norwalk Route
- Transit Road
- Tri-State Trail
- Troy East Greenbush Route
- Trunk Highway
- Tuxedo Trail
- Twin City-Aberdeen-Yellowstone Park Trail
- Twin City Black Hills Cut Off
- Twin City Black Hills Yellowstone Trail
- Two "C" Highway
