CDH17

Cadherin-17 is a protein that in humans is encoded by the CDH17 gene.

CDH17
Identifiers
Aliases	CDH17, CDH16, HPT-1, HPT1, cadherin 17
External IDs	OMIM: 603017; MGI: 1095414; HomoloGene: 56859; GeneCards: CDH17; OMA:CDH17 - orthologs
Gene location (Human) Chr. Chromosome 8 (human) Band 8q22.1 Start 94,127,162 bp End 94,217,303 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 A1 Start 11,758,147 bp End 11,817,895 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of colon mucosa of sigmoid colon mucosa of ileum jejunal mucosa rectum mucosa of transverse colon duodenum pancreatic ductal cell secondary oocyte appendix Top expressed in ileum intestinal villus left colon duodenum epithelium of small intestine crypt of lieberkuhn of small intestine jejunum migratory enteric neural crest cell Paneth cell zygote More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding transporter activity metal ion binding integrin binding proton-dependent oligopeptide secondary active transmembrane transporter activity cytoskeletal protein binding protein homodimerization activity cadherin binding Cellular component integral component of membrane membrane cell surface plasma membrane basolateral plasma membrane nucleus cell junction catenin complex Biological process spleen development marginal zone B cell differentiation integrin-mediated signaling pathway positive regulation of integrin activation by cell surface receptor linked signal transduction germinal center B cell differentiation B cell differentiation adherens junction organization oligopeptide transport calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules oligopeptide transmembrane transport homophilic cell adhesion via plasma membrane adhesion molecules cell adhesion cell-cell junction assembly cell-cell adhesion mediated by cadherin cell-cell adhesion cell morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1015 12557 Ensembl ENSG00000079112 ENSMUSG00000028217 UniProt Q12864 Q9R100 RefSeq (mRNA) NM_001144663 NM_004063 NM_019753 RefSeq (protein) NP_001138135 NP_004054 NP_062727 Location (UCSC) Chr 8: 94.13 – 94.22 Mb Chr 4: 11.76 – 11.82 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine.

Further reading

• Gessner R, Tauber R (2001). "Intestinal cell adhesion molecules. Liver-intestine cadherin". Ann. N. Y. Acad. Sci. 915: 136–43. doi:10.1111/j.1749-6632.2000.tb05236.x. PMID 11193569. S2CID 27317315.
• Gilston A (1978). "Reducing the hazard of disconnected tubes". Anaesthesia. 32 (9): 922. doi:10.1111/j.1365-2044.1977.tb10133.x. PMID 603017. S2CID 31703359.
• Dantzig AH, Hoskins JA, Tabas LB, et al. (1994). "Association of intestinal peptide transport with a protein related to the cadherin superfamily". Science. 264 (5157): 430–3. Bibcode:1994Sci...264..430D. doi:10.1126/science.8153632. PMID 8153632.
• Suzuki Y, Tsunoda T, Sese J, et al. (2001). "Identification and characterization of the potential promoter regions of 1031 kinds of human genes". Genome Res. 11 (5): 677–84. doi:10.1101/gr.gr-1640r. PMC 311086. PMID 11337467.
• Grötzinger C, Kneifel J, Patschan D, et al. (2001). "LI-cadherin: a marker of gastric metaplasia and neoplasia". Gut. 49 (1): 73–81. doi:10.1136/gut.49.1.73. PMC 1728355. PMID 11413113.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Takamura M, Sakamoto M, Ino Y, et al. (2003). "Expression of liver-intestine cadherin and its possible interaction with galectin-3 in ductal adenocarcinoma of the pancreas". Cancer Sci. 94 (5): 425–30. doi:10.1111/j.1349-7006.2003.tb01459.x. PMC 11160223. PMID 12824888. S2CID 25229564.
• Wendeler MW, Praus M, Jung R, et al. (2004). "Ksp-cadherin is a functional cell-cell adhesion molecule related to LI-cadherin". Exp. Cell Res. 294 (2): 345–55. doi:10.1016/j.yexcr.2003.11.022. PMID 15023525.
• Ko S, Chu KM, Luk JM, et al. (2004). "Overexpression of LI-cadherin in gastric cancer is associated with lymph node metastasis". Biochem. Biophys. Res. Commun. 319 (2): 562–8. doi:10.1016/j.bbrc.2004.04.197. PMID 15178443.
• Takamura M, Ichida T, Matsuda Y, et al. (2004). "Reduced expression of liver-intestine cadherin is associated with progression and lymph node metastasis of human colorectal carcinoma". Cancer Lett. 212 (2): 253–9. doi:10.1016/j.canlet.2004.03.016. PMID 15279905.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Wang XQ, Luk JM, Leung PP, et al. (2005). "Alternative mRNA splicing of liver intestine-cadherin in hepatocellular carcinoma". Clin. Cancer Res. 11 (2 Pt 1): 483–9. doi:10.1158/1078-0432.483.11.2. PMID 15701831.
• Wang XQ, Luk JM, Garcia-Barcelo M, et al. (2007). "Liver intestine-cadherin (CDH17) haplotype is associated with increased risk of hepatocellular carcinoma". Clin. Cancer Res. 12 (17): 5248–52. doi:10.1158/1078-0432.CCR-06-0558. PMID 16951245. S2CID 22423581.

External links

• CDH17 human gene location in the UCSC Genome Browser.
• CDH17 human gene details in the UCSC Genome Browser.
• Human CDH16 genome location and CDH16 gene details page in the UCSC Genome Browser.