CD49d is an integrin alpha subunit. It makes up half of the α4β1 lymphocyte homing receptor.

ITGA4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesITGA4, CD49D, IA4, integrin subunit alpha 4
External IDsOMIM: 192975; MGI: 96603; HomoloGene: 37364; GeneCards: ITGA4; OMA:ITGA4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000885
NM_001316312

NM_010576

RefSeq (protein)

NP_000876
NP_001303241

NP_034706

Location (UCSC)Chr 2: 181.46 – 181.54 MbChr 2: 79.09 – 79.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain.[5]

Interactions

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CD49d has been shown to interact with LGALS8[6] and Paxillin.[7][8]

See also

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  • Carotegrast methyl, an integrin alpha 4 antagonist used for the treatment of ulcerative colitis

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000115232Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027009Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)".
  6. ^ Hadari YR, Arbel-Goren R, Levy Y, Amsterdam A, Alon R, Zakut R, Zick Y (2000). "Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis". J. Cell Sci. 113 (Pt 13): 2385–97. doi:10.1242/jcs.113.13.2385. PMID 10852818.
  7. ^ Han J, Liu S, Rose DM, Schlaepfer DD, McDonald H, Ginsberg MH (November 2001). "Phosphorylation of the integrin alpha 4 cytoplasmic domain regulates paxillin binding". J. Biol. Chem. 276 (44): 40903–9. doi:10.1074/jbc.M102665200. PMID 11533025.
  8. ^ Liu S, Kiosses WB, Rose DM, Slepak M, Salgia R, Griffin JD, Turner CE, Schwartz MA, Ginsberg MH (June 2002). "A fragment of paxillin binds the alpha 4 integrin cytoplasmic domain (tail) and selectively inhibits alpha 4-mediated cell migration". J. Biol. Chem. 277 (23): 20887–94. doi:10.1074/jbc.M110928200. PMID 11919182.

Further reading

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