Integrin alpha 3

ITGA3
Identifiers
Aliases	ITGA3, CD49C, GAP-B3, GAPB3, ILNEB, MSK18, VCA-2, VL3A, VLA3a, FRP-2, integrin subunit alpha 3, JEB7
External IDs	OMIM: 605025; MGI: 96602; HomoloGene: 21129; GeneCards: ITGA3; OMA:ITGA3 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	50,090,481 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	94,967,627 bp
RNA expression pattern
	Top expressed in
	metanephric glomerulus; ; right coronary artery; ; upper lobe of left lung; ; Descending thoracic aorta; ; popliteal artery; ; tibial arteries; ; right lung; ; right lobe of thyroid gland; ; ascending aorta; ; left lobe of thyroid gland;
	Top expressed in
	genital tubercle; ; lumbar spinal ganglion; ; decidua; ; tail of embryo; ; corneal stroma; ; yolk sac; ; crypt of lieberkuhn of small intestine; ; right lung lobe; ; epithelium of lens; ; ileum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding; protein domain specific binding; laminin binding; collagen binding; protease binding; protein heterodimerization activity; integrin binding; fibronectin binding; protein binding;
Cellular component	extracellular exosome; synapse; integral component of membrane; cell projection; cell periphery; cell junction; growth cone; membrane; focal adhesion; cell surface; receptor complex; synaptic membrane; perinuclear region of cytoplasm; excitatory synapse; integrin complex; basolateral plasma membrane; filopodium membrane; external side of plasma membrane; integrin alpha3-beta1 complex; plasma membrane; growth cone filopodium;
Biological process	positive regulation of neuron projection development; extracellular matrix organization; lung development; mesodermal cell differentiation; skin development; maternal process involved in female pregnancy; cell-matrix adhesion; negative regulation of cell projection organization; positive regulation of cell-substrate adhesion; heart development; dendritic spine maintenance; positive regulation of gene expression; nephron development; memory; integrin-mediated signaling pathway; response to gonadotropin; leukocyte migration; renal filtration; regulation of transforming growth factor beta receptor signaling pathway; regulation of Wnt signaling pathway; regulation of BMP signaling pathway; negative regulation of Rho protein signal transduction; exploration behavior; positive regulation of epithelial cell migration; neuron migration; cell adhesion; positive regulation of protein localization to plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	3675
	16400
	ENSG00000005884
	ENSMUSG00000001507
	P26006
	Q62470
	NM_002204; NM_005501
	NM_013565; NM_001306071; NM_001306162
	NP_002195
	NP_001293000; NP_001293091; NP_038593
	Wikidata
View/Edit Human	View/Edit Mouse

Integrin alpha-3 is a protein that in humans is encoded by the ITGA3 gene.^[5]^[6] ITGA3 is an integrin alpha subunit. Together with beta-1 subunit, it makes up half of the α3β1 integrin duplex that plays a role in neural migration and corticogenesis, acted upon by such factors as netrin-1 and reelin.

ITGA3 encodes the integrin alpha 3 chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 3 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form an integrin that interacts with many extracellular matrix proteins.

Alternative names

The alpha 3 beta 1 integrin is known variously as: very late (activation) antigen 3 ('VLA-3'), very common antigen 2 ('VCA-2'), extracellular matrix receptor 1 ('ECMR1'), and galactoprotein b3 ('GAPB3').^[7]

Interactions

CD49c has been shown to interact with:

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000005884 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000001507 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Takada Y, Murphy E, Pil P, Chen C, Ginsberg MH, Hemler ME (October 1991). "Molecular cloning and expression of the cDNA for alpha 3 subunit of human alpha 3 beta 1 (VLA-3), an integrin receptor for fibronectin, laminin, and collagen". J Cell Biol. 115 (1): 257–66. doi:10.1083/jcb.115.1.257. PMC 2289928. PMID 1655803.
^ Jones SD, van der Flier A, Sonnenberg A (September 1998). "Genomic organization of the human alpha 3 integrin subunit gene". Biochem Biophys Res Commun. 248 (3): 896–8. doi:10.1006/bbrc.1998.9071. PMID 9704023.
^ "Entrez Gene: ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)".
^ Park KR, Inoue T, Ueda M, Hirano T, Higuchi T, Maeda M, Konishi I, Fujiwara H, Fujii S (March 2000). "CD9 is expressed on human endometrial epithelial cells in association with integrins alpha(6), alpha(3) and beta(1)". Mol. Hum. Reprod. 6 (3): 252–7. doi:10.1093/molehr/6.3.252. PMID 10694273.
^ Hirano T, Higuchi T, Ueda M, Inoue T, Kataoka N, Maeda M, Fujiwara H, Fujii S (February 1999). "CD9 is expressed in extravillous trophoblasts in association with integrin alpha3 and integrin alpha5". Mol. Hum. Reprod. 5 (2): 162–7. doi:10.1093/molehr/5.2.162. PMID 10065872.
^ Wixler V, Geerts D, Laplantine E, Westhoff D, Smyth N, Aumailley M, Sonnenberg A, Paulsson M (October 2000). "The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes". J. Biol. Chem. 275 (43): 33669–78. doi:10.1074/jbc.M002519200. PMID 10906324.
^ Hadari YR, Arbel-Goren R, Levy Y, Amsterdam A, Alon R, Zakut R, Zick Y (July 2000). "Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis". J. Cell Sci. 113 (13): 2385–97. doi:10.1242/jcs.113.13.2385. PMID 10852818.
^ Tachibana I, Bodorova J, Berditchevski F, Zutter MM, Hemler ME (November 1997). "NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins". J. Biol. Chem. 272 (46): 29181–9. doi:10.1074/jbc.272.46.29181. PMID 9360996.

External links

CD49c+antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
ITGA3 Info with links in the Cell Migration Gateway Archived 2014-12-11 at the Wayback Machine
Human ITGA3 genome location and ITGA3 gene details page in the UCSC Genome Browser.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000005884 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000001507 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1655803-5] Takada Y, Murphy E, Pil P, Chen C, Ginsberg MH, Hemler ME (October 1991). "Molecular cloning and expression of the cDNA for alpha 3 subunit of human alpha 3 beta 1 (VLA-3), an integrin receptor for fibronectin, laminin, and collagen". J Cell Biol. 115 (1): 257–66. doi:10.1083/jcb.115.1.257. PMC 2289928. PMID 1655803.

[pmid9704023-6] Jones SD, van der Flier A, Sonnenberg A (September 1998). "Genomic organization of the human alpha 3 integrin subunit gene". Biochem Biophys Res Commun. 248 (3): 896–8. doi:10.1006/bbrc.1998.9071. PMID 9704023.

[7] "Entrez Gene: ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)".

[pmid10694273-8] Park KR, Inoue T, Ueda M, Hirano T, Higuchi T, Maeda M, Konishi I, Fujiwara H, Fujii S (March 2000). "CD9 is expressed on human endometrial epithelial cells in association with integrins alpha(6), alpha(3) and beta(1)". Mol. Hum. Reprod. 6 (3): 252–7. doi:10.1093/molehr/6.3.252. PMID 10694273.

[pmid10065872-9] Hirano T, Higuchi T, Ueda M, Inoue T, Kataoka N, Maeda M, Fujiwara H, Fujii S (February 1999). "CD9 is expressed in extravillous trophoblasts in association with integrin alpha3 and integrin alpha5". Mol. Hum. Reprod. 5 (2): 162–7. doi:10.1093/molehr/5.2.162. PMID 10065872.

[pmid10906324-10] Wixler V, Geerts D, Laplantine E, Westhoff D, Smyth N, Aumailley M, Sonnenberg A, Paulsson M (October 2000). "The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes". J. Biol. Chem. 275 (43): 33669–78. doi:10.1074/jbc.M002519200. PMID 10906324.

[pmid10852818-11] Hadari YR, Arbel-Goren R, Levy Y, Amsterdam A, Alon R, Zakut R, Zick Y (July 2000). "Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis". J. Cell Sci. 113 (13): 2385–97. doi:10.1242/jcs.113.13.2385. PMID 10852818.

[pmid9360996-12] Tachibana I, Bodorova J, Berditchevski F, Zutter MM, Hemler ME (November 1997). "NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins". J. Biol. Chem. 272 (46): 29181–9. doi:10.1074/jbc.272.46.29181. PMID 9360996.

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Integrin alpha 3

Contents

Alternative names

Interactions

References

Further reading

External links