Alpha-(1,3)-fucosyltransferase is an enzyme that in humans is encoded by the FUT7 gene .[ 5] [ 6] [ 7]
The sialyl Lewis x oligosaccharide determinant is an essential component of leukocyte counterreceptors for E-selectin- (MIM 131210) and P-selectin- (MIM 173610) mediated adhesions of leukocytes. This oligosaccharide molecule is displayed on the surfaces of granulocytes, monocytes, and natural killer cells. Formation of leukocyte adhesions to these selectins is an early and important step in the process that ultimately allows leukocytes to leave the vascular tree and become recruited into lymphoid tissues and sites of inflammation.[supplied by OMIM][ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000180549 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036587 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Natsuka S, Gersten KM, Zenita K, Kannagi R, Lowe JB (June 1994). "Molecular cloning of a cDNA encoding a novel human leukocyte alpha-1,3-fucosyltransferase capable of synthesizing the sialyl Lewis x determinant" . The Journal of Biological Chemistry . 269 (24): 16789–94. doi :10.1016/S0021-9258(19)89461-9 PMID 8207002 . ^ Sasaki K, Kurata K, Funayama K, Nagata M, Watanabe E, Ohta S, Hanai N, Nishi T (May 1994). "Expression cloning of a novel alpha 1,3-fucosyltransferase that is involved in biosynthesis of the sialyl Lewis x carbohydrate determinants in leukocytes" . The Journal of Biological Chemistry . 269 (20): 14730–7. doi :10.1016/S0021-9258(17)36686-3 PMID 8182079 . ^ a b "Entrez Gene: FUT7 fucosyltransferase 7 (alpha (1,3) fucosyltransferase)" .
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