The HBV RNA encapsidation signal epsilon (HBV_epsilon) is an element essential for HBV virus replication.
| HBV RNA encapsidation signal epsilon | |
|---|---|
 Predicted secondary structure and sequence conservation of HBV_epsilon | |
| Identifiers | |
| Symbol | HBV_epsilon |
| Alt. Symbols | HBV |
| Rfam | RF01047 |
| Other data | |
| RNA type | Cis-reg |
| Domain(s) | Viruses |
| GO | GO:0019079 |
| SO | SO:0005836 |
| PDB structures | PDBe |
It is an RNA structure situated near the 5' end of the HBV pregenomic RNA.[1] The structure consists of a lower stem, a bulge region, an upper stem and a tri-loop. The structure was determined and refined through enzymatic probing and NMR spectroscopy.[2] The closure of the tri-loop was not predicted by RNA structure prediction programs but observed in the NMR structure. The regions shown to be critical for encapsidation of the RNA in the viral lifecycle are the bulge, upper stem and tri-loop which interact with the terminal protein domain of the HBV viral polymerase.[3][4]
See also
editReferences
edit- ^ Beck J, Nassal M (January 2007). "Hepatitis B virus replication". World J. Gastroenterol. 13 (1): 48–64. doi:10.3748/wjg.v13.i1.48. PMC 4065876. PMID 17206754.
- ^ Flodell S, Schleucher J, Cromsigt J, Ippel H, Kidd-Ljunggren K, Wijmenga S (November 2002). "The apical stem-loop of the hepatitis B virus encapsidation signal folds into a stable tri-loop with two underlying pyrimidine bulges". Nucleic Acids Res. 30 (21): 4803–4811. doi:10.1093/nar/gkf603. PMC 135823. PMID 12409471.
- ^ Kramvis A, Kew MC (November 1998). "Structure and function of the encapsidation signal of hepadnaviridae". J. Viral Hepat. 5 (6): 357–367. doi:10.1046/j.1365-2893.1998.00124.x. PMID 9857345. S2CID 6726175.
- ^ Beck, J; Nassal, M (2003). "Efficient Hsp90-independent in vitro activation by Hsc70 and Hsp40 of duck hepatitis B virus reverse transcriptase, an assumed Hsp90 client protein". The Journal of Biological Chemistry. 278 (38): 36128–36138. doi:10.1074/jbc.M301069200. PMID 12851401.
External links
edit- Page for HBV RNA encapsidation signal epsilon at Rfam
- HBVRegDB Hepatitis B Virus HBV Regulatory Sequence Database (HBVRegDB)
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