Hepatitis B virus PRE 1151–1410 (HBV post-transcriptional regulatory element, nucleotides 1151–1410) is a part of 500 base pair long HBV PRE, that has been proposed to be the hepatitis B virus (HBV) RNA export element.[1][2][3] However, the function is controversial and new regulatory elements have been predicted within PRE.[4] PRE 1151–1410 enhances nuclear export of intronless transcripts and represses the splicing mechanism to a comparable degree to that of the full-length PRE. Hence it was proposed to be the core HBV PRE element.[4] PRE1151–1410 contains 3 known regulatory elements: PRE SL-alpha (nucleotides 1292–1321),[5] human La protein binding site (nucleotide 1275–1291),[6] SRE-1 (nucleotides 1252–1348).[7]
| Hepatitis B virus PRE 1151–1410 | |
|---|---|
 Predicted secondary structure and sequence conservation of Hepatitis B virus PRE 1151–1410 | |
| Identifiers | |
| Rfam | RF02816 |
| Other data | |
| Domain(s) | Viruses |
| GO | GO:0051168,GO:0043484 |
| SO | SO:0005836 |
| PDB structures | PDBe |
See also
editReferences
edit- ^ Panjaworayan N, Roessner SK, Firth AE, Brown CM (December 2007). "HBVRegDB: annotation, comparison, detection and visualization of regulatory elements in hepatitis B virus sequences". Virology Journal. 4: 136. doi:10.1186/1743-422X-4-136. PMC 2235840. PMID 18086305.
- ^ Huang J, Liang TJ (December 1993). "A novel hepatitis B virus (HBV) genetic element with Rev response element-like properties that is essential for expression of HBV gene products". Molecular and Cellular Biology. 13 (12): 7476–7486. doi:10.1128/mcb.13.12.7476. PMC 364819. PMID 8246965.
- ^ Huang ZM, Yen TS (May 1994). "Hepatitis B virus RNA element that facilitates accumulation of surface gene transcripts in the cytoplasm". Journal of Virology. 68 (5): 3193–3199. doi:10.1128/JVI.68.5.3193-3199.1994. PMC 236810. PMID 8151782.
- ^ a b Visootsat A, Payungporn S, T-Thienprasert NP (December 2015). "A conserved RNA structural element within the hepatitis B virus post-transcriptional regulatory element enhance nuclear export of intronless transcripts and repress the splicing mechanism". Molecular Biology Reports. 42 (12): 1603–1614. doi:10.1007/s11033-015-3928-0. PMID 26514143. S2CID 254829761.
- ^ Panjaworayan N, Payungporn S, Poovorawan Y, Brown CM (September 2010). "Identification of an effective siRNA target site and functional regulatory elements, within the hepatitis B virus posttranscriptional regulatory element". Virology Journal. 7: 216. doi:10.1186/1743-422X-7-216. PMC 2945954. PMID 20822550.
- ^ Ehlers I, Horke S, Reumann K, Rang A, Grosse F, Will H, Heise T (October 2004). "Functional characterization of the interaction between human La and hepatitis B virus RNA". The Journal of Biological Chemistry. 279 (42): 43437–43447. doi:10.1074/jbc.M402227200. PMID 15302879.
- ^ Heise T, Sommer G, Reumann K, Meyer I, Will H, Schaal H (2006). "The hepatitis B virus PRE contains a splicing regulatory element". Nucleic Acids Research. 34 (1): 353–363. doi:10.1093/nar/gkj440. PMC 1331995. PMID 16410615.
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