Tobamovirus internal ribosome entry site (IRES)

The Tobamovirus internal ribosome entry site (IRES) is an element that allows cap and end-independent translation of mRNA in the host cell.[1] The IRES achieves this by mediating the internal initiation of translation by recruiting a ribosomal 43S pre-initiation complex directly to the initiation codon and eliminates the requirement for the eukaryotic initiation factor, eIF4F.[2]

Tobamovirus internal ribosome entry site (IRES)
Predicted secondary structure and sequence conservation of IRES_Tobamo
Identifiers
SymbolIRES_Tobamo
Alt. SymbolsTobamo_IRES
RfamRF00225
Other data
RNA typeCis-reg; IRES
Domain(s)Viruses
GOGO:0043022
SOSO:0000243
PDB structuresPDBe

See also

edit

References

edit
  1. ^ Ivanov PA, Karpova OV, Skulachev MV, Tomashevskaya OL, Rodionova NP, Atabekov JG (May 1997). "A tobamovirus genome that contains an internal ribosome entry site functional in vitro". Virology. 232 (1): 32–43. doi:10.1006/viro.1997.8525. PMID 9185586.
  2. ^ Kolupaeva VG, Pestova TV, Hellen CU (December 2000). "Ribosomal binding to the internal ribosomal entry site of classical swine fever virus". RNA. 6 (12): 1791–1807. doi:10.1017/S1355838200000662. PMC 1370049. PMID 11142379.
edit