The Tobamovirus internal ribosome entry site (IRES) is an element that allows cap and end-independent translation of mRNA in the host cell.[1] The IRES achieves this by mediating the internal initiation of translation by recruiting a ribosomal 43S pre-initiation complex directly to the initiation codon and eliminates the requirement for the eukaryotic initiation factor, eIF4F.[2]
| Tobamovirus internal ribosome entry site (IRES) | |
|---|---|
 Predicted secondary structure and sequence conservation of IRES_Tobamo | |
| Identifiers | |
| Symbol | IRES_Tobamo |
| Alt. Symbols | Tobamo_IRES |
| Rfam | RF00225 |
| Other data | |
| RNA type | Cis-reg; IRES |
| Domain(s) | Viruses |
| GO | GO:0043022 |
| SO | SO:0000243 |
| PDB structures | PDBe |
See also
editReferences
edit- ^ Ivanov PA, Karpova OV, Skulachev MV, Tomashevskaya OL, Rodionova NP, Atabekov JG (May 1997). "A tobamovirus genome that contains an internal ribosome entry site functional in vitro". Virology. 232 (1): 32–43. doi:10.1006/viro.1997.8525. PMID 9185586.
- ^ Kolupaeva VG, Pestova TV, Hellen CU (December 2000). "Ribosomal binding to the internal ribosomal entry site of classical swine fever virus". RNA. 6 (12): 1791–1807. doi:10.1017/S1355838200000662. PMC 1370049. PMID 11142379.
External links
edit | This molecular or cell biology article is a stub. You can help Wikipedia by expanding it. |