The TrkB internal ribosome entry site (IRES) is an RNA element which is present in the 5' UTR sequence of the mRNA. TrkB is a neurotrophin receptor which is essential for the development and maintenance of the nervous system. The internal ribosome entry site IRES element allows cap-independent translation of TrkB which may be needed for efficient translation in neuronal dendrites.[1]
| TrkB IRES | |
|---|---|
 Predicted secondary structure and sequence conservation of IRES_TrkB | |
| Identifiers | |
| Symbol | IRES_TrkB |
| Rfam | RF00547 |
| Other data | |
| RNA type | Cis-reg; IRES |
| Domain(s) | Eukaryota |
| GO | GO:0043022 |
| SO | SO:0000243 |
| PDB structures | PDBe |
See also
editReferences
edit- ^ Dobson T, Minic A, Nielsen K, Amiott E, Krushel L (2005). "Internal initiation of translation of the TrkB mRNA is mediated by multiple regions within the 5' leader". Nucleic Acids Research. 33 (9): 2929–2941. doi:10.1093/nar/gki605. PMC 1133793. PMID 15908588.
External links
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