| Issue Date | Song | Artist(s) |
|---|---|---|
| January 3 | "Open Your Heart" | Madonna |
| January 10 | ||
| January 17 | ||
| January 24 | ||
| January 31 | "Walk Like an Egyptian" | The Bangles |
| February 7 | ||
| February 14 | "Land of Confusion" | Genesis |
| February 21 | ||
| February 28 | ||
| March 4 | "I Knew You Were Waiting (For Me)" | Aretha Franklin featuring George Michael |
| March 14 | ||
| March 20 | ||
| March 28 | ||
| April 4 | ||
| April 11 | "Sign o' the Times" | Prince |
| April 18 | ||
| April 25 | "Nothing's Gonna Stop Us Now" | Starship |
| May 2 | ||
| May 9 | ||
| May 16 | "La Isla Bonita" | Madonna |
| May 23 | ||
| May 30 | ||
| June 6 | ||
| June 13 | "I Wanna Dance with Somebody (Who Loves Me)" | Whitney Houston |
| June 20 | ||
| June 27 | ||
| July 4 | ||
| July 11 | "I Want Your Sex" † | George Michael |
| July 18 | ||
| July 25 | ||
| August 1 | ||
| August 8 | ||
| August 15 | ||
| August 22 | ||
| August 29 | ||
| September 5 | "Wishing Well" | Terence Trent D'Arby |
| September 12 | ||
| September 19 | ||
| September 26 | "Bad" | Michael Jackson |
| October 3 | ||
| October 10 | ||
| October 17 | "You Win Again" | Bee Gees |
| October 24 | ||
| October 31 | ||
| November 7 | ||
| November 14 | ||
| November 21 | "Never Gonna Give You Up" ‡ | Rick Astley |
| November 28 | ||
| December 5 | ||
| December 12 | ||
| December 19 | ||
| December 26 |
