| Issue Date | Song | Artist(s) |
|---|---|---|
| January 1 | "Hot n Cold" | Katy Perry |
| January 8 | ||
| January 15 | ||
| January 22 | "Single Ladies (Put a Ring on It)" | Beyoncé |
| January 29 | ||
| February 5 | ||
| February 12 | ||
| February 19 | ||
| February 26 | "Broken Strings" | James Morrison featuring Nelly Furtado |
| March 5 | ||
| March 12 | ||
| March 19 | "Poker Face" † | Lady Gaga |
| March 26 | ||
| April 2 | ||
| April 9 | ||
| April 16 | ||
| April 23 | ||
| April 30 | ||
| May 7 | ||
| May 14 | ||
| May 21 | "Jai Ho! (You Are My Destiny)" | A. R. Rahman and The Pussycat Dolls featuring Nicole Scherzinger |
| May 28 | ||
| June 4 | ||
| June 11 | ||
| June 18 | "Boom Boom Pow" | The Black Eyed Peas |
| June 25 | ||
| July 2 | ||
| July 9 | ||
| July 16 | "When Love Takes Over" | David Guetta featuring Kelly Rowland |
| July 23 | ||
| July 30 | ||
| August 6 | ||
| August 13 | ||
| August 20 | "I Know You Want Me (Calle Ocho)" | Pitbull |
| August 27 | ||
| September 3 | ||
| September 10 | "I Gotta Feeling" ‡ | The Black Eyed Peas |
| September 17 | ||
| September 24 | ||
| October 1 | ||
| October 8 | ||
| October 15 | ||
| October 22 | ||
| October 29 | ||
| November 5 | ||
| November 12 | "Sexy Bitch" | David Guetta featuring Akon |
| November 19 | ||
| November 26 | ||
| December 3 | "Bad Romance" | Lady Gaga |
| December 10 | ||
| December 17 | ||
| December 24 | ||
| December 31 |
