- INFO: Beginning work on ELTD1... {November 26, 2007 2:18:57 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 26, 2007 2:19:46 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = EGF, latrophilin and seven transmembrane domain containing 1
| HGNCid = 20822
| Symbol = ELTD1
| AltSymbols =; ETL; KPG_003
| OMIM =
| ECnumber =
| Homologene = 11170
| MGIid = 2655562
| GeneAtlas_image1 = PBB_GE_ELTD1_219134_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004930 |text = G-protein coupled receptor activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007218 |text = neuropeptide signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 64123
| Hs_Ensembl = ENSG00000162618
| Hs_RefseqProtein = XP_371262
| Hs_RefseqmRNA = XM_371262
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 79128037
| Hs_GenLoc_end = 79244991
| Hs_Uniprot = Q9HBW9
| Mm_EntrezGene = 170757
| Mm_Ensembl = ENSMUSG00000039167
| Mm_RefseqmRNA = NM_133222
| Mm_RefseqProtein = NP_573485
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 3
| Mm_GenLoc_start = 151375273
| Mm_GenLoc_end = 151482474
| Mm_Uniprot = Q923X1
}}
}}
'''EGF, latrophilin and seven transmembrane domain containing 1''', also known as '''ELTD1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ELTD1 EGF, latrophilin and seven transmembrane domain containing 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64123| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Nechiporuk T, Urness LD, Keating MT |title=ETL, a novel seven-transmembrane receptor that is developmentally regulated in the heart. ETL is a member of the secretin family and belongs to the epidermal growth factor-seven-transmembrane subfamily. |journal=J. Biol. Chem. |volume=276 |issue= 6 |pages= 4150-7 |year= 2001 |pmid= 11050079 |doi= 10.1074/jbc.M004814200 }}
*{{cite journal | author=Venter JC, Adams MD, Myers EW, ''et al.'' |title=The sequence of the human genome. |journal=Science |volume=291 |issue= 5507 |pages= 1304-51 |year= 2001 |pmid= 11181995 |doi= 10.1126/science.1058040 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
*{{cite journal | author=Bjarnadóttir TK, Fredriksson R, Höglund PJ, ''et al.'' |title=The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. |journal=Genomics |volume=84 |issue= 1 |pages= 23-33 |year= 2005 |pmid= 15203201 |doi= 10.1016/j.ygeno.2003.12.004 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Liu T, Qian WJ, Gritsenko MA, ''et al.'' |title=Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070-80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065 }}
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GPR107... {November 26, 2007 2:12:37 PM PST}
- CREATE: Found no pages, creating new page. {November 26, 2007 2:14:54 PM PST}
- CREATED: Created new protein page: GPR107 {November 26, 2007 2:15:03 PM PST}
- INFO: Beginning work on GPR126... {November 26, 2007 2:10:57 PM PST}
- CREATE: Found no pages, creating new page. {November 26, 2007 2:11:40 PM PST}
- CREATED: Created new protein page: GPR126 {November 26, 2007 2:11:48 PM PST}
- INFO: Beginning work on GPR135... {November 26, 2007 2:19:46 PM PST}
- CREATE: Found no pages, creating new page. {November 26, 2007 2:21:27 PM PST}
- CREATED: Created new protein page: GPR135 {November 26, 2007 2:21:35 PM PST}
- INFO: Beginning work on GPR158... {November 26, 2007 2:11:48 PM PST}
- CREATE: Found no pages, creating new page. {November 26, 2007 2:12:28 PM PST}
- CREATED: Created new protein page: GPR158 {November 26, 2007 2:12:37 PM PST}
- INFO: Beginning work on HRH4... {November 26, 2007 2:15:03 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 26, 2007 2:16:00 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Histamine receptor H4
| HGNCid = 17383
| Symbol = HRH4
| AltSymbols =; H4; AXOR35; BG26; GPCR105; GPRv53; H4R; HH4R; MGC133027
| OMIM = 606792
| ECnumber =
| Homologene = 11002
| MGIid = 2429635
| GeneAtlas_image1 = PBB_GE_HRH4_221169_s_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004969 |text = histamine receptor activity}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0008150 |text = biological_process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 59340
| Hs_Ensembl = ENSG00000134489
| Hs_RefseqProtein = NP_067637
| Hs_RefseqmRNA = NM_021624
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 18
| Hs_GenLoc_start = 20294591
| Hs_GenLoc_end = 20311567
| Hs_Uniprot = Q9H3N8
| Mm_EntrezGene = 225192
| Mm_Ensembl = ENSMUSG00000037346
| Mm_RefseqmRNA = NM_153087
| Mm_RefseqProtein = NP_694727
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 18
| Mm_GenLoc_start = 13150159
| Mm_GenLoc_end = 13166051
| Mm_Uniprot =
}}
}}
'''Histamine receptor H4''', also known as '''HRH4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HRH4 histamine receptor H4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=59340| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H4 belongs to the family 1 of G protein-coupled receptors and has the highest homology to histamine receptor H3 among known G protein-coupled receptors.<ref name="entrez">{{cite web | title = Entrez Gene: HRH4 histamine receptor H4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=59340| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Oda T, Morikawa N, Saito Y, ''et al.'' |title=Molecular cloning and characterization of a novel type of histamine receptor preferentially expressed in leukocytes. |journal=J. Biol. Chem. |volume=275 |issue= 47 |pages= 36781-6 |year= 2001 |pmid= 10973974 |doi= 10.1074/jbc.M006480200 }}
*{{cite journal | author=Nakamura T, Itadani H, Hidaka Y, ''et al.'' |title=Molecular cloning and characterization of a new human histamine receptor, HH4R. |journal=Biochem. Biophys. Res. Commun. |volume=279 |issue= 2 |pages= 615-20 |year= 2001 |pmid= 11118334 |doi= 10.1006/bbrc.2000.4008 }}
*{{cite journal | author=Liu C, Ma X, Jiang X, ''et al.'' |title=Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow. |journal=Mol. Pharmacol. |volume=59 |issue= 3 |pages= 420-6 |year= 2001 |pmid= 11179434 |doi= }}
*{{cite journal | author=Nguyen T, Shapiro DA, George SR, ''et al.'' |title=Discovery of a novel member of the histamine receptor family. |journal=Mol. Pharmacol. |volume=59 |issue= 3 |pages= 427-33 |year= 2001 |pmid= 11179435 |doi= }}
*{{cite journal | author=Zhu Y, Michalovich D, Wu H, ''et al.'' |title=Cloning, expression, and pharmacological characterization of a novel human histamine receptor. |journal=Mol. Pharmacol. |volume=59 |issue= 3 |pages= 434-41 |year= 2001 |pmid= 11179436 |doi= }}
*{{cite journal | author=Morse KL, Behan J, Laz TM, ''et al.'' |title=Cloning and characterization of a novel human histamine receptor. |journal=J. Pharmacol. Exp. Ther. |volume=296 |issue= 3 |pages= 1058-66 |year= 2001 |pmid= 11181941 |doi= }}
*{{cite journal | author=Cogé F, Guénin SP, Rique H, ''et al.'' |title=Structure and expression of the human histamine H4-receptor gene. |journal=Biochem. Biophys. Res. Commun. |volume=284 |issue= 2 |pages= 301-9 |year= 2001 |pmid= 11394877 |doi= 10.1006/bbrc.2001.4976 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Lippert U, Artuc M, Grützkau A, ''et al.'' |title=Human skin mast cells express H2 and H4, but not H3 receptors. |journal=J. Invest. Dermatol. |volume=123 |issue= 1 |pages= 116-23 |year= 2004 |pmid= 15191551 |doi= 10.1111/j.0022-202X.2004.22721.x }}
*{{cite journal | author=Nakayama T, Kato Y, Hieshima K, ''et al.'' |title=Liver-expressed chemokine/CC chemokine ligand 16 attracts eosinophils by interacting with histamine H4 receptor. |journal=J. Immunol. |volume=173 |issue= 3 |pages= 2078-83 |year= 2004 |pmid= 15265943 |doi= }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Cianchi F, Cortesini C, Schiavone N, ''et al.'' |title=The role of cyclooxygenase-2 in mediating the effects of histamine on cell proliferation and vascular endothelial growth factor production in colorectal cancer. |journal=Clin. Cancer Res. |volume=11 |issue= 19 Pt 1 |pages= 6807-15 |year= 2006 |pmid= 16203768 |doi= 10.1158/1078-0432.CCR-05-0675 }}
*{{cite journal | author=Maslinska D, Laure-Kamionowska M, Maslinski KT, ''et al.'' |title=Histamine H(4) receptors on mammary epithelial cells of the human breast with different types of carcinoma. |journal=Inflamm. Res. |volume=55 Suppl 1 |issue= |pages= S77-8 |year= 2006 |pmid= 16547802 |doi= 10.1007/s00011-005-0051-z }}
*{{cite journal | author=Horr B, Borck H, Diel J, ''et al.'' |title=The role of the histamine H(4) receptor in signal transduction of atopic and non-atopic human lymphocytes ex vivo. |journal=Inflamm. Res. |volume=55 Suppl 1 |issue= |pages= S53-4 |year= 2006 |pmid= 16547812 |doi= 10.1007/s00011-005-0039-8 }}
*{{cite journal | author=Dijkstra D, Leurs R, Chazot P, ''et al.'' |title=Histamine downregulates monocyte CCL2 production through the histamine H4 receptor. |journal=J. Allergy Clin. Immunol. |volume=120 |issue= 2 |pages= 300-7 |year= 2007 |pmid= 17507084 |doi= 10.1016/j.jaci.2007.03.024 }}
*{{cite journal | author=Godot V, Arock M, Garcia G, ''et al.'' |title=H4 histamine receptor mediates optimal migration of mast cell precursors to CXCL12. |journal=J. Allergy Clin. Immunol. |volume=120 |issue= 4 |pages= 827-34 |year= 2007 |pmid= 17681365 |doi= 10.1016/j.jaci.2007.05.046 }}
*{{cite journal | author=Szewczyk G, Maślińska D, Szukiewicz D, ''et al.'' |title=Histamine H4 receptors in human placenta in diabetes-complicated pregnancy. |journal=Inflamm. Res. |volume=56 Suppl 1 |issue= |pages= S31-2 |year= 2007 |pmid= 17806168 |doi= }}
*{{cite journal | author=Grzybowska-Kowalczyk A, Wojtecka-Lukasik E, Maslinska D, ''et al.'' |title=Distribution pattern of histamine H4 receptor in human synovial tissue from patients with rheumatoid arthritis. |journal=Inflamm. Res. |volume=56 Suppl 1 |issue= |pages= S59-60 |year= 2007 |pmid= 17806182 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on LGR6... {November 26, 2007 2:17:07 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 26, 2007 2:18:00 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Leucine-rich repeat-containing G protein-coupled receptor 6
| HGNCid = 19719
| Symbol = LGR6
| AltSymbols =; GPCR; FLJ14471; VTS20631
| OMIM = 606653
| ECnumber =
| Homologene = 49680
| MGIid = 2441805
| GeneAtlas_image1 = PBB_GE_LGR6_gnf1h10211_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016500 |text = protein-hormone receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 59352
| Hs_Ensembl = ENSG00000133067
| Hs_RefseqProtein = NP_001017403
| Hs_RefseqmRNA = NM_001017403
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 200429652
| Hs_GenLoc_end = 200555532
| Hs_Uniprot = Q9HBX8
| Mm_EntrezGene = 329252
| Mm_Ensembl = ENSMUSG00000042793
| Mm_RefseqmRNA = NM_001033409
| Mm_RefseqProtein = NP_001028581
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 136802764
| Mm_GenLoc_end = 136921687
| Mm_Uniprot =
}}
}}
'''Leucine-rich repeat-containing G protein-coupled receptor 6''', also known as '''LGR6''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: LGR6 leucine-rich repeat-containing G protein-coupled receptor 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=59352| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane protein superfamily. The encoded protein is a glycoprotein hormone receptor with a large N-terminal extracellular domain that contains leucine-rich repeats important for the formation of a horseshoe-shaped interaction motif for ligand binding. Alternative splicing of this gene results in multiple transcript variants.<ref name="entrez">{{cite web | title = Entrez Gene: LGR6 leucine-rich repeat-containing G protein-coupled receptor 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=59352| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
*{{cite journal | author=Hsu SY, Kudo M, Chen T, ''et al.'' |title=The three subfamilies of leucine-rich repeat-containing G protein-coupled receptors (LGR): identification of LGR6 and LGR7 and the signaling mechanism for LGR7. |journal=Mol. Endocrinol. |volume=14 |issue= 8 |pages= 1257-71 |year= 2001 |pmid= 10935549 |doi= }}
*{{cite journal | author=Takeda S, Kadowaki S, Haga T, ''et al.'' |title=Identification of G protein-coupled receptor genes from the human genome sequence. |journal=FEBS Lett. |volume=520 |issue= 1-3 |pages= 97-101 |year= 2002 |pmid= 12044878 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on NPFFR1... {November 26, 2007 2:18:00 PM PST}
- CREATE: Found no pages, creating new page. {November 26, 2007 2:18:47 PM PST}
- CREATED: Created new protein page: NPFFR1 {November 26, 2007 2:18:56 PM PST}
- INFO: Beginning work on OR10G6... {November 26, 2007 2:28:28 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 26, 2007 2:28:48 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Olfactory receptor, family 10, subfamily G, member 6
| HGNCid = 14836
| Symbol = OR10G6
| AltSymbols =; OR10G6P; OR10G6Q
| OMIM =
| ECnumber =
| Homologene =
| MGIid =
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004984 |text = olfactory receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007608 |text = sensory perception of smell}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 79490
| Hs_Ensembl =
| Hs_RefseqProtein =
| Hs_RefseqmRNA =
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Olfactory receptor, family 10, subfamily G, member 6''', also known as '''OR10G6''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OR10G6 olfactory receptor, family 10, subfamily G, member 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79490| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez">{{cite web | title = Entrez Gene: OR10G6 olfactory receptor, family 10, subfamily G, member 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79490| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Malnic B, Godfrey PA, Buck LB |title=The human olfactory receptor gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2584-9 |year= 2004 |pmid= 14983052 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on OR13A1... {November 26, 2007 2:22:34 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 26, 2007 2:22:55 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Olfactory receptor, family 13, subfamily A, member 1
| HGNCid = 14772
| Symbol = OR13A1
| AltSymbols =; FLJ16797
| OMIM =
| ECnumber =
| Homologene = 17434
| MGIid = 3030045
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004984 |text = olfactory receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007608 |text = sensory perception of smell}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 79290
| Hs_Ensembl = ENSG00000172678
| Hs_RefseqProtein = NP_001004297
| Hs_RefseqmRNA = NM_001004297
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 10
| Hs_GenLoc_start = 45118108
| Hs_GenLoc_end = 45123282
| Hs_Uniprot = Q8NGR1
| Mm_EntrezGene = 258914
| Mm_Ensembl = ENSMUSG00000053391
| Mm_RefseqmRNA = NM_146912
| Mm_RefseqProtein = NP_667123
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 116459230
| Mm_GenLoc_end = 116460159
| Mm_Uniprot =
}}
}}
'''Olfactory receptor, family 13, subfamily A, member 1''', also known as '''OR13A1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OR13A1 olfactory receptor, family 13, subfamily A, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79290| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez">{{cite web | title = Entrez Gene: OR13A1 olfactory receptor, family 13, subfamily A, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79290| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Malnic B, Godfrey PA, Buck LB |title=The human olfactory receptor gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2584-9 |year= 2004 |pmid= 14983052 |doi= }}
*{{cite journal | author=Deloukas P, Earthrowl ME, Grafham DV, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 10. |journal=Nature |volume=429 |issue= 6990 |pages= 375-81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on OR2A4... {November 26, 2007 2:28:48 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 26, 2007 2:29:09 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Olfactory receptor, family 2, subfamily A, member 4
| HGNCid = 14729
| Symbol = OR2A4
| AltSymbols =; OR2A10; HSDJ0798C17; OR2A21
| OMIM =
| ECnumber =
| Homologene = 27232
| MGIid = 104812
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004984 |text = olfactory receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007608 |text = sensory perception of smell}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 79541
| Hs_Ensembl =
| Hs_RefseqProtein = NP_112170
| Hs_RefseqmRNA = NM_030908
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 18310
| Mm_Ensembl = ENSMUSG00000043605
| Mm_RefseqmRNA = NM_146652
| Mm_RefseqProtein = NP_666863
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 43103595
| Mm_GenLoc_end = 43104527
| Mm_Uniprot = Q0VAZ7
}}
}}
'''Olfactory receptor, family 2, subfamily A, member 4''', also known as '''OR2A4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OR2A4 olfactory receptor, family 2, subfamily A, member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79541| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez">{{cite web | title = Entrez Gene: OR2A4 olfactory receptor, family 2, subfamily A, member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79541| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Dias Neto E, Correa RG, Verjovski-Almeida S, ''et al.'' |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491-6 |year= 2000 |pmid= 10737800 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal | author=Malnic B, Godfrey PA, Buck LB |title=The human olfactory receptor gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2584-9 |year= 2004 |pmid= 14983052 |doi= }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on OR4C5... {November 26, 2007 2:27:56 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 26, 2007 2:28:11 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Olfactory receptor, family 4, subfamily C, member 5
| HGNCid = 14702
| Symbol = OR4C5
| AltSymbols =; OR4C5P; OR4C5Q
| OMIM =
| ECnumber =
| Homologene =
| MGIid =
| Function =
| Component =
| Process =
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 79346
| Hs_Ensembl =
| Hs_RefseqProtein =
| Hs_RefseqmRNA =
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Olfactory receptor, family 4, subfamily C, member 5''', also known as '''OR4C5''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OR4C5 olfactory receptor, family 4, subfamily C, member 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79346| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez">{{cite web | title = Entrez Gene: OR4C5 olfactory receptor, family 4, subfamily C, member 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79346| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on OR4F4... {November 26, 2007 2:09:23 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 26, 2007 2:09:56 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Olfactory receptor, family 4, subfamily F, member 4
| HGNCid = 8301
| Symbol = OR4F4
| AltSymbols =; OLA-7501; OR4F18; OR4F11P; OR4F19
| OMIM =
| ECnumber =
| Homologene = 88410
| MGIid =
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004984 |text = olfactory receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007608 |text = sensory perception of smell}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 26682
| Hs_Ensembl = ENSG00000186092
| Hs_RefseqProtein = NP_001004195
| Hs_RefseqmRNA = NM_001004195
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 15
| Hs_GenLoc_start = 100279868
| Hs_GenLoc_end = 100280785
| Hs_Uniprot = Q96R69
| Mm_EntrezGene = 623583
| Mm_Ensembl =
| Mm_RefseqmRNA = XM_888068
| Mm_RefseqProtein = XP_893161
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Olfactory receptor, family 4, subfamily F, member 4''', also known as '''OR4F4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OR4F4 olfactory receptor, family 4, subfamily F, member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26682| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez">{{cite web | title = Entrez Gene: OR4F4 olfactory receptor, family 4, subfamily F, member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26682| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Trask BJ, Friedman C, Martin-Gallardo A, ''et al.'' |title=Members of the olfactory receptor gene family are contained in large blocks of DNA duplicated polymorphically near the ends of human chromosomes. |journal=Hum. Mol. Genet. |volume=7 |issue= 1 |pages= 13-26 |year= 1998 |pmid= 9384599 |doi= }}
*{{cite journal | author=Mefford HC, Linardopoulou E, Coil D, ''et al.'' |title=Comparative sequencing of a multicopy subtelomeric region containing olfactory receptor genes reveals multiple interactions between non-homologous chromosomes. |journal=Hum. Mol. Genet. |volume=10 |issue= 21 |pages= 2363-72 |year= 2002 |pmid= 11689483 |doi= }}
*{{cite journal | author=Linardopoulou E, Mefford HC, Nguyen O, ''et al.'' |title=Transcriptional activity of multiple copies of a subtelomerically located olfactory receptor gene that is polymorphic in number and location. |journal=Hum. Mol. Genet. |volume=10 |issue= 21 |pages= 2373-83 |year= 2002 |pmid= 11689484 |doi= }}
*{{cite journal | author=Fuchs T, Malecova B, Linhart C, ''et al.'' |title=DEFOG: a practical scheme for deciphering families of genes. |journal=Genomics |volume=80 |issue= 3 |pages= 295-302 |year= 2003 |pmid= 12213199 |doi= }}
*{{cite journal | author=Malnic B, Godfrey PA, Buck LB |title=The human olfactory receptor gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2584-9 |year= 2004 |pmid= 14983052 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on OR4K1... {November 26, 2007 2:29:09 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 26, 2007 2:29:26 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Olfactory receptor, family 4, subfamily K, member 1
| HGNCid = 14726
| Symbol = OR4K1
| AltSymbols =; OR14-19
| OMIM =
| ECnumber =
| Homologene = 74224
| MGIid = 3030562
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004984 |text = olfactory receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007608 |text = sensory perception of smell}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 79544
| Hs_Ensembl = ENSG00000155249
| Hs_RefseqProtein = NP_001004063
| Hs_RefseqmRNA = NM_001004063
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 14
| Hs_GenLoc_start = 19473666
| Hs_GenLoc_end = 19474601
| Hs_Uniprot = Q8NGD4
| Mm_EntrezGene = 258039
| Mm_Ensembl = ENSMUSG00000050030
| Mm_RefseqmRNA = NM_001011809
| Mm_RefseqProtein = NP_001011809
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 14
| Mm_GenLoc_start = 49061653
| Mm_GenLoc_end = 49062588
| Mm_Uniprot =
}}
}}
'''Olfactory receptor, family 4, subfamily K, member 1''', also known as '''OR4K1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OR4K1 olfactory receptor, family 4, subfamily K, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79544| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez">{{cite web | title = Entrez Gene: OR4K1 olfactory receptor, family 4, subfamily K, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79544| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Fuchs T, Malecova B, Linhart C, ''et al.'' |title=DEFOG: a practical scheme for deciphering families of genes. |journal=Genomics |volume=80 |issue= 3 |pages= 295-302 |year= 2003 |pmid= 12213199 |doi= }}
*{{cite journal | author=Malnic B, Godfrey PA, Buck LB |title=The human olfactory receptor gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2584-9 |year= 2004 |pmid= 14983052 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on OR4K5... {November 26, 2007 2:26:07 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 26, 2007 2:26:27 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Olfactory receptor, family 4, subfamily K, member 5
| HGNCid = 14745
| Symbol = OR4K5
| AltSymbols =; OR14-16
| OMIM =
| ECnumber =
| Homologene = 17167
| MGIid = 3030563
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004984 |text = olfactory receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007608 |text = sensory perception of smell}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 79317
| Hs_Ensembl = ENSG00000176281
| Hs_RefseqProtein = NP_001005483
| Hs_RefseqmRNA = NM_001005483
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 14
| Hs_GenLoc_start = 19458606
| Hs_GenLoc_end = 19459577
| Hs_Uniprot = Q8NGD3
| Mm_EntrezGene = 258275
| Mm_Ensembl = ENSMUSG00000049011
| Mm_RefseqmRNA = NM_146278
| Mm_RefseqProtein = NP_666390
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 14
| Mm_GenLoc_start = 49069852
| Mm_GenLoc_end = 49070823
| Mm_Uniprot =
}}
}}
'''Olfactory receptor, family 4, subfamily K, member 5''', also known as '''OR4K5''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OR4K5 olfactory receptor, family 4, subfamily K, member 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79317| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez">{{cite web | title = Entrez Gene: OR4K5 olfactory receptor, family 4, subfamily K, member 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79317| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Malnic B, Godfrey PA, Buck LB |title=The human olfactory receptor gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2584-9 |year= 2004 |pmid= 14983052 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on OR51B2... {November 26, 2007 2:27:37 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 26, 2007 2:27:56 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Olfactory receptor, family 51, subfamily B, member 2
| HGNCid = 14703
| Symbol = OR51B2
| AltSymbols =; HOR5'Beta3; OR51B1P
| OMIM =
| ECnumber =
| Homologene = 56593
| MGIid = 1341900
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004984 |text = olfactory receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007608 |text = sensory perception of smell}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 79345
| Hs_Ensembl = ENSG00000184881
| Hs_RefseqProtein = NP_149420
| Hs_RefseqmRNA = NM_033180
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 5301165
| Hs_GenLoc_end = 5302103
| Hs_Uniprot = Q9Y5P1
| Mm_EntrezGene = 18366
| Mm_Ensembl = ENSMUSG00000063615
| Mm_RefseqmRNA = NM_013617
| Mm_RefseqProtein = NP_038645
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 103766631
| Mm_GenLoc_end = 103767563
| Mm_Uniprot =
}}
}}
'''Olfactory receptor, family 51, subfamily B, member 2''', also known as '''OR51B2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OR51B2 olfactory receptor, family 51, subfamily B, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79345| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez">{{cite web | title = Entrez Gene: OR51B2 olfactory receptor, family 51, subfamily B, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79345| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Bulger M, van Doorninck JH, Saitoh N, ''et al.'' |title=Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 9 |pages= 5129-34 |year= 1999 |pmid= 10220430 |doi= }}
*{{cite journal | author=Bulger M, Bender MA, van Doorninck JH, ''et al.'' |title=Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 26 |pages= 14560-5 |year= 2001 |pmid= 11121057 |doi= 10.1073/pnas.97.26.14560 }}
*{{cite journal | author=Fuchs T, Malecova B, Linhart C, ''et al.'' |title=DEFOG: a practical scheme for deciphering families of genes. |journal=Genomics |volume=80 |issue= 3 |pages= 295-302 |year= 2003 |pmid= 12213199 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on OR51B4... {November 26, 2007 2:27:21 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 26, 2007 2:27:37 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Olfactory receptor, family 51, subfamily B, member 4
| HGNCid = 14708
| Symbol = OR51B4
| AltSymbols =; HOR5'Beta1
| OMIM =
| ECnumber =
| Homologene = 88376
| MGIid = 1341906
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004984 |text = olfactory receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007608 |text = sensory perception of smell}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 79339
| Hs_Ensembl = ENSG00000183251
| Hs_RefseqProtein = NP_149419
| Hs_RefseqmRNA = NM_033179
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 5278820
| Hs_GenLoc_end = 5279802
| Hs_Uniprot = Q9Y5P0
| Mm_EntrezGene = 18367
| Mm_Ensembl = ENSMUSG00000058200
| Mm_RefseqmRNA = NM_013618
| Mm_RefseqProtein = NP_038646
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 103755127
| Mm_GenLoc_end = 103756062
| Mm_Uniprot =
}}
}}
'''Olfactory receptor, family 51, subfamily B, member 4''', also known as '''OR51B4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OR51B4 olfactory receptor, family 51, subfamily B, member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79339| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez">{{cite web | title = Entrez Gene: OR51B4 olfactory receptor, family 51, subfamily B, member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79339| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Bulger M, van Doorninck JH, Saitoh N, ''et al.'' |title=Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 9 |pages= 5129-34 |year= 1999 |pmid= 10220430 |doi= }}
*{{cite journal | author=Bulger M, Bender MA, van Doorninck JH, ''et al.'' |title=Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 26 |pages= 14560-5 |year= 2001 |pmid= 11121057 |doi= 10.1073/pnas.97.26.14560 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on OR51G1... {November 26, 2007 2:26:27 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 26, 2007 2:27:21 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Olfactory receptor, family 51, subfamily G, member 1
| HGNCid = 14738
| Symbol = OR51G1
| AltSymbols =; OR11-29; OR51G3P
| OMIM =
| ECnumber =
| Homologene = 17513
| MGIid = 3030412
| GeneAtlas_image1 = PBB_GE_OR51G1_gnf1h11128_at_tn.png
| GeneAtlas_image2 = PBB_GE_OR51G1_gnf1h11129_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004984 |text = olfactory receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007608 |text = sensory perception of smell}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 79324
| Hs_Ensembl = ENSG00000176879
| Hs_RefseqProtein = NP_001005237
| Hs_RefseqmRNA = NM_001005237
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 4901180
| Hs_GenLoc_end = 4902145
| Hs_Uniprot = Q8NGK1
| Mm_EntrezGene = 259119
| Mm_Ensembl = ENSMUSG00000045792
| Mm_RefseqmRNA = NM_147115
| Mm_RefseqProtein = NP_667326
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 102858042
| Mm_GenLoc_end = 102858983
| Mm_Uniprot =
}}
}}
'''Olfactory receptor, family 51, subfamily G, member 1''', also known as '''OR51G1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OR51G1 olfactory receptor, family 51, subfamily G, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79324| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez">{{cite web | title = Entrez Gene: OR51G1 olfactory receptor, family 51, subfamily G, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79324| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Malnic B, Godfrey PA, Buck LB |title=The human olfactory receptor gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2584-9 |year= 2004 |pmid= 14983052 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on OR52N1... {November 26, 2007 2:28:11 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 26, 2007 2:28:28 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Olfactory receptor, family 52, subfamily N, member 1
| HGNCid = 14853
| Symbol = OR52N1
| AltSymbols =; OR11-61
| OMIM =
| ECnumber =
| Homologene = 72057
| MGIid = 3030498
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004984 |text = olfactory receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007608 |text = sensory perception of smell}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 79473
| Hs_Ensembl = ENSG00000181001
| Hs_RefseqProtein = NP_001001913
| Hs_RefseqmRNA = NM_001001913
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 5765660
| Hs_GenLoc_end = 5766622
| Hs_Uniprot = Q8NH53
| Mm_EntrezGene = 667918
| Mm_Ensembl =
| Mm_RefseqmRNA = XM_890097
| Mm_RefseqProtein = XP_895190
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Olfactory receptor, family 52, subfamily N, member 1''', also known as '''OR52N1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OR52N1 olfactory receptor, family 52, subfamily N, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79473| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez">{{cite web | title = Entrez Gene: OR52N1 olfactory receptor, family 52, subfamily N, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79473| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Malnic B, Godfrey PA, Buck LB |title=The human olfactory receptor gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2584-9 |year= 2004 |pmid= 14983052 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on OR5H2... {November 26, 2007 2:24:33 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 26, 2007 2:26:07 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Olfactory receptor, family 5, subfamily H, member 2
| HGNCid = 14752
| Symbol = OR5H2
| AltSymbols =; OR3-10
| OMIM =
| ECnumber =
| Homologene = 74113
| MGIid = 3030020
| GeneAtlas_image1 = PBB_GE_OR5H2_gnf1h01993_at_tn.png
| GeneAtlas_image2 = PBB_GE_OR5H2_gnf1h01995_at_tn.png
| GeneAtlas_image3 = PBB_GE_OR5H2_gnf1h01996_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004984 |text = olfactory receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007608 |text = sensory perception of smell}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 79310
| Hs_Ensembl = ENSG00000197938
| Hs_RefseqProtein = NP_001005482
| Hs_RefseqmRNA = NM_001005482
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 99484422
| Hs_GenLoc_end = 99485366
| Hs_Uniprot = Q8NGV7
| Mm_EntrezGene = 258318
| Mm_Ensembl = ENSMUSG00000047960
| Mm_RefseqmRNA = NM_146321
| Mm_RefseqProtein = NP_666433
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 16
| Mm_GenLoc_start = 58969232
| Mm_GenLoc_end = 58970161
| Mm_Uniprot = Q8VEX5
}}
}}
'''Olfactory receptor, family 5, subfamily H, member 2''', also known as '''OR5H2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OR5H2 olfactory receptor, family 5, subfamily H, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79310| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez">{{cite web | title = Entrez Gene: OR5H2 olfactory receptor, family 5, subfamily H, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79310| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Malnic B, Godfrey PA, Buck LB |title=The human olfactory receptor gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2584-9 |year= 2004 |pmid= 14983052 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on OR5H6... {November 26, 2007 2:22:55 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 26, 2007 2:24:33 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Olfactory receptor, family 5, subfamily H, member 6
| HGNCid = 14767
| Symbol = OR5H6
| AltSymbols =; OR3-11
| OMIM =
| ECnumber =
| Homologene = 84613
| MGIid = 3030021
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004984 |text = olfactory receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007608 |text = sensory perception of smell}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 79295
| Hs_Ensembl = ENSG00000197621
| Hs_RefseqProtein = NP_001005479
| Hs_RefseqmRNA = NM_001005479
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 99465819
| Hs_GenLoc_end = 99466796
| Hs_Uniprot = Q8NGV6
| Mm_EntrezGene = 258319
| Mm_Ensembl = ENSMUSG00000043357
| Mm_RefseqmRNA = NM_146322
| Mm_RefseqProtein = NP_666434
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 16
| Mm_GenLoc_start = 58978065
| Mm_GenLoc_end = 58978991
| Mm_Uniprot = Q8VEX6
}}
}}
'''Olfactory receptor, family 5, subfamily H, member 6''', also known as '''OR5H6''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OR5H6 olfactory receptor, family 5, subfamily H, member 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79295| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez">{{cite web | title = Entrez Gene: OR5H6 olfactory receptor, family 5, subfamily H, member 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79295| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Malnic B, Godfrey PA, Buck LB |title=The human olfactory receptor gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2584-9 |year= 2004 |pmid= 14983052 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on P2RY12... {November 26, 2007 2:21:35 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 26, 2007 2:22:34 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Purinergic receptor P2Y, G-protein coupled, 12
| HGNCid = 18124
| Symbol = P2RY12
| AltSymbols =; ADPG-R; HORK3; P2T(AC); P2Y(AC); P2Y(ADP); P2Y(cyc); P2Y12; SP1999
| OMIM = 600515
| ECnumber =
| Homologene = 11260
| MGIid = 1918089
| Function = {{GNF_GO|id=GO:0001609 |text = adenosine receptor activity, G-protein coupled}} {{GNF_GO|id=GO:0001621 |text = platelet ADP receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007188 |text = G-protein signaling, coupled to cAMP nucleotide second messenger}} {{GNF_GO|id=GO:0007599 |text = hemostasis}} {{GNF_GO|id=GO:0030168 |text = platelet activation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 64805
| Hs_Ensembl = ENSG00000169313
| Hs_RefseqProtein = NP_073625
| Hs_RefseqmRNA = NM_022788
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 152538066
| Hs_GenLoc_end = 152585234
| Hs_Uniprot = Q9H244
| Mm_EntrezGene = 70839
| Mm_Ensembl = ENSMUSG00000036353
| Mm_RefseqmRNA = NM_027571
| Mm_RefseqProtein = NP_081847
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 3
| Mm_GenLoc_start = 59304198
| Mm_GenLoc_end = 59350754
| Mm_Uniprot = Q546L4
}}
}}
'''Purinergic receptor P2Y, G-protein coupled, 12''', also known as '''P2RY12''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: P2RY12 purinergic receptor P2Y, G-protein coupled, 12| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64805| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelets aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Two transcript variants encoding the same isoform have been identified for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: P2RY12 purinergic receptor P2Y, G-protein coupled, 12| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64805| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Nicholas RA |title=Identification of the P2Y(12) receptor: a novel member of the P2Y family of receptors activated by extracellular nucleotides. |journal=Mol. Pharmacol. |volume=60 |issue= 3 |pages= 416-20 |year= 2001 |pmid= 11502870 |doi= }}
*{{cite journal | author=Ohlmann P, Laugwitz KL, Nürnberg B, ''et al.'' |title=The human platelet ADP receptor activates Gi2 proteins. |journal=Biochem. J. |volume=312 ( Pt 3) |issue= |pages= 775-9 |year= 1996 |pmid= 8554519 |doi= }}
*{{cite journal | author=Zhang FL, Luo L, Gustafson E, ''et al.'' |title=ADP is the cognate ligand for the orphan G protein-coupled receptor SP1999. |journal=J. Biol. Chem. |volume=276 |issue= 11 |pages= 8608-15 |year= 2001 |pmid= 11104774 |doi= 10.1074/jbc.M009718200 }}
*{{cite journal | author=Hollopeter G, Jantzen HM, Vincent D, ''et al.'' |title=Identification of the platelet ADP receptor targeted by antithrombotic drugs. |journal=Nature |volume=409 |issue= 6817 |pages= 202-7 |year= 2001 |pmid= 11196645 |doi= 10.1038/35051599 }}
*{{cite journal | author=Takasaki J, Kamohara M, Saito T, ''et al.'' |title=Molecular cloning of the platelet P2T(AC) ADP receptor: pharmacological comparison with another ADP receptor, the P2Y(1) receptor. |journal=Mol. Pharmacol. |volume=60 |issue= 3 |pages= 432-9 |year= 2001 |pmid= 11502873 |doi= }}
*{{cite journal | author=Takeda S, Kadowaki S, Haga T, ''et al.'' |title=Identification of G protein-coupled receptor genes from the human genome sequence. |journal=FEBS Lett. |volume=520 |issue= 1-3 |pages= 97-101 |year= 2002 |pmid= 12044878 |doi= }}
*{{cite journal | author=Simon J, Filippov AK, Göransson S, ''et al.'' |title=Characterization and channel coupling of the P2Y(12) nucleotide receptor of brain capillary endothelial cells. |journal=J. Biol. Chem. |volume=277 |issue= 35 |pages= 31390-400 |year= 2002 |pmid= 12080041 |doi= 10.1074/jbc.M110714200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Ding Z, Kim S, Dorsam RT, ''et al.'' |title=Inactivation of the human P2Y12 receptor by thiol reagents requires interaction with both extracellular cysteine residues, Cys17 and Cys270. |journal=Blood |volume=101 |issue= 10 |pages= 3908-14 |year= 2003 |pmid= 12560222 |doi= 10.1182/blood-2002-10-3027 }}
*{{cite journal | author=Cattaneo M, Zighetti ML, Lombardi R, ''et al.'' |title=Molecular bases of defective signal transduction in the platelet P2Y12 receptor of a patient with congenital bleeding. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 4 |pages= 1978-83 |year= 2003 |pmid= 12578987 |doi= 10.1073/pnas.0437879100 }}
*{{cite journal | author=Reséndiz JC, Feng S, Ji G, ''et al.'' |title=Purinergic P2Y12 receptor blockade inhibits shear-induced platelet phosphatidylinositol 3-kinase activation. |journal=Mol. Pharmacol. |volume=63 |issue= 3 |pages= 639-45 |year= 2003 |pmid= 12606772 |doi= }}
*{{cite journal | author=Jagroop IA, Burnstock G, Mikhailidis DP |title=Both the ADP receptors P2Y1 and P2Y12, play a role in controlling shape change in human platelets. |journal=Platelets |volume=14 |issue= 1 |pages= 15-20 |year= 2003 |pmid= 12623443 |doi= }}
*{{cite journal | author=Nesbitt WS, Giuliano S, Kulkarni S, ''et al.'' |title=Intercellular calcium communication regulates platelet aggregation and thrombus growth. |journal=J. Cell Biol. |volume=160 |issue= 7 |pages= 1151-61 |year= 2003 |pmid= 12668663 |doi= 10.1083/jcb.200207119 }}
*{{cite journal | author=Fontana P, Dupont A, Gandrille S, ''et al.'' |title=Adenosine diphosphate-induced platelet aggregation is associated with P2Y12 gene sequence variations in healthy subjects. |journal=Circulation |volume=108 |issue= 8 |pages= 989-95 |year= 2003 |pmid= 12912815 |doi= 10.1161/01.CIR.0000085073.69189.88 }}
*{{cite journal | author=Nylander S, Mattsson C, Ramström S, Lindahl TL |title=The relative importance of the ADP receptors, P2Y12 and P2Y1, in thrombin-induced platelet activation. |journal=Thromb. Res. |volume=111 |issue= 1-2 |pages= 65-73 |year= 2004 |pmid= 14644082 |doi= }}
*{{cite journal | author=Haserück N, Erl W, Pandey D, ''et al.'' |title=The plaque lipid lysophosphatidic acid stimulates platelet activation and platelet-monocyte aggregate formation in whole blood: involvement of P2Y1 and P2Y12 receptors. |journal=Blood |volume=103 |issue= 7 |pages= 2585-92 |year= 2004 |pmid= 14645014 |doi= 10.1182/blood-2003-04-1127 }}
*{{cite journal | author=Fontana P, Gaussem P, Aiach M, ''et al.'' |title=P2Y12 H2 haplotype is associated with peripheral arterial disease: a case-control study. |journal=Circulation |volume=108 |issue= 24 |pages= 2971-3 |year= 2004 |pmid= 14662702 |doi= 10.1161/01.CIR.0000106904.80795.35 }}
*{{cite journal | author=Soulet C, Sauzeau V, Plantavid M, ''et al.'' |title=Gi-dependent and -independent mechanisms downstream of the P2Y12 ADP-receptor. |journal=J. Thromb. Haemost. |volume=2 |issue= 1 |pages= 135-46 |year= 2004 |pmid= 14717977 |doi= }}
*{{cite journal | author=Dorsam RT, Tuluc M, Kunapuli SP |title=Role of protease-activated and ADP receptor subtypes in thrombin generation on human platelets. |journal=J. Thromb. Haemost. |volume=2 |issue= 5 |pages= 804-12 |year= 2005 |pmid= 15099288 |doi= 10.1111/j.1538-7836.2004.00692.x }}
}}
{{refend}}
{{protein-stub}}
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