- INFO: Beginning work on AP1B1... {December 18, 2007 12:40:40 AM PST}
- UPLOAD: Added new Image to wiki: {December 18, 2007 12:41:31 AM PST}
- REDIRECT: Protein Redirected to: AP1B1 {December 18, 2007 12:41:47 AM PST}
- CREATED: Created new protein page: AP1B1 {December 18, 2007 12:41:57 AM PST}
- INFO: Beginning work on AP2B1... {December 18, 2007 12:41:57 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein AP2B1 image.jpg {December 18, 2007 12:42:30 AM PST}
- REDIRECT: Protein Redirected to: AP2B1 {December 18, 2007 12:42:37 AM PST}
- CREATED: Created new protein page: AP2B1 {December 18, 2007 12:42:46 AM PST}
- INFO: Beginning work on CAMK1... {December 18, 2007 12:53:15 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein CAMK1 image.jpg {December 18, 2007 12:53:48 AM PST}
- REDIRECT: Protein Redirected to: CAMK1 {December 18, 2007 12:53:56 AM PST}
- CREATED: Created new protein page: CAMK1 {December 18, 2007 12:54:04 AM PST}
- INFO: Beginning work on CDC2L1... {December 18, 2007 12:42:46 AM PST}
- REDIRECT: Protein Redirected to: CDC2L1 {December 18, 2007 12:42:59 AM PST}
- CREATED: Created new protein page: CDC2L1 {December 18, 2007 12:43:07 AM PST}
- INFO: Beginning work on CGB... {December 18, 2007 12:43:07 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {December 18, 2007 12:43:38 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CGB_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1hcn.
| PDB = {{PDB2|1hcn}}, {{PDB2|1hrp}}, {{PDB2|1qfw}}
| Name = Chorionic gonadotropin, beta polypeptide
| HGNCid = 1886
| Symbol = CGB
| AltSymbols =; CGB3; hCGB; HCG; MGC119822
| OMIM = 118860
| ECnumber =
| Homologene = 37338
| MGIid =
| Function = {{GNF_GO|id=GO:0005179 |text = hormone activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process =
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1082
| Hs_Ensembl =
| Hs_RefseqProtein = NP_000728
| Hs_RefseqmRNA = NM_000737
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Chorionic gonadotropin, beta polypeptide''', also known as '''CGB''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CGB chorionic gonadotropin, beta polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1082| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 3 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene.<ref name="entrez">{{cite web | title = Entrez Gene: CGB chorionic gonadotropin, beta polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1082| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*cite journal | author=Bo M, Boime I |title=Identification of the transcriptionally active genes of the chorionic gonadotropin beta gene cluster in vivo. |journal=J. Biol. Chem. |volume=267 |issue= 5 |pages= 3179-84 |year= 1992 |pmid= 1371113 |doi=
*cite journal | author=Maruo T, Ladines-Llave CA, Matsuo H, ''et al.'' |title=A novel change in cytologic localization of human chorionic gonadotropin and human placental lactogen in first-trimester placenta in the course of gestation. |journal=Am. J. Obstet. Gynecol. |volume=167 |issue= 1 |pages= 217-22 |year= 1992 |pmid= 1442929 |doi=
*cite journal | author=Rothman PA, Chao VA, Taylor MR, ''et al.'' |title=Extraplacental human fetal tissues express mRNA transcripts encoding the human chorionic gonadotropin-beta subunit protein. |journal=Mol. Reprod. Dev. |volume=33 |issue= 1 |pages= 1-6 |year= 1992 |pmid= 1510839 |doi= 10.1002/mrd.1080330102
*{{cite journal | author=Weisshaar G, Hiyama J, Renwick AG |title=Site-specific N-glycosylation of human chorionic gonadotrophin--structural analysis of glycopeptides by one- and two-dimensional 1H NMR spectroscopy. |journal=Glycobiology |volume=1 |issue= 4 |pages= 393-404 |year= 1992 |pmid= 1820200 |doi= }}
*cite journal | author=Xie YB, Wang H, Segaloff DL |title=Extracellular domain of lutropin/choriogonadotropin receptor expressed in transfected cells binds choriogonadotropin with high affinity. |journal=J. Biol. Chem. |volume=265 |issue= 35 |pages= 21411-4 |year= 1991 |pmid= 2254302 |doi=
*{{cite journal | author=Policastro PF, Daniels-McQueen S, Carle G, Boime I |title=A map of the hCG beta-LH beta gene cluster. |journal=J. Biol. Chem. |volume=261 |issue= 13 |pages= 5907-16 |year= 1986 |pmid= 2422163 |doi= }}
*cite journal | author=Jameson JL, Lindell CM, Habener JF |title=Evolution of different transcriptional start sites in the human luteinizing hormone and chorionic gonadotropin beta-subunit genes. |journal=DNA |volume=5 |issue= 3 |pages= 227-34 |year= 1986 |pmid= 2424697 |doi=
*cite journal | author=Morrish DW, Marusyk H, Bhardwaj D |title=Ultrastructural localization of human placental lactogen in distinctive granules in human term placenta: comparison with granules containing human chorionic gonadotropin. |journal=J. Histochem. Cytochem. |volume=36 |issue= 2 |pages= 193-7 |year= 1988 |pmid= 2447154 |doi=
*{{cite journal | author=Otani T, Otani F, Krych M, ''et al.'' |title=Identification of a promoter region in the CG beta gene cluster. |journal=J. Biol. Chem. |volume=263 |issue= 15 |pages= 7322-9 |year= 1988 |pmid= 2452822 |doi= }}
*cite journal | author=Jameson JL, Lindell CM |title=Isolation and characterization of the human chorionic gonadotropin beta subunit (CG beta) gene cluster: regulation of transcriptionally active CG beta gene by cyclic AMP. |journal=Mol. Cell. Biol. |volume=8 |issue= 12 |pages= 5100-7 |year= 1989 |pmid= 2468994 |doi=
*cite journal | author=Matzuk MM, Keene JL, Boime I |title=Site specificity of the chorionic gonadotropin N-linked oligosaccharides in signal transduction. |journal=J. Biol. Chem. |volume=264 |issue= 5 |pages= 2409-14 |year= 1989 |pmid= 2536708 |doi=
*cite journal | author=Jameson JL, Lindell CM, Habener JF |title=Gonadotropin and thyrotropin alpha- and beta-subunit gene expression in normal and neoplastic tissues characterized using specific messenger ribonucleic acid hybridization probes. |journal=J. Clin. Endocrinol. Metab. |volume=64 |issue= 2 |pages= 319-27 |year= 1987 |pmid= 3098775 |doi=
*{{cite journal | author=Gaspard UJ, Hustin J, Reuter AM, ''et al.'' |title=Immunofluorescent localization of placental lactogen, chorionic gonadotrophin and its alpha and beta subunits in organ cultures of human placenta. |journal=Placenta |volume=1 |issue= 2 |pages= 135-44 |year= 1981 |pmid= 6160572 |doi= }}
*cite journal | author=Policastro P, Ovitt CE, Hoshina M, ''et al.'' |title=The beta subunit of human chorionic gonadotropin is encoded by multiple genes. |journal=J. Biol. Chem. |volume=258 |issue= 19 |pages= 11492-9 |year= 1983 |pmid= 6194155 |doi=
*cite journal | author=Keutmann HT, Ratanabanangkoon K, Pierce MW, ''et al.'' |title=Phosphorylation of human choriogonadotropin. Stoichiometry and sites of phosphate incorporation. |journal=J. Biol. Chem. |volume=258 |issue= 23 |pages= 14521-6 |year= 1984 |pmid= 6196363 |doi=
*cite journal | author=Julier C, Weil D, Couillin P, ''et al.'' |title=The beta chorionic gonadotropin-beta luteinizing gene cluster maps to human chromosome 19. |journal=Hum. Genet. |volume=67 |issue= 2 |pages= 174-7 |year= 1984 |pmid= 6204923 |doi=
*cite journal | author=Talmadge K, Boorstein WR, Fiddes JC |title=The human genome contains seven genes for the beta-subunit of chorionic gonadotropin but only one gene for the beta-subunit of luteinizing hormone. |journal=DNA |volume=2 |issue= 4 |pages= 281-9 |year= 1984 |pmid= 6319099 |doi=
*cite journal | author=Talmadge K, Vamvakopoulos NC, Fiddes JC |title=Evolution of the genes for the beta subunits of human chorionic gonadotropin and luteinizing hormone. |journal=Nature |volume=307 |issue= 5946 |pages= 37-40 |year= 1984 |pmid= 6690982 |doi=
*cite journal | author=Fiddes JC, Goodman HM |title=The cDNA for the beta-subunit of human chorionic gonadotropin suggests evolution of a gene by readthrough into the 3'-untranslated region. |journal=Nature |volume=286 |issue= 5774 |pages= 684-7 |year= 1980 |pmid= 6774259 |doi=
*cite journal | author=McGregor WG, Raymoure WJ, Kuhn RW, Jaffe RB |title=Fetal tissue can synthesize a placental hormone. Evidence for chorionic gonadotropin beta-subunit synthesis by human fetal kidney. |journal=J. Clin. Invest. |volume=68 |issue= 1 |pages= 306-9 |year= 1981 |pmid= 7251865 |doi=
}}
{{refend}}
{{protein-stub}}
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- CREATED: Created new protein page: CHRNB4 {December 18, 2007 12:44:21 AM PST}
- INFO: Beginning work on CLDN3... {December 18, 2007 12:45:32 AM PST}
- REDIRECT: Protein Redirected to: CLDN3 {December 18, 2007 12:46:26 AM PST}
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- INFO: Beginning work on CUL5... {December 18, 2007 12:49:18 AM PST}
- REDIRECT: Protein Redirected to: CUL5 {December 18, 2007 12:50:47 AM PST}
- CREATED: Created new protein page: CUL5 {December 18, 2007 12:50:57 AM PST}
- INFO: Beginning work on DBT... {December 18, 2007 12:46:34 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein DBT image.jpg {December 18, 2007 12:48:05 AM PST}
- REDIRECT: Protein Redirected to: DBT (gene) {December 18, 2007 12:48:12 AM PST}
- CREATED: Created new protein page: DBT (gene) {December 18, 2007 12:48:21 AM PST}
- INFO: Beginning work on FLOT1... {December 18, 2007 12:57:47 AM PST}
- REDIRECT: Protein Redirected to: FLOT1 {December 18, 2007 12:58:59 AM PST}
- CREATED: Created new protein page: FLOT1 {December 18, 2007 12:59:08 AM PST}
- INFO: Beginning work on FXR1... {December 18, 2007 12:50:57 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein FXR1 image.jpg {December 18, 2007 12:52:11 AM PST}
- REDIRECT: Protein Redirected to: FXR1 {December 18, 2007 12:52:18 AM PST}
- CREATED: Created new protein page: FXR1 {December 18, 2007 12:52:28 AM PST}
- INFO: Beginning work on M6PRBP1... {December 18, 2007 12:59:08 AM PST}
- REDIRECT: Protein Redirected to: M6PRBP1 {December 18, 2007 12:59:45 AM PST}
- CREATED: Created new protein page: M6PRBP1 {December 18, 2007 12:59:54 AM PST}
- INFO: Beginning work on NOG... {December 18, 2007 12:57:15 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein NOG image.jpg {December 18, 2007 12:57:31 AM PST}
- REDIRECT: Protein Redirected to: NOG (gene) {December 18, 2007 12:57:38 AM PST}
- CREATED: Created new protein page: NOG (gene) {December 18, 2007 12:57:47 AM PST}
- INFO: Beginning work on NOLC1... {December 18, 2007 12:55:48 AM PST}
- REDIRECT: Protein Redirected to: NOLC1 {December 18, 2007 12:57:06 AM PST}
- CREATED: Created new protein page: NOLC1 {December 18, 2007 12:57:15 AM PST}
- INFO: Beginning work on PLK3... {December 18, 2007 12:44:21 AM PST}
- REDIRECT: Protein Redirected to: PLK3 {December 18, 2007 12:45:15 AM PST}
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- REDIRECT: Protein Redirected to: PPP1R1B {December 18, 2007 1:08:35 AM PST}
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- REDIRECT: Protein Redirected to: TNFRSF10C {December 18, 2007 12:55:39 AM PST}
- CREATED: Created new protein page: TNFRSF10C {December 18, 2007 12:55:48 AM PST}
- INFO: Beginning work on TNFRSF6B... {December 18, 2007 12:54:04 AM PST}
- REDIRECT: Protein Redirected to: TNFRSF6B {December 18, 2007 12:54:19 AM PST}
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- INFO: Beginning work on UBA52... {December 18, 2007 12:48:21 AM PST}
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- REDIRECT: Protein Redirected to: UBA52 {December 18, 2007 12:49:10 AM PST}
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- INFO: Beginning work on USP9Y... {December 18, 2007 12:52:28 AM PST}
- REDIRECT: Protein Redirected to: USP9Y {December 18, 2007 12:53:06 AM PST}
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end log.