- INFO: Beginning work on ANP32A... {December 20, 2007 2:38:15 PM PST}
- REDIRECT: Protein Redirected to: ANP32A {December 20, 2007 2:38:43 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {December 20, 2007 2:38:53 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {December 20, 2007 2:38:53 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {December 20, 2007 2:38:53 PM PST}
- UPDATED: Updated protein page: ANP32A {December 20, 2007 2:39:01 PM PST}
- INFO: Beginning work on BAT3... {December 20, 2007 2:36:20 PM PST}
- REDIRECT: Protein Redirected to: BAT3 {December 20, 2007 2:36:40 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {December 20, 2007 2:36:41 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {December 20, 2007 2:36:41 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {December 20, 2007 2:36:41 PM PST}
- UPDATED: Updated protein page: BAT3 {December 20, 2007 2:36:48 PM PST}
- INFO: Beginning work on CASP6... {December 20, 2007 2:35:50 PM PST}
- REDIRECT: Protein Redirected to: Caspase 6 {December 20, 2007 2:36:10 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {December 20, 2007 2:36:13 PM PST}
- SKIP SUMMARY: SKIPPING Summary, No Errors. {December 20, 2007 2:36:13 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {December 20, 2007 2:36:13 PM PST}
- UPDATED: Updated protein page: Caspase 6 {December 20, 2007 2:36:20 PM PST}
- INFO: Beginning work on CDC45L... {December 20, 2007 2:40:10 PM PST}
- REDIRECT: Protein Redirected to: CDC45L {December 20, 2007 2:40:49 PM PST}
- CREATED: Created new protein page: CDC45L {December 20, 2007 2:41:00 PM PST}
- INFO: Beginning work on CDC7... {December 20, 2007 2:39:36 PM PST}
- REDIRECT: Protein Redirected to: CDC7 {December 20, 2007 2:39:53 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {December 20, 2007 2:40:04 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {December 20, 2007 2:40:04 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {December 20, 2007 2:40:04 PM PST}
- UPDATED: Updated protein page: CDC7 {December 20, 2007 2:40:10 PM PST}
- INFO: Beginning work on CDT1... {December 20, 2007 2:44:28 PM PST}
- REDIRECT: Protein Redirected to: CDT1 {December 20, 2007 2:44:47 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {December 20, 2007 2:44:50 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {December 20, 2007 2:44:50 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {December 20, 2007 2:44:50 PM PST}
- UPDATED: Updated protein page: CDT1 {December 20, 2007 2:44:56 PM PST}
- INFO: Beginning work on COIL... {December 20, 2007 2:39:01 PM PST}
- REDIRECT: Protein Redirected to: COIL (gene) {December 20, 2007 2:39:27 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {December 20, 2007 2:39:30 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {December 20, 2007 2:39:30 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {December 20, 2007 2:39:30 PM PST}
- UPDATED: Updated protein page: COIL (gene) {December 20, 2007 2:39:36 PM PST}
- INFO: Beginning work on EPPK1... {December 20, 2007 2:44:56 PM PST}
- REDIRECT: Protein Redirected to: EPPK1 {December 20, 2007 2:45:10 PM PST}
- CREATED: Created new protein page: EPPK1 {December 20, 2007 2:45:19 PM PST}
- INFO: Beginning work on GEMIN6... {December 20, 2007 2:42:57 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein GEMIN6 image.jpg {December 20, 2007 2:43:32 PM PST}
- REDIRECT: Protein Redirected to: GEMIN6 {December 20, 2007 2:43:39 PM PST}
- CREATED: Created new protein page: GEMIN6 {December 20, 2007 2:43:48 PM PST}
- INFO: Beginning work on GEMIN7... {December 20, 2007 2:41:52 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein GEMIN7 image.jpg {December 20, 2007 2:42:41 PM PST}
- REDIRECT: Protein Redirected to: GEMIN7 {December 20, 2007 2:42:48 PM PST}
- CREATED: Created new protein page: GEMIN7 {December 20, 2007 2:42:57 PM PST}
- INFO: Beginning work on HIST1H2BC... {December 20, 2007 2:41:00 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein HIST1H2BC image.jpg {December 20, 2007 2:41:36 PM PST}
- REDIRECT: Protein Redirected to: HIST1H2BC {December 20, 2007 2:41:44 PM PST}
- CREATED: Created new protein page: HIST1H2BC {December 20, 2007 2:41:52 PM PST}
- INFO: Beginning work on JTV1... {December 20, 2007 2:36:48 PM PST}
- REDIRECT: Protein Redirected to: JTV1 {December 20, 2007 2:38:04 PM PST}
- CREATED: Created new protein page: JTV1 {December 20, 2007 2:38:15 PM PST}
- INFO: Beginning work on NANOG... {December 20, 2007 2:43:48 PM PST}
- REDIRECT: Page directory gave bad page (NANOG (medicine)). Continuing with search.. Please correct entry: <79923,NANOG (medicine)>. {December 20, 2007 2:44:24 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {December 20, 2007 2:44:28 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Nanog homeobox
| HGNCid = 20857
| Symbol = NANOG
| AltSymbols =;
| OMIM = 607937
| ECnumber =
| Homologene = 78027
| MGIid = 1919200
| GeneAtlas_image1 = PBB_GE_NANOG_220184_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0009790 |text = embryonic development}} {{GNF_GO|id=GO:0045595 |text = regulation of cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 79923
| Hs_Ensembl = ENSG00000111704
| Hs_RefseqProtein = NP_079141
| Hs_RefseqmRNA = NM_024865
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 7833330
| Hs_GenLoc_end = 7839738
| Hs_Uniprot = Q9H9S0
| Mm_EntrezGene = 71950
| Mm_Ensembl =
| Mm_RefseqmRNA = XM_132755
| Mm_RefseqProtein = XP_132755
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Nanog homeobox''', also known as '''NANOG''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NANOG Nanog homeobox| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79923| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Cavaleri F, Schöler HR |title=Nanog: a new recruit to the embryonic stem cell orchestra. |journal=Cell |volume=113 |issue= 5 |pages= 551-2 |year= 2003 |pmid= 12787492 |doi= }}
*{{cite journal | author=Constantinescu S |title=Stemness, fusion and renewal of hematopoietic and embryonic stem cells. |journal=J. Cell. Mol. Med. |volume=7 |issue= 2 |pages= 103-12 |year= 2004 |pmid= 12927049 |doi= }}
*{{cite journal | author=Pan G, Thomson JA |title=Nanog and transcriptional networks in embryonic stem cell pluripotency. |journal=Cell Res. |volume=17 |issue= 1 |pages= 42-9 |year= 2007 |pmid= 17211451 |doi= 10.1038/sj.cr.7310125 }}
*{{cite journal | author=Mitsui K, Tokuzawa Y, Itoh H, ''et al.'' |title=The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. |journal=Cell |volume=113 |issue= 5 |pages= 631-42 |year= 2003 |pmid= 12787504 |doi= }}
*{{cite journal | author=Chambers I, Colby D, Robertson M, ''et al.'' |title=Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. |journal=Cell |volume=113 |issue= 5 |pages= 643-55 |year= 2003 |pmid= 12787505 |doi= }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Clark AT, Rodriguez RT, Bodnar MS, ''et al.'' |title=Human STELLAR, NANOG, and GDF3 genes are expressed in pluripotent cells and map to chromosome 12p13, a hotspot for teratocarcinoma. |journal=Stem Cells |volume=22 |issue= 2 |pages= 169-79 |year= 2004 |pmid= 14990856 |doi= }}
*{{cite journal | author=Hart AH, Hartley L, Ibrahim M, Robb L |title=Identification, cloning and expression analysis of the pluripotency promoting Nanog genes in mouse and human. |journal=Dev. Dyn. |volume=230 |issue= 1 |pages= 187-98 |year= 2004 |pmid= 15108323 |doi= 10.1002/dvdy.20034 }}
*{{cite journal | author=Booth HA, Holland PW |title=Eleven daughters of NANOG. |journal=Genomics |volume=84 |issue= 2 |pages= 229-38 |year= 2005 |pmid= 15233988 |doi= 10.1016/j.ygeno.2004.02.014 }}
*{{cite journal | author=Hatano SY, Tada M, Kimura H, ''et al.'' |title=Pluripotential competence of cells associated with Nanog activity. |journal=Mech. Dev. |volume=122 |issue= 1 |pages= 67-79 |year= 2005 |pmid= 15582778 |doi= 10.1016/j.mod.2004.08.008 }}
*{{cite journal | author=Deb-Rinker P, Ly D, Jezierski A, ''et al.'' |title=Sequential DNA methylation of the Nanog and Oct-4 upstream regions in human NT2 cells during neuronal differentiation. |journal=J. Biol. Chem. |volume=280 |issue= 8 |pages= 6257-60 |year= 2005 |pmid= 15615706 |doi= 10.1074/jbc.C400479200 }}
*{{cite journal | author=Zaehres H, Lensch MW, Daheron L, ''et al.'' |title=High-efficiency RNA interference in human embryonic stem cells. |journal=Stem Cells |volume=23 |issue= 3 |pages= 299-305 |year= 2005 |pmid= 15749924 |doi= 10.1634/stemcells.2004-0252 }}
*{{cite journal | author=Hoei-Hansen CE, Almstrup K, Nielsen JE, ''et al.'' |title=Stem cell pluripotency factor NANOG is expressed in human fetal gonocytes, testicular carcinoma in situ and germ cell tumours. |journal=Histopathology |volume=47 |issue= 1 |pages= 48-56 |year= 2005 |pmid= 15982323 |doi= 10.1111/j.1365-2559.2005.02182.x }}
*{{cite journal | author=Hyslop L, Stojkovic M, Armstrong L, ''et al.'' |title=Downregulation of NANOG induces differentiation of human embryonic stem cells to extraembryonic lineages. |journal=Stem Cells |volume=23 |issue= 8 |pages= 1035-43 |year= 2006 |pmid= 15983365 |doi= 10.1634/stemcells.2005-0080 }}
*{{cite journal | author=Oh JH, Do HJ, Yang HM, ''et al.'' |title=Identification of a putative transactivation domain in human Nanog. |journal=Exp. Mol. Med. |volume=37 |issue= 3 |pages= 250-4 |year= 2005 |pmid= 16000880 |doi= }}
*{{cite journal | author=Boyer LA, Lee TI, Cole MF, ''et al.'' |title=Core transcriptional regulatory circuitry in human embryonic stem cells. |journal=Cell |volume=122 |issue= 6 |pages= 947-56 |year= 2005 |pmid= 16153702 |doi= 10.1016/j.cell.2005.08.020 }}
*{{cite journal | author=Kim JS, Kim J, Kim BS, ''et al.'' |title=Identification and functional characterization of an alternative splice variant within the fourth exon of human nanog. |journal=Exp. Mol. Med. |volume=37 |issue= 6 |pages= 601-7 |year= 2006 |pmid= 16391521 |doi= }}
*{{cite journal | author=Darr H, Mayshar Y, Benvenisty N |title=Overexpression of NANOG in human ES cells enables feeder-free growth while inducing primitive ectoderm features. |journal=Development |volume=133 |issue= 6 |pages= 1193-201 |year= 2006 |pmid= 16501172 |doi= 10.1242/dev.02286 }}
}}
{{refend}}
{{protein-stub}}
end log.
