- INFO: Beginning work on AATF... {December 20, 2007 12:22:52 PM PST}
- REDIRECT: Protein Redirected to: AATF (gene) {December 20, 2007 12:23:19 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {December 20, 2007 12:23:22 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {December 20, 2007 12:23:22 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {December 20, 2007 12:23:22 PM PST}
- UPDATED: Updated protein page: AATF (gene) {December 20, 2007 12:23:27 PM PST}
- INFO: Beginning work on ANXA2... {December 20, 2007 12:16:02 PM PST}
- REDIRECT: Protein Redirected to: Annexin A2 {December 20, 2007 12:16:59 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {December 20, 2007 12:17:01 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {December 20, 2007 12:17:01 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {December 20, 2007 12:17:01 PM PST}
- UPDATED: Updated protein page: Annexin A2 {December 20, 2007 12:17:07 PM PST}
- INFO: Beginning work on ANXA3... {December 20, 2007 12:17:07 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein ANXA3 image.jpg {December 20, 2007 12:17:52 PM PST}
- REDIRECT: Protein Redirected to: ANXA3 {December 20, 2007 12:17:59 PM PST}
- CREATED: Created new protein page: ANXA3 {December 20, 2007 12:18:08 PM PST}
- INFO: Beginning work on DAZAP1... {December 20, 2007 12:21:45 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein DAZAP1 image.jpg {December 20, 2007 12:22:37 PM PST}
- REDIRECT: Protein Redirected to: DAZAP1 {December 20, 2007 12:22:44 PM PST}
- CREATED: Created new protein page: DAZAP1 {December 20, 2007 12:22:52 PM PST}
- INFO: Beginning work on GDF9... {December 20, 2007 12:18:08 PM PST}
- REDIRECT: Page directory gave bad page (Growth differentiation factor-9). Continuing with search.. Please correct entry: <2661,Growth differentiation factor-9>. {December 20, 2007 12:18:52 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {December 20, 2007 12:18:56 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Growth differentiation factor 9
| HGNCid = 4224
| Symbol = GDF9
| AltSymbols =;
| OMIM = 601918
| ECnumber =
| Homologene = 3851
| MGIid = 95692
| GeneAtlas_image1 = PBB_GE_GDF9_221314_at_tn.png
| Function = {{GNF_GO|id=GO:0005125 |text = cytokine activity}} {{GNF_GO|id=GO:0008083 |text = growth factor activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0007179 |text = transforming growth factor beta receptor signaling pathway}} {{GNF_GO|id=GO:0007292 |text = female gamete generation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2661
| Hs_Ensembl = ENSG00000164404
| Hs_RefseqProtein = NP_005251
| Hs_RefseqmRNA = NM_005260
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 132224772
| Hs_GenLoc_end = 132228824
| Hs_Uniprot = O60383
| Mm_EntrezGene = 14566
| Mm_Ensembl = ENSMUSG00000018238
| Mm_RefseqmRNA = NM_008110
| Mm_RefseqProtein = NP_032136
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 53276791
| Mm_GenLoc_end = 53281323
| Mm_Uniprot = Q3UWR9
}}
}}
'''Growth differentiation factor 9''', also known as '''GDF9''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GDF9 growth differentiation factor 9| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2661| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Growth factors synthesized by ovarian somatic cells directly affect oocyte growth and function. Growth differentiation factor-9 (GDF9) is expressed in oocytes and is thought to be required for ovarian folliculogenesis. GDF9 is a member of the transforming growth factor-beta superfamily.<ref name="entrez">{{cite web | title = Entrez Gene: GDF9 growth differentiation factor 9| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2661| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=McGrath SA, Esquela AF, Lee SJ |title=Oocyte-specific expression of growth/differentiation factor-9. |journal=Mol. Endocrinol. |volume=9 |issue= 1 |pages= 131-6 |year= 1995 |pmid= 7760846 |doi= }}
*{{cite journal | author=McPherron AC, Lee SJ |title=GDF-3 and GDF-9: two new members of the transforming growth factor-beta superfamily containing a novel pattern of cysteines. |journal=J. Biol. Chem. |volume=268 |issue= 5 |pages= 3444-9 |year= 1993 |pmid= 8429021 |doi= }}
*{{cite journal | author=Dong J, Albertini DF, Nishimori K, ''et al.'' |title=Growth differentiation factor-9 is required during early ovarian folliculogenesis. |journal=Nature |volume=383 |issue= 6600 |pages= 531-5 |year= 1996 |pmid= 8849725 |doi= 10.1038/383531a0 }}
*{{cite journal | author=Aaltonen J, Laitinen MP, Vuojolainen K, ''et al.'' |title=Human growth differentiation factor 9 (GDF-9) and its novel homolog GDF-9B are expressed in oocytes during early folliculogenesis. |journal=J. Clin. Endocrinol. Metab. |volume=84 |issue= 8 |pages= 2744-50 |year= 1999 |pmid= 10443672 |doi= }}
*{{cite journal | author=Gilboa L, Nohe A, Geissendörfer T, ''et al.'' |title=Bone morphogenetic protein receptor complexes on the surface of live cells: a new oligomerization mode for serine/threonine kinase receptors. |journal=Mol. Biol. Cell |volume=11 |issue= 3 |pages= 1023-35 |year= 2000 |pmid= 10712517 |doi= }}
*{{cite journal | author=Vitt UA, Mazerbourg S, Klein C, Hsueh AJ |title=Bone morphogenetic protein receptor type II is a receptor for growth differentiation factor-9. |journal=Biol. Reprod. |volume=67 |issue= 2 |pages= 473-80 |year= 2003 |pmid= 12135884 |doi= }}
*{{cite journal | author=Liao WX, Moore RK, Otsuka F, Shimasaki S |title=Effect of intracellular interactions on the processing and secretion of bone morphogenetic protein-15 (BMP-15) and growth and differentiation factor-9. Implication of the aberrant ovarian phenotype of BMP-15 mutant sheep. |journal=J. Biol. Chem. |volume=278 |issue= 6 |pages= 3713-9 |year= 2003 |pmid= 12446716 |doi= 10.1074/jbc.M210598200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Liao WX, Moore RK, Shimasaki S |title=Functional and molecular characterization of naturally occurring mutations in the oocyte-secreted factors bone morphogenetic protein-15 and growth and differentiation factor-9. |journal=J. Biol. Chem. |volume=279 |issue= 17 |pages= 17391-6 |year= 2004 |pmid= 14970198 |doi= 10.1074/jbc.M401050200 }}
*{{cite journal | author=Schmutz J, Martin J, Terry A, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 5. |journal=Nature |volume=431 |issue= 7006 |pages= 268-74 |year= 2004 |pmid= 15372022 |doi= 10.1038/nature02919 }}
*{{cite journal | author=Goehler H, Lalowski M, Stelzl U, ''et al.'' |title=A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease. |journal=Mol. Cell |volume=15 |issue= 6 |pages= 853-65 |year= 2004 |pmid= 15383276 |doi= 10.1016/j.molcel.2004.09.016 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Stelzl U, Worm U, Lalowski M, ''et al.'' |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957-68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 }}
*{{cite journal | author=Dixit H, Rao LK, Padmalatha V, ''et al.'' |title=Mutational screening of the coding region of growth differentiation factor 9 gene in Indian women with ovarian failure. |journal=Menopause (New York, N.Y.) |volume=12 |issue= 6 |pages= 749-54 |year= 2007 |pmid= 16278619 |doi= 10.1097/01.gme.0000184424.96437.7a }}
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal | author=Laissue P, Christin-Maitre S, Touraine P, ''et al.'' |title=Mutations and sequence variants in GDF9 and BMP15 in patients with premature ovarian failure. |journal=Eur. J. Endocrinol. |volume=154 |issue= 5 |pages= 739-44 |year= 2006 |pmid= 16645022 |doi= 10.1530/eje.1.02135 }}
*{{cite journal | author=Palmer JS, Zhao ZZ, Hoekstra C, ''et al.'' |title=Novel variants in growth differentiation factor 9 in mothers of dizygotic twins. |journal=J. Clin. Endocrinol. Metab. |volume=91 |issue= 11 |pages= 4713-6 |year= 2007 |pmid= 16954162 |doi= 10.1210/jc.2006-0970 }}
*{{cite journal | author=Chand AL, Ponnampalam AP, Harris SE, ''et al.'' |title=Mutational analysis of BMP15 and GDF9 as candidate genes for premature ovarian failure. |journal=Fertil. Steril. |volume=86 |issue= 4 |pages= 1009-12 |year= 2006 |pmid= 17027369 |doi= 10.1016/j.fertnstert.2006.02.107 }}
*{{cite journal | author=Kovanci E, Rohozinski J, Simpson JL, ''et al.'' |title=Growth differentiating factor-9 mutations may be associated with premature ovarian failure. |journal=Fertil. Steril. |volume=87 |issue= 1 |pages= 143-6 |year= 2007 |pmid= 17156781 |doi= 10.1016/j.fertnstert.2006.05.079 }}
*{{cite journal | author=Hanavadi S, Martin TA, Watkins G, ''et al.'' |title=The role of growth differentiation factor-9 (GDF-9) and its analog, GDF-9b/BMP-15, in human breast cancer. |journal=Ann. Surg. Oncol. |volume=14 |issue= 7 |pages= 2159-66 |year= 2007 |pmid= 17453295 |doi= 10.1245/s10434-007-9397-5 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GOT2... {December 20, 2007 12:18:56 PM PST}
- REDIRECT: Protein Redirected to: GOT2 {December 20, 2007 12:19:22 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {December 20, 2007 12:19:25 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {December 20, 2007 12:19:25 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {December 20, 2007 12:19:25 PM PST}
- UPDATED: Updated protein page: GOT2 {December 20, 2007 12:19:31 PM PST}
- INFO: Beginning work on GRB7... {December 20, 2007 12:19:31 PM PST}
- REDIRECT: Page directory gave bad page (GRB7). Continuing with search.. Please correct entry: <2886,GRB7>. {December 20, 2007 12:20:02 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {December 20, 2007 12:20:05 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_GRB7_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1mw4.
| PDB = {{PDB2|1mw4}}, {{PDB2|1wgr}}
| Name = Growth factor receptor-bound protein 7
| HGNCid = 4567
| Symbol = GRB7
| AltSymbols =;
| OMIM = 601522
| ECnumber =
| Homologene = 3881
| MGIid = 102683
| GeneAtlas_image1 = PBB_GE_GRB7_210761_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005070 |text = SH3/SH2 adaptor activity}}
| Component =
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007173 |text = epidermal growth factor receptor signaling pathway}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2886
| Hs_Ensembl = ENSG00000141738
| Hs_RefseqProtein = NP_001025173
| Hs_RefseqmRNA = NM_001030002
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 35147713
| Hs_GenLoc_end = 35157061
| Hs_Uniprot = Q14451
| Mm_EntrezGene = 14786
| Mm_Ensembl = ENSMUSG00000019312
| Mm_RefseqmRNA = NM_010346
| Mm_RefseqProtein = NP_034476
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 98262929
| Mm_GenLoc_end = 98271460
| Mm_Uniprot = Q3TH55
}}
}}
'''Growth factor receptor-bound protein 7''', also known as '''GRB7''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GRB7 growth factor receptor-bound protein 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2886| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Alternative splicing results in multiple transcript variants encoding different isoforms, although the full-length natures of only two of the variants have been determined to date.<ref name="entrez">{{cite web | title = Entrez Gene: GRB7 growth factor receptor-bound protein 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2886| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Han DC, Shen TL, Guan JL |title=The Grb7 family proteins: structure, interactions with other signaling molecules and potential cellular functions. |journal=Oncogene |volume=20 |issue= 44 |pages= 6315-21 |year= 2001 |pmid= 11607834 |doi= 10.1038/sj.onc.1204775 }}
*{{cite journal | author=Margolis B, Silvennoinen O, Comoglio F, ''et al.'' |title=High-efficiency expression/cloning of epidermal growth factor-receptor-binding proteins with Src homology 2 domains. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 19 |pages= 8894-8 |year= 1992 |pmid= 1409582 |doi= }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
*{{cite journal | author=Pandey A, Liu X, Dixon JE, ''et al.'' |title=Direct association between the Ret receptor tyrosine kinase and the Src homology 2-containing adapter protein Grb7. |journal=J. Biol. Chem. |volume=271 |issue= 18 |pages= 10607-10 |year= 1996 |pmid= 8631863 |doi= }}
*{{cite journal | author=Yokote K, Margolis B, Heldin CH, Claesson-Welsh L |title=Grb7 is a downstream signaling component of platelet-derived growth factor alpha- and beta-receptors. |journal=J. Biol. Chem. |volume=271 |issue= 48 |pages= 30942-9 |year= 1997 |pmid= 8940081 |doi= }}
*{{cite journal | author=Tanaka S, Mori M, Akiyoshi T, ''et al.'' |title=Coexpression of Grb7 with epidermal growth factor receptor or Her2/erbB2 in human advanced esophageal carcinoma. |journal=Cancer Res. |volume=57 |issue= 1 |pages= 28-31 |year= 1997 |pmid= 8988034 |doi= }}
*{{cite journal | author=Janes PW, Lackmann M, Church WB, ''et al.'' |title=Structural determinants of the interaction between the erbB2 receptor and the Src homology 2 domain of Grb7. |journal=J. Biol. Chem. |volume=272 |issue= 13 |pages= 8490-7 |year= 1997 |pmid= 9079677 |doi= }}
*{{cite journal | author=Kishi T, Sasaki H, Akiyama N, ''et al.'' |title=Molecular cloning of human GRB-7 co-amplified with CAB1 and c-ERBB-2 in primary gastric cancer. |journal=Biochem. Biophys. Res. Commun. |volume=232 |issue= 1 |pages= 5-9 |year= 1997 |pmid= 9125150 |doi= 10.1006/bbrc.1997.6218 }}
*{{cite journal | author=Dong LQ, Du H, Porter SG, ''et al.'' |title=Cloning, chromosome localization, expression, and characterization of an Src homology 2 and pleckstrin homology domain-containing insulin receptor binding protein hGrb10gamma. |journal=J. Biol. Chem. |volume=272 |issue= 46 |pages= 29104-12 |year= 1997 |pmid= 9360986 |doi= }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal | author=Fiddes RJ, Campbell DH, Janes PW, ''et al.'' |title=Analysis of Grb7 recruitment by heregulin-activated erbB receptors reveals a novel target selectivity for erbB3. |journal=J. Biol. Chem. |volume=273 |issue= 13 |pages= 7717-24 |year= 1998 |pmid= 9516479 |doi= }}
*{{cite journal | author=Tanaka S, Mori M, Akiyoshi T, ''et al.'' |title=A novel variant of human Grb7 is associated with invasive esophageal carcinoma. |journal=J. Clin. Invest. |volume=102 |issue= 4 |pages= 821-7 |year= 1998 |pmid= 9710451 |doi= }}
*{{cite journal | author=Thömmes K, Lennartsson J, Carlberg M, Rönnstrand L |title=Identification of Tyr-703 and Tyr-936 as the primary association sites for Grb2 and Grb7 in the c-Kit/stem cell factor receptor. |journal=Biochem. J. |volume=341 ( Pt 1) |issue= |pages= 211-6 |year= 1999 |pmid= 10377264 |doi= }}
*{{cite journal | author=Han DC, Guan JL |title=Association of focal adhesion kinase with Grb7 and its role in cell migration. |journal=J. Biol. Chem. |volume=274 |issue= 34 |pages= 24425-30 |year= 1999 |pmid= 10446223 |doi= }}
*{{cite journal | author=Jones N, Master Z, Jones J, ''et al.'' |title=Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration. |journal=J. Biol. Chem. |volume=274 |issue= 43 |pages= 30896-905 |year= 1999 |pmid= 10521483 |doi= }}
*{{cite journal | author=Vayssière B, Zalcman G, Mahé Y, ''et al.'' |title=Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family. |journal=FEBS Lett. |volume=467 |issue= 1 |pages= 91-6 |year= 2000 |pmid= 10664463 |doi= }}
*{{cite journal | author=Kasus-Jacobi A, Béréziat V, Perdereau D, ''et al.'' |title=Evidence for an interaction between the insulin receptor and Grb7. A role for two of its binding domains, PIR and SH2. |journal=Oncogene |volume=19 |issue= 16 |pages= 2052-9 |year= 2000 |pmid= 10803466 |doi= 10.1038/sj.onc.1203469 }}
*{{cite journal | author=Han DC, Shen TL, Guan JL |title=Role of Grb7 targeting to focal contacts and its phosphorylation by focal adhesion kinase in regulation of cell migration. |journal=J. Biol. Chem. |volume=275 |issue= 37 |pages= 28911-7 |year= 2000 |pmid= 10893408 |doi= 10.1074/jbc.M001997200 }}
*{{cite journal | author=Lee H, Volonte D, Galbiati F, ''et al.'' |title=Constitutive and growth factor-regulated phosphorylation of caveolin-1 occurs at the same site (Tyr-14) in vivo: identification of a c-Src/Cav-1/Grb7 signaling cassette. |journal=Mol. Endocrinol. |volume=14 |issue= 11 |pages= 1750-75 |year= 2001 |pmid= 11075810 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GTF2H2... {December 20, 2007 12:20:56 PM PST}
- REDIRECT: Protein Redirected to: GTF2H2 {December 20, 2007 12:21:36 PM PST}
- CREATED: Created new protein page: GTF2H2 {December 20, 2007 12:21:45 PM PST}
- INFO: Beginning work on LSM1... {December 20, 2007 12:24:03 PM PST}
- REDIRECT: Protein Redirected to: LSM1 {December 20, 2007 12:24:47 PM PST}
- CREATED: Created new protein page: LSM1 {December 20, 2007 12:24:55 PM PST}
- INFO: Beginning work on LSM3... {December 20, 2007 12:24:55 PM PST}
- REDIRECT: Protein Redirected to: LSM3 {December 20, 2007 12:25:11 PM PST}
- CREATED: Created new protein page: LSM3 {December 20, 2007 12:25:20 PM PST}
- INFO: Beginning work on MSH6... {December 20, 2007 12:20:05 PM PST}
- REDIRECT: Protein Redirected to: MSH6 {December 20, 2007 12:20:46 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {December 20, 2007 12:20:48 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {December 20, 2007 12:20:48 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {December 20, 2007 12:20:48 PM PST}
- UPDATED: Updated protein page: MSH6 {December 20, 2007 12:20:56 PM PST}
- INFO: Beginning work on PELP1... {December 20, 2007 12:23:27 PM PST}
- REDIRECT: Page directory gave bad page (PELP-1). Continuing with search.. Please correct entry: <27043,PELP-1>. {December 20, 2007 12:23:54 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {December 20, 2007 12:24:03 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Proline, glutamic acid and leucine rich protein 1
| HGNCid = 30134
| Symbol = PELP1
| AltSymbols =; P160; HMX3; MNAR
| OMIM = 609455
| ECnumber =
| Homologene = 8664
| MGIid = 1922523
| Function =
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 27043
| Hs_Ensembl =
| Hs_RefseqProtein = NP_055204
| Hs_RefseqmRNA = NM_014389
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 75273
| Mm_Ensembl = ENSMUSG00000018921
| Mm_RefseqmRNA = NM_029231
| Mm_RefseqProtein = NP_083507
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 70209079
| Mm_GenLoc_end = 70226226
| Mm_Uniprot = Q9DBD5
}}
}}
'''Proline, glutamic acid and leucine rich protein 1''', also known as '''PELP1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PELP1 proline, glutamic acid and leucine rich protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27043| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = PELP1 is a coactivator of estrogen receptor (see ESR1; MIM 133430)-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors (Choi et al., 2004).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: PELP1 proline, glutamic acid and leucine rich protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27043| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Rajhans R, Vadlamudi RK |title=Comprehensive analysis of recent biochemical and biologic findings regarding a newly discovered protein-PELP1/MNAR. |journal=Clin. Exp. Metastasis |volume=23 |issue= 1 |pages= 1-7 |year= 2007 |pmid= 16826428 |doi= 10.1007/s10585-006-9019-9 }}
*{{cite journal | author=Nair S, Vadlamudi RK |title=Emerging significance of ER-coregulator PELP1/MNAR in cancer. |journal=Histol. Histopathol. |volume=22 |issue= 1 |pages= 91-6 |year= 2007 |pmid= 17128415 |doi= }}
*{{cite journal | author=Vadlamudi RK, Wang RA, Mazumdar A, ''et al.'' |title=Molecular cloning and characterization of PELP1, a novel human coregulator of estrogen receptor alpha. |journal=J. Biol. Chem. |volume=276 |issue= 41 |pages= 38272-9 |year= 2001 |pmid= 11481323 |doi= 10.1074/jbc.M103783200 }}
*{{cite journal | author=Andersen JS, Lyon CE, Fox AH, ''et al.'' |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1-11 |year= 2002 |pmid= 11790298 |doi= }}
*{{cite journal | author=Barkhem T, Haldosén LA, Gustafsson JA, Nilsson S |title=Transcriptional synergism on the pS2 gene promoter between a p160 coactivator and estrogen receptor-alpha depends on the coactivator subtype, the type of estrogen response element, and the promoter context. |journal=Mol. Endocrinol. |volume=16 |issue= 11 |pages= 2571-81 |year= 2003 |pmid= 12403846 |doi= }}
*{{cite journal | author=Wong CW, McNally C, Nickbarg E, ''et al.'' |title=Estrogen receptor-interacting protein that modulates its nongenomic activity-crosstalk with Src/Erk phosphorylation cascade. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 23 |pages= 14783-8 |year= 2003 |pmid= 12415108 |doi= 10.1073/pnas.192569699 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Balasenthil S, Vadlamudi RK |title=Functional interactions between the estrogen receptor coactivator PELP1/MNAR and retinoblastoma protein. |journal=J. Biol. Chem. |volume=278 |issue= 24 |pages= 22119-27 |year= 2003 |pmid= 12682072 |doi= 10.1074/jbc.M212822200 }}
*{{cite journal | author=Barletta F, Wong CW, McNally C, ''et al.'' |title=Characterization of the interactions of estrogen receptor and MNAR in the activation of cSrc. |journal=Mol. Endocrinol. |volume=18 |issue= 5 |pages= 1096-108 |year= 2005 |pmid= 14963108 |doi= 10.1210/me.2003-0335 }}
*{{cite journal | author=Colland F, Jacq X, Trouplin V, ''et al.'' |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324-32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 }}
*{{cite journal | author=Ballif BA, Villén J, Beausoleil SA, ''et al.'' |title=Phosphoproteomic analysis of the developing mouse brain. |journal=Mol. Cell Proteomics |volume=3 |issue= 11 |pages= 1093-101 |year= 2005 |pmid= 15345747 |doi= 10.1074/mcp.M400085-MCP200 }}
*{{cite journal | author=Nair SS, Mishra SK, Yang Z, ''et al.'' |title=Potential role of a novel transcriptional coactivator PELP1 in histone H1 displacement in cancer cells. |journal=Cancer Res. |volume=64 |issue= 18 |pages= 6416-23 |year= 2004 |pmid= 15374949 |doi= 10.1158/0008-5472.CAN-04-1786 }}
*{{cite journal | author=Choi YB, Ko JK, Shin J |title=The transcriptional corepressor, PELP1, recruits HDAC2 and masks histones using two separate domains. |journal=J. Biol. Chem. |volume=279 |issue= 49 |pages= 50930-41 |year= 2005 |pmid= 15456770 |doi= 10.1074/jbc.M406831200 }}
*{{cite journal | author=Unni E, Sun S, Nan B, ''et al.'' |title=Changes in androgen receptor nongenotropic signaling correlate with transition of LNCaP cells to androgen independence. |journal=Cancer Res. |volume=64 |issue= 19 |pages= 7156-68 |year= 2004 |pmid= 15466214 |doi= 10.1158/0008-5472.CAN-04-1121 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Vadlamudi RK, Balasenthil S, Broaddus RR, ''et al.'' |title=Deregulation of estrogen receptor coactivator proline-, glutamic acid-, and leucine-rich protein-1/modulator of nongenomic activity of estrogen receptor in human endometrial tumors. |journal=J. Clin. Endocrinol. Metab. |volume=89 |issue= 12 |pages= 6130-8 |year= 2005 |pmid= 15579769 |doi= 10.1210/jc.2004-0909 }}
*{{cite journal | author=Manavathi B, Nair SS, Wang RA, ''et al.'' |title=Proline-, glutamic acid-, and leucine-rich protein-1 is essential in growth factor regulation of signal transducers and activators of transcription 3 activation. |journal=Cancer Res. |volume=65 |issue= 13 |pages= 5571-7 |year= 2005 |pmid= 15994929 |doi= 10.1158/0008-5472.CAN-04-4664 }}
*{{cite journal | author=Vadlamudi RK, Balasenthil S, Sahin AA, ''et al.'' |title=Novel estrogen receptor coactivator PELP1/MNAR gene and ERbeta expression in salivary duct adenocarcinoma: potential therapeutic targets. |journal=Hum. Pathol. |volume=36 |issue= 6 |pages= 670-5 |year= 2005 |pmid= 16021574 |doi= 10.1016/j.humpath.2005.03.016 }}
*{{cite journal | author=Vadlamudi RK, Manavathi B, Balasenthil S, ''et al.'' |title=Functional implications of altered subcellular localization of PELP1 in breast cancer cells. |journal=Cancer Res. |volume=65 |issue= 17 |pages= 7724-32 |year= 2005 |pmid= 16140940 |doi= 10.1158/0008-5472.CAN-05-0614 }}
*{{cite journal | author=Rayala SK, Hollander P, Balasenthil S, ''et al.'' |title=Hepatocyte growth factor-regulated tyrosine kinase substrate (HRS) interacts with PELP1 and activates MAPK. |journal=J. Biol. Chem. |volume=281 |issue= 7 |pages= 4395-403 |year= 2006 |pmid= 16352611 |doi= 10.1074/jbc.M510368200 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on RND1... {December 20, 2007 12:25:20 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein RND1 image.jpg {December 20, 2007 12:26:00 PM PST}
- REDIRECT: Protein Redirected to: RND1 {December 20, 2007 12:26:07 PM PST}
- CREATED: Created new protein page: RND1 {December 20, 2007 12:26:16 PM PST}
end log.
