Vestigial-like family member 3

VGLL3
Identifiers
Aliases	VGLL3, VGL-3, VGL3, Vestigial-like family member 3, vestigial like family member 3
External IDs	OMIM: 609980; MGI: 1920819; HomoloGene: 53442; GeneCards: VGLL3; OMA:VGLL3 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	86,991,149 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	65,663,254 bp
RNA expression pattern
	Top expressed in
	lower lobe of lung; ; saphenous vein; ; placenta; ; parietal pleura; ; superficial temporal artery; ; Achilles tendon; ; pericardium; ; germinal epithelium; ; stromal cell of endometrium; ; visceral pleura;
	Top expressed in
	sciatic nerve; ; gastrula; ; calvaria; ; umbilical cord; ; decidua; ; stroma of bone marrow; ; skin of external ear; ; ascending aorta; ; skin of abdomen; ; transitional epithelium of urinary bladder;
	More reference expression data
	n/a
Gene ontology
Molecular function	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	regulation of transcription, DNA-templated; transcription, DNA-templated; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	389136
	73569
	ENSG00000206538
	ENSMUSG00000091243
	A8MV65
	P85442
	NM_016206; NM_001320493; NM_001320494
	NM_028572; NM_001368760; NM_001368761
	NP_001307422; NP_001307423; NP_057290
	NP_082848; NP_001355689; NP_001355690
	Wikidata
View/Edit Human	View/Edit Mouse

Vestigial-like family member 3 is a protein that in humans is encoded by the VGLL3 gene.^[5]

This protein is one of four mammalian homologs (VGLL1-4) of the vestigial gene found in the fruit fly Drosophila.^[6] VGLL3 functions as a transcription coregulator by binding to TEA domain (TEAD) transcription factors (TEAD1, TEAD2, TEAD3, TEAD4 ) through its TDU motif.^[6]^[7] VGLL3 has been implicated in various biological processes including myogenesis (formation of muscle tissue), cell proliferation, and cancer progression.^[7] VGLL3 can also promote epithelial-to-mesenchymal transition (EMT) and cell motility in certain cancer types, suggesting it may play a role in tumor development and metastasis.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000206538 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000091243 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Vestigial-like family member 3".
^ ^a ^b Yamaguchi N (2020). "Multiple Roles of Vestigial-Like Family Members in Tumor Development". Frontiers in Oncology. 10: 1266. doi:10.3389/fonc.2020.01266. PMC 7393262. PMID 32793503.
^ ^a ^b ^c Hori N, Takakura Y, Sugino A, Iwasawa S, Nomizo K, Yamaguchi N, et al. (May 2022). "Vestigial-like family member 3 stimulates cell motility by inducing high-mobility group AT-hook 2 expression in cancer cells". Journal of Cellular and Molecular Medicine. 26 (9): 2686–2697. doi:10.1111/jcmm.17279. PMC 9077286. PMID 35366053.

Tao S, Wang Z, Feng J, Hsu FC, Jin G, Kim ST, et al. (March 2012). "A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants". Carcinogenesis. 33 (3): 598–603. doi:10.1093/carcin/bgr316. PMC 3291863. PMID 22219177.
Gambaro K, Quinn MC, Wojnarowicz PM, Arcand SL, de Ladurantaye M, Barrès V, et al. (June 2013). "VGLL3 expression is associated with a tumor suppressor phenotype in epithelial ovarian cancer". Molecular Oncology. 7 (3): 513–30. doi:10.1016/j.molonc.2012.12.006. PMC 5528482. PMID 23415753.
Zhou W, Chen H, Zhang L (March 2009). "The PcG protein hPc2 interacts with the N-terminus of histone demethylase JARID1B and acts as a transcriptional co-repressor" (PDF). BMB Reports. 42 (3): 154–9. doi:10.5483/bmbrep.2009.42.3.154. PMID 19336002.
Halperin DS, Pan C, Lusis AJ, Tontonoz P (February 2013). "Vestigial-like 3 is an inhibitor of adipocyte differentiation". Journal of Lipid Research. 54 (2): 473–81. doi:10.1194/jlr.M032755. PMC 3541706. PMID 23152581.
Hélias-Rodzewicz Z, Pérot G, Chibon F, Ferreira C, Lagarde P, Terrier P, et al. (December 2010). "YAP1 and VGLL3, encoding two cofactors of TEAD transcription factors, are amplified and overexpressed in a subset of soft tissue sarcomas". Genes, Chromosomes & Cancer. 49 (12): 1161–71. doi:10.1002/gcc.20825. PMID 20842732. S2CID 205828045.
Wang L, Lu W, Chen YG, Zhou XM, Gu JR (December 1999). "Comparison of gene expression between normal colon mucosa and colon carcinoma by means of messenger RNA differential display". World Journal of Gastroenterology. 5 (6): 533–534. doi:10.3748/wjg.v5.i6.533. PMC 4688801. PMID 11819507.
Maeda T, Chapman DL, Stewart AF (December 2002). "Mammalian vestigial-like 2, a cofactor of TEF-1 and MEF2 transcription factors that promotes skeletal muscle differentiation". The Journal of Biological Chemistry. 277 (50): 48889–98. doi:10.1074/jbc.M206858200. PMID 12376544.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000206538 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000091243 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Vestigial-like family member 3".

[Yamaguchi_2020-6] Yamaguchi N (2020). "Multiple Roles of Vestigial-Like Family Members in Tumor Development". Frontiers in Oncology. 10: 1266. doi:10.3389/fonc.2020.01266. PMC 7393262. PMID 32793503.

[Hori_2022-7] Hori N, Takakura Y, Sugino A, Iwasawa S, Nomizo K, Yamaguchi N, et al. (May 2022). "Vestigial-like family member 3 stimulates cell motility by inducing high-mobility group AT-hook 2 expression in cancer cells". Journal of Cellular and Molecular Medicine. 26 (9): 2686–2697. doi:10.1111/jcmm.17279. PMC 9077286. PMID 35366053.

[5]

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Vestigial-like family member 3

See also

References

Further reading