FGF7

Keratinocyte growth factor is a protein that in humans is encoded by the FGF7 gene.

FGF7
Identifiers
Aliases	FGF7, HBGF-7, KGF, fibroblast growth factor 7
External IDs	OMIM: 148180; MGI: 95521; HomoloGene: 7316; GeneCards: FGF7; OMA:FGF7 - orthologs
Gene location (Human) Chr. Chromosome 15 (human) Band 15q21.2 Start 49,423,237 bp End 49,488,775 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 F1 Start 125,876,578 bp End 125,933,105 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon stromal cell of endometrium gallbladder epithelium of colon tibial nerve canal of the cervix left uterine tube body of uterus sural nerve ectocervix Top expressed in stroma of bone marrow calvaria lobe of cerebellum cerebellar vermis endothelial cell of lymphatic vessel intercostal muscle left lung lobe ankle myotome detrusor urinae muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function heparin binding fibroblast growth factor receptor binding protein binding chemoattractant activity growth factor activity 1-phosphatidylinositol-3-kinase activity protein tyrosine kinase activity phosphatidylinositol-4,5-bisphosphate 3-kinase activity Cellular component Golgi apparatus extracellular region Biological process actin cytoskeleton reorganization mesenchymal cell proliferation positive regulation of keratinocyte proliferation positive regulation of epithelial cell proliferation involved in lung morphogenesis secretion by lung epithelial cell involved in lung growth positive regulation of epithelial cell proliferation regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling MAPK cascade positive regulation of transcription, DNA-templated fibroblast growth factor receptor signaling pathway positive regulation of keratinocyte migration protein localization to cell surface response to wounding positive regulation of cell population proliferation epidermis development positive regulation of peptidyl-tyrosine phosphorylation hair follicle morphogenesis positive chemotaxis positive regulation of cell division signal transduction branching involved in salivary gland morphogenesis phosphatidylinositol phosphate biosynthetic process peptidyl-tyrosine phosphorylation phosphatidylinositol-3-phosphate biosynthetic process regulation of signaling receptor activity positive regulation of protein kinase B signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2252 14178 Ensembl ENSG00000140285 ENSMUSG00000027208 UniProt P21781 P36363 RefSeq (mRNA) NM_002009 NM_008008 RefSeq (protein) NP_002000 NP_032034 Location (UCSC) Chr 15: 49.42 – 49.49 Mb Chr 2: 125.88 – 125.93 Mb PubMed search
Wikidata
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Function

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis.

Interactions

FGF7 has been shown to interact with Perlecan.

Further reading

• Beer HD, Gassmann MG, Munz B, Steiling H, Engelhardt F, Bleuel K, Werner S (Dec 2000). "Expression and function of keratinocyte growth factor and activin in skin morphogenesis and cutaneous wound repair". The Journal of Investigative Dermatology. Symposium Proceedings. 5 (1): 34–9. doi:10.1046/j.1087-0024.2000.00009.x. PMID 11147673.
• Ware LB, Matthay MA (May 2002). "Keratinocyte and hepatocyte growth factors in the lung: roles in lung development, inflammation, and repair". American Journal of Physiology. Lung Cellular and Molecular Physiology. 282 (5): L924–40. doi:10.1152/ajplung.00439.2001. PMID 11943656.
• Finch PW, Rubin JS (2004). Keratinocyte growth factor/fibroblast growth factor 7, a homeostatic factor with therapeutic potential for epithelial protection and repair. Advances in Cancer Research. Vol. 91. pp. 69–136. doi:10.1016/S0065-230X(04)91003-2. ISBN 978-0-12-006691-9. PMID 15327889.
• Ishibashi T, Bottaro DP, Chan A, Miki T, Aaronson SA (Dec 1992). "Expression cloning of a human dual-specificity phosphatase". Proceedings of the National Academy of Sciences of the United States of America. 89 (24): 12170–4. Bibcode:1992PNAS...8912170I. doi:10.1073/pnas.89.24.12170. PMC 50720. PMID 1281549.
• Aaronson SA, Bottaro DP, Miki T, Ron D, Finch PW, Fleming TP, Ahn J, Taylor WG, Rubin JS (1992). "Keratinocyte growth factor. A fibroblast growth factor family member with unusual target cell specificity". Annals of the New York Academy of Sciences. 638: 62–77. doi:10.1111/j.1749-6632.1991.tb49018.x. PMID 1664700. S2CID 32054089.
• Finch PW, Rubin JS, Miki T, Ron D, Aaronson SA (Aug 1989). "Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth". Science. 245 (4919): 752–5. Bibcode:1989Sci...245..752F. doi:10.1126/science.2475908. PMID 2475908.
• Rubin JS, Osada H, Finch PW, Taylor WG, Rudikoff S, Aaronson SA (Feb 1989). "Purification and characterization of a newly identified growth factor specific for epithelial cells". Proceedings of the National Academy of Sciences of the United States of America. 86 (3): 802–6. Bibcode:1989PNAS...86..802R. doi:10.1073/pnas.86.3.802. PMC 286565. PMID 2915979.
• Ron D, Reich R, Chedid M, Lengel C, Cohen OE, Chan AM, Neufeld G, Miki T, Tronick SR (Mar 1993). "Fibroblast growth factor receptor 4 is a high affinity receptor for both acidic and basic fibroblast growth factor but not for keratinocyte growth factor". The Journal of Biological Chemistry. 268 (8): 5388–94. doi:10.1016/S0021-9258(18)53334-2. PMID 7680645.
• Yan G, Fukabori Y, McBride G, Nikolaropolous S, McKeehan WL (Aug 1993). "Exon switching and activation of stromal and embryonic fibroblast growth factor (FGF)-FGF receptor genes in prostate epithelial cells accompany stromal independence and malignancy". Molecular and Cellular Biology. 13 (8): 4513–22. doi:10.1128/MCB.13.8.4513. PMC 360063. PMID 7687739.
• Werner S, Smola H, Liao X, Longaker MT, Krieg T, Hofschneider PH, Williams LT (Nov 1994). "The function of KGF in morphogenesis of epithelium and reepithelialization of wounds". Science. 266 (5186): 819–22. Bibcode:1994Sci...266..819W. doi:10.1126/science.7973639. PMID 7973639.
• Wilson SE, Walker JW, Chwang EL, He YG (Jul 1993). "Hepatocyte growth factor, keratinocyte growth factor, their receptors, fibroblast growth factor receptor-2, and the cells of the cornea". Investigative Ophthalmology & Visual Science. 34 (8): 2544–61. PMID 8392040.
• Guo L, Degenstein L, Fuchs E (Jan 1996). "Keratinocyte growth factor is required for hair development but not for wound healing". Genes & Development. 10 (2): 165–75. doi:10.1101/gad.10.2.165. PMID 8566750.
• Ornitz DM, Xu J, Colvin JS, McEwen DG, MacArthur CA, Coulier F, Gao G, Goldfarb M (Jun 1996). "Receptor specificity of the fibroblast growth factor family". The Journal of Biological Chemistry. 271 (25): 15292–7. doi:10.1074/jbc.271.25.15292. PMID 8663044.
• Post M, Souza P, Liu J, Tseu I, Wang J, Kuliszewski M, Tanswell AK (Oct 1996). "Keratinocyte growth factor and its receptor are involved in regulating early lung branching". Development. 122 (10): 3107–15. doi:10.1242/dev.122.10.3107. PMID 8898224.
• Zimonjic DB, Kelley MJ, Rubin JS, Aaronson SA, Popescu NC (Oct 1997). "Fluorescence in situ hybridization analysis of keratinocyte growth factor gene amplification and dispersion in evolution of great apes and humans". Proceedings of the National Academy of Sciences of the United States of America. 94 (21): 11461–5. Bibcode:1997PNAS...9411461Z. doi:10.1073/pnas.94.21.11461. PMC 23506. PMID 9326632.
• Winkles JA, Alberts GF, Chedid M, Taylor WG, DeMartino S, Rubin JS (Dec 1997). "Differential expression of the keratinocyte growth factor (KGF) and KGF receptor genes in human vascular smooth muscle cells and arteries". Journal of Cellular Physiology. 173 (3): 380–6. doi:10.1002/(SICI)1097-4652(199712)173:3<380::AID-JCP10>3.0.CO;2-G. PMID 9369951. S2CID 45221064.
• Ishibashi T, Tanaka T, Nibu K, Ishimoto S, Kaga K (Oct 1998). "Keratinocyte growth factor and its receptor messenger RNA expression in nasal mucosa and nasal polyps". The Annals of Otology, Rhinology, and Laryngology. 107 (10 Pt 1): 885–90. doi:10.1177/000348949810701013. PMID 9794620. S2CID 26406331.
• Mongiat M, Taylor K, Otto J, Aho S, Uitto J, Whitelock JM, Iozzo RV (Mar 2000). "The protein core of the proteoglycan perlecan binds specifically to fibroblast growth factor-7". The Journal of Biological Chemistry. 275 (10): 7095–100. doi:10.1074/jbc.275.10.7095. PMID 10702276.