TUBGCP3

Gamma-tubulin complex component 3 is a protein that in humans is encoded by the TUBGCP3 gene. It is part of the gamma tubulin complex, which required for microtubule nucleation at the centrosome.

TUBGCP3
Identifiers
Aliases	TUBGCP3, 104p, GCP3, Grip104, SPBC98, Spc98, Spc98p, tubulin gamma complex associated protein 3, ALP6
External IDs	OMIM: 617818; MGI: 2183752; HomoloGene: 4609; GeneCards: TUBGCP3; OMA:TUBGCP3 - orthologs
Gene location (Human) Chr. Chromosome 13 (human) Band 13q34 Start 112,485,011 bp End 112,588,205 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8|8 A1.1 Start 12,664,277 bp End 12,722,248 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte ventricular zone bone marrow cells ganglionic eminence right ovary left ovary gastric mucosa gonad testicle body of uterus Top expressed in Ileal epithelium tail of embryo ventricular zone genital tubercle thymus Gonadal ridge neural layer of retina cerebellar cortex granulocyte superior frontal gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural molecule activity structural constituent of cytoskeleton protein binding microtubule minus-end binding gamma-tubulin binding Cellular component cytoplasm cytosol centrosome spindle pole equatorial microtubule organizing center membrane spindle microtubule organizing center gamma-tubulin small complex polar microtubule spindle pole body centriole cytoskeleton microtubule gamma-tubulin complex Biological process centrosome duplication microtubule nucleation by interphase microtubule organizing center single fertilization mitotic spindle assembly cytoplasmic microtubule organization microtubule cytoskeleton organization microtubule nucleation meiosis mitotic cell cycle spindle assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10426 259279 Ensembl ENSG00000282003 ENSG00000126216 ENSMUSG00000000759 UniProt Q96CW5 P58854 RefSeq (mRNA) NM_001286277 NM_001286278 NM_001286279 NM_006322 NM_198031 RefSeq (protein) NP_001273206 NP_001273207 NP_001273208 NP_006313 NP_932148 Location (UCSC) Chr 13: 112.49 – 112.59 Mb Chr 8: 12.66 – 12.72 Mb PubMed search
Wikidata
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See also

• Tubulin
• TUBGCP2
• TUBGCP4
• TUBGCP5
• TUBGCP6

Further reading

• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. Bibcode:2004Natur.428..522D. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Takahashi M, Yamagiwa A, Nishimura T, et al. (2003). "Centrosomal proteins CG-NAP and kendrin provide microtubule nucleation sites by anchoring gamma-tubulin ring complex". Mol. Biol. Cell. 13 (9): 3235–45. doi:10.1091/mbc.E02-02-0112. PMC 124155. PMID 12221128.
• Murphy SM, Preble AM, Patel UK, et al. (2002). "GCP5 and GCP6: two new members of the human gamma-tubulin complex". Mol. Biol. Cell. 12 (11): 3340–52. doi:10.1091/mbc.12.11.3340. PMC 60259. PMID 11694571.