TUBGCP6

Gamma-tubulin complex component 6 is a protein that in humans is encoded by the TUBGCP6 gene. It is part of the gamma tubulin complex, which required for microtubule nucleation at the centrosome.

TUBGCP6
Identifiers
Aliases	TUBGCP6, GCP-6, GCP6, MCCRP, MCPHCR, MCCRP1, tubulin gamma complex associated protein 6
External IDs	OMIM: 610053; MGI: 2146071; HomoloGene: 32477; GeneCards: TUBGCP6; OMA:TUBGCP6 - orthologs
Gene location (Human) Chr. Chromosome 22 (human) Band 22q13.33 Start 50,217,689 bp End 50,245,023 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15|15 E3 Start 88,982,560 bp End 89,007,315 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum anterior pituitary right lobe of thyroid gland left lobe of thyroid gland body of pancreas granulocyte sural nerve right frontal lobe right ovary apex of heart Top expressed in tail of embryo genital tubercle otic vesicle granulocyte ventricular zone cerebellar cortex superior frontal gyrus yolk sac spermatocyte dentate gyrus of hippocampal formation granule cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function microtubule binding structural constituent of cytoskeleton microtubule minus-end binding gamma-tubulin binding Cellular component cytoplasm cytosol centrosome spindle pole equatorial microtubule organizing center membrane microtubule organizing center spindle pole body microtubule extracellular exosome cytoskeleton gamma-tubulin complex gamma-tubulin small complex Biological process centrosome duplication microtubule nucleation by interphase microtubule organizing center mitotic spindle assembly cytoplasmic microtubule organization microtubule cytoskeleton organization microtubule nucleation meiosis mitotic cell cycle spindle assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 85378 328580 Ensembl ENSG00000128159 ENSMUSG00000051786 UniProt Q96RT7 G5E8P0 RefSeq (mRNA) NM_001008658 NM_020461 NM_001163319 RefSeq (protein) NP_065194 NP_001156791 Location (UCSC) Chr 22: 50.22 – 50.25 Mb Chr 15: 88.98 – 89.01 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

See also

• Tubulin
• TUBGCP2
• TUBGCP3
• TUBGCP4
• TUBGCP5

Further reading

• Oriolo AS, Wald FA, Canessa G, Salas PJ (2007). "GCP6 binds to intermediate filaments: a novel function of keratins in the organization of microtubules in epithelial cells". Mol. Biol. Cell. 18 (3): 781–94. doi:10.1091/mbc.E06-03-0201. PMC 1805110. PMID 17182859.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
• Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.