TUBGCP5

Gamma-tubulin complex component 5 is a protein that in humans is encoded by the TUBGCP5 gene. It is part of the gamma tubulin complex, which required for microtubule nucleation at the centrosome.

TUBGCP5
Identifiers
Aliases	TUBGCP5, GCP5, tubulin gamma complex associated protein 5
External IDs	OMIM: 608147; MGI: 2178836; HomoloGene: 14172; GeneCards: TUBGCP5; OMA:TUBGCP5 - orthologs
Gene location (Human) Chr. Chromosome 15 (human) Band 15q11.2 Start 22,983,192 bp End 23,039,572 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 B5 Start 55,443,902 bp End 55,481,425 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve Achilles tendon testicle corpus callosum gonad endometrium body of pancreas tonsil canal of the cervix smooth muscle tissue Top expressed in spermatocyte ascending aorta aortic valve tail of embryo genital tubercle neural layer of retina superior cervical ganglion Rostral migratory stream ventricular zone facial motor nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function microtubule binding structural constituent of cytoskeleton microtubule minus-end binding gamma-tubulin binding Cellular component centrosome spindle pole equatorial microtubule organizing center microtubule organizing center spindle pole body microtubule cytoskeleton cytoplasm cytosol gamma-tubulin complex Biological process centrosome duplication microtubule nucleation by interphase microtubule organizing center mitotic spindle assembly cytoplasmic microtubule organization microtubule cytoskeleton organization microtubule nucleation meiosis mitotic cell cycle spindle assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 114791 233276 Ensembl ENSG00000276856 ENSG00000275835 ENSG00000280807 ENSMUSG00000033790 UniProt Q96RT8 Q8BKN5 RefSeq (mRNA) NM_001102610 NM_052903 NM_001354372 NM_001354373 NM_001354374 NM_001354375 NM_001354376 NM_001354377 NM_001354378 NM_146190 NM_001360873 NM_001360874 RefSeq (protein) NP_001096080 NP_443135 NP_001341301 NP_001341302 NP_001341303 NP_001341304 NP_001341305 NP_001341306 NP_001341307 NP_666302 NP_001347802 NP_001347803 Location (UCSC) Chr 15: 22.98 – 23.04 Mb Chr 7: 55.44 – 55.48 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

See also

• Tubulin
• TUBGCP2
• TUBGCP3
• TUBGCP4
• TUBGCP6

Further reading

• Bittel DC, Kibiryeva N, Butler MG (2006). "Expression of 4 genes between chromosome 15 breakpoints 1 and 2 and behavioral outcomes in Prader–Willi syndrome". Pediatrics. 118 (4): e1276–83. doi:10.1542/peds.2006-0424. PMC 5453799. PMID 16982806.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Chai JH, Locke DP, Greally JM, et al. (2003). "Identification of four highly conserved genes between breakpoint hotspots BP1 and BP2 of the Prader-Willi/Angelman syndromes deletion region that have undergone evolutionary transposition mediated by flanking duplicons". Am. J. Hum. Genet. 73 (4): 898–925. doi:10.1086/378816. PMC 1180611. PMID 14508708.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Nagase T, Kikuno R, Ohara O (2002). "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins". DNA Res. 8 (4): 179–87. doi:10.1093/dnares/8.4.179. PMID 11572484.