TUBGCP4

Tubulin, gamma complex associated protein 4 is a protein in humans that is encoded by the TUBGCP4 gene. It is part of the gamma tubulin complex, which required for microtubule nucleation at the centrosome.

TUBGCP4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3RIP
Identifiers
Aliases	TUBGCP4, 76P, GCP-4, GCP4, Grip76, MCCRP3, tubulin gamma complex associated protein 4
External IDs	OMIM: 609610; MGI: 1196293; HomoloGene: 8690; GeneCards: TUBGCP4; OMA:TUBGCP4 - orthologs
Gene location (Human) Chr. Chromosome 15 (human) Band 15q15.3 Start 43,369,221 bp End 43,409,771 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2 E5|2 60.37 cM Start 121,001,135 bp End 121,029,251 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm secondary oocyte buccal mucosa cell ganglionic eminence ventricular zone gonad testicle tibialis anterior muscle epithelium of colon cerebellar hemisphere Top expressed in ascending aorta spermatocyte tail of embryo genital tubercle aortic valve supraoptic nucleus neural layer of retina internal carotid artery thymus spermatid More reference expression data BioGPS n/a
Gene ontology Molecular function structural constituent of cytoskeleton microtubule minus-end binding protein binding gamma-tubulin binding Cellular component cytoplasm microtubule organizing center gamma-tubulin complex cytosol spindle pole body spindle pole recycling endosome equatorial microtubule organizing center membrane microtubule microtubule cytoskeleton cytoskeleton centrosome Biological process microtubule nucleation by interphase microtubule organizing center microtubule cytoskeleton organization mitotic spindle assembly centrosome duplication cytoplasmic microtubule organization microtubule nucleation meiosis mitotic cell cycle spindle assembly protein-containing complex assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27229 51885 Ensembl ENSG00000137822 ENSMUSG00000027263 UniProt Q9UGJ1 Q9D4F8 RefSeq (mRNA) NM_001286414 NM_014444 NM_001290824 NM_153387 RefSeq (protein) NP_001273343 NP_055259 NP_001277753 NP_700436 Location (UCSC) Chr 15: 43.37 – 43.41 Mb Chr 2: 121 – 121.03 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

See also

• Tubulin
• TUBGCP2
• TUBGCP3
• TUBGCP5
• TUBGCP6

Further reading

• Hsu HL, Yeh NH (February 1996). "Dynamic changes of NuMA during the cell cycle and possible appearance of a truncated form of NuMA during apoptosis". Journal of Cell Science. 109 ( Pt 2) (2): 277–88. doi:10.1242/jcs.109.2.277. PMID 8838651.
• Haren L, Merdes A (May 2002). "Direct binding of NuMA to tubulin is mediated by a novel sequence motif in the tail domain that bundles and stabilizes microtubules". Journal of Cell Science. 115 (Pt 9): 1815–24. doi:10.1242/jcs.115.9.1815. PMID 11956313.
• Murphy SM, Preble AM, Patel UK, O'Connell KL, Dias DP, Moritz M, Agard D, Stults JT, Stearns T (November 2001). "GCP5 and GCP6: two new members of the human gamma-tubulin complex". Molecular Biology of the Cell. 12 (11): 3340–52. doi:10.1091/mbc.12.11.3340. PMC 60259. PMID 11694571.
• Fava F, Raynaud-Messina B, Leung-Tack J, Mazzolini L, Li M, Guillemot JC, Cachot D, Tollon Y, Ferrara P, Wright M (November 1999). "Human 76p: A new member of the gamma-tubulin-associated protein family". The Journal of Cell Biology. 147 (4): 857–68. doi:10.1083/jcb.147.4.857. PMC 2156165. PMID 10562286.
• Takahashi M, Yamagiwa A, Nishimura T, Mukai H, Ono Y (September 2002). "Centrosomal proteins CG-NAP and kendrin provide microtubule nucleation sites by anchoring gamma-tubulin ring complex". Molecular Biology of the Cell. 13 (9): 3235–45. doi:10.1091/mbc.E02-02-0112. PMC 124155. PMID 12221128.