Enprofylline

Enprofylline
Clinical data
ATC code	None;
Identifiers
	IUPAC name 3-Propyl-7H-purine-2,6-dione;
CAS Number	41078-02-8 ;
PubChem CID	1676;
DrugBank	DB00824 ;
ChemSpider	1613 ;
UNII	DT7DT5E518;
KEGG	D04006 ;
ChEBI	CHEBI:126237 ;
ChEMBL	ChEMBL279898 ;
CompTox Dashboard (EPA)	DTXSID9045186 ;
ECHA InfoCard	100.050.166
Chemical and physical data
Formula	C8H10N4O2
Molar mass	194.194 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCCn2c(=O)[nH]c(=O)c1nc[nH]c12;
	InChI InChI=1S/C8H10N4O2/c1-2-3-12-6-5(9-4-10-6)7(13)11-8(12)14/h4H,2-3H2,1H3,(H,9,10)(H,11,13,14) ; Key:SIQPXVQCUCHWDI-UHFFFAOYSA-N ;
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Enprofylline (3-propylxanthine) is a xanthine derivative used in the treatment of asthma, which acts as a bronchodilator. It acts primarily as a competitive nonselective phosphodiesterase inhibitor with relatively little activity as a nonselective adenosine receptor antagonist.^[1]^[2]

References

^ Lunell E, Svedmyr N, Andersson KE, Persson CG (1982). "Effects of enprofylline, a xanthine lacking adenosine receptor antagonism, in patients with chronic obstructive lung disease". European Journal of Clinical Pharmacology. 22 (5): 395–402. doi:10.1007/bf00542541. PMID 6288396. S2CID 3240010.
^ Laursen LC (December 1987). "Anti asthmatic effects and pharmacokinetics of enprofylline--a new xanthine derivate". Danish Medical Bulletin. 34 (6): 289–97. PMID 3325233.

Clinical data


ATC code	None
Identifiers
IUPAC name 3-Propyl-7H-purine-2,6-dione
CAS Number	41078-02-8^Y
PubChem CID	1676
DrugBank	DB00824^N
ChemSpider	1613^Y
UNII	DT7DT5E518
KEGG	D04006^N
ChEBI	CHEBI:126237^N
ChEMBL	ChEMBL279898^N
CompTox Dashboard (EPA)	DTXSID9045186
ECHA InfoCard	100.050.166
Chemical and physical data
Formula	C₈H₁₀N₄O₂
Molar mass	194.194 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CCCn2c(=O)[nH]c(=O)c1nc[nH]c12
InChI InChI=1S/C8H10N4O2/c1-2-3-12-6-5(9-4-10-6)7(13)11-8(12)14/h4H,2-3H2,1H3,(H,9,10)(H,11,13,14)^Y Key:SIQPXVQCUCHWDI-UHFFFAOYSA-N^Y
^NY (what is this?) (verify)