3',5'-cyclic-AMP phosphodiesterase
(Redirected from PDE7)
| 3′,5′-cyclic-AMP phosphodiesterase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.1.4.53 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
3′,5′-cyclic-AMP phosphodiesterase (EC 3.1.4.53, cAMP-specific phosphodiesterase, cAMP-specific PDE, PDE1, PDE2A, PDE2B, PDE4, PDE7, PDE8, PDEB1, PDEB2) is an enzyme with systematic name 3′,5′-cyclic-AMP 5′-nucleotidohydrolase.[1] It catalyses the following reaction
The enzyme characterised from Escherichia coli and mammalian cardiac tissue hydrolyses cyclic adenosine monophosphate to adenosine monophosphate. It requires Mg2+ or Mn2+ for activity.[2][3] It has also been found in Trypanosoma species,[4][5] Dictyostelium,[6] and Leishmania major.[7]
References
[edit]- ↑ Enzyme 3.1.4.53 at KEGG Pathway Database.
- ↑ Imamura R, Yamanaka K, Ogura T, Hiraga S, Fujita N, Ishihama A, Niki H (October 1996). "Identification of the cpdA gene encoding cyclic 3′,5′-adenosine monophosphate phosphodiesterase in Escherichia coli". The Journal of Biological Chemistry. 271 (41): 25423–9. doi:10.1074/jbc.271.41.25423. PMID 8810311.
- ↑ Lugnier C, Keravis T, Le Bec A, Pauvert O, Proteau S, Rousseau E (November 1999). "Characterization of cyclic nucleotide phosphodiesterase isoforms associated to isolated cardiac nuclei". Biochimica et Biophysica Acta (BBA) - General Subjects. 1472 (3): 431–446. doi:10.1016/S0304-4165(99)00145-2. PMID 10564757.
- ↑ Rascón A, Soderling SH, Schaefer JB, Beavo JA (April 2002). "Cloning and characterization of a cAMP-specific phosphodiesterase (TbPDE2B) from Trypanosoma brucei". Proceedings of the National Academy of Sciences of the United States of America. 99 (7): 4714–9. Bibcode:2002PNAS...99.4714R. doi:10.1073/pnas.002031599. PMC 123713. PMID 11930017.
- ↑ Alonso GD, Schoijet AC, Torres HN, Flawiá MM (January 2006). "TcPDE4, a novel membrane-associated cAMP-specific phosphodiesterase from Trypanosoma cruzi". Molecular and Biochemical Parasitology. 145 (1): 40–9. doi:10.1016/j.molbiopara.2005.09.005. hdl:11336/79656. PMID 16225937.
- ↑ Bader S, Kortholt A, Snippe H, Van Haastert PJ (July 2006). "DdPDE4, a novel cAMP-specific phosphodiesterase at the surface of Dictyostelium cells". The Journal of Biological Chemistry. 281 (29): 20018–26. doi:10.1074/jbc.M600040200. hdl:11370/9184dd4b-bc7c-469b-bb3b-9174235c0994. PMID 16644729.
- ↑ Johner A, Kunz S, Linder M, Shakur Y, Seebeck T (March 2006). "Cyclic nucleotide specific phosphodiesterases of Leishmania major". BMC Microbiology. 6 25. doi:10.1186/1471-2180-6-25. PMC 1431542. PMID 16522215.
External links
[edit]- 3',5'-cyclic-AMP+phosphodiesterase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
