PHTPP

PHTPP
Identifiers
	IUPAC name 4-[2-Phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]phenol;
CAS Number	805239-56-9 ;
PubChem CID	11201035;
ChemSpider	9376104;
UNII	NN82CVN36N;
CompTox Dashboard (EPA)	DTXSID10458573 ;
Chemical and physical data
Formula	C20H11F6N3O
Molar mass	423.318 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1=CC=C(C=C1)C2=NN3C(=CC(=NC3=C2C4=CC=C(C=C4)O)C(F)(F)F)C(F)(F)F;
	InChI InChI=1S/C20H11F6N3O/c21-19(22,23)14-10-15(20(24,25)26)29-18(27-14)16(11-6-8-13(30)9-7-11)17(28-29)12-4-2-1-3-5-12/h1-10,30H; Key:AEZPAUSGTAHLOQ-UHFFFAOYSA-N;

PHTPP is a synthetic, nonsteroidal, and highly selective antagonist of ERβ that is used in scientific research to study the function of this receptor.^[1]^[2] It possesses 36-fold selectivity for ERβ over ERα, and is a silent antagonist of ERβ.^[3]

References

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Identifiers

IUPAC name 4-[2-Phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]phenol
CAS Number	805239-56-9^Y
PubChem CID	11201035
ChemSpider	9376104
UNII	NN82CVN36N
CompTox Dashboard (EPA)	DTXSID10458573
Chemical and physical data
Formula	C₂₀H₁₁F₆N₃O
Molar mass	423.318 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C1=CC=C(C=C1)C2=NN3C(=CC(=NC3=C2C4=CC=C(C=C4)O)C(F)(F)F)C(F)(F)F
InChI InChI=1S/C20H11F6N3O/c21-19(22,23)14-10-15(20(24,25)26)29-18(27-14)16(11-6-8-13(30)9-7-11)17(28-29)12-4-2-1-3-5-12/h1-10,30H Key:AEZPAUSGTAHLOQ-UHFFFAOYSA-N