Serine/threonine-protein kinase VRK2 is an enzyme that in humans is encoded by the VRK2 gene.[5]

VRK2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesVRK2, vaccinia related kinase 2, VRK serine/threonine kinase 2
External IDsOMIM: 602169; MGI: 1917172; HomoloGene: 55966; GeneCards: VRK2; OMA:VRK2 - orthologs
EC number2.7.11.1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001252447
NM_027260

RefSeq (protein)

NP_001239376
NP_081536

Location (UCSC)Chr 2: 57.91 – 58.16 MbChr 11: 26.42 – 26.54 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, leukocytes, fetal liver, and carcinomas. Its protein localizes to the endoplasmic reticulum and has been shown to phosphorylate casein and undergo autophosphorylation.

While several transcript variants may exist for this gene, the full-length nature of only one has been biologically validated to date.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000028116Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000064090Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: VRK2 vaccinia related kinase 2".

Further reading

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