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Outline of immunology

(Redirected from List of basic immunology topics)

The following outline is provided as an overview of and topical guide to immunology:

Immunology – study of all aspects of the immune system in all organisms.[1] It deals with the physiological functioning of the immune system in states of both health and disease; malfunctions of the immune system in immunological disorders (autoimmune diseases, hypersensitivities, immune deficiency, transplant rejection); the physical, chemical and physiological characteristics of the components of the immune system in vitro, in situ, and in vivo.

Essence of immunology

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Immunology

  1. Branches of immunology:

1. General Immunology 2. Basic Immunology 3. Advanced Immunology 4. Medical Immunology 5. Pharmaceutical Immunology 9. Clinical Immunology 6. Environmental Immunology 8. Cellular and Molecular Immunology 9. Food and Agricultural Immunology

History of immunology

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History of immunology

General immunological concepts

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  • Immunity against:

Components of the immune system

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Immune system

  Adaptive immune system

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Adaptive immune system

  • Kinds of antibodies
  • Classification
  • Functions
  • Regions

  Innate immune system

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Innate immune system

  • Positive
  • Negative

Organs of the immune system

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Lymphatic system

  Primary lymphoid organs

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Primary lymphoid organs

  Secondary lymphoid organs

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Secondary lymphoid organs

Cells of the immune system

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White blood cells

  Myeloid cells

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Main articles: Myeloid cells and Phagocytes
See also: Sentinel cell

  Lymphoid cells

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Lymphoid cells

  Others

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(Non-hematopoietic cells with immune functions)

  Hematopoiesis

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Main articles: Hematopoiesis and Hematopoietic stem cell
See also: Leukopoiesis, Extramedullary hematopoiesis, and Cellular differentiation

Molecules of the immune system

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Immune receptors

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Main articles: Immune receptor and co-receptors
See also: List of immune receptors

   Antigen receptors

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  • Stimulatory
  • Inhibitory
  • Accessory molecule (CD79)
  • Co-receptors
  • Accessory molecules

   Pattern recognition receptors (PRRs)

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Pattern recognition receptor

See also: List of pattern recognition receptors
See also: Pathogen-associated molecular pattern and Damage-associated molecular pattern
See also: C-type lectin
  • Dectin 1 subfamily
  • DCIR subfamily
  • Class A - Trimers
  • Class B - Two transmembrane domains
  • Others
  • NLRA (A for acidic transactivating domain)
  • NLRX

   Complement receptors

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Complement receptor

   Fc receptors

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Fc receptor

See also: List of Fc receptors
  • Secreted Fc receptors

   Cytokine receptors

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Cytokine receptor

See also: List of cytokine receptors
  • Others
  • EPOR (Erythropoietin receptor) - Homodimer
  • G-CSFR (CD114) - Homodimer upon ligand binding
  • MPL (CD110, Thrombopoietin receptor) - Homodimer upon ligand binding
  • GHR (Growth hormone receptor) - Homodimer upon ligand binding
  • PRLR (Prolactin receptor)
  • Interleukin receptors

   Natural killer cell receptors

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Natural killer cell receptors

  • Activating KIRs
  • Two domains, long cytoplasmic tail
  • Two domains, short cytoplasmic tail
  • Three domains, long cytoplasmic tail
  • Three domains, short cytoplasmic tail

   Others

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Antibodies

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Antibodies

Cytokines

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Cytokine

See also: Proinflammatory cytokine, Monokine, and Lymphokine
See also: Chemotaxis
  • CX3CL1 (Fractalkine, Neurotactin)

MHCs

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Major histocompatibility complex

See also: Human leukocyte antigen

Complement proteins

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  • Early stage (divided by pathway)
  • Middle stage
  • Late stage
  • Complement pathway inhibitors

Antimicrobial peptides

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Antimicrobial peptides

Transcription factors

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  • T-bet - TH1 differentiation
  • GATA3 - TH2 differentiation
  • RORγT - TH17 differentiation
  • BCL6 - TFH differentiation
  • FoxP3 - Treg differentiation

Signaling pathways

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Cell adhesion molecules (CAMs)

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Cell adhesion molecules

See also: List of cell adhesion molecules
  • Alpha subunits
  • Beta subunits
  • Dimers
  • Cytoadhesin receptor
  • Leukocyte-adhesion receptor:
  • Very late antigen receptor:
  • Others

Others

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  • CD28 - Expressed by T Cells
  • CD278 (ICOS) - Homodimer, expressed by T Cells
  • CTLA-4 (CD152)
  • PD-1 (CD279)

Immune system disorders

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Immune disorder

Hypersensitivity and Allergy

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Main articles: Hypersensitivity, Autoimmunity, and Autoimmune disease
  • Foreign
  • Autoimmune
  • Foreign
  • Autoimmune
  • Foreign
  • Autoimmune
  • GVHD (Graft-versus-host disease)
  • Unknown/Multiple types
  • Foreign
  • Autoimmune

Immunodeficiency

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Immunodeficiency

See also: Immunocompetence

Cancers of the immune system

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Myeloid diseases

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Inflammatory diseases

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Immunoproliferative immunoglobulin disorders

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Immunoproliferative immunoglobulin disorders

Lymphatic organ disease

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Immunologic techniques and tests

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Immunology and health

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Immunologists

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List of immunologists

Immunology lists

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References

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  1. ^ Janeway's Immunobiology textbook Searchable free online version at the National Center for Biotechnology Information
  2. ^ "HGNC Gene Group: C-type lectin domain containing". Retrieved 2019-08-30.
  3. ^ Geijtenbeek TB, Gringhuis SI (July 2009). "Signalling through C-type lectin receptors: shaping immune responses". Nat. Rev. Immunol. 9 (7): 465–79. doi:10.1038/nri2569. PMC 7097056. PMID 19521399.
  4. ^ Royet J, Gupta D, Dziarski R (December 2011). "Peptidoglycan recognition proteins: modulators of the microbiome and inflammation". Nat. Rev. Immunol. 11 (12): 837–51. doi:10.1038/nri3089. PMID 22076558. S2CID 5266193.
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