Synaptotagmin-7 is a protein that in humans is encoded by the SYT7 gene.[5][6]

SYT7
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSYT7, IPCA-7, IPCA7, PCANAP7, SYT-VII, SYTVII, synaptotagmin 7
External IDsOMIM: 604146; MGI: 1859545; HomoloGene: 20889; GeneCards: SYT7; OMA:SYT7 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_018801
NM_173067
NM_173068
NM_001373944

RefSeq (protein)

NP_061271
NP_775090
NP_775091

Location (UCSC)Chr 11: 61.51 – 61.58 MbChr 19: 10.37 – 10.43 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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Synaptotagmins, such as SYT7, are calcium-dependent phospholipid-binding proteins known for their role in synaptic exocytosis and neurotransmitter release. Significant expression has also been observed in the prostate and other tissues. See MIM 600782 [supplied by OMIM][6]

Interactions

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SYT7 has been shown to interact with SYNCRIP.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000011347Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024743Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Cooper PR, Nowak NJ, Higgins MJ, Church DM, Shows TB (May 1998). "Transcript mapping of the human chromosome 11q12-q13.1 gene-rich region identifies several newly described conserved genes". Genomics. 49 (3): 419–29. doi:10.1006/geno.1998.5291. PMID 9615227.
  6. ^ a b "Entrez Gene: SYT7 synaptotagmin VII".
  7. ^ Mizutani A, Fukuda M, Ibata K, Shiraishi Y, Mikoshiba K (March 2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms". The Journal of Biological Chemistry. 275 (13): 9823–31. doi:10.1074/jbc.275.13.9823. PMID 10734137.

Further reading

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  • Overview of all the structural information available in the PDB for UniProt: O43581 (Human Synaptotagmin-7) at the PDBe-KB.
  • Overview of all the structural information available in the PDB for UniProt: Q9R0N7 (Mouse Synaptotagmin-7) at the PDBe-KB.