CCBP2

Chemokine-binding protein 2 is a protein that in humans is encoded by the CCBP2 gene.

ACKR2
Identifiers
Aliases	ACKR2, CCBP2, CCR10, CCR9, CMKBR9, D6, hD6, atypical chemokine receptor 2
External IDs	OMIM: 602648; MGI: 1891697; HomoloGene: 992; GeneCards: ACKR2; OMA:ACKR2 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3p22.1 Start 42,804,752 bp End 42,887,974 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 F4 Start 121,727,421 bp End 121,740,140 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in placenta right lobe of liver testicle gonad tibial nerve sural nerve subcutaneous adipose tissue tibialis anterior muscle mucosa of transverse colon left coronary artery Top expressed in right lung lobe ankle left lung lobe embryo skin of external ear carotid body decidua gastrula submandibular gland mesenteric lymph nodes More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signal transducer activity chemokine receptor activity C-C chemokine binding G protein-coupled receptor activity scavenger receptor activity C-C chemokine receptor activity chemokine binding Cellular component integral component of membrane early endosome recycling endosome membrane actin filament endosome plasma membrane integral component of plasma membrane nucleoplasm cytosol nuclear membrane intracellular membrane-bounded organelle external side of plasma membrane Biological process signal transduction multicellular organism development inflammatory response immune response chemokine-mediated signaling pathway G protein-coupled receptor signaling pathway chemotaxis receptor-mediated endocytosis positive regulation of cytosolic calcium ion concentration calcium-mediated signaling cell chemotaxis vesicle-mediated transport endocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1238 59289 Ensembl ENSG00000144648 ENSMUSG00000044534 UniProt O00590 O08707 RefSeq (mRNA) NM_001296 NM_001276719 NM_021609 RefSeq (protein) NP_001287 NP_001263648 NP_067622 Location (UCSC) Chr 3: 42.8 – 42.89 Mb Chr 9: 121.73 – 121.74 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes.

Further reading

• Nibbs RJ, Wylie SM, Pragnell IB, Graham GJ (1997). "Cloning and characterization of a novel murine beta chemokine receptor, D6. Comparison to three other related macrophage inflammatory protein-1alpha receptors, CCR-1, CCR-3, and CCR-5". J. Biol. Chem. 272 (19): 12495–504. doi:10.1074/jbc.272.19.12495. PMID 9139699.
• Nibbs RJ, Yang J, Landau NR, et al. (1999). "LD78beta, a non-allelic variant of human MIP-1alpha (LD78alpha), has enhanced receptor interactions and potent HIV suppressive activity". J. Biol. Chem. 274 (25): 17478–83. doi:10.1074/jbc.274.25.17478. PMID 10364178.
• Maho A, Bensimon A, Vassart G, Parmentier M (2000). "Mapping of the CCXCR1, CX3CR1, CCBP2 and CCR9 genes to the CCR cluster within the 3p21.3 region of the human genome". Cytogenet. Cell Genet. 87 (3–4): 265–8. doi:10.1159/000015443. PMID 10702689. S2CID 1178132.
• Gosling J, Dairaghi DJ, Wang Y, et al. (2000). "Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK". J. Immunol. 164 (6): 2851–6. doi:10.4049/jimmunol.164.6.2851. PMID 10706668.
• Jarmin DI, Rits M, Bota D, et al. (2000). "Cutting edge: identification of the orphan receptor G-protein-coupled receptor 2 as CCR10, a specific receptor for the chemokine ESkine". J. Immunol. 164 (7): 3460–4. doi:10.4049/jimmunol.164.7.3460. PMID 10725696.
• Homey B, Wang W, Soto H, et al. (2000). "Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC)". J. Immunol. 164 (7): 3465–70. doi:10.4049/jimmunol.164.7.3465. PMID 10725697.
• Wang W, Soto H, Oldham ER, et al. (2000). "Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2)". J. Biol. Chem. 275 (29): 22313–23. doi:10.1074/jbc.M001461200. PMID 10781587.
• Nibbs RJ, Kriehuber E, Ponath PD, et al. (2001). "The beta-chemokine receptor D6 is expressed by lymphatic endothelium and a subset of vascular tumors". Am. J. Pathol. 158 (3): 867–77. doi:10.1016/s0002-9440(10)64035-7. PMC 1850343. PMID 11238036.
• Homey B, Alenius H, Müller A, et al. (2002). "CCL27-CCR10 interactions regulate T cell-mediated skin inflammation". Nat. Med. 8 (2): 157–65. doi:10.1038/nm0202-157. PMID 11821900. S2CID 35433583.
• Soler D, Humphreys TL, Spinola SM, Campbell JJ (2003). "CCR4 versus CCR10 in human cutaneous TH lymphocyte trafficking". Blood. 101 (5): 1677–82. doi:10.1182/blood-2002-07-2348. PMID 12406880.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Fra AM, Locati M, Otero K, et al. (2003). "Cutting edge: scavenging of inflammatory CC chemokines by the promiscuous putatively silent chemokine receptor D6". J. Immunol. 170 (5): 2279–82. doi:10.4049/jimmunol.170.5.2279. PMID 12594248.
• Kunkel EJ, Kim CH, Lazarus NH, et al. (2003). "CCR10 expression is a common feature of circulating and mucosal epithelial tissue IgA Ab-secreting cells". J. Clin. Invest. 111 (7): 1001–10. doi:10.1172/JCI17244. PMC 152588. PMID 12671049.
• Galliera E, Jala VR, Trent JO, et al. (2004). "beta-Arrestin-dependent constitutive internalization of the human chemokine decoy receptor D6". J. Biol. Chem. 279 (24): 25590–7. doi:10.1074/jbc.M400363200. PMID 15084596.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Neil SJ, Aasa-Chapman MM, Clapham PR, et al. (2005). "The promiscuous CC chemokine receptor D6 is a functional coreceptor for primary isolates of human immunodeficiency virus type 1 (HIV-1) and HIV-2 on astrocytes". J. Virol. 79 (15): 9618–24. doi:10.1128/JVI.79.15.9618-9624.2005. PMC 1181543. PMID 16014924.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

External links

• Human ACKR2 genome location and ACKR2 gene details page in the UCSC Genome Browser.
• Human CCR10 genome location and CCR10 gene details page in the UCSC Genome Browser.
• Human CCR9 genome location and CCR9 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.